Effect of protein kinase Cβ inhibitor on Ca2+ homeostasis in diabetic sensory neurons

NeuroReport

Volumn 17, Issue 6, 2006, Pages 683-688

  Tahara, Masayuki ^a   Omatsu Kanbe, Mariko ^a   Sanada, Mitsuru ^a   Maeda, Kengo ^a   Koya, Daisuke ^b   Matsuura, Hiroshi ^a   Kashiwagi, Atsunori ^a   Yasuda, Hitoshi ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^b KANAZAWA MEDICAL UNIVERSITY   (Japan)

Author keywords

Calcium homeostasis; Diabetic neuropathy; LY333531; Protein kinase C; Ruthenium 360; Sensory neuron

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CALCIUM ION; CALCIUM UNIPORTER INHIBITOR; FURA 2; PROTEIN KINASE C BETA INHIBITOR; PROTEIN KINASE C INHIBITOR; RUBOXISTAURIN; RUTHENIUM; RUTHENIUM 360; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CONTROLLED STUDY; DIABETIC NEUROPATHY; DOSE RESPONSE; DRUG EFFECT; FLUORESCENCE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL; SPINAL GANGLION; STREPTOZOCIN DIABETES;

ANIMALS; CALCIUM; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME INHIBITORS; GANGLIA, SPINAL; HOMEOSTASIS; INDOLES; MALE; MALEIMIDES; MEMBRANE POTENTIALS; MITOCHONDRIA; NEURONS, AFFERENT; POTASSIUM CHLORIDE; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33646365376     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001756-200604240-00026     Document Type: Article

References (25)

1. Yasuda H, Terada M, Maeda K, Kogawa S, Sanada M, Haneda M, et al. Diabetic neuropathy and nerve regeneration. Prog Neurobiol 2003; 69:229-285.
2. Koya D, King GL. Protein kinase C activation and the development of diabetic complications. Diabetes 1998; 47:859-866.
3. Cotter MA, Jack AM, Cameron NE. Effects of the protein kinase C beta inhibitor LY333531 on neural and vascular function in rats with streptozotocin-induced diabetes. Clin Sci (London) 2002; 103:311-321.
4. Nakamura J, Kato K, Hamada Y, Nakayama M, Chaya S, Nakashima E. A protein kinase C-beta-selective inhibitor ameliorates neural dysfunction in streptozotocin-induced diabetic rats. Diabetes 1999; 48:2090-2095.
5. Kim H, Sasaki T, Maeda K, Koya D, Kashiwagi A, Yasuda H. Protein kinase Cβ selective inhibitor LY333531 attenuates diabetic hyperalgesia through ameliorating cGMP level of dorsal root ganglion neurons. Diabetes 2003; 52:2102-2109.
6. Koya D, Haneda M, Nakagawa H, Isshiki K, Sato H, Maeda S, et al. Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes. FASEB J 2000; 14:439-447.
7. Yamagishi S, Uehara K, Otsuki S, Yagihashi S. Differential influence of increased polyol pathway on protein kinase C expressions between endoneurial and epineurial tissues in diabetic mice. J Neurochem 2003; 87:497-507.
8. Uehara K, Yamagishi SI, Otsuki S, Chin S, Yagihashi S. Effects of polyol pathway hyperactivity on protein kinase C activity, nociceptive peptide expression, and neuronal structure in dorsal root ganglia in diabetic mice. Diabetes 2004; 53:3239-3247.
9. Huang TJ, Sayers NM, Fernyhough P, Verkhratsky A. Diabetes-induced alterations in calcium homeostasis in sensory neurones of streptozotocin-diabetic rats are restricted to lumbar ganglia and are prevented by neurotrophin-3. Diabetologia 2002; 45:560-570.
10. Hall KE, Liu J, Sima AA, Wiley JW. Impaired inhibitory G-protein function contributes to increased calcium currents in rats with diabetic neuropathy. J Neurophysiol 2001; 86:760-770.
11. Kruglikov I, Gryshchenko O, Shutov L, Kostyuk E, Kostyuk P, Voitenko N. Diabetes-induced abnormalities in ER calcium mobilization in primary and secondary nociceptive neurons. Pflugers Arch 2004; 448:395-401.
12. Shishkin V, Potapenko E, Kostyuk E, Girnyk O, Voitenko N, Kostyuk P. Role of mitochondrial in intracellular calcium signaling in primary and secondary sensory neurons of rats. Cell Calcium 2002; 32:121-130.
13. Fernyhough P, Huang TJ, Verkhratsky A. Mechanism of mitochondrial dysfunction in diabetic sensory neuropathy. J Peripher Nerv Syst 2003; 8:227-235.
14. 2+ and calcitonin gene-related peptide release through metabotrophic P2Y receptors in rat dorsal root ganglion neurons. Neuroscience 2002; 111:413-422.
15. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985; 260:3440-3450.
16. Huang TJ, Price SA, Chilton L, Calcutt NA, Tomlinson DR, Verkhratsky A, et al. Insulin prevents depolarization of the mitochondrial inner membrane in sensory neurons of type 1 diabetic rats in the presence of sustained hyperglycemia. Diabetes 2003; 52:2129-2136.
17. Bernardi P. Mitochondrial transport of cations: channels, exchangers, and permeability transition. Physiol Rev 1999; 79:1127-1155.
18. Cesare P, Dekker LV, Sardini A, Parker PJ, McNaughton PA. Specific involvement of PKC-epsilon in sensitization of the neuronal response to painful heat. Neuron 1999; 23:617-624.
19. Sakaue Y, Sanada M, Sasaki T, Kashiwagi A, Yasuda H. Amelioration of retarded neurite outgrowth of dorsal root ganglion neurons by overexpression of PKCdelta in diabetic rats. Neuroreport 2003; 14:431-436.
20. Braz JC, Gregory K, Pathak A, Zhao W, Sahin B, Klevitsky R. PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nat Med 2004; 10:248-254.
21. 2+ signals by protein kinase C isozymes. J Cell Biol 2004; 165:223-232.
22. Hajnoczky G, Csordas G, Yi M. Old players in a new role: mitochondria-associated membrane, VDAC, and ryanodine receptors as contributors to calcium signal propagation from endoplasmic reticulum to the mitochondria. Cell Calcium 2002; 32:363-377.
23. Sasaki H, Schmelzer JD, Zollman PJ, Low PA. Neuropathology and blood flow of nerve, spinal roots and dorsal root ganglia in longstanding diabetic rats. Acta Neuropathol 1997; 93:118-128.
24. 2+ signaling and apoptosis of medium spiny neurons in Huntington's disease. Proc Natl Acad Sci USA 2005; 102:2602-2607.
25. Butow RA, Avadhani NG. Mitochondrial signaling: the retrograde response. Mol Cell 2004; 14:1-15.