An in vitro inhibition of human malignant cell growth of crude water extract of cassava (Manihot esculenta Crantz) and commercial linamarin

Songklanakarin Journal of Science and Technology

Volumn 28, Issue SUPPL. 1, 2006, Pages 145-155

  Yusuf, Umar F ^a   Ahmadun, FakhrU'L Razi ^a   Rosli, Rozita ^b   Iyuke, Sunny E ^a   Billa, Nashiru ^c   Abdullah, Nurhafizah ^a   Umar Tsafe, Nasir ^b  

^a Faculty of Engineering

^b UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^c INTERNATIONAL MEDICAL UNIVERSITY   (Malaysia)

Author keywords

Antineoplastic; Bystander effect; Cancer; Epidemiological; Linamarin; Toxicity

Indexed keywords

EID: 33646379125     PISSN: 01253395     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (43)

1. Balagopalan, C., Padmaja, G., Nanda, S.K., and Moorthy, S.N. 1988. Cassava in food, feed, and industry. CRC Press Inc., Florida.
2. Bradbury, J.H., and Holloway, W.D. 1988. Chemistry of tropical root crops: Significance for nutrition and agriculture in the Pacific. Australian Center for International Agriculture.
3. Bradbury, M.G., Egan, S.V., and Bradbury, J.H. 1999. Picrate paper kits for determination of total cyanogens in cassava roots and all forms of cyanogens in cassava products. J. Sci. Food Agric., 79: 593-601.
4. Brigger, N., Dubernet, C. and Couvreur, P. 2002. Nanoparticles in cancer therapy and diagnosis. Adv. Drug Deliv. Rev., 54: 631-651.
5. nd ed. Jones and Barlett, Massachusetts.
6. Cereda, M.P. and Mattos, M.C.Y. 1996. Linamarin the toxic compound in cassava. J. Venom Anim. Toxins, 2: 1-6.
7. Cliff, I., Lundquist, P., Martensson, I., Rosling, H., and Sorbo, B.1985. Association of high cyanide and low sulphur intake in cassava induced spastic paraparesis. Lancet, II: 1211-1213.
8. Connors, T.A., Duncan, R., and Knox, R.J. 1995. The chemotherapy of colon cancer. Eur. J. Cancer, 31A: 1373-1378.
9. Cooke, R.D. 1978. An enzymatic assay for the total cyanide content of cassava. J. Sci. Food Agric., 29: 345-352.
10. Cortes, M.L., de Felipe, P., Martin, V., Hughes, M.A., and Izquierdo, M. 1998. Successful use of aplani gene in the treatment of cancer in vivo. Gene Ther., 5:1499-1507.
11. DeSantis, P.C. 1983. Some observations on the use of enzymes in paper conservation. J. Am. Inst. Conserv., 23: 7-27.
12. Fainaro, S.R, Wrasidlo, W., Lode, N.H. and Shabat, D. 2002. Synthesis and Characterisation of a catalytic antibody - HPMA copolymer conjugates as a tool for tumor selective prodrug activation. Bioorg. Med. Chem., 10: 3023-3029.
13. Fonseca, C., Simoes, S. and Gaspar, R. 2002. Paclitaxel - loaded PLGA nanoparticles: preparation, physicochemical characterisation and in vitro anti - tumoral activity. J. Control. Release, 83: 272-286.
14. Graaf, D.M., Pinedo, H.M., Quadir, R., Haisma, J.H. and Boven, E. 2003. Cytosolic β - glycosidases for activation of glycoside prodrug of daunorubicin. Biochem. Pharm., 65: 1875-1881.
15. Greenwald, P., 1999. Diet and cancer, perspective of prevention in: advances in nutrition and cancer 2, ed. By Zappia, V. et al., Kluwer/Plenum, New York.
16. Grindley, P.A.B., Omoruyi, F., Asemota, H.N. and Morrison, E.Y.S.A. 2002. Carbohydrate digestion and intestinal ATPases in streptozotocin - induced diabetic rats fed extract of yam (Dioscorea cayenensis) or dasheen (Colocasia esculenta). Nutr. Res., 22: 333-341.
17. Hagihira, H., Wilson, T.H. and Lin, E.C.C. 1963. Studies on the glucose transport system in Escherichia coli with a - methyl glucoside as substrate. Biochim. et Biophys. Acta, 78: 505-515.
18. Haque, M.R., and Bradbury, J.H. 1999. Preparation of linamarase solution from cassava latex for use in the cassava cyanide kit. Food Chem., 67: 305-309.
19. John, A.W., Robert, J.M., Roger, S., and Kenneth, B. 1996. Changes in plasma carotenoid, alpha - tocopherol and lipid peroxidase level in response to supplementation with concentrated fruit and vegetable extracts: a pilot study. Current Ther. Res., 50:445-461.
20. Joseph, T., Yeoh, H., and Loh, C., 2001. Linamarin content and genetic stability of cassava plants derived by somatic embryogenesis. Euphytica, 120:7-13
