Testosterone therapy in men with parkinson disease: Results of the TEST-PD study

Archives of Neurology

Volumn 63, Issue 5, 2006, Pages 729-735

  Okun, Michael S ^a,b   Fernandez, Hubert H ^a   Rodriguez, Ramon L ^a   Romrell, Janet ^a   Suelter, Michele ^a   Munson, Sarah ^a   Louis, Elan D ^b   Mulligan, Thomas ^a   Foster, Paul S ^a   Shenal, Brian V ^a   Armaghani, Sheyan J ^a   Jacobson, Charles ^a   Wu, Samuel ^c   Crucian, Gregory ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the Gertrude H Sergievsky Center   (United States)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEVODOPA; PROSTATE SPECIFIC ANTIGEN; TESTOSTERONE; TESTOSTERONE ENANTATE;

ADULT; AGED; ARTHRALGIA; ARTICLE; ASTHENIA; BEHAVIOR CHANGE; BLEEDING; CHEILITIS; CLINICAL ARTICLE; CLINICAL TRIAL; COGNITIVE DEFECT; COMMON COLD; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; DIAPHORESIS; DIARRHEA; DIZZINESS; DOSE RESPONSE; DROWSINESS; DRUG SAFETY; DRUG TOLERABILITY; DRY EYE; DYSKINESIA; DYSPHAGIA; DYSPNEA; EPISTAXIS; FATIGUE; FLU LIKE SYNDROME; FOLLOW UP; GAIT DISORDER; GASTROINTESTINAL SYMPTOM; HALLUCINATION; HEADACHE; HEART ARRHYTHMIA; HIRSUTISM; HORMONE SUBSTITUTION; HUMAN; HYPERSALIVATION; HYPERTENSION; LEG EDEMA; LIBIDO; MALE; MOOD; MOTOR DYSFUNCTION; MUSCLE CRAMP; NAUSEA; PAIN; PARESTHESIA; PARKINSON DISEASE; PRIORITY JOURNAL; QUALITY OF LIFE; QUESTIONNAIRE; RASH; RESTLESS LEGS SYNDROME; SCORING SYSTEM; SIDE EFFECT; SLEEP DISORDER; SPEECH DISORDER; TESTOSTERONE BLOOD LEVEL; TOOTH INJURY; TREATMENT OUTCOME; VISUAL IMPAIRMENT; XEROSTOMIA;

EID: 33646389228     PISSN: 00039942     EISSN: 15383687     Source Type: Journal    
DOI: 10.1001/archneur.63.5.729     Document Type: Article

References (53)

