Short report: Cloning of the Babesia gibsoni cytochrome b gene and isolation of three single nucleotide polymorphisms from parasites present after atovaquone treatment

American Journal of Tropical Medicine and Hygiene

Volumn 74, Issue 4, 2006, Pages 593-597

  Matsuu, Aya ^a   Miyamoto, Kayoko ^a   Ikadai, Hiromi ^a   Okano, Shozo ^a   Higuchi, Seiichi ^a  

^a KITASATO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ATOVAQUONE; CYTOCHROME B; UBIQUINONE; ANTIPROTOZOAL AGENT; NAPHTHOQUINONE;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ARTICLE; BABESIA; BABESIA GIBSONI; BINDING SITE; CONTROLLED STUDY; DNA EXTRACTION; DOG; GENE ISOLATION; GENE MUTATION; GENE SEQUENCE; JAPAN; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE ISOLATION; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PROTOZOAL INFECTION; SINGLE NUCLEOTIDE POLYMORPHISM; AMINO ACID SEQUENCE; ANIMAL; ANIMAL DISEASE; BABESIOSIS; BLOOD; DOG DISEASE; DRUG EFFECT; DRUG RESISTANCE; GENETICS; MOLECULAR GENETICS;

BABESIA; BABESIA GIBSONI; CANIS FAMILIARIS; PLASMODIUM FALCIPARUM; PROTOZOA;

AMINO ACID SEQUENCE; ANIMALS; ANTIPROTOZOAL AGENTS; ATOVAQUONE; BABESIA; BABESIOSIS; BASE SEQUENCE; CYTOCHROME B GROUP; DOG DISEASES; DOGS; DRUG RESISTANCE; MOLECULAR SEQUENCE DATA; NAPHTHOQUINONES; PLASMODIUM FALCIPARUM; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 33646383862     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.2006.74.593     Document Type: Article

References (23)

1. Groves MG, Debbis GL, 1972. Babesia gibsoni: field and laboratory studies of canine infections. Exp Parasitol 31: 153-159.
2. Farwell GE, LeGrand EK, Cobb CC, 1988. Clinical observation on Babesia gibsoni and Babesia canis infections in dogs. J Am Vet Med Assoc 180: 507-511.
3. Boozer AL, Macintire DK, 2003. Canine babesiosis. Vet Clin North Am Small Anim Pract 33: 885-904.
4. Fowler JL, Ruff MD, Fernau RC, Furusho Y, 1972. Babesia gibsoni: chemotherapy in dogs. Am J Vet Res 33: 1109-1114.
5. Grove MG, Vanniasingham JA, 1970. Treatment of Babesia gibsoni infections with phenamidine isethonate. Vet Recb 86: 8-10.
6. Wulansari R, Wijaya A, Ano H, Horii Y, Makimura S, 2003. Lymphocyte subsets and specific IgG antibody levels in clindamycin-treated and untreated dogs experimentally infected with Babesia gibsoni. J Vet Med Sci 65: 579-584.
7. Baggish AL, Hill DR, 2002. Antiparasitic agent atovaquone. Antimicrob Agents Chemother 40: 914-919.
8. Hughes WT, Oz H, 1995. Successful prevention and treatment of babesiosis with atovaquone. J Infect Dis 172: 1042-1046.
9. Pudney M, Gray JS, 1997. Therapeutic efficacy of atovaquone against the bovine intraerythrocytic parasites, Babesia divergens. J Parasitol 83: 307-310.
10. Gray J, Pudney M, 1999. Activity of atovaquone against Babesia microti in the Mongolian gerbil, Meriones unguiculatus. J Parasitol 85: 723-728.
11. Weiss LM, 2002. Babesiosis in humans: a treatment review. Expert Opin Pharmacother 3: 1109-1115.
12. Hudson AT, Dickins MM, Ginger CD, Gutteridge WE, Holdich T, Hutchinson DB, 1991. 566C80: A broad spectrum anti-infective agent with activity against malaria and opportunistic infections in AIDS patients. Drug Exp Clin Res 17: 427-435.
13. Syafruddin E, Siregar JE, Marzuki S, 1999. Mutations in the cytochrome b gene of Plasmodium berghei conferring resistance to atovaquone. Mol Biochem Parasitol 104: 185-194.
14. Suswam E, Kyle D, Lang-Unnasch N, 2001. Plasmodium falciparum: the effecet of atovaquone resistance on repiration. Exp Parasitol 98: 180-187.
15. McFadden DC, Tomavo S, Berry A, Boothroyd JC, 2000. Characterization of cytochrome b from Toxoplasma gondii and Q (o) domain mutation as a mechanism of atovaquone resistance. Mol Biochem Parasitol 108: 1-12.
16. Walker DJ, Wakefrield AE, Dohnn MN, Miller RF, Baughman RP, Hossler PA, Bartlett MS, Smith JW, Kazanjian P, Meshnick R, 1998. Sequence polymorphisms in the Pneumocystis carinii cytochrome b gene and their association with atovaquone prophylaxis failure. J Infect Dis 178: 1767-1775.
17. Birkenheuer AJ, Levy MG, Breitschwerdt EB, 2004. Efficacy of combined atovaquone and azithromycin for therapy of chronic Babesia gibsoni (Asian genotype) infectious in dogs. J Vet Intern Med 18: 494-498.
18. Matsuu A, Koshida Y, Kawahara M, Inoue K, Ikadai H, Hikasa Y, Okano S, Higuchi S, 2004. Efficacy of atovaquone against Babesia gibsoni in vivo and in vitro. Vet Parasitol 124: 9-18.
19. Ikadai H, Tanaka H, Shibahara N, Matsuu A, Uechi M, Itoh N, Oshiro S, Kudo N, Igarashi I, Oyamada T, 2004. Molecular evidence of infections with Babesia gibsoni parasites in Japan and evaluation of the diagnostic potential of a loop-mediated isothermal amplification method. J Clin Microbiol 42: 2465-2469.
20. Matsuu A, Kawabe A, Koshida Y, Ikadai H, Okano S, Higuchi S, 2004. Incidence of canine Babesia gibsoni infection and subclinical infection among Tosa dogs in Aomori prefecture, Japan. J Vet Med Sci 66: 893-897.
21. Salem GH, Liu XJ, Johnsrude JD, Dame JB, Reddy GR, 1998. Development and evaluation of an extra chromosomal DNA-based PCR test for diagnosing bovine babesiosis. Mol Cell Probes 13: 107-113.
22. Megson A, Inman GJ, Hunt PD, Baylis HA, Hall R, 1991. The gene for apocytochrome B of Theileria annulata resides on a small linear extrachromosomal element. Mol Biochem Parasitol 48: 113-115.
23. Korsinczky M, Chen N, Kotecka B, Saul A, Rieckmann K, Cheng Q, 2000. Mutations in Plasmodium falciparum cytochrome b that are associated with atovaquone resistance are located at a putative drug-binding site. Antimicrob Agents Chemother 44: 2100-2108.