21. Kallay, E., Bajna, E., Kriwanek, S., Bonner, E., and Peterlik, M. 1999. Role of dietary calcium in growth modulation of human coon cells: dietary anticarcinogens and antimutagens, chemical and biological aspects. Johnson, I.T. et al. (ed.) Proc. Food and Cancer Prevention III Meet. Univer. East Anglia Norwich. Sept. 5-8, 1999: 324-326.
22. Keresztessy, Z., Brown, K., Dunn, M.A., and Hughes, M.A. 2001. Identification of essential active site residues in the cyanogenic β-glucosidase (linamarase) from cassava by site directed muta-genesis. Biochem. J., 353: 199-205.
23. Kousparou, A.C., Epenetos, A.A., and Deonarain, P.M. 2002. Antibody guided enzyme therapy of cancer producing cyanide results in necrosis of targeted cells. Int. J. Cancer, 99: 138-148.
24. Lieberman, M.M., Patterson, G.M.L. and Moore, R.E. 2001. In vitro bioassays for anticancer drug screening; effects of cell concentration and other assay parameters on growth inhibitory activity. Cancer Lett., 173:21-29.
25. Manju, V., Sailaja, J.K. and Nalini, N. 2002. Circulating lipid peroxidation and antioxidation status in cervical cancer patients: a case control study. Clin. Biochem., 35: 621-625.
26. Matsumura, Y. and Maeda, H. 1986. A new concept for macromolecular therapeutics in cancer therapy: Mechanism of tumoritropic accumulation of protein and the anticancer agent SMANCS. Cancer Res., 46: 6387-6392.
27. Nambisan, B. 1999. Cassava latex as a source of linamarase for determination of linamarin. J. Agric. Food Chem., 47: 372-373.
28. Nesaretnam, K., Lim, E.J., Reimann, K. and Lai, L.C. 2000. Effect of a carotene concentrate on the growth of human breast cancer and pS2 gene expression. Toxicol., 151: 117-126.
29. Ngudi, D.D., Kou, Y., and Lambien, F., 2003. Cassava leaves, a non-negligible source of dietary exposure to cyanogens. Cassava Cyanide Diseases Network Issue 2: 1-4.
30. Oke, O.L. 1979. Some aspect s of the role of cyanogenic glycosides in nutrition. World Rev. Nutr. Diet., 33:70-103.
31. Oke, O.L. 1980. Toxicity of cyanogenic glycosides. Food Chem., 6: 97-109.
32. Osuntokun, B.O. 1981. Cassava diet, chronic cyanide intoxication and neuropathy in the Nigerian Africans. World Rev. Nutr. Diet., 36: 141-173.
33. Pietersz, G. and McKenzie, I. 1992. Immunotherapy for cancer toxin antibody conjugates in: toxins and targets. Watters et al., (ed.) Harwood Academic, Switzerland.
34. Ragoobirsingh, D., Robinson, H.M. and Morrison, E.Y.St.A. 1993. Effects of cassava cyanogluco-side, linamarin and blood sugar levels in the dog. J. Nutr. Biochem., 4: 625-9.
35. Rao, P.V., and Hahn, S.K. 1984. An automated enzymatic assay for determining the cyanide content of cassava and cassava products. J. Sc. Food Agric., 35: 426-436.
36. Renvoize, C., Biola, A., Pallardy, M. and Breard, J. 1998. Apoptosis: Identification of dying cells. Cell Biol. Toxicol. 14: 111-120.
37. Saleem, A., Husheem, M., Harkonen, P. and Pihlaja, K. 2002. Inhibition of cancer cell growth by crude extract and the phenolics of Terminalia chebula retz fruit. J. Ethnopharmacol., 81: 327-336.
38. Smith, M. 2002. Overview of cancer in Asia. Oncology forum - Feature article. Forum Scientific communications, U.K., 6: 1-14.
39. Smith, T.A.D. and Titley, J.C. 1999. Uptake of glucose analogues by colonic tumor cells during growth and after treatment with hyroxyurea. Cancer Lett., 141: 85-91.
40. Soppimath, S.K., Aminabhavi, M.T., Kulkarni, A.R., Rudzinski, W.E. 2001. Biodegradable polymeric nanoparticles as drug delivery devices. J. Control. Release. 70: 1-20.
41. Sreeja, V.G., Nagahara, N., Li, Q., and Minami, M. 2003. New aspects in the pathogenesis of konzo: neural cell damage directly caused by linamarin contained in cassava. Brit. J. Nutr., 90: 467-472.
42. Syrigos, K.N., Busza, G.R. and Epenetos, A.A. 1998. In vitro cytotoxicity following specific activation of amygdalin by β-glucosidase conjugated to a bladder cancer-associated monoclonal antibody. Int. J. Cancer, 78: 712-719.
43. Zhivotovsky, B., and Orrenius, S. 2003. Defects in the apoptotic machinery of cancer cells: role in drug resistance. Semin. Cancer Biol., 13: 125-134.