Molecular mechanisms of TNF-α-induced apoptosis in naïve and memory T cell subsets

Autoimmunity Reviews

Volumn 5, Issue 4, 2006, Pages 264-268

  Gupta, Sudhir ^a   Gollapudi, Sastry ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aging; Calcium; Death receptors; Endoplasmic reticulum; Mitochondria

Indexed keywords

AUTOANTIBODY; CELL SURFACE MARKER; TUMOR NECROSIS FACTOR ALPHA;

AGING; APOPTOSIS; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CELL DIVISION; CELL TYPE; CHEMOTHERAPY; EFFECTOR CELL; ENDOPLASMIC RETICULUM; HUMAN; HYPERIMMUNOGLOBULINEMIA; MEMORY T LYMPHOCYTE; MOLECULAR MECHANICS; REVIEW; SENESCENCE; SEROPREVALENCE; T LYMPHOCYTE SUBPOPULATION; TELOMERE;

AGING; ANTIGENS, CD95; APOPTOSIS; CD8-POSITIVE T-LYMPHOCYTES; ENDOPLASMIC RETICULUM; IMMUNOLOGIC MEMORY; MITOCHONDRIA; T-LYMPHOCYTE SUBSETS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33646372437     PISSN: 15689972     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.autrev.2005.09.007     Document Type: Review

References (27)

1. Kramer P.H. CD95's deadly mission in the immune system. Nature 407 (2000) 789-795
2. Ashkanazi A., and Dixit V.M. Death receptors: signaling and modulation. Science 281 (1998) 1305-1308
3. Gupta S. Molecular steps of death receptor and mitochondrial pathways of apoptosis. Life Sci 69 (2001) 2957-2964
4. Green D.R., and Reed J.C. Mitochondria and apoptosis. Science 281 (1998) 1309-1312
5. Rao R.V., Ellerby H.M., and Bredesen D.E. Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ 11 (2004) 372-380
6. Orrenius S., Zhivotovsky B., and Nicotera P. Regulation of cell death: the calcium-apoptosis link. Nat Rev Mol Cell Biol 4 (2003) 552-565
7. + T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells. Nat Immunol 2 (2001) 415-422
8. Sallusto F., Lenig D., Forster R., Lipp M., and Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401 (1999) 708-712
9. + memory T cell subsets in response to antigen or homeostatic traffic. Blood 101 (2003) 4260-4266
10. + T cells in centenarians and in long-term T cell cultures: a possible cause of both in vivo and in vitro immunosenescence. Exp Gerontol 29 (1994) 601-609
11. Posnett D.N., Sinha R., Kabak S., and Russo C. Clonal populations of T cells in normal elderly humans: the cell equivalent to "benign monoclonal gammopathy". J Exp Med 179 (1994) 609-618
12. Gupta S. Molecular steps of TNF receptor-mediated apoptosis. Curr Mol Med 1 (2001) 299-306
13. Gupta S. A decision between life and death during TNF-α-induced signaling. J Clin Immunol 22 (2002) 229-239
14. Aggarwal S., and Gupta S. Increased apoptosis of T cell subsets in aging humans: altered expression of Fas (CD95), Fas ligand, Bcl-2, and Bax. J Immunol 160 (1998) 1627-1637
15. Gupta S. A road to ruines: an insight into immunosenscence. Adv Cell Aging Gerontol 13 (2003) 169-185
16. Gupta S. Molecular steps of cell suicide: an insight into immune senescence. J Clin Immunol 20 (2000) 229-239
17. Gupta S., Kim C., Yel L., and Gollapudi S. A role of fas-associated death domain (FADD) in increased apoptosis in aged humans. J Clin Immunol 24 (2004) 24-29
18. Aggarwal S., and Gupta S. Increased activity of caspase-3 and caspase-8 during Fas-mediated apoptosis in lymphocytes from aging humans. Clin Exp Immunol 117 (1999) 285-290
19. Aggarwal S., Gollapudi S., and Gupta S. Increased TNF-α-induced apoptosis in lymphocytes from aged humans: changes in TNF-α receptor expression and activation of caspases. J Immunol 162 (1999) 2154-2161
20. Gupta S. Tumor necrosis factor-α-induced apoptosis in T cell subsets from aged humans. Receptor expression and downstream signaling events. Exp Gerontol 37 (2002) 293-299
21. Gupta S., Chiplunkar S., Kim C., Yel L., and Gollapudi S. Effect of age on molecular signaling of TNF-α-induced apoptosis in human lymphocytes. Mech Ageing Dev 124 (2003) 503-509
22. Gupta S., Bi R., Kim C., Yel L., Chiplunkar S., and Gollapudi S. Role of NF-κB signaling pathway in increased tumor necrosis factor-α-induced apoptosis of lymphocytes in aged humans. Cell Death Differ 12 (2005) 177-183
23. Trebilcock G.U., and Ponnappan U. Evidence for lowered induction of nuclear factor kappa B in activated human T lymphocytes during aging. Gerontology 42 (1996) 137-146
24. Ponnappan U., Zhong M., and Trebilcock G.U. Decreased proteosome-mediated degradation in T cells from the elderly: a role in immune senescence. Cell Immunol 192 (1999) 167-174
25. Gupta S. A role of inhibitor of apoptosis (IAP) proteins in increased lymphocyte apoptosis in aged humans. Mech Ageing Dev 125 (2004) 99-101
26. ++-dependent endonuclease in thymocyte nuclei leads to cell death. J Immunol 132 (1984) 38-42
27. Wyllie A.H. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284 (1980) 555-556