Consumption of redox energy by glutathione metabolism contributes to hypoxia/reoxygenation-induced injury in astrocytes

Molecular and Cellular Biochemistry

Volumn 286, Issue 1-2, 2006, Pages 95-101

  Makarov, Petr ^a,b   Kropf, Siegfried ^c   Wiswedel, Ingrid ^a   Augustin, Wolfgang ^a   Schild, Lorenz ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b INSTITUTE OF THEORETICAL AND EXPERIMENTAL BIOPHYSICS   (Russian Federation)

^c Medical Faculty Institute of Biometry and Medical Informatics   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; BUTHIONINE SULFOXIMINE; GLUTATHIONE; GLYCOGEN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL CULTURE; CELL DAMAGE; CELL ENERGY; CELL FUNCTION; CELL HYPOXIA; CONTROLLED STUDY; ENERGY CONSUMPTION; FOLLOW UP; GLUTATHIONE METABOLISM; ISCHEMIA; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; RAT; REOXYGENATION; REPERFUSION INJURY;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BUTHIONINE SULFOXIMINE; CELL HYPOXIA; CELLS, CULTURED; GLUTATHIONE; GLYCOGEN; OXIDATION-REDUCTION; OXYGEN; RATS; RATS, WISTAR; TETRAZOLIUM SALTS; THIAZOLES; TIME FACTORS;

ANIMALIA;

EID: 33646244996     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-005-9098-y     Document Type: Article

References (46)

