Pharmacogenetics of antipsychotic-induced weight gain [2]

Medical Science Monitor

Volumn 12, Issue 5, 2006, Pages

  Fraguas, David ^a   Kirchoff, Daniel ^b  

^a HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^b Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORPROMAZINE; CLOZAPINE; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA3 SUBUNIT; LEPTIN; NEUROLEPTIC AGENT; OLANZAPINE; RISPERIDONE; SEROTONIN 1 RECEPTOR; SEROTONIN 2C RECEPTOR; UNCLASSIFIED DRUG;

ALLELE; DNA POLYMORPHISM; DRUG RESPONSE; GENE EXPRESSION; GENETIC VARIABILITY; GENOTYPE; HUMAN; LETTER; NEUROBIOLOGY; PHARMACOGENETICS; PILOT STUDY; PSYCHOSIS; SCHIZOPHRENIA; SECOND MESSENGER; SIDE EFFECT; WEIGHT GAIN;

ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; PHARMACOGENETICS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN SUBUNITS; SCHIZOPHRENIA; WEIGHT GAIN;

EID: 33646474011     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: None     Document Type: Letter

References (9)

1. Bishop JR, Ellingrod VL, Moline J, Miller D: Pilot study of the G-protein beta3 subunit gene (C825T) polymorphism and clinical response to Olanzapine or Olanzapine-related weight gain in persons with schizophrenia. Med Sci Monit, 2006; 12(2): BR47-50
2. Reynolds GP, Zhang ZJ, Zhang XB: Association of antipsychotic drug-induced weight gain with a 5-HT2C receptor gene polymorphism. Lancet, 2002; 359: 2086-87
3. Buckland PR, Hoogendoorn B, Guy CA et al: Low gene expression conferred by association of an allele of the 5-HT2C receptor gene with antipsychotic-induced weight gain. Am J Psychiatry, 2005; 162(3): 613-15
4. Basile VS, Masellis M, De Luca V et al: 759C/T genetic variation of 5HT(2C) receptor and clozapine-induced weight gain. Lancet, 2002; 360: 1790-91
5. Reynolds GP, Zhang ZJ, Zhang XB: Polymorphism of the promoter region of the serotonin 5-HT2C receptor gene and clozapine- induced weight gain. Am J Psychiatry, 2003; 160: 677-79
6. Theisen FM, Hinney A, Bromel T et al: Lack of association between the -759C/T polymorphism of the 5-HT2C receptor gene and clozapine-induced weight gain among German schizophrenic individuals. Psychiatr Genet, 2004; 14(3): 139-42
7. Templeman LA, Reynolds GP, Arranz B, San L: Polymorphisms of the 5-HT2C receptor and leptin genes are associated with antipsychotic drug-induced weight gain in Caucasian subjects with a first-episode psychosis. Pharmacogenet Genomics, 2005; 15(4): 195-200
8. Ellingrod VL, Perry PJ, Ringold JC et al: Weight gain associated with the -759C/T polymorphism of the 5HT2C receptor and olanzapine. Am J Med Genet B Neuropsychiatr Genet, 2005; 134(1): 76-78
9. Wang YC, Bai YM, Chen JY et al: C825T polymorphism in the human G protein beta3 subunit gene is associated with long-term clozapine treatment-induced body weight change in the Chinese population. Pharmacogenet Genomics, 2005; 15(10): 743-48