Cloning and expression of a short Fas ligand: A new alternatively spliced product of the mouse Fas ligand gene

Blood

Volumn 94, Issue 10, 1999, Pages 3456-3467

  Ayroldi, Emira ^a   D'Adamio, Francesca ^a   Zollo, Ornella ^a   Agostini, Massimiliano ^a   Moraca, Rosalba ^a   Cannarile, Lorenza ^a   Migliorati, Graziella ^a   Delfino, Domenico V ^a   Riccardi, Carlo ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; FAS LIGAND; FLUORESCEIN ISOTHIOCYANATE; HYBRID PROTEIN; MESSENGER RNA; MONOCLONAL ANTIBODY CD3; PROPIDIUM IODIDE; TUMOR NECROSIS FACTOR;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; EXON; GENE EXPRESSION; IMMUNOPRECIPITATION; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RIBONUCLEASE PROTECTION ASSAY; SPLEEN CELL; T LYMPHOCYTE;

EID: 0033571340     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v94.10.3456.422k33_3456_3467     Document Type: Article

References (41)

1. Wyllie AH, Kerr JFR, Currie AR: Cell death: The significance of apoptosis. Int Rev Cytol 68:251, 1980
2. Golstein P, Ojcius DM, Young JD: Cell death mechanisms and the immune system. Immunol Rev 121:29, 1991
3. Cohen JJ: Apoptosis. Immunol Today 14:126, 1993
4. Osborne BA, Smith SW, Liu ZG, McLaughlin KA, Grimm L, Schwartz LM: Identification of genes induced during apoptosis in T lymphocytes. Immunol Rev 142:301, 1994
5. Steller H: Mechanisms and genes of cellular suicide. Science 267:1445, 1995
6. Smith CA, Williams GT, Kingston R, Jenkinson EJ, Owen JJ: Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures. Nature 337:181, 1989
7. Dent AL, Matis LA, Hooshmand F, Widacki SM, Bluestone JA, Hedrick SM: Self-reactive gamma delta T cells are eliminated in the thymus. Nature 343:642, 1990
8. McDonald HR, Lees RK: Programmed death of autoreactive thymocytes. Nature 343:642, 1990
9. Webb S, Morris C, Sprent J: Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity. Cell 63:1249, 1990
10. + T cells in mice tolerant to Staphylococcus aureus enterotoxin B. Nature 349:245, 1991
11. Kabelitz D, Pohl T, Pechhold K: Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes. Immunol Today 14:338, 1993
12. Yonehara S, Ishii A, Yonehara M: A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor. J Exp Med 169:1747, 1989
13. Itoh N, Yonehara S, Ishii A, Yonehara M, Mizushima S, Sameshima M, Hase A, Seto Y, Nagata S: The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66:233, 1991
14. +)-independent T cell-mediated cytotoxicity. J Exp Med 177:195, 1993
15. Alderson MR, Tough TW, Davis-Smith T, Braddy S, Falk B, Schooley KA, Goodwin RG, Smith CA, Ramsdell F, Lynch DH: Fas ligand mediates activation-induced cell death in human T lymphocytes. J Exp Med 181:71, 1995
16. Dhein J, Walczak H, Bäumler C, Debatin KM, Krammer PH: Autocrine T-cell suicide mediated by APO-1/(Fas/CD95). Nature 373:438, 1995
17. Lynch DH, Ramsdell F, Alderson MR: Fas and FasL in the homeostatic regulation of immune responses. Immunol Today 16:569, 1995
18. Ju ST, Panka DJ, Cui H, Ettinger R, el-Khatib M, Sherr DH, Stanger BZ, Marshak-Rothstein A: Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature 373:444, 1995
19. Suda T, Takahashi T, Golstein P, Nagata S: Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 75:1169, 1993