1. Harman SM, Tsitouras P. Reproductive hormones in aging men, I: measurement of sex steroids, basal luteinizing hormone, and Leydig cell response to human chorionic gonadotropin. J Clin Endocrinol Metab. 1980;51:35-41.
2. Okun MS, DeLong MR, Hanfelt J, Gearing M, Levey A. Plasma testosterone levels in Alzheimer and Parkinson diseases. Neurology. 2004;62:411-413.
3. Okun MS, McDonald WM, DeLong MR. Refractory nonmotor symptoms in male patients with Parkinson disease due to testosterone deficiency: a common unrecognized comorbidity. Arch Neurol. 2002;59:807-811.
4. Hogervorst E, Bandelow S, Combrinck M, Smith AD. Low free testosterone is an independent risk factor for Alzheimer's disease. Exp Gerontol. 2004;39:1633-1639.
5. Markianos M, Panas M, Kalfakis N, Vassilopoulos D. Plasma testosterone in male patients with Huntington's disease: relations to severity of illness and dementia. Ann Neurol. 2005;57:520-525.
6. Nutt JG, Wooten GF. Clinical practice. Diagnosis and initial management of Parkinson's disease. N Engl J Med. 2005;353:1021-1027.
7. Lang AE, Obeso JA. Challenges in Parkinson's disease: restoration of the nigrostriatal dopamine system is not enough. Lancet Neurol. 2004;3:309-316.
8. Okun MS, Walter BL, McDonald WM, et al. Beneficial effects of testosterone replacement for the nonmotor symptoms of Parkinson disease. Arch Neurol. 2002;59:1750-1753.
9. Morley JE, Charlton E, Patrick P, et al. Validation of a screening questionnaire for androgen deficiency in aging males. Metabolism. 2000;49:1239-1242.
10. Smith KW, Feldman HA, McKinlay JB. Construction and field validation of a self-administered screener for testosterone deficiency (hypogonadism) in ageing men. Clin Endocrinol (Oxf ). 2000;53:703-711.
11. Zenzola A, Masi G, De Mari M, Defazio G, Livrea P, Lamberti P. Fatigue in Parkinson's disease. Neurol Sci. 2003;24:225-226.
12. Bergner M, Bobbitt RA, Pollard WE, Martin DP, Gilson BS. The Sickness Impact Profile: validation of a health status measure. Med Care. 1976;14:57-67.
13. Jenkinson C, Fitzpatrick R, Peto V, Greenhall R, Hyman N. The Parkinson's Disease Questionnaire (PDQ-39): development and validation of a Parkinson's disease summary index score. Age Ageing. 1997;26:353-357.
14. Yesavage JA, Brink TL, Rose TL, et al. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res. 1982;17:37-49.
15. Vedana L, Baiardi P, Sommaruga M, et al. Clinical validation of an anxiety and depression screening test for intensive in-hospital rehabilitation. Monaldi Arch Chest Dis. 2002;58:101-106.
16. Stern RA. Assessment of mood states in neurodegenerative disease: methodological issues and diagnostic recommendations. Semin Clin Neuropsychiatry. 1996;1:315-324.
17. Martinez-Martin P, Gil-Nagel A, Gracia LM, Gomez JB, Martinez-Sarries J, Bermejo F; the Cooperative Multicentric Group. Unified Parkinson's Disease Rating Scale characteristics and structure. Mov Disord. 1994;9:76-83.
18. Lezak MD, Howieson DB, Loring DW. Neuropsychological Assessment. New York, NY: Oxford University Press; 2004.
19. Tinklenberg J, Brooks JO III, Tanke ED, et al. Factor analysis and preliminary validation of the Mini-Mental State Examination from a longitudinal perspective. Int Psychogeriatr. 1990;2:123-134.
20. Eslinger PJ, Damasio AR, Benton AL, Van Allen M. Neuropsychologic detection of abnormal mental decline in older persons. JAMA. 1985;253:670-674.
21. Amolsch TJ, Henrichs TF. Behavioral correlates of WAIS profile patterns: an exploratory study. J Pers Assess. 1975;39:55-63.
22. Howard AR. Further validation studies of the Wechsler Memory Scale. J Clin Psychol. 1954;10:164-167.
23. Leli DA, Filskov SB. Actuarial assessment of Wechsler Verbal-Performance Scale differences as signs of lateralized cerebral impairment. Percept Mot Skills. 1981;53:491-496.
24. Wechsler D. Wechsler Memory Scale, Manual. 3rd ed. San Antonio, Tex: Psychological Corp; 1997.
25. Petrides M. Frontal lobes and behavior. Curr Opin Neurobiol. 1994;4:207-211.
26. Petrides M. Impairments on nonspatial self-ordered and externally ordered working memory tasks after lesions of the mid-dorsal part of the lateral frontal cortex in the monkey. J Neurosci. 1995;15:359-375.
