Partial reconstitution of the CD4+-T-cell compartment in CD4 gene knockout mice restores responses to tuberculosis DNA vaccines

Infection and Immunity

Volumn 74, Issue 5, 2006, Pages 2751-2759

  D'Souza, Sushila ^a   Romano, Marta ^a   Korf, Johanna ^a   Wang, Xiao Ming ^a   Adnet, Pierre Yves ^a   Huygen, Kris ^a  

^a PASTEUR INSTITUTE OF BRUSSELS   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE; CD4 ANTIGEN; CD8 ANTIGEN; DNA VACCINE; EPITOPE; GAMMA INTERFERON; PLASMID DNA; PROTEIN AG85A; PROTEIN AG85B; PROTEIN PSTS 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BCG VACCINATION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; DRUG EFFICACY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE DEFICIENCY; IMMUNE RESPONSE; INFECTION RESISTANCE; KNOCKOUT MOUSE; LUNG; LYMPHOCYTE MIGRATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PLASMID; PRIORITY JOURNAL; RECURRENT DISEASE; TUBERCULOSIS;

ACYLTRANSFERASES; ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; ANTIGENS, CD4; BACTERIAL PROTEINS; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; FEMALE; INTERFERON TYPE II; LUNG; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; T-LYMPHOCYTES, CYTOTOXIC; TUBERCULOSIS VACCINES; VACCINATION; VACCINES, DNA;

EID: 33646371217     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.74.5.2751-2759.2006     Document Type: Article

References (36)

