Tp53-associated growth arrest and DNA damage repair gene expression is attenuated in mammary epithelial cells of rats fed whey proteins

Journal of Nutrition

Volumn 136, Issue 5, 2006, Pages 1156-1160

  Dave, Bhuvanesh ^a   Eason, Renea R ^a   Geng, Yan ^a   Su, Ying ^a   Badger, Thomas M ^a   Simmen, Rosalia C M ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

DNA damage; Mammary gland; Monocyte chemoattractant protein 1; Tp53; Whey proteins

Indexed keywords

CASEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN HYDROLYSATE; PROTEIN P21; PROTEIN P53;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; BREAST EPITHELIUM; CELL STRAIN MCF 7; CONTROLLED STUDY; DIET; DIETARY INTAKE; DNA DAMAGE; FEMALE; GENE EXPRESSION; GESTATION PERIOD; IMMUNOSURVEILLANCE; NONHUMAN; RAT; WHEY;

ANIMALIA; MINK CELL FOCUS-FORMING VIRUS;

EID: 33646416165     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/136.5.1156     Document Type: Article

References (35)

1. Jemal A, Murray T, Ward E, Samuels A, Tiwari RC, Ghafoor A, Feuer EJ. Thun MJ Cancer Statistics 2005. CA Cancer J Clin. 2005;55:10-30.
2. Hankinson SE, Colditz GA, Willett WC. Towards an integrated model for breast cancer etiology: the lifelong interplay of genes, lifestyle, and hormones. Breast Cancer Res. 2004;6:213-8.
3. Barker DJ. Maternal nutrition, fetal nutrition, and disease in later life. Nutrition. 1997;13:807-13.
4. Wu AH, Wan P, Hankin J, Tseng CC, Yu MC, Pike MC. Adolescent and adult soy intake and risk of breast cancer in Asian-Americans. Carcinogenesis. 2002;23:1491-6.
5. Hawrylewicz EJ, Huang HH, Blair WH. Dietary soybean isolate and methionine supplementation affect mammary tumor progression in rats. J Nutr. 1991;121:1693-8.
6. Mizunuma H, Kanazawa K, Ogura S, Otsuka S, Nagai H. Anticarcinogenic effects of isoflavones may be mediated by genistein in mouse mammary tumor virus-induced breast cancer. Oncology. 2002;62:78-84.
7. Eason RR, Velarde MC, Chatman L Jr, Till SR, Geng Y, Ferguson M, Badger TM, Simmen RCM. Dietary exposure to whey proteins alters rat mammary gland proliferation, apoptosis, and gene expression during postnatal development. J Nutr. 2004;134:3370-7.
8. Hursting SD, Perkins SN, Phang JM, Barrett JC. Diet and cancer prevention studies in p53-deficient mice. J Nutr. 2001;131:3092S-4.
9. Vissac-Sabatier C, Coxam V, Dechelotte P, Picherit C, Horcajada MN, Davicco MJ, Lbecque P, Bignon YJ, Bernard-Gallon D. Phytoestrogen-rich diets modulate expression of Brca1 and Brca2 tumor suppressor genes in mammary glands of female Wistar rats. Cancer Res. 2003;63:6607-12.
10. Dave B, Eason RR, Till SR, Geng Y, Velarde MC, Badger TM, Simmen RCM. The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN. Carcinogenesis. 2005;26:1793-803.
11. Harris CC. Structure and function of the p53 tumor suppressor gene: clues for national cancer therapeutic strategies. J Natl Cancer Inst. 1996;88:1442-55.
12. Levine AJ. p53, the cellular gatekeeper for growth and division. Cell. 1997;88:323-31.
13. Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA, Butel JS, Bradley A. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature. 1992;356:215-21.
14. Albrechtsen N, Dornreiter I, Grosse F, Kim E, Wiesmüller L, Deppert W. Maintenance of genomic integrity by p53: complementary roles for activated and non-activated p53. Oncogene. 1999;18:7706-17.
