Fifty years of genetic epidemiology, with special reference to Japan

Journal of Human Genetics

Volumn 51, Issue 4, 2006, Pages 269-277

  Morton, Newton E ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Association mapping; Genetic diversity; Genetic epidemiology; Genetic loads; Human genome; Linkage; Linkage disequilibrium; Segregation

Indexed keywords

DNA;

CYTOGENETICS; DNA HELIX; DNA POLYMORPHISM; GENE SEGREGATION; GENETIC EPIDEMIOLOGY; GENETIC LINKAGE; GENETIC RECOMBINATION; HISTORY OF MEDICINE; HUMAN; HUMAN GENOME PROJECT; INHERITANCE; JAPAN; POPULATION RESEARCH; SHORT SURVEY;

EPIDEMIOLOGY; GENETICS; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; JAPAN;

EID: 33646455747     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10038-006-0366-9     Document Type: Short Survey

References (70)

1. Allison AC (1964) Polymorphism and natural selection in human populations. Cold Spring Harbour Symp Quant Biol 24:137-149
2. Carlson EA (2004) Mendel's legacy. The origin of classical genetics. Cold Spring Harbor Laboratory Press, Long Island
3. Collins A, Morton NE (1998) Mapping a disease locus by allelic association. Proc Natl Acad Sci USA 95:1741-1745
4. Collins A, Frezal J, Teague J, Morton NE (1996) A metric map of humans: 23,500 loci in 850 bands. Proc Natl Acad Sci USA 93:14771-14775
5. Cook-Deegan RM (1991) The human genome project: the formation of federal policies in the United States, 1986-1990. In: Hanna KE (ed) Biomedical politics. National Academy Press, Washington, DC
6. Crow JF (1987) Muller, Dobzhansky, and overdominance. J Hist Biol 20:351-380
7. Dalmasso C, Broet P, Moreau T (2004) A simple procedure for estimating the false discovery rate. Bioinformatics 21:660-668
8. Elston RC, Stewart J (1971) A general model for the genetic analysis of pedigree data. Hum Hered 21:523-542
9. Feder JN, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy DA, Basava A, Dormishian F, Domingo R Jr, Ellis MC, Fullan A et al (1996) A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 13:399-408
10. Fujii T, Moloney WC, Morton NE (1955) Data on linkage of ovalocytosis and blood groups. Am J Hum Genet 7:72-75
11. Goodall HB, Hendry DWW, Lawler SD, Stephen SA (1953) Data on linkage in man: elliptocytosis and blood groups II. Family 3. Ann Eugen 17:272-278
12. Haga H, Yamoda R, Ohnishi Y, Nakamura Y, Tanaka T (2002) Gene-based SNP discovery as part of the Japanese Millennium Genome Project: identification of 190562 genetic variations in the human genome. J Hum Genet 47:605-610
13. Haldane JBS (1957) The cost of natural selection. J Genet 55: 511-524
14. Hill WG, Robertson A (1968) Linkage disequilibrium in finite populations. Theor Appl Genet 38:226-231
15. Imaizumi Y (1986) A recent survey of consanguineous marriages in Japan. Clin Genet 30:230-233
16. International HapMap Consortium (2005) A haplotype map of the human genome. Nature 437:1299-1320
17. International Human Genome Sequencing Consortium (2004) Finishing the euchromatic sequence of the human genome. Nature 431:931-945
18. Jeffreys AJ, Kauppi L, Neumann R (2001) Intensely punctate meiotic recombination in the class II region of the major histocompatibility complex. Nat Genet 29:217-222
19. Kerem B, Rommens JM, Buchanan JA, Markiewicz D, Cox TK, Chakravarti A, Buchwald M, Tsui L-C (1989) Identification of the cystic fibrosis gene: genetic analysis. Science 245:1073-1080
20. Kimura M (1960) Optimum mutation rate and degree of dominance as determined by the principle of minimum genetic load. J Genet 57: 21-34
21. Kimura M (1968) Evolutionary rate at the molecular level. Nature 217: 624-626
22. King M-C, Ree GM, Spinner NB, Thomson G, Wrensch MR (1984) Genetic epidemiology. Annu Rev Public Health 5:1-52
23. Lander E, Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:244-247
24. Lewontin RC (1964) The interaction of selection and linkage. I General considerations. Genetics 49:49-67
25. Lewontin RC (1975) Genetic aspects of intelligence. Annu Rev Genet 9:387-405
26. Lonjou C, Collins A, Ajioka RS, Jorde LB, Kushner JP, Morton NE (1998) Allelic association under map error and recombinational heterogeneity: a tale of two sites. Proc Natl Acad Sci USA 95:11366-11370
27. Lynn A, Ashley T, Hassold T (2004) Variation in human meiotic recombination. Annu Rev Genomics Hum Genet 5:317-349
28. Malecot G (1948) Les mathématiques de l'héré dité. Masson, Paris
29. Maniatis N, Collins A, Xu C-F, McCarthy LC, Hewett DR, Tapper W, Ennis S, Ke K, Morton NE (2002) The first linkage disequilibrium (LD) maps: delineation of hot and cold blocks by diplotype analysis. Proc Natl Acad Sci USA 99:2228-2233
30. Maniatis N, Morton NE, Gibson J, Xu C-F, Hosking LK, Collins A (2005) The optimal measure of linkage disequilibrium reduces error in association mapping of affection status. Hum Mol Genet 14:145-153
31. Mohr J (1951) Estimation of linkage between the Lutheran and the Lewis blood groups. Acta Pathol Microbiol Scand 29:339-344
