Development of congenic rat strains for alcohol consumption derived from the alcohol-preferring and nonpreferring rats

Behavior Genetics

Volumn 36, Issue 2, 2006, Pages 285-290

  Carr, Lucinda G ^a   Habegger, Kirk ^a   Spence, John P ^a   Liu, Lixiang ^a   Lumeng, Lawrence ^a   Foroud, Tatiana ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alcoholism; Congenics; Gene mapping; Rat

Indexed keywords

ALCOHOL CONSUMPTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACKCROSSING; CHROMOSOME 4; CONGENIC STRAIN; CONTROLLED STUDY; DRINKING BEHAVIOR; GENETIC LINKAGE; INBRED STRAIN; NONHUMAN; QUANTITATIVE TRAIT LOCUS; RAT;

ALCOHOL DRINKING; ANIMALS; ANIMALS, CONGENIC; CHOICE BEHAVIOR; CHROMOSOMES, MAMMALIAN; FEMALE; GENETIC MARKERS; MALE; MICE; MICROSATELLITE REPEATS; MODELS, GENETIC; PHENOTYPE; RATS; RATS, INBRED STRAINS; RATS, WISTAR;

ANIMALIA;

EID: 33646368181     PISSN: 00018244     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10519-005-9021-z     Document Type: Article

References (20)

1. Beavis, W. D. (1994). The power and deceit of QTL experiments: lessons from comparative QTL studies. 49th Annual Corn & Sorghum Research Conference, Johnston, IA, pp. 250-266.
2. Bennett, B., Beeson, M., Gordon, L., Carosone-Link, P., and Johnson, T. E. (2002). Genetic dissection of quantitative trait loci specifying sedative/hypnotic sensitivity to ethanol: mapping with interval-specific congenic recombinant lines. Alcohol Clin. Exp. Res. 26:1615-24.
3. Bennett, B., and Johnson, T. E. (1998). Development of congenics for hypnotic sensitivity to ethanol by QTL-marker-assisted counter selection. Mamm. Genome 9:969-974.
4. Bice, P., Foroud, T., Bo, R., Castelluccio, P., Lumeng, L., Li, T. K., and Carr, L. G. (1998). Genomic screen for QTLs underlying alcohol consumption in the P and NP rat lines. Mamm. Genome 9:949-955.
5. Carr, L. G., Foroud, T., Bice, P., Gobbett, T., Ivashina, J., Edenberg, H., Lumeng, L., and Li, T. K. (1998). A quantitative trait locus for alcohol consumption in selectively bred rat lines. Alcohol Clin. Exp. Res. 22:884-887.
6. Cicero, T .J. (1979). A critique of animal analogues of alcoholism. In E. Majchrowicz and E. P. Noble (eds.), Biochemistry and Pharmacology of Ethanol Vol 2. New York: Plenum Press, pp. 533-560.
7. Crabbe, J. C., Belknap, J. K., Metten, P., Grisel, J. E., and Buck, K. J. (1998). Quantitative trait loci: mapping drug and alcohol-related genes. Adv. Pharmacol. 42:1033-7.
8. Demarest, K., Koyner, J., McCaughran, J. Jr, and Hitzemann, R. (2000). Mapping of a major QTL on mouse chromosome 2 for ethanol-induced locomotor activity in a heterogeneous stock population. Alcohol Clin. Exp. Res. 24:96A .
9. Fehr, C., Shirley, R. L., Belknap, J. K., Crabbe, J. C., and Buck, K. J. (2002). Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a < 1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene. J. Neurosci. 22:3730-3738.
10. Flaherty, L. (1981). Congenic strains. In H. L. Foster, F. D. Small and F. G. Fox (eds.), The Mouse in Biomedical Research. New York: Academic Press, pp. 215-222Inc.
11. Flint, J., Valdar, W., Shifman, S., and Mott, R. (2005). Strategies for mapping and cloning quantitative trait genes in rodents. Nat. Rev. Genet. 6:271-286.
12. Garrett, M. R., and Rapp, J. P. (2002a). Two closely linked interactive blood pressure QTL on rat chromosome 5 defined using congenic Dahl rats. Physiol. Genomics 8:81-86.
13. Garrett, M. R., and Rapp, J. P. (2002b). Multiple blood pressure QTL on rat Chromosome 2 defined by congenic Dahl rats. Mamm. Genome 13:41-44.
14. Lander, E. S., and Schork, N. J. (1994). Genetic dissection of complex traits. Science 265:2037-2048.
15. Legare, M. E., and Frankel, W. N. (2000). Multiple seizure susceptibility genes on chromosome 7 in SWXL-4 congenic mouse strains. Genomics 70:62-65.
16. Legare, M. E., Bartlett, F. S. II, and Frankel, W. N. (2000). A major effect QTL determined by multiple genes in epileptic EL mice. Genome Res. 10:42-48.
17. Li, T.-K., Lumeng, L., Doolittle, D. P., and Carr, L. G. (1991). Molecular associations of alcohol seeking behavior in rat lines selectively bred for high and low voluntary ethanol drinking. Alcohol Alcohol Suppl. 1:121-124.
18. Lumeng, L., Hawkins, D.T., and Li, T.-K. (1997). New strains of rats with alcohol consumption and nonconsumption. In R. G. Thurman, J. R. Williamson, H. Drott and B. Chance (eds.), Alcohol and Aldehyde Metabolizing Systems Vol 3. New York: Academic Press, pp. 537-44.
19. Morel, L., Blenman, K. R., Croker, B. P., and Wakeland, E. K. (2001). The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes. Proc. Natl. Acad. Sci. USA 98:1787-1792.
20. Shirley, R. L., Walter, N. A., Reilly, M. T., Fehr, C., and Buck, K. J. (2004). Mpdz is a quantitative trait gene for drug withdrawal seizures. Nat. Neurosci. 7:699-700.