Signaling on the endocytic pathway

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Volumn 2, Issue 6, 2001, Pages 375-384

  McPherson, Peter S ^a,b   Kay, Brian K ^a   Hussain, Natasha K ^a  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Clathrin; Dynamin; EGF; Endocytosis; ERK; Intersectin; MAP kinase; NGF; Ras

Indexed keywords

CLATHRIN; DYNAMIN; G PROTEIN COUPLED RECEPTOR; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE;

ANIMAL CELL; CELL MEMBRANE; COATED PIT; CONTROLLED STUDY; ENDOCYTOSIS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN TRANSPORT; RAT; RECEPTOR BINDING; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; ENDOCYTOSIS; ENZYME ACTIVATION; LIGANDS; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; PROTEIN-TYROSINE KINASES; RATS; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 0034976247     PISSN: 13989219     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0854.2001.002006375.x     Document Type: Review

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6. The endocytosis machinery
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11. 11 PACSIN, a brain protein that is upregulated upon differentiation into neuronal cells
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14. Splice variants of intersectin are components of the endocytic machinery in neurons and nonneuronal cells
15. Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis
16. The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps 15
17. SH3 domain-containing proteins function at distinct steps in clathrin-coated vesicle formation
18. The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain
19. Intersectin can regulate the Ras/MAP kinase pathway independent of its role in endocytosis
20. Intersectin, an adaptor protein involved in clathrin-mediated endocytosis, activates mitogenic signaling pathways
21. Compartmentalization of SHC, GRB2 and mSOS, and hyperphosphorylation of Raf-1 by EGF but not insulin in liver parenchyma
22. Internalized epidermal growth factor receptors participate in the activation of p21 (ras) in fibroblasts
23. Cell communication: The inside story
24. Regulation of receptor tyrosine kinase signaling by endocytic trafficking
25. Compartmentalized signal transduction by receptor tyrosine kinases
26. Induction of mutant dynamin specifically blocks endocytic coated vesicle formation
27. Control of EGF receptor signaling by clathrin-mediated endocytosis
28. Inhibition of clathrin-mediated endocytosis selectively attenuates specific insulin receptor signal transduction pathways
29. Insulin-like growth factor-I receptor internalization regulates signaling via the Shc/mitogen-activated protein kinase pathway, but not the insulin receptor substrate-1 pathway
30. Dynamin is required for the activation of mitogen-activated protein (MAP) kinase by MAP kinase kinase
31. Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes
32. Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase
33. Serotonin 5-HT1A receptor-mediated ERK activation requires calcium/calmodulin-dependent receptor endocytosis
34. Regulation of muscarinic acetylcholine receptor sequestration and function by beta-arrestin
35. Requirement of receptor internalization for opioid stimulation of mitogen-activated protein kinase: Biochemical and immunofluorescence confocal microscopic evidence
36. Dissociation of functional roles of dynamin in receptor-mediated endocytosis and mitogenic signal transduction
37. Activation of the MAPK signal cascade by the neural cell adhesion molecule L1 requires L1 internalization
38. A MAP kinase-signaling pathway mediates neurite outgrowth on L1 and requires Src-dependent endocytosis
39. Role of arrestins in endocytosis and signaling of alpha2-adrenergic receptor subtypes
40. 40 Stimulation of mitogen-activated protein kinase by G protein-coupled alpha (2) -adrenergic receptors does not require agonist-elicited endocytosis
41. A mutation in the second transmembrane region of the CB1 receptor selectively disrupts G protein signaling and prevents receptor internalization
42. Activation of the mitogen-activated protein kinase pathway by a Gq/11-coupled muscarinic receptor is independent of receptor internalization
43. Activation of mitogen-activated protein kinase by the bradykinin B2 receptor is independent of receptor phosphorylation and phosphorylation-triggered internalization
44. Role of clathrin-mediated endocytosis in CXCR2 sequestration, resensitization, and signal transduction
45. Epidermal growth factor receptor efficiently activates mitogen-activated protein kinase in HeLa cells and Hep2 cells conditionally defective in clathrin-dependent endocytosis
46. Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors
47. The beta (2) -adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor
48. EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake
49. NGF signals through TrkA to increase clathrin at the plasma membrane and enhance clathrin-mediated membrane trafficking
50. Epidermal growth factor and membrane trafficking. EGF receptor activation of endocytosis requires Rab5a
51. The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5
52. Tyrosine phosphorylation of eps15 is required for ligand-regulated, but not constitutive, endocytosis
53. 53 Beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2
54. Beta-arrestin 2: A receptor-regulated MAPK scaffold for the activation of JNK3
55. An arresting start for MAPK
56. Neurotrophin signal transduction in the nervous system
57. Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation
58. Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via ras and rap1
59. An NGF-TrkA-mediated retrograde signal to transcription factor CREB in sympathetic neurons
60. Endocytosis of activated TrkA: Evidence that nerve growth factor induces formation of signaling endosomes
61. Rapid nuclear responses to target-derived neurotrophins require retrograde transport of ligand-receptor complex
62. Actin-dependent propulsion of endosomes and lysosomes by recruitment of N-WASP
63. Two isoforms of a human intersectin (ITSN) protein are produced by brain-specific alternative splicing in a stop codon
64. Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis
65. The brain specific longform of intersectin functions as a guanine-nucleotide exchange factor for cdc42
66. Signaling to actin dynamics