A new antihypertensive agent that antagonizes the prohypertensive effect of endogenous Ouabain and Adducin

Cardiovascular and Hematological Agents in Medicinal Chemistry

Volumn 4, Issue 1, 2006, Pages 61-66

  Manunta, Paolo ^a   Ferrandi, Mara ^b   Messaggio, Elisabetta ^a   Ferrari, Patrizia ^b  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b Prassis Sigma Tau Research Institute   (Italy)

Author keywords

Genetic; Hypertension; Hypertrophy; Na K ATPase; Rat

Indexed keywords

17BETA (3 FURYL) 5BETA ANDROSTANE 3BETA,14BETA,17ALPHA TRIOL; ADDUCIN; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALKALINE PHOSPHATASE; ANTIHYPERTENSIVE AGENT; ASPARTATE AMINOTRANSFERASE; DIGITOXIGENIN; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OUABAIN; PROTEIN TYROSINE KINASE; SODIUM ION; TRIACYLGLYCEROL; 17 (3 FURYL) 5BETA ANDROSTANE 3,14,17 TRIOL; 17-(3-FURYL)-5BETA-ANDROSTANE-3,14,17-TRIOL; ANDROSTANE DERIVATIVE; CALMODULIN BINDING PROTEIN; SODIUM CHLORIDE;

ABSENCE OF SIDE EFFECTS; ARTICLE; BLOOD PRESSURE REGULATION; CARDIOTOXICITY; CLINICAL TRIAL; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG EFFICACY; DRUG FATALITY; DRUG MECHANISM; DRUG SAFETY; DRUG TARGETING; DRUG TOLERABILITY; DYSLIPIDEMIA; ENZYME ACTIVATION; ENZYME REGULATION; GASTROINTESTINAL DISEASE; GENE MUTATION; GENETIC REGULATION; GUINEA PIG; HEART FAILURE; HEART INFARCTION; HEART LEFT VENTRICLE HYPERTROPHY; HOMEOSTASIS; HUMAN; HYPERTENSION; INHIBITION KINETICS; KIDNEY HYPERTROPHY; KIDNEY TUBULE ABSORPTION; LIVER TOXICITY; MONKEY; MUTAGENICITY; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; RAT; RESPIRATORY TRACT DISEASE; SALT INTAKE; SIGNAL TRANSDUCTION; TREATMENT DURATION; BLOOD; BLOOD PRESSURE; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; RISK FACTOR;

ANDROSTANOLS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CALMODULIN-BINDING PROTEINS; HUMANS; HYPERTENSION; NA(+)-K(+)-EXCHANGING ATPASE; OUABAIN; RISK FACTORS; SODIUM CHLORIDE;

EID: 33646352478     PISSN: 18715257     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152506775268811     Document Type: Article

References (43)

