Genomic and proteomic approaches to vaccine candidate identification for Anaplasma marginale

Expert Review of Vaccines

Volumn 5, Issue 1, 2006, Pages 95-101

  Brayton, Kelly A ^a   Palmer, Guy H ^a   Brown, Wendy C ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

Anaplasma marginale; Anaplasmosis; Genomics; Major surface protein; Outer membrain protein; Oxytetracycline; proteomics

Indexed keywords

OUTER MEMBRANE PROTEIN; PROTEIN MSP1; PROTEIN MSP2; UNCLASSIFIED DRUG;

ANAPLASMA MARGINALE; BACTERIAL GENOME; GENE IDENTIFICATION; GENE MAPPING; GENE SEQUENCE; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEOMICS; REVIEW;

ANAPLASMA MARGINALE; ANAPLASMOSIS; ANIMALS; BACTERIAL VACCINES; GENOMICS; HUMANS; PROTEOMICS;

EID: 33646471882     PISSN: 14760584     EISSN: 17448395     Source Type: Journal    
DOI: 10.1586/14760584.5.1.95     Document Type: Review

References (51)

1. Lincoln SD. Large Animal Internal Medicine. Smith BP (Ed.). Mosby Publishing, St Louis, MD, USA, 1214-1217 (1996).
2. Palmer GH. Veterinary Protozoan and Hemoparasite Vaccines. Wright IS (Ed.), CRC Press, Boca Raton, FL, USA, 1-29 (1989).
3. National Cattlemen's Beef Association, Animal Disease Research Subcommittee. Resolution for assignment of anaplasmosis as a high priority disease for USDA research. (Appendix 1) (2000).
4. Goodger WJ, Carpenter T, Riemann H. Estimation of economic loss associated with anaplasmosis in California beef cattle. J. Am. Vet. Med. Assoc. 174, 1333-1336 (1979).
5. USDA National Agricultural Statistics Service. Meat animals - production, disposition and income. 1998 summary. Agricultural Statistics Board, Washington DC, USA, 1-30 (1999).
6. Palmer GH, Brown WC, Rurangirwa FR. Antigenic variation in the persistence and transmission of the ehrlichia Anaplasma marginale. Microbes Infect. 2(2), 167-176 (2000).
7. Alderink FJ, Dietrich, R. Proceedings of the Seventh National Anaplasmosis Conference. Hidalgo RJ, Jones EW (Eds), Mississippi State University Press, Starkville, MS, USA, 27-44 (1981).
8. French DM, McElwain TF, McGuire TC, Palmer GH. Expression of Anaplasma marginale major surface protein 2 variants during persistent cyclic rickettsemia. Infect. Immun. 66(3), 1200-1207 (1998).
9. Kieser ST, Eriks IS, Palmer GH. Cyclic rickettsemia during persistent Anaplasma marginale infection of cattle. Infect. Immun. 58(4), 1117-1119 (1990).
10. Stich RW, Kocan KM, Palmer GH et al. Transstadial and attempted transovarial transmission of Anaplasma marginale by Dermacentor variabilis. Am. J. Vet. Res. 50(8), 1377-1380 (1989).
11. Knowles D, Torioni de Echaide S, Palmer G et al. Antibody against an Anaplasma marginale MSP5 epitope common to tick and erythrocyte stages identifies persistently infected cattle. J. Clin. Microbiol. 34(9), 2225-2230 (1996).
12. Coetzee JF, Apley MD, Kocan KM, Rurangirwa FR, Van Donkersgoed J. Comparison of three oxytetracycline regimes for the treatment of persistent Anaplasma marginale infections in beef cattle. Vet. Parasitol. 127(1), 61-73 (2005).
13. Losos GJ in Infectious Tropical Diseases of Domestic Animals. Losos GJ (Ed.), Longman Press, Essex, UK, 742-795 (1986).
14. Rogers RJ, Dimmock CK, de Vos AJ, Rodwell BJ. Bovine leucosis virus contamination of a vaccine produced in vivo against bovine babesiosis and anaplasmosis. Aust. Vet. J. 65(9), 285-287 (1988).
15. Palmer GH, Rurangirwa FR, Kocan, Brown WC. Molecular basis for vaccine development against the ehrlichial pathogen Anaplasma marginale. Parasitol. Today 15(7), 281-286 (1999). Discusses the protective immune response to Anaplasma marginale.