1. Merad-Saidoune M, Boitier E, Nicole A, Marsac C, Martinou JC, Sola B, Sinet PM, Ceballos-Picot I: Overproduction of Cu/Zn-superoxide dismutase or Bcl-2 prevents the brain mitochondrial respiratory dysfunction induced by glutathione depletion. Exp Neurol 158: 428-436, 1999
2. Beal MF, Ferrante RJ, Henshaw R, Matthews RT, Chan PH, Kowall NW, Epstein CJ, Schulz JB: 3-Nitropropionic acid neurotoxicity is attenuated in copper/zinc superoxide dismutase transgenic mice. J Neurochem 65: 919-922, 1995
3. Chen Y, Chan PH, Swanson RA: Astrocytes overexpressing Cu, Zn superoxide dismutase have increased resistance to oxidative injury. Glia 33: 343-347, 2001
4. Chan PH: Role of Oxidants in Ischemic Brain Damage. Stroke 27: 1124-1129, 1996
5. Dringen R: Metabolism and functions of glutathione in brain. Prog Neurobiol 62:649-671, 2000
6. Wilson JX: Antioxidant defenAe of the brain: a role for astrocytes. Can J Physiol Pharmacol 75: 1149-1163, 1997
7. Aschner M: Neuron-astrocyIe interactions: implications for cellular energetics and antioxidant levels. Neurotoxicology 21: 1101-1107, 2000
8. Ransom BR, Fern R: Does astrocytic glycogen benefit axon function and survival in CNS white matter during glucose deprivation?: Glia 21: 134-141, 1997
9. Sagara JI, Miura K, Bannai S: Maintenance of neuronal glutathione by glial cells. J Neurochem 61: 1672-1676, 1993
10. Wang XF, Cynader MS: Astrocytes provide cysteine to neurons by releasing glutathione. J Neurochem 74: 1434-1442, 2000
11. Chen Y, Vartiainen NE, Ying W, Chan PH, Koistinaho J, Swanson RA: Astrocytes protect neurons from nitric oxide toxicity by a glutathione-dependent mechanism. J Neurochem 77: 1601-1610, 2001
12. Dringen R, Gutterer JM, Hirrlinger J: Glutathione metabolism in brain metabolic interaction between astrocytes and neurons in the defense against reactive oxygen species. Eur J Biochem 267: 4912-4916, 2000
13. Langeveld CH, Jongenelen CA, Schepens E, Stoof JC, Bast A, Drukarch B: Cultured rat striatal and cortical astrocytes protect mesencephalic dopaminergic neurons against hydrogen peroxide toxicity independent of their effect on neuronal development. Neurosci Lett 192: 13-16, 1995
14. Makar TK, Nedergaard M, Preuss A, Gelbard AS, Perumal AS, Cooper AJ: Vitamin E, ascorbate, glutathione, glutathione disulfide, and enzymes of glutathione metabolism in cultures of chick astrocytes and neurons: evidence that astrocytes play an important role in antioxidative processes in the brain. J Neurochem 62: 45-53, 1994
15. Raps SP, Lai JC, Hertz L, Cooper AJ: Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons. Brain Res 493: 398-401, 1989
16. Juurlink BH: Response of glial Rells to ischemia: roles of reactive oxygen species and glutathione. Neurosci Biobehav Rev 21: 151-66, 1977
17. Makarov PR, Wiswedel I, Augustin W, Schild L: Hypoxia/ reoxyg-tenation-induced damage to mitochondrial activity is determined by glutathione threshold in astroglia-rich cell cultures. Brain Res 933: 91-97, 2002
18. Masukawa T, Sai M, Tochino Y: Anti-hypoxic effect of glutathione depletors. Life Sci 44: 311-318, 1989
19. Martinez G, Carnazza ML, Campisi A, Sorrenti V, Di Giacomo C, Perez Polo JR, Vanella A: Effects of glutathione depletors on post-ischemic reperfusion in rat brain. Neurochem Res 23: 961-968, 1998
20. Vanella A, Di Giacomo C, Sorrenti V, Russo A, Castorina C, Campisi A, Renis M, Perez-Polo JR: Free radical scavenger depletion in post-ischemic reperfusion brain damage. Neurochem Res 18: 1337-1340, 1993
21. Scaduto Jr RC, Gattone 2nd VH, Martin LF, Yang HC: Elevation of renal glutathione enhances ischemic injury. Ren Physiol Biochem 14: 259-270, 1991
22. Regan RF, Guo Y: Extracellular reduced glutathione increases neuronal vulnerability to combined chemical hypoxia and glucose deprivation. Brain Res 817: 145-150, 1999
23. Hertz L, Peng L, Lai JCK: Functional studies in cultured astrocytes. Methods: A companion in methods in enzymology 16: 293-310, 1998
24. Musser DA, Oseroff AR: The use of tetrazolium salts to determinate sites of damage to the mitochondrial electron transport chain in intact cells following in vivo photodynamic therapy with photofrin II. Photochem Photobiol 59: 621-626, 1994
25. Takahashi S, Abe T, Gotoh J, Fukuuchi Y: Substrate-dependence of reduction of MTT: A tetrazolium dye differs in cultured astroglia and neurons. Neurochem Int 40: 441-448, 2002
26. Bernas T, Dobruki J: Mitochondrial and nonmitochondrial reduction of MTT: Ineraction of MTT with TMRE, JC-1, and NAO mitochondrial fluorescent probes. Cytometry 47: 236-242, 2002
27. Lu YY, Cheng J, Yang YP, Liu Y, Wang L, Li K, Zhang LX: Cloning and characterization of a novel hepatitis B virus core binding protein C12. World J Gastroenterol 11: 5666-5671, 2005
28. Berridge MV, Tan AS: Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction. Arch Biochem Biophys 303: 474-482, 1993
29. Berridge MV, Herst PM, Tan AS: Tetreazolium dyes as tools in cell biology: New insights into their cellular reduction. Biotechnol Annu Rev 11: 127-152, 2005
30. Takahashi S, Abe T, Gotoh J, Fukuuchi Y: Substrate-dependence of reduction of MTT: A tetrazolium dye differs in cultured astroglia and neurons. Neurochem Int 40: 441-448, 2002
31. Kowalski WB, Chatterton Jr RT: Enzymatic determination of endometrial tissue glycogen in the presence of reducing groups. Anal Biochem 252: 207-210, 1997
32. Tietze F: Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues. Anal Biochem 27: 502-522, 1969
33. Lowry OH, Rosebrough WJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275, 1951
34. Almeida A, Delgado-Esteban M, Bolanos JP, Medina JM: Oxygen and glucose deprivation induces mitochondrial dysfunction and oxidative stress in neurones but not in astrocytes in primary culture. J Neurochem 81: 207-217, 2002
35. Gonzalez-Flecha B, Cutrin JC, Boveris A: Time course and mechnism of oxidative stress and tissue damage in rat liver subjected to in vivo ischemia-reperfusion. J Clin Invest 91: 456-464, 1993
36. - generation in reduction and oxidation cycle of ubiquinones in a model of mitochondrial electron transport systems Biochim Biophys Acta 936: 377-385, 1988
37. Hori O, Matsumoto M, Maeda Y, Ueda H, Ohtsuki T, Stern DM, Kinoshita T, Ogawa S, Kamada T: Metabolic and biosynthetic alterations in cultured astrocytes exposed to hypoxia/reoxygenation. J Neurochem 62: 1489-1495, 1994
38. Maeda Y, Matsumoto M, Hori O, Kuwabara K, Ogawa S, Yan SD, Ohtsuki T, Kinoshita T, Kamada T, Stern DM: Hypoxia/reoxygenation-mediated induction of astrocyte interleukin 6: A paracrine mechanism potentially enhancing neuron survival. J Exp Med 180: 2297-2308, 1994
39. Kang YJ, Emery D, Enger MD: Buthionine sulfoximine induced growth inhibition in human lung carcinoma cells does not correlate with glutathione depletion. Cell Biol Toxicol 7: 249-261, 1991
40. Liebmann JE, Hahn SM, Cook JA, Lipschultz C, Mitchell JB, Kaufman DC: Glutathione depletion by L-buthionine sulfoximine antagonizes taxol cytotoxicity. Cancer Res 53: 2066-2070, 1993
41. Masukawa T, Sai M, Tochino Y: Brain glutathione and the anti-hypoxic effect of glutathione depletors in mice. Jpn J Phamacol 51: 125-127, 1989
42. Matsuo N, Ogawa S, Imai Y, Takagi T, Tohyama M, Stern D, Wanaka A: Cloning of a novel RNA binding polypeptide (RA301) induced by hypoxia/ reoxygenation. J Biol Chem 270: 28216-28222, 1995
43. Hertz L, Yager JY, Juurlink BH: Astrocyte survival in the absence of exogenous substrate: Comparison of immature and mature cells. Int J Dev Neurosci 13: 523-527, 1995
44. Yager JY, Kala G, Hertz L, Juurlink BH: Correlation between content of high-energy phosphates and hypoxic-ischemic damage in immature and mature astrocytes. Brain Res Dev Brain Res 82: 62-68, 1994
45. Ben-Yoseph O, Boxer PA, Ross BD: Assessment of the role of the glutathione and pentose phosphate pathways in the protection of primary cerebrocortical cultures from oxidative stress. J Neurochem 66: 2329-2337, 1996
46. Han SK, Mytilineou C, Cohen G: L-DOPA up-regulates glutathione and protects mesencephalic cultures against oxidative stress. J Neurochem 66: 501-510, 1996