1. Hamlyn, J.M.; Blaustein, M.P.; Bova, S.; DuCharme, D.W.; Harris, D.; Mandel, F. Proc. Natl. Acad. Sci., 1991, 88, 6259.
2. Hamlyn, J.M.; Lu, Z.; Manuma, P.; Ludens, J.H.; Kimura, K.; Shah, J.; Laredo, J.; Hamilton, J.; Hamilton, M.; Hamilton, B. Clin. Exp. Hypertens., 1998, 20(5&6), 523.
3. Kawamura, A.; Guo, J.; Itagaki, Y.; Bell, C.; Wang, Y.; Haupert, G.; Magil, S.; Gallagher, R.; Berova, N.; Nakanishi, K. Proc. Natl. Acad. Sci., 1999, 96, 6654.
4. Ferrandi, M.; Manunta, P.; Balzan, S.; Hamlyn, J.M.; Bianchi, G.; Ferrari, P. Hypertension, 1997, 30, 886.
5. Goto, A.; Yamada, K.; Ishii, M.; Yoshioka, M.; Ishiguro, T., Eguchi, C.; Sugimoto, T. Biochem. Bioph. Res. Co., 1988, 154, 847.
6. Gottlieb, S.S.; Rogowski, A.; Weinberg, M.; Krichten, C.; Hamilton, B.; Hamlyn, J.M. Circulation, 1992, 86, 420.
7. Balzan, S.; Neglia, D.; Ghione, S.; D'Urso, G.; Baldacchino, M.C.; Montali, U.; L'Abbate, A. Eur. J. Heart Fail., 2001, 3, 165.
8. Manunta, P.; Messaggio, E.; Ballabeni, C.; Sciarrone, M.T.; Lanzani, C.; Ferrandi, M.; Hamlyn, J.M.; Cusi, D.; Galletti, F.; Bianchi, G. Hypertension, 2001, 38, 198.
9. Aizman, O.; Uhlen, P.; Lal, M.; Brismar, H.; Aperia, A. Proc. Natl. Acad Sci., 2001, 98, 13420.
10. Xie, Z.; Askari, A. Eur. J. Biochem., 2002, 269, 2434.
11. Ferrari, P.; Torielli, L.; Ferrandi, M.; Padoani, G.; Duzzi, L Florio, M.; Conti, F.; Melloni, P.; Vesci, L.; Corsico, N.; Bianchi, G. J. Pharmacol. Exp. Ther., 1998, 285, 83.
12. Quadri, L.; Bianchi, G.; Cerri, A.; Fedrizzi, G.; Ferrari, P., Gobbini, M.; Melloni, P. J. Med. Chem.,1997, 40, 1561.
13. Ferrari, P.; Ferrandi, M.; Torielli, L.; Tripodi, G.; Melloni, P.; Bianchi, G. Cardiovasc. Drug Rev., 1999, 17, 39.
14. Ferrari, P.; Ferrandi, M.; Tripodi, G.; Torielli, L.; Padoani, G., Minotti, E.; Melloni, P.; Bianchi, G. J. Pharmacol. Exp. Ther., 1999, 288, 1074.
15. Lingrel, J.B.; Orlowski, J.; Shull, M.M.; Price, E.M. Prog. Nucleic Acid Res., 1990, 38, 37.
16. Ferrari, P.; Bianchi, G. Hypertension, Pathophysiology, Diagnosis and Management; Raven Press Ltd.: New York, 1995, 74, 1261
17. Bianchi, G.; Fox, U.; Di Francesco, G.F.; Giovanetti, A.M.; Pagetti, D. Clin. Sci. Mol. Med, 1974, 47, 435.
18. Ferrari, P.; Cusi, D.; Barber, B.R.; Barlassina, C.; Vezzoli, L.; Duzzi, L.; Minotti, E.; Bianchi, G. Clin. Sci., 1982, 63, 61 s.
19. Bianchi, G.; Tripodi, G.; Casari, G.; Salardi, S.; Barber, B.R.; Garcia, R.; Leoni, P.; Torielli, L.; Cusi, D.; Ferrandi, M.; Pinna, LA.; Baralle, F.E.; Ferrari, P. Proc. Nad. Acad. Sci., 1994, 91, 3999.
20. Tripodi, G.; Valtorta, F.; Torielli, L.; Chieregatti, E.; Salardi, S.; Trusolino, L.; Menegon, A.; Ferrari, P.; Marchisio, P.C.; Bianchi, G. J Clin. Invest., 1996, 97, 2815.
