ANG II induces apoptosis of human vascular smooth muscle via extrinsic pathway involving inhibition of Akt phosphorylation and increased FasL expression

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 290, Issue 5, 2006, Pages

  Li, Yangxin ^a   Song, Yao Hua ^a   Mohler, Jessica ^a   Delafontaine, Patrick ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cell signaling; Growth factors; Insulin like growth factor 1

Indexed keywords

ANGIOTENSIN II; CASPASE 8; FAS LIGAND; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

APOPTOSIS; ARTICLE; CELL CYCLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; VASCULAR SMOOTH MUSCLE;

ANGIOTENSIN II; APOPTOSIS; CELLS, CULTURED; FAS LIGAND PROTEIN; HUMANS; MEMBRANE GLYCOPROTEINS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; ONCOGENE PROTEIN V-AKT; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTORS;

EID: 33646398849     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00551.2005     Document Type: Article

References (50)

1. Ayroldi E, D'Adamio F, Zollo O, Agostini M, Moraca R, Cannarile L, Migliorati G, Delfino DV, and Riccardi C. Cloning and expression of a short Fas ligand: a new alternatively spliced product of the mouse Fas ligand gene. Blood 94: 3456-3467, 1999.
2. Babaev VR, Bobryshev YV, Stenina OV, Tararak EM, and Gabbiani G. Heterogeneity of smooth muscle cells in atheromatous plaque of human aorta. Am J Pathol 136: 1031-1042, 1990.
3. Bascands JL, Girolami JP, Troly M, Escargueil-Blanc I, Nazzal D, Salvayre R, and Blaes N. Angiotensin II induces phenotype-dependent apoptosis in vascular smooth muscle cells. Hypertension 38: 1294-1299, 2001.
4. Bennett MR, Littlewood TD, Schwartz SM, and Weissberg PL. Increased sensitivity of human vascular smooth muscle cells from atherosclerotic plaques to p53-mediated apoptosis. Circ Res 81: 591-599, 1997.
5. Bhaskaran M, Reddy K, Radhakrishanan N, Franki N, Ding G, and Singhal PC. Angiotensin II induces apoptosis in renal proximal tubular cells. Am J Physiol Renal Physiol 284: F955-F965, 2003.
6. Braun-Dullaeus RC, Mann MJ, Ziegler A, von der Leyen HE, and Dzau VJ. A novel role for the cyclin-dependent kinase inhibitor p27(Kip1) in angiotensin II-stimulated vascular smooth muscle cell hypertrophy. J Clin Invest 104: 815-823, 1999.
7. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, and Greenberg ME. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96: 857-868, 1999.
8. Chamley-Campbell JH, Campbell GR, and Ross R. Phenotype-dependent response of cultured aortic smooth muscle to serum mitogens. J Cell Biol 89: 379-383, 1981.
9. Datta SR, Brunet A, and Greenberg ME. Cellular survival: a play in three Akts. Genes Dev 13: 2905-2927, 1999.
10. Daugherty A, Manning MW, and Cassis LA. Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. J Clin Invest 105: 1605-1612, 2000.
11. Daugherty A, Rateri DL, Lu H, Inagami T, and Cassis LA. Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1A receptor. Circulation 110: 3849-3857, 2004.
12. Delafontaine P, Song YH, and Li Y. Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels. Arterioscler Thromb Vasc Biol 24: 435-444, 2004.
13. Diep QN, Li JS, and Schiffrin EL. In vivo study of AT1 and AT2 angiotensin receptors in apoptosis in rat blood vessels. Hypertension 34: 617-624, 1999.
14. Diet F, Pratt RE, Berry GJ, Momose N, Gibbons GH, and Dzau VJ. Increased accumulation of tissue ACE in human atherosclerotic coronary artery disease. Circulation 94: 2756-2767, 1996.