1. Aichele, P., K. Brduscha-Riem, S. Oehen, B. Odermatt, R. M. Zinkernagel, H. Hengartner, and H. Pircher. 1997. Peptide antigen treatment of naïve and virus-immune mice: antigen-specific tolerance versus immunopathology. Immunity 6:519-529.
2. Autran, B. 1999. Effects of antiretroviral therapy on immune reconstitution. Antivir. Ther. 4(Suppl. 3):3-6.
3. Bennett, S. R., F. R. Carbone, F. Karamalis, J. F. Miller, and W. R. Heath. 1997. Induction of a CD8+ cytotoxic T lymphocyte response by cross-priming requires cognate CD4+ T cell help. J. Exp. Med. 186:65-70.
4. Borremans, M., L. de Wit, G. Volkaert, J. Ooms, J. de Bruyn, K. Huygen, J. P. Van Vooren, M. Stelandre, R. Verhofstadt, and J. Content. 1989. Cloning, sequence determination, and expression of a 32-kilodalton-protein gene of Mycobacterium tuberculosis. Infect. Immun. 57:3123-3130.
5. Chan, J., and J. Flynn. 2004. The immunological aspects of latency of tuberculosis. Clin. Immunol. 110:2-12.
6. Cooper, A. M., D. K. Dalton, T. A. Stewart, J. P. Griffin, D. G. Russell, and I. M. Orme. 1993. Disseminated tuberculosis in interferon gamma gene-disrupted mice. J. Exp. Med. 178:2243-2247.
7. Corbett, E. L., C. J. Watt, N. Walker, D. Maher, B. G. Williams, M. C. Raviglione, and C. Dye. 2003. The global burden of tuberculosis: global trends and interactions with the HIV epidemic. Arch. Intern. Med. 163:1009-1021.
8. De Bruyn, J., K. Huygen, R. Bosmans, M. Fauville, R. Lippens, J. P. Van Vooren, P. Falmagne, M. Weckx, H. G. Wiker, M. Harboe, et al. 1987. Purification, characterization and identification of a 32 kDa protein antigen of Mycobacterium bovis BCG. Microb. Pathog. 2:351-366.
9. + T-cell epitopic repertoire broader than that stimulated by Mycobacterium tuberculosis H37Rv infection. Infect. Immun. 66:1527-1533.
10. Derrick, S. C., A. Li Yang, and S. L. Morris. 2005. Vaccination with a Sindbis virus-based DNA vaccine expressing antigen 85B induces protective immunity against Mycobacterium tuberculosis. Infect. Immun. 73:7727-7735.
11. D'Souza, S., O. Denis, T. Scorza, F. Nzabintwali, H. Verschueren, and K. Huygen. 2000. CD4+ T cells contain Mycobacterium tuberculosis infection in the absence of CD8+ T cells in mice vaccinated with DNA encoding Ag85A. Eur. J. Immunol. 30:2455-2459.
12. D'Souza, S., V. Rosseels, M. Romano, O. Denis, F. Jurion, N. Castiglioni, A. Vanonckelen, K. Palfliet, and K. Huygen. 2003. Mapping of murine Th1 helper T-cell epitopes of mycolyl transferases Ag85A, Ag85B, and Ag85C from Mycobacterium tuberculosis. Infect. Immun. 71:483-493.
13. Dye, C., S. Scheels, P. Dolin, V. Pathania, and M. C. Raviglione. 1999. Consensus statement. Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country. WHO Global Surveillance and Monitoring Project. JAMA 282:6776-6786.
14. Dye, C., C. J. Watt, D. M. Bleed, and B. G. Williams. 2003. What is the limit to case detection under the DOTS strategy for tuberculosis control? Tuberculosis (Edinburgh) 83:35-43.
15. Fu, T. M., J. B. Ulmer, M. J. Caulfield, R. R. Deck, A. Friedman, S. Wang, X. Liu, J. J. Donnelly, and M. A. Liu. 1997. Priming of cytotoxic T lymphocytes by DNA vaccines: requirement for professional antigen presenting cells and evidence for antigen transfer from myocytes. Mol. Med. 3:362-371.
16. Geluk, A., K. E. van Meijgaarden, K. L. Franken, J. W. Drijfhout, S. D'Souza, A. Necker, K. Huygen, and T. H. Ottenhoff. 2000. Identification of major epitopes of Mycobacterium tuberculosis AG85B that are recognized by HLA-A*0201-restricted CD8+ T cells in HLA-transgenic mice and humans. J. Immunol. 165:6463-6471.
17. Gillerons, M., V. F. J. Quesniaux, and G. Puzo. 2003. Acylation state of the phosphatidylinositol hexamannosides from Mycobacterium bovis bacillus Calmette Guérin and Mycobacterium tuberculosis H37Rv and its implication in Toll-like receptor response. J. Biol. Chem. 278:29880-29889.
18. Hesseling, A. C., H. S. Schaaf, W. A. Hanekom, N. Beyers, M. F. Cotton, R. P. Gie, B. J. Marais, P. van Helden, and R. M. Warren. 2003. Danish bacille Calmette-Guerin vaccine-induced disease in human immunodeficiency virus-infected children. Clin. Infect. Dis. 37:1226-1233.
19. Huygen, K., J. P. Van Vooren, M. Turneer, R. Bosmans, P. Dierckx, and J. De Bruyn. 1988. Specific lymphoproliferation, gamma interferon production, and serum immunoglobulin G directed against a purified 32 kDa mycobacterial protein antigen (P32) in patients with active tuberculosis. Scand. J. Immunol. 27:187-194.
20. Huygen, K., D. Abramowicz, P. Vandenbussche, F. Jacobs, J. De Bruyn, A. Kentos, A. Drowart, J. P. Van Vooren, and M. Goldman. 1992. Spleen cell cytokine secretion in Mycobacterium bovis BCG-infectcd mice. Infect. Immun. 60:2880-2886.
21. Huygen, K., J. Content, O. Denis, D. L. Montgomery, A. M. Yawman, R. R. Deck, C. M. DeWitt, I. M. Orme, S. Baldwin, C. D'Souza, A. Drowart, E. Lozes, P. Vandenbussche, J. P. Van Vooren, M. A. Liu, and J. B. Ulmer. 1996. Immunogenicity and protective efficacy of a tuberculosis DNA vaccine. Nat. Med. 2:893-898.
22. Huygen, K. 2005. Plasmid DNA vaccination. Microb. Infect. 7:932-938.
23. Kaufmann, S. H. E. 2001. How can immunology contribute to the control of tuberculosis? Nat. Rev. Immunol. 1:20-30.
24. + T cells in tuberculosis. Am. J. Respir. Crit. Care Med. 166:1116-1121.
25. MacMicking, J. D., G. A. Taylor, and J. D. McKinney. 2003. Immune control of tuberculosis by IFN-gamma-inducible LRG-47. Science 302:654-659.
26. Mak, T. W., A. Rahemtulla, M. Schilham, D. R. Kohl, and W. P. Fung-Leung. 1992. Generation of mutant mice lacking surface expression of CD4 or CD8 by gene targeting. J. Autoimmun. 5(Suppl. A):55-59.
27. Orme, I. M., A. D. Roberts, J. P. Griffin, and J. S. Abrams. 1993. Cytokine secretion by CD4 T lymphocytes acquired in response to Mycobacterium tuberculosis infection. J. Immunol. 151:518-525.
28. Rahemtulla, A., W. P. Fung-Leung, M. W. Schilham, T. M. Kündig, S. R. Sambhara, A. Narendran, A. Arabian, A. Wakeham, C. J. Paige, R. M. Zinkernagel, R. G. Miller, and T. W. Mak. 1991. Normal development and function of CD8+ cells but markedly decreased helper activity in mice lacking CD4. Nature 353:180-184.
29. b-restricted cytolytic T cell activity against a putative phosphate transport receptor of Mycobacterium tuberculosis. J. Immunol. 172:6913-6921.
30. Serbina, N. V., V. Lazarevic, and J. L. Flynn. 2001. CD4(+) T cells are required for the development of cytotoxic CD8(+) T cells during Mycobacterium tuberculosis infection. J. Immunol. 167:6991-7000.
31. Shedlock, D. J., and H. Shen. 2003. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 300:337-342.
32. Small, P. M., R. W. Shafer, P. C. Hopewell, S. P. Singh, M. J. Murphy, E. Desmond, M. F. Sierra, and G. K. Schoolnik. 1993. Exogenous reinfection with multidrug-resistant Mycobacterium tuberculosis in patients with advanced HIV infection. N. Engl. J. Med. 328:1137-1144.
33. Snewin, V. A., M. P. Gares, P. O. Gaora, Z. Hasan, I. N. Brown, and D. B. Young. 1999. Assessment of immunity to mycobacterial infection with luciferase reporter constructs. Infect. Immun. 67:4586-4593.
34. Tanghe, A., P. Lefevre, O. Denis, S. D'Souza, M. Braibant, E. Lozes, M. Singh, D. Montgomery, J. Content, and K. Huygen. 1999. Immunogenicity and protective efficacy of tuberculosis DNA vaccines encoding putative phosphate transport receptors. J. Immunol. 162:1113-1119.
35. Tanghe, A., S. D'Souza, V. Rosseels, O. Denis, T. H. M. Ottenhoff, W. Dalemans, C. Wheeler, and K. Huygen. 2001. Improved immunogenicity and protective efficacy of a tuberculosis DNA vaccine encoding Ag85 by protein boosting. Infect. Immun. 69:3041-3047.
36. + T cells against influenza virus induced by vaccination with nucleoprotein DNA. J. Virol. 72:5648-5653.