Expression, purification, and characterization of an enzymatically active truncated human Rho-Kinase I (ROCK I) domain expressed in Sf-9 insect cells

Protein and Peptide Letters

Volumn 13, Issue 4, 2006, Pages 369-376

  Khandekar, Sanjay S ^a   Yi, Tracey ^a   Dul, Ed ^a   Wright, Lois L ^a   Chen, Susan ^a   Scott, Gilbert F ^a   Smith, Gary K ^a   Lee, Dennis ^a   Hu, Erding ^a   Kirkpatrick, Robert B ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Expression; Inhibition; Kinase domain; Kinetics; ROCK I

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; AMIDE; DRUG DERIVATIVE; FASUDIL; PROTEIN SERINE THREONINE KINASE; PYRIDINE DERIVATIVE; RHO KINASE; RHO-ASSOCIATED KINASE; SIGNAL PEPTIDE; STAUROSPORINE;

AMINO ACID SEQUENCE; ANIMAL; ARMYWORM; ARTICLE; BIOSYNTHESIS; DRUG ANTAGONISM; HUMAN; IC 50; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR GENETICS; MOLECULAR WEIGHT; PROTEIN TERTIARY STRUCTURE;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; AMIDES; AMINO ACID SEQUENCE; ANIMALS; HUMANS; INHIBITORY CONCENTRATION 50; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; SPODOPTERA; STAUROSPORINE;

INSECTA;

EID: 33646427496     PISSN: 09298665     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986606775974357     Document Type: Article

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