27. Petrides M, Pandya DN. Dorsolateral prefrontal cortex: comparative cytoarchitectonic analysis in the human and the macaque brain and corticocortical connection patterns. Eur J Neurosci. 1999;11:1011-1036.
28. Spreen O, Strauss E. A Compendium of Neuropsychological Tests. 2nd ed. New York, NY: Oxford University Press; 1998.
29. Rubino IA, Fedeli B, Zanna V, Fortuna E. A multivariate study of the Serial Color-Word Test. Percept Mot Skills. 1997;84:275-282.
30. Hogervorst E, Combrinck M, Lapuerta P, Rue J, Swales K, Budge M. The Hopkins Verbal Learning Test and screening for dementia. Dement Geriatr Cogn Disord. 2002;13:13-20.
31. Tenover JL. Experience with testosterone replacement in the elderly. Mayo Clin Proc. 2000;75(suppl):S77-S82.
32. Tenover JS. Prevalence and management of mild hypogonadism: introduction. Int J Impot Res. 2003;15(suppl 4):S1-S2.
33. Tenover JL. Testosterone replacement therapy in older adult men. Int J Androl. 1999;22:300-306.
34. Braak H, Ghebremedhin E, Rub U, Bratzke H, Del Tredici K. Stages in the development of Parkinson's disease-related pathology. Cell Tissue Res. 2004;318:121-134.
35. Braak H, Braak E. Pathoanatomy of Parkinson's disease. J Neurol. 2000;247(suppl 2):II3-II10.
36. Wakabayashi K, Takahashi H. Neuropathology of autonomic nervous system in Parkinson's disease. Eur Neurol. 1997;38(suppl 2):2-7.
37. Nakamura S, Ohnishi K, Nishimura M, et al. Large neurons in the tuberomammillary nucleus in patients with Parkinson's disease and multiple system atrophy. Neurology. 1996;46:1693-1696.
38. Kremer HP, Bots GT. Lewy bodies in the lateral hypothalamus: do they imply neuronal loss? Mov Disord. 1993;8:315-320.
39. Kremer HP. The hypothalamic lateral tuberal nucleus: normal anatomy and changes in neurological diseases. Prog Brain Res. 1992;93:249-261.
40. American Association of Clinical Endocrinologists. American Association of Clinical Endocrinologists Medical Guidelines for clinical practice for the evaluation and treatment of hypogonadism in adult male patients-2002 update. Endocr Pract. 2002;8:440-456.
41. Hanna KE. No fountain of youth: FDA and NIH review off-label use of hormones. Hastings Cent Rep. 2003;33:8-9.
42. Morley JE, Patrick P, Perry HM III. Evaluation of assays available to measure free testosterone. Metabolism. 2002;51:554-559.
43. Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR; Baltimore Longitudinal Study of Aging. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. J Clin Endocrinol Metab. 2001;86:724-731.
44. Gray A, Berlin JA, McKinlay JB, Longcope C. An examination of research design effects on the association of testosterone and male ageing: results of a meta-analysis. J Clin Epidemiol. 1991;44:671-684.
45. Vermeulen A. Clinical review 24: androgens in the aging male. J Clin Endocrinol Metab. 1991;73:221-224.
46. Vermeulen A. Environment, human reproduction, menopause, and andropause. Environ Health Perspect. 1993;101(suppl 2):91-100.
47. Vermeulen A, Kaufman JM. Ageing of the hypothalamo-pituitary-testicular axis in men. Horm Res. 1995;43:25-28.
48. Tal S, Berner Y, Levy S. Influence of estrogen replacement therapy on cognitive function and dementia in postmenopausal women [in Hebrew]. Harefuah. 1999;137:636-639.
49. Tenover JS, Matsumoto AM, Plymate SR, Bremner WJ. The effects of aging in normal men on bioavailable testosterone and luteinizing hormone secretion: response to clomiphene citrate. J Clin Endocrinol Metab. 1987;65:1118-1126.
50. Tenover JS, Bremner WJ. The effects of normal aging on the response of the pituitary-gonadal axis to chronic clomiphene administration in men. J Androl. 1991;12:258-263.
51. Barrett-Connor E, Von Muhlen DG, Kritz-Silverstein D. Bioavailable testosterone and depressed mood in older men: the Rancho Bernardo Study. J Clin Endocrinol Metab. 1999;84:573-577.
52. Ferrini RL, Barrett-Connor E. Sex hormones and age: a cross-sectional study of testosterone and estradiol and their bioavailable fractions in community-dwelling men. Am J Epidemiol. 1998;147:750-754.
53. Krause W, Mueller U, Mazur A. Testosterone supplementation in the aging male: which questions have been answered? Aging Male. 2005;8:31-38.