16. Tebele N, McGuire TC, Palmer GH. Induction of protective immunity by using Anaplasma marginale initial body membranes. Infect. Immun. 59(9), 3199-3204(1991). Describes outer membrane protein (OMP)-induced protection.
17. Brown WC, Shkap V, Zhu D et al. CD4(+) T-lymphocyte and immunoglobulin G responses in calves immunized with Anaplasma marginale outer membranes and protected against homologous challenge. Infect. Immun. 66(11), 5406-5413 (1998). Describes OMP-induced protection.
18. Barbet AF & Allred, DR. The msp1-b multigene family of Anaplasma marginale: nucleotide sequence analysis of an expressed copy. Infect. Immun. 59(3), 971-976 (1991).
19. Allred DR, McGuire TC, Palmer GH et al. Molecular basis for surface antigen size polymorphisms and conservation of a neutralization-sensitive epitope in Anaplasma marginale. Proc. Natl Acad. Sci. USA 87(8), 3220-3224 (1990).
20. Palmer GH, Eid G, Barbet AF, McGuire TC, McElwain TF. The immunoprotective Anaplasma marginale major surface protein 2 is encoded by a polymorphic multigene family. Infect. Immun. 62(9), 3808-3816 (1994).
21. Alleman AR, Palmer GH, McGuire TC et al. Anaplasma marginale major surface protein 3 is encoded by a polymorphic, multigene family. Infect. Immun. 65(1), 156-163 (1997).
22. Oberle SM, Barbet AF. Derivation of the complete msp4 gene sequence of Anaplasma marginale without cloning. Gene 136(1-2), 291-294 (1993).
23. Visser ES, McGuire TC, Palmer GH et al. The Anaplasma marginale msp5 gene encodes a 19-kilodalton protein conserved in all recognized Anaplasma species. Infect. Immun. 60(12), 5139-5144 (1992).
24. Brayton KA, Kappmeyer LS, Herndon DR et al. Complete genome sequencing of Anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins. Proc. Natl Acad. Sci. USA 102(3), 844-849 (2005). Contains the details of the genome sequencing project for A. marginale.
25. Futse JE, Ueti MW, Knowles DP Jr, Palmer GH. Transmission of Anaplasma marginale by Boophilus microplus: retention of vector competence in the absence of vector-pathogen interaction. J. Clin. Microbiol. 41(8), 3829-3834 (2003).
26. Eriks IS, Stiller D, Goff WL et al. Molecular and biological characterization of a newly isolated Anaplasma marginale strain. J. Vet. Diagn. Invest. 6(4), 435-441 (1994).
27. Tettelin H, Saunders NJ, Heidelberg J et al. Complete genome sequence of Neisseria meningitidis serogroup B strain MC58. Science 287(5459), 1809-1815 (2000).
28. Fraser CM, Casjens S, Huang WM et al. Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi. Nature 390(6660), 580-586 (1997).
29. Vidotto MC, McGuire TC, McElwain TF, Palmer GH, Knowles DP Jr. Intermolecular relationships of major surface proteins of Anaplasma marginale. Infect. Immun. 62(7), 2940-2946 (1994).
30. Bateman A, Coin L, Durbin R et al. The Pfam protein families database. Nucleic Acids Res. 32 (Database issue) D138-D141 (2004).
31. Meeus PF, Brayton KA, Palmer GH, Barbet AF. Conservation of a gene conversion mechanism in two distantly related paralogues of Anaplasma marginale. Mol. Microbiol. 47(3), 633-643 (2003).
32. French DM, Brown WC, Palmer GH. Emergence of Anaplasma marginale antigenic variants during persistent rickettsemia. Infect. Immun. 67(11), 5834-5840 (1999).
33. + T-lymphocyte epitopes that elicit variant-specific proliferative and IFN-γ responses in MSP2 vaccinates. J. Immunol. 170(7), 3790-3798 (2003).
34. Brayton KA, Palmer GH, Lundgren A, Yi J, Barbet AF. Antigenic variation of Anaplasma marginale msp2 occurs by combinatorial gene conversion. Mol. Microbiol. 43(5), 1151-1159 (2002). Describes the antigenic variation mechanism for major surface protein (msp)2 (also used by msp3), which makes them particularly challenging for vaccine development.