15. Dore S, Kar S, and Quirion R. Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid- and human amylin-induced toxicity. Proc Natl Acad Sci USA 94: 4772-4777, 1997.
16. Dzau VJ. Tissue angiotensin and pathobiology of vascular disease: a unifying hypothesis (Theodore Cooper Lecture). Hypertension 37: 1047-1052, 2001.
17. Feener EP, Northrup JM, Aiello LP, and King GL. Angiotensin II induces plasminogen activator inhibitor-1 and -2 expression in vascular endothelial and smooth muscle cells. J Clin Invest 95: 1353-1362, 1995.
18. Folli F, Kahn CR, Hansen H, Bouchie JL, and Feener EP. Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk. J Clin Invest 100: 2158-2169, 1997.
19. Frid MG, Aldashev AA, Dempsey EC, and Stenmark KR. Smooth muscle cells isolated from discrete compartments of the mature vascular media exhibit unique phenotypes and distinct growth capabilities. Circ Res 81: 940-952, 1997.
20. Fukuo K, Hata S, Suhara T, Nakahashi T, Shinto Y, Tsujimoto Y, Morimoto S, and Ogihara T. Nitric oxide induces upregulation of Fas and apoptosis in vascular smooth muscle. Hypertension 27: 823-826, 1996.
21. Geisterfer AA, Peach MJ, and Owens GK. Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells. Circ Res 62: 749-756, 1988.
22. Geng YJ, Henderson LE, Levesque EB, Muszynski M, and Libby P. Fas is expressed in human atherosclerotic intima and promotes apoptosis of cytokine-primed human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 17: 2200-2208, 1997.
23. Gibbons GH, Pratt RE, and Dzau VJ. Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II. J Clin Invest 90: 456-461, 1992.
24. Haider A, Lee I, Grabarek J, Darzynkiewicz Z, and Ferreri NR. Dual functionality of cyclooxygenase-2 as a regulator of tumor necrosis factor-mediated G1 shortening and nitric oxide-mediated inhibition of vascular smooth muscle cell proliferation. Circulation 108: 1015-1021, 2003.
25. Haunstetter A and Izumo S. Apoptosis: basic mechanisms and implications for cardiovascular disease. Circ Res 82: 1111-1129, 1998.
26. Horiuchi M, Yamada T, Hayashida W, and Dzau VJ. Interferon regulatory factor-1 up-regulates angiotensin II type 2 receptor and induces apoptosis. J Biol Chem 272: 11952-11958, 1997.
27. Kiely PA, Sant A, and O'Connor R. RACK1 is an insulin-like growth factor 1 (IGF-1) receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death. J Biol Chem 277: 22581-22589, 2002.
28. Li JH, Kluger MS, Madge LA, Zheng L, Bothwell AL, and Pober JS. Interferon-gamma augments CD95(APO-1/Fas) and pro-caspase-8 expression and sensitizes human vascular endothelial cells to CD95-mediated apoptosis. Am J Pathol 161: 1485-1495, 2002.
29. Li Y, Higashi Y, Itabe H, Song YH, Du J, and Delafontaine P. Insulin-like growth factor-1 receptor activation inhibits oxidized LDL-induced cytochrome-c release and apoptosis via the phosphatidylinositol 3 kinase/Akt signaling pathway. Arterioscler Thromb Vasc Biol 23: 2178-2184, 2003.
30. Li Y, Higashi Y, Itabe H, Song YH, Du J, and Delafontaine P. Insulin-like growth factor-1 receptor activation inhibits oxidized LDL-induced cytochrome-c release and apoptosis via the phosphatidylinositol 3 kinase/Akt signaling pathway. Arterioscler Thromb Vasc Biol 23: 2178-2184, 2003.
31. Li Y, Meyer EM, Walker DW, Millard WJ, He YJ, and King MA. Alpha7 nicotinic receptor activation inhibits ethanol-induced mitochondrial dysfunction, cytochrome-c release and neurotoxicity in primary rat hippocampal neuronal cultures. J Neurochem 81: 853-858, 2002.