21. Ferrandi, M.; Tripodi, G.; Salardi, S.; Florio, M.; Modica, R.; Barassi, P.; Parenti, P.; Shainskaia, A.; Karlish, S.; Bianchi, G.; Ferrari, P. Hypertension, 1996, 28, 101.
22. Manunta, P.; Rogowski, A.C.; Hamilton B.P.; Hamlyn.; J.M. J. Hypertens., 1994, 12, 549.
23. Cusi, D.; Barlassina, C.; Azzani, T.; Casari, G.; Citterio, L.; Devoto, M.; Glorioso, N.; Lanzani, C.; Manuma, P.; Righetti, M.; Rivera, R.; Stella, P.; Troffa, C.; Zagato, L.; Bianchi, G. Lancet, 1997, 349, 1353.
24. Manunta, P.; Burnier, M.; D'Amico, M.; Buzzi, L.; Maillard, M.; Barlassina, C.; Lanella, G.; Cusi, D.; Bianchi G. Hypertension, 1999, 33, 694.
25. Efendiev, R.; Krmar, RT.; Ogimoto, G.; Zwiller, J.; Tripodi, G.; Katz, AI.; Bianchi, G.; Pedemonte, C.H.; Bertorello, A.M. Circ. Res., 2004, 26, 95.
26. Ferrandi, M.; Salardi, S.; Tripodi, G.; Barassi, P.; Goldslager, R.; Manunta, P.; Ferrari, P.; Bianchi, G.; Karlish, S. Am. J. Phys., 1999, 277, H1338.
27. Ferrandi, M.; Molinari, I.; Barassi, P.; Minotti, E.; Bianchi, G.; Ferrari, P. J Biol. Chem., 2004, 279, 33306.
28. deWardener, H.E.; MacGregor, G.A. Kidney Int., 1980, 18, 1.
29. Blaustein, M.P. Am. J. Phys., 1977, 232, C165.
30. Liu, J.; Kesiry, R.; Sankaridrug, M.P.; Malhotra, D.; Xie, J.; Shapiro, J. Kidney Int., 2004, 66, 227.
31. Ferrandi, M.; Manunta, P. Curr. Opin. Nephrol. Hypertens., 2000, 9, 165.
32. Will, P.C.; Longworth, J.W.; Broke, E.T.; Cook, J.S. Mol. Pharmacol., 1977, 13, 161.
33. Wang, J.; Staessen, J.; Messaggio, E.; Nawrot, T.; Fagard, R.; Hamlyn, J.M.; Bianchi, G.; Manunta, P. J. Hypertens., 2003, 21, 1475.
34. Manunta, P.; Stella, P.; Rivera, R.; Ciurlino, D.; Cusi, D.; Ferrandi, M.; Hamlyn, J.M.; Bianchi, G. Hypertension, 1999, 34, 450.
35. Pierdomenico, S.; Bucci, A.; Manunta, P.; Rivera, R.; Ferrandi, M.; Hamlyn, J.M.; Lapenna, D.; Cuccurullo, F.; Mezzetti, A. Am. J. Hypertens., 2001, 14, 44.
36. Pitzalis, M.V.; Hamlyn, J.M.; Messaggio, E.; Iacoviello, M.; Forleo, C.; Romita, R.; De Tommasi, E.; Rizzon, P.; Massari, F.; Bianchi, G.; Manunta, P. Eur. J. Heart Failure, 2005, in press.
37. Delva, P.; Devynch, M.A.; Degan, M.; Pernollet, M.G.; Carraroli, M.; Capra, C.; Steele, A.; Lechi, A. Clin. Sci., 1991, 81, 23.
38. Haas, M.; Wang, H.; Tian, J.; Xie, Z. J. Biol. Chem., 2002, 277, 18694.
39. Ferrandi, M.; Barassi, P.; Minotti, E.; Duzzi, L.; Molinari, I.; Bianchi, G.; Ferrari, P. J. Cadiovasc. Pharm., 2002, 40, 881.
40. Kojima, I.; Yoshihara, S.; Ogata, E. Life Sci., 1982, 30, 1775.
41. Sekihara, S.; Yazaki, Y.; Kojima, T. Endocrinology, 1992, 131, 3077.
42. Pamnani, M.B.; Withehorn, W.V.; Clough, D.L.; Haddy, F.G. Am. J. Hypertens., 1990, 3, 188.
43. Ferrari, P.; Bianchi, G. Cardiovasc. Drug Ther., 2000, 14, 387.