32. Mohr J (1954) A study of linkage in man. Munksgaard, Copenhagen
33. Morton NE (1955) Sequential tests for the detection of linkage. Am J Hum Genet 7:277-318
34. Morton NE (1956) The detection and estimation of linkage between the genes for elliptocytosis and the Rh blood group. Am J Hum Genet 8:80-96
35. Morton NE (1959) Genetic tests under incomplete ascertainment. Am J Hum Genet 11:1-16
36. Morton NE (1982) Outline of genetic epidemiology. Karger, Basle
37. Morton NE (1998) Significance tests in complex inheritance. Am J Hum Genet 62:690-697
38. Morton NE (1997) Genetic epidemiology. Ann Hum Genet 61:1-13
39. Morton NE, Chung CS (1978) Genetic epidemiology. Academic Press, New York
40. Morton NE, Crow JF, Muller HJ (1956) An estimate of the mutational damage in man from data on consanguineous marriages. Proc Natl Acad Sci USA 42:855-865
41. Morton NE, Zhang W, Taillon-Miller P, Ennis S, Kwok P-Y, Collins A (2001) The optimal measure of allelic association. Proc Natl Acad Sci USA 98:5217-5221
42. Mullis KB, Faloona FA (1987) Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. Methods Enzymol 155:335-350
43. Nakamura Y (2005) Scientists create Japan's largest BioBank for genetic studies of 47 common diseases (Interview). Affymetrix Microarray Bull 1:16-19
44. Neel JV, Schull WJ (1954) Human heredity. University of Chicago Press, Chicago
45. Neel JV, Morton NE, Schull WJ, McDonald DJ, Kodani M, Takeshima K, Anderson RC, Wood J, Brewer K, Wright S, Yamazaki J, Suzuki M, Kitamura S (1953) The effects of exposure of parents to the atomic bombs on the first generation offspring in Hiroshima and Nagasaki: (preliminary report). Jpn J Genet 28:211-218
46. Ott J (1976) A computer program for linkage analysis of general human pedigrees. Am J Hum Genet 28:528-529
47. Ozaki K, Ohnishi Y, Iida A, Akihiko S, Yamada R, Tsunoda T, Sato H, Hori M, Nakamura Y, Tanaka T (2002) Functional SNPs in the lymphotoxin-α gene that are associated with susceptibility to myocardial infarction. Nat Genet 32:650-654
48. Pawlowitski I-H, Edwards JH, Thompson EA (1997) Genetic mapping of disease genes. Academic, San Diego
49. Rao DC, Province MA (2001) Genetic dissection of complex traits. Academic, San Diego
50. Rao DC, Morton NE, Elston RC, Yee S (1977) Causal analysis of academic performance. Behav Genet 7:147-159
51. Rao DC, Morton NE, Cloninger CR (1979 Path analysis under generalized assortative mating. I Theory Genet Res 33:175-188
52. Rao DC, Morton NE, Lalouel JM, Lew R (1982) Path analysis under generalized assortative mating. II American IQ. Genet Res 39:187-198
53. Risch N, Merikangas K (1996) The future of genetic studies of complex human diseases. Science 273:1516-1517
54. Schull WJ, Neel JV, Hashizumi A (1966) Some further observations on the sex ratio among infants born to survivors of the atomic bombings of Hiroshima and Nagasaki. Am J Hum Genet 18:328-338
55. Simon M, Bourel M, Fouchet R, Genetet B (1976) Idiopathic hemochromatosis and HLA-antigens. Diabete Metab 2:113-118
56. Smith CAB (1953) The detection of linkage in human genetics. J R Stat Soc B 15:153-192
57. Smithies O (1955) Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults. Biochem J 61:629-641
58. Solomon E, Bodmer WF (1979) Evolution of sickle variant gene. Lancet 1(8122):923
59. Storey JD, Tibshirani R (2003) Statistical significance for genome-wide studies. Proc Natl Acad Sci USA 100:9440-9445
60. Suarez BK, Rice J, Reich T (1978) The generalized sib pair IBD distribution: its use in the detection of linkage. Ann Hum Genet 42:87-94
61. Sved JA (1971) Linkage disequilibrium and homozygosity of chromosome segments in finite populations. Theor Popul Biol 2:125-141
62. Tapper W, Collins A, Gibson J, Maniatis N, Ennis S, Morton NE (2005) A map of the human genome in linkage disequilibrium units. Proc Natl Acad Sci 102:11835-11839
63. Terwilliger JD (1995) A powerful likelihood method for the analysis of linkage disequilibrium between loci and one or more polymorphic marker loci. Am J Hum Genet 56:777-787
64. Thomas DC, Haile RW, Duggan D (2005) Recent developments in genomewide association scans: a workshop summary and review. Am J Hum Genet 77:337-345
65. Tjio JH, Levan A (1956) The chromosome number of man. Hereditas 42:1-6
66. Watson JD, Crick FHC (1953) Molecular structure of nucleic acids. Nature 171:737-738
67. Watson J, Cyranoski D (2005) Beset by practical hurdles, U.K. BioBank moves at sluggish pace. Nat Med 11:696
68. Yanase T (1997) Human genetics: past, present, and future, with special reference to major trends in Japan. Jpn J Hum Genet 42:265-316
69. Zhang W, Collins A, Maniatis N, Tapper W, Morton NE (2002) Properties of linkage disequilibrium maps. Proc Natl Acad Sci USA 99:17004-17007
70. Zhang W, Collins A, Morton NE (2004) Does haplotype diversity predict power for association mapping of disease susceptibility? Hum Genet 115:157-164