32. Lu B, Mu Y, Cao C, Zeng F, Schneider S, Tan J, Price J, Chen J, Freeman M, and Hallahan DE. Survivin as a therapeutic target for radiation sensitization in lung cancer. Cancer Res 64: 2840-2845, 2004.
33. Matsui T, Li L, del Monte F, Fukui Y, Franke TF, Hajjar RJ, and Rosenzweig A. Adenoviral gene transfer of activated phosphatidylinositol 3′-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro. Circulation 100: 2373-2379, 1999.
34. Muller DN, Heissmeyer V, Dechend R, Hampich F, Park JK, Fiebeler A, Shagdarsuren E, Theuer J, Elger M, Pilz B, Breu V, Schroer K, Ganten D, Dietz R, Haller H, Scheidereit C, and Luft FC. Aspirin inhibits NF-kappaB and protects from angiotensin II-induced organ damage. FASEB J 15: 1822-1824, 2001.
35. Nagata S. Apoptosis by death factor. Cell 88: 355-365, 1997.
36. Nagata S and Golstein P. The Fas death factor. Science 267: 1449-1456, 1995.
37. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362: 801-809, 1993.
38. Sata M, Suhara T, and Walsh K. Vascular endothelial cells and smooth muscle cells differ in expression of Fas and Fas ligand and in sensitivity to Fas ligand-induced cell death: implications for vascular disease and therapy. Arterioscler Thromb Vasc Biol 20: 309-316, 2000.
39. Suda T, Hashimoto H, Tanaka M, Ochi T, and Nagata S. Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing. J Exp Med 186: 2045-2050, 1997.
40. Suhara T, Kim HS, Kirshenbaum LA, and Walsh K. Suppression of Akt signaling induces Fas ligand expression: involvement of caspase and Jun kinase activation in Akt-mediated Fas ligand regulation. Mol Cell Biol 22: 680-691, 2002.
41. Tanaka M, Itai T, Adachi M, and Nagata S. Downregulation of Fas ligand by shedding. Nat Med 4: 31-36, 1998.
42. Velloso LA, Folli F, Sun XJ, White MF, Saad MJ, and Kahn CR. Cross-talk between the insulin and angiotensin signaling systems. Proc Natl Acad Sci USA 93: 12490-12495, 1996.
43. Wajant H. The Fas signaling pathway: more than a paradigm. Science 296: 1635-1636, 2002.
44. Wang Z, Rao PJ, Shillcutt SD, and Newman WH. Angiotensin II induces proliferation of human cerebral artery smooth muscle cells through a basic fibroblast growth factor (bFGF) dependent mechanism. Neurosci Lett 373: 38-41, 2005.
45. Wassmann S, Czech T, van Eickels M, Fleming I, Bohm M, and Nickenig G. Inhibition of diet-induced atherosclerosis and endothelial dysfunction in apolipoprotein E/angiotensin II type 1A receptor double-knockout mice. Circulation 110: 3062-3067, 2004.
46. Weber H, Taylor DS, and Molloy CJ. Angiotensin II induces delayed mitogenesis and cellular proliferation in rat aortic smooth muscle cells. Correlation with the expression of specific endogenous growth factors and reversal by suramin. J Clin Invest 93: 788-798, 1994.
47. Wolf G and Wenzel UO. Angiotensin II and cell cycle regulation. Hypertension 43: 693-698, 2004.
48. Xiao F, Puddefoot JR, Barker S, and Vinson GP. Mechanism for aldosterone potentiation of angiotensin II-stimulated rat arterial smooth muscle cell proliferation. Hypertension 44: 340-345, 2004.
49. Yamada T, Horiuchi M, and Dzau VJ. Angiotensin II type 2 receptor mediates programmed cell death. Proc Natl Acad Sci USA 93: 156-160, 1996.
50. Zheng WH, Kar S, and Quirion R. Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells. J Biol Chem 275: 39152-39158, 2000.