15. Yu J, Zhang L, Hwang PM, Rago C, Kinzler KW, Vogelstein B. Identification and classification of p53-regulated genes. Proc Natl Acad Sci U S A. 1999;96:14517-22.
16. Yakovlev AG, DiGiovanni S, Wang G, Liu W, Stoica B, Faden AI. Bok and NOXA are essential mediators of p53-dependent apoptosis. J Biol Chem. 2004;279:28367-74.
17. el-Deiry WS. Regulation of p53 downstream genes. Semin Cancer Biol. 1998;8:345-57.
18. Fiscella M, Zhang H, Fan S, Sakaguchi K, Shen S, Mercer WE, Vande Woude GF, O'Connor PM, Appella E. Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner. Proc Natl Acad Sci U S A. 1997;94:6048-53.
19. Stambolic V, MacPherson D, Sas D, Lin Y, Snow B, Jang Y, Benchimol S, Mak TW. Regulation of PTEN transcription by p53. Mol Cell. 2001;8:317-25.
20. Xu X, Qiao W, Linke SP, Cao L, Li W-M, Furth PA, Harris CC, Deng CX. Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Nat Genet. 2001;28:266-71.
21. North S, Hainaut P. p53 and cell-cycle control: a finger in every pie. Pathol Biol. 2000;48:255-70.
22. Bode AM, Dong Z. Post-translational modifications of p53 in tumorigenesis. Nat Rev Cancer. 2004;4:793-805.
23. Marshall K. Therapeutic applications of whey protein. Altern Med Rev. 2004;9:136-56.
24. Kennedy RS, Konok GP, Bounous G, Baruchel S, Lee TD. The use of a whey protein concentrate in the treatment of patients with metastatic carcinoma: a phase I-II clinical trial study. Anticancer Res. 1995;15:2643-9.
25. Rossi D, Zlotnik A. The biology of chemokines and their receptors. Annu Rev Immunol. 2000;18:217-42.
26. Monti P, Leone BE, Marchesi F, Balzano G, Zerbi A, Scaltrini F, Pasquali C, Calori G, Pessi F, et al. The CC chemokine MCP-1/CCL2 in pancreatic cancer progression: regulation of expression and potential mechanisms of antimalignant activity. Cancer Res. 2003;63:7451-61.
27. Reeves PG, Nielsen FH, Fahey GC Jr. AIN93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr. 1993;123:1939-51.
28. Kurata S. Selective activation of p38 MAPK cascade and mitotic arrest caused by low level oxidative stress. J Biol Chem. 2000;275:23413-6.
29. Maffini MV, Calabro JM, Soto AM, Sonnenschein C. Stromal regulation of neoplastic development: age-dependent normalization of neoplastic mammary cells by mammary stroma. Am J Pathol. 2005;167:1405-10.
30. L, NF-kappa B, and p53. Clin Immunol. 1999;93:152-61.
31. Wang J, Friedman E. Downregulation of p53 by sustained JNK activation during apoptosis. Mol Carcinog. 2000;29:179-88.
32. Kagaya T, Nakamoto Y, Sakai Y, Tsuchiyama T, Yagita H, Mukaida N, Kaneko S. Monocyte chemoattractant protein-1 gene delivery enhances antitumor effects of herpes simplex virus thymidine kinase/ganciclovir system in a model of colon cancer. Cancer Gene Ther. 2005 doi:10.1038/sj.cgt.7700908.
33. Hu Y, Sun H, Drake J, Kittrell F, Abba MC, Deng L, Gaddis S, Sahin A, Baggerly K, et al. From mice to humans; identification of commonly regulated genes in mammary cancer via comparative SAGE studies. Cancer Res. 2004;64:7748-55.
34. Fanti P, Nazareth M, Bucelli R, Mineo M, Gibbs K, Kumin M, Grzybek K, Hoeltke J, Raiber L, et al. Estrogen decreases chemokine levels in murine mammary tissue: implications for the regulatory role of MIP-1a and MCP-1/JE in mammary tumor formation. Endocrine. 2003;22:161-8.
35. Inadera H, Sekiya T, Yoshimura T, Matsushima K. Molecular analysis of the inhibition of monocyte chemoattractant protein-1 gene expression by estrogens and xenoestrogens in MCF-7 cells. Endocrinology. 2000;141:50-9.