20. Kayagaki N, Kawasaki A, Ebata T, Ohmoto H, Ikeda S, Inoue S, Yoshino K, Okumura K, Yagita H: Metalloproteinase-mediated release of human Fas ligand. J Exp Med 182:1777, 1995
21. Tanaka M, Suda T, Takahashi T, Nagata S: Expression of the functional soluble form of human Fas ligand in activated lymphocytes. EMBO J 14:1129, 1995
22. Tanaka M, Suda T, Yatomi T, Nakamura N, Nagata S: Lethal effect of recombinant human Fas ligand in mice pretreated with Propionibacterium acnes. J Immunol 158:2303, 1997
23. Douglas RG, Ware CF: Fas-ligand: Privilege and peril. Proc Natl Acad Sci USA 94:5986, 1997
24. Cheng J, Zhou T, Liu C, Shapiro JP, Brauer MJ, Kiefer MC, Barr PJ, Mountz JD: Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule. Science 263:1759, 1994
25. Cascino I, Fiucci G, Papoff G, Ruberti G: Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing. J Immunol 154:2706, 1995
26. Hughes DP, Crispe IN: A naturally occurring soluble isoform of murine Fas generated by alternative splicing. J Exp Med 182:1395, 1995
27. Ayroldi E, Migliorati G, Cannarile L, Moraca R, Delfino DV, Riccardi C: CD2 rescues T cell from T-cell receptor/CD3 apoptosis: A role for the Fas/Fas-L system. Blood 89:3717, 1997
28. D'Adamio F, Zollo O, Moraca R, Ayroldi E, Bruscoli S, Bartoli A, Cannarile L, Migliorati G, Riccardi C: A new dexamethasone-induced gene of the leucine zipper family protects T lymphocytes from TCR/CD3-activated cell death. Immunity 7:803, 1997
29. Nocentini G, Giunchi L, Ronchetti S, Krausz LT, Bartoli A, Moraca R, Migliorati G, Riccardi C: A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc Natl Acad Sci USA 94:6216, 1997
30. Shimonkevitz R, Kappler J, Marrack P, Grey H: Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing. J Exp Med 158:303, 1983
31. Migliorati G, Nicoletti I, Pagliacci MC, D'Adamio L, Riccardi C: Interleukin-4 protects double-negative and CD4 single-positive thymocytes from dexamethasone-induced apoptosis. Blood 81:1352, 1993
32. Gruss HJ, Dower SK: Tumor necrosis factor ligand superfamily: Involvement in the pathology of malignant lymphomas. Blood 85:3378, 1995
33. Fernandez-Botran R: Soluble cytokine receptors: Their role in immunoregulation. FASEB J 5:2567, 1991
34. Colotta F, Re F, Muzio M, Bertini R, Polentarutti N, Sironi M, Giri JG, Dower SK, Sims JE, Mantovani A: Interleukin-1 type II receptor: A decoy target for IL-1 that is regulated by IL-4. Science 261:472, 1993
35. Bjornberg F, Lantz M, Gullberg U: Metalloproteases and serine-proteases are involved in the cleavage of two tumor necrosis factor (TNF) receptors to soluble forms in the myeloid cell lines U-937 and THP-1. Scand J Immunol 42:418, 1995
36. Yang Y, Mercep M, Ware CF, Ashwell JD: Fas and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: Inhibition of Fas ligand expression by retinoic acid and glucocorticoids. J Exp Med 181:1673, 1995
37. Jackson JJ: A reappraisal of non-consensus mRNA splice sites. Nucleic Acids Res 19:3595, 1991
38. Mount SM: AT-AC introns: An ATtACk on dogma. Science 271:1690, 1996
39. Nagata S: Apoptosis by death factor. Cell 88:355, 1997
40. Suda T, Hashimoto H, Tanaka M, Ochi T, Nagata S: Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing. J Exp Med 186:2045, 1997
41. Tanaka M, Itai T, Adachi M, Nagata S: Downregulation of Fas ligand by shedding. Nat Med 4:31, 1998