35. Brayton KA, Knowles DP, McGuire TC, Palmer GH. Efficient use of a small genome to generate antigenic diversity in tick-borne ehrlichial pathogens. Proc. Natl Acad. Sci. USA 98(7), 4130-4135 (2001).
36. Lohr CV, Brayton KA, Shkap V et al. Expression of Anaplasma marginale major surface protein 2 operon-associated proteins during mammalian and arthropod infection. Infect. Immun. 70(11), 6005-6012 (2002).
37. Noh SM, Brayton KA, Knowles DP et al. Differential expression and sequence conservation of the Anaplasma marginale msp2 gene superfamily outer membrane proteins. Infect. Immun. (In Press)
38. Palmer GH, Rurangirwa FR, McElwain TF. Strain composition of the ehrlichia Anaplasma marginale within persistently infected cattle, a mammalian reservoir for tick transmission. J. Clin. Microbiol. 39(2), 631-635 (2001).
39. Brown WC, Palmer GH, Lewin HA, McGuire TC. CD4(+) T-lymphocytes from calves immunized with Anaplasma marginale major surface protein 1 (MSP1), a heteromeric complex of MSP1a and MSP1b, preferentially recognize the MSP1a carboxyl terminus that is conserved among strains. Infect. Immun. 69(11), 6853-6862 (2001).
40. Palmer GH, Knowles DP Jr, Rodriguez JL et al. Stochastic transmission of multiple genotypically distinct Anaplasma marginale strains in a herd with high prevalence of Anaplasma infection. J. Clin. Microbiol. 42(11), 5381-5384 (2004).
41. de La Fuente J, Passos LM, van Den Bussche RA et al. Genetic diversity and molecular phylogeny of Anaplasma marginale isolates from Minas Gerais, Brazil. Vet. Parasitol. 121(3-4), 307-316 (2004).
42. Viseshakul N, Kamper S, Bowie MV, Barbet AF. Sequence and expression analysis of a surface antigen gene family of the rickettsia Anaplasma marginale. Gene 253(1), 45-53 (2000).
43. Palmer GH, Barbet AF, Cantor GH, McGuire, TC. Immunization of cattle with the MSP-1 surface protein complex induces protection against a structurally variant Anaplasma marginale isolate. Infect. Immun. 57(11), 3666-3669 (1989).
44. Palmer GH, Barbet AF, Davis WC, McGuire TC. Immunization with an isolate-common surface protein protects cattle against anaplasmosis. Science 231(4743), 1299-1302 (1986).
45. Lopez JE, Siems WF, Palmer GH et al. Identification of novel antigenic proteins in a complex Anaplasma marginale outer membrane immunogen by mass spectrometry and genomic mapping. Infect. Immun. 73(12), 8109-8118 (2005). Describes the proteomic approach used to identify vaccine candidates.
46. Palmer GH, Kocan KM, Barron SJ et al. Presence of common antigens, including major surface protein epitopes, between the cattle (intraerythrocytic) and tick stages of Anaplasma marginale. Infect. Immun. 50(3), 881-886 (1985).
47. Stich RW, Olah GA, Brayton KA et al. Identification of a novel Anaplasma marginale appendage-associated protein that localizes with actin filaments during intraerythrocytic infection. Infect. Immun. 72(12), 7257-7264 (2004).
48. Riding G, Hope M, Waltisbuhl D, Willadsen P. Identification of novel protective antigens from Anaplasma marginale. Vaccine 21(17-18), 1874-1883 (2003).
49. Barigye R, Garcia-Ortiz MA, Rojas Ramirez EE, Rodriguez SD. Identification of IgG2-specific antigens in Mexican Anaplasma marginale strains. Ann. NY Acad. Sci. 102684-102694 (2004).
50. Hope M, Riding G, Menzies M, Willadsen P. A novel antigen from Anaplasma marginale: characterization, expression and preliminary evaluation of the recombinant protein. Vaccine 22(3-4), 407-415 (2004).
51. Eid G, French DM, Lundgren AM et al. Expression of major surface protein 2 antigenic variants during acute Anaplasma marginale rickettsemia. Infect. Immun. 64(3), 836-841 (1996).