Assessment of the role of the glutathione and pentose phosphate pathways in the protection of primary cerebrocortical cultures from oxidative stress

Journal of Neurochemistry

Volumn 66, Issue 6, 1996, Pages 2329-2337

  Ben Yoseph, Oded ^b   Boxer, Peter A ^a   Ross, Brian D ^b  

^a PFIZER INC   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Deferoxamine; Fenton reaction; Glutathione pathway; Oxidative stress; Pentose phosphate pathway; Primary cerebrocortical cultures

Indexed keywords

DEFEROXAMINE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LACTATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ARTICLE; AUTOOXIDATION; BRAIN CORTEX; BRAIN PROTECTION; CELL CULTURE; DETOXIFICATION; DNA STRAND BREAKAGE; ELECTRON TRANSPORT; GLUCOSE METABOLISM; LIPID PEROXIDATION; NERVE CELL LESION; NONHUMAN; OXIDATIVE STRESS; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0030008721     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.66062329.x     Document Type: Article

References (40)

1. Aust S. D. and White B. C. (1985) Iron chelation prevents tissue injury following ischemia. Adv. Radic. Biol. Med. 1, 1-17.
2. Baquer N. J., Hothersall J. S., McLean P., and Greenbaum A. L. (1977) Aspects of carbohydrate metabolism in the developing brain. Dev. Med. Child NeurOl. 19, 81-104.
3. Ben-Shachar D., Eshel G., Finberg J. P. M., and Youdim M. B. H. (1991) The iron chelator desferioxamine (desferal) retards 6-hydroxydopamine-induced degeneration of nigrostriatal dopamine neurons. J. Neurochem. 56, 1441-1444.
4. Ben-Yoseph O., Kingsley P. B., Camp D. M., Robinson T. E., and Ross B. D. (1994a) Measurement of pentose phosphate pathway activity by microdialysis in vivo and in a single incubation in vitro. Neurosci. Protocols 94-060-02-01-13.
5. Ben-Yoseph O., Boxer P. A., and Ross B. D. (1994b) Oxidative stress in the CNS: monitoring the metabolic response using the pentose phosphate pathway. Dev. Neurosci. 16, 328-336.
6. 2] glucose and microdialysis. J. Neurochem. 64, 1336-1342.
7. Boveris A. and Chance B. (1973) The mitochondrial generation of hydrogen peroxide: general properties and the effects of hyperbaric oxygen. Biochem. J. 134, 707-716.
8. Brannan T., Maker H. S., and Raes I. P. (1981) Regional distribution of catalase in the adult rat brain. J. Neurochem. 36, 307-309.
9. Bridges J. R., Koh J.-Y., Hatalski C. G., and Cotman C. W. (1991) Increased excitotoxic vulnerability of cortical cultures with reduced levels of glutathione. Eur. J. Pharmacol. 192, 199-200.
10. Chan P. H. and Fishman R. A. (1980) Transient formation of superoxide radicals in polyunsaturated fatty acid-induced brain swelling. J. Neurochem. 35, 1004-1007.
11. Chow H. S., Lynch J. J. III, Rose K., and Choi D. W. (1994) Trolox attenuates cortical neuronal injury induced by iron, ultraviolet light, glucose deprivation, or AMPA. Brain Res. 639, 102-108.
12. Cohen G. (1988) Oxygen radicals and Parkinson's disease, in Oxygen Radicals and Tissue Injury (Halliwell B., ed), pp. 130-135. FASEB, Bethesda, Maryland.
13. Coyle J. T. and Puttfarcken P. (1993) Oxidative stress, glutamate and neurodegenerative disorders. Science 262, 689-695.
14. Fridovich I. (1989) Superoxide dismutases. An adaptation to a paramagnetic gas. J. Biol. Chem. 264, 7761-7764.
15. Gaunt G. L. and De Duve C. (1976) Subcellular distribution of D-amino acid oxidase and catalase in rat brain. J Neurochem. 26, 749-759.
16. Gerlach M., Ben-Shachar D., Riederer P., and Youdim M. B. H. (1994) Altered brain metabolism of iron as a cause of neurodegenerative diseases? J. Neurochem. 63, 793-807.
17. Graham D. G., Tiffany S. M., Bell W. R., and Gutknecht W. F. (1978) Autooxidation versus covalent binding quinones as the mechanisms of toxicity of dopamine, 6-hydroxydopamine and related compounds towards C1300 neuroblastoma cells in vitro. Mot. Pharmacol. 14, 644-653.
18. Griffith O. W. (1982) Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis. J. Biol Chem. 257, 13704-13712.
19. Griffith O. W. and Meister A. (1985) Origin and turnover of mitochondrial glutathione. Proc. Natl. Acad. Sci. USA 82, 4668-4672.
20. Gutteridge J. M. C., Richmond R., and Halliwell B. (1979) Inhibition of iron-catalyzed formation of hydroxyl radicals from superoxide and of lipid peroxidation by desferioxamine. Biochem. J. 184, 469-472.
21. Halliwell B. (1992) Reactive oxygen species and the central nervous system. J. Neurochem. 59, 1609-1623.
22. Halliwell B. and Gutteridge I. M. C. (1989) Free Radicals in Biology and Medicine. Clarendon Press, Oxford.
23. Heikkila R. E. and Cohen G. (1972) Further studies on generation of hydrogen peroxide by 6-hydroxydopamine: potentiation by ascorbic acid. Mol. Pharmacol. 8, 241-248.
24. Hoe S., Rowley D. A., and Halliwell B. (1982) Reaction of ferrioxamine and desferrioxamine with the hydroxyl radical. Chem. Biol. Interact. 41, 75-81.
25. Jain A., Martensson J., Stole E., Auld P. A. M., and Meister A. (1991) Glutathione deficiency leads to mitochondrial damage in brain. Proc. Natl. Acad. Sci. USA 88, 1913-1917.
26. Keberle H. (1964) The biochemistry of desferrioxamine and its relation to iron metabolism. Ann. NY Acad. Sci. 119, 758-768.
27. Kish S. J., Morito C., and Hornykiewicz O. (1985) Glutathione peroxidase in Parkinson's disease brain. Neurosci. Lett. 58, 343-346.
28. Koh J. Y. and Choi D. W. (1987) Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay. J. Neurosci. Methods 149, 279-293.
29. Krause G. S., Kumar K., White B. C., and Weigenstein J. G. (1986) Ischemia, resuscitation and reperfusion: mechanisms of tissue injury and prospects for protection. Am. Heart J. 111, 768-780.
30. McKenna O., Arnold G., and Holtzman E. (1976) Microperoxisome distribution in the central nervous system of the rat. Brain Res. 117, 181-194.
31. O'Neill J. J., Simon S. H. L., and Shreeve W. W. (1965) Alternate glycolytic pathways in brain. A comparison between the action of artificial electron acceptors and electrical stimulation. J. Neurochem. 12, 797-802.
32. Palmer C., Roberts R. L., and Ber C. (1994) Deferoxamine posttreatment reduces ischemic brain injury in neonatal rats. Stroke 25, 1039-1045.
33. Raps S. P., Lai J. C. K., Hertz L., and Cooper A. J. L. (1989) Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons. Brain Res. 493, 398-401.
34. Rose K., Goldberg M. P., and Choi D. W. (1993) Cytotoxicity in murine cortical culture, in In Vitro Biological Methods (Tyson C. A. and Frazier J. M., eds), pp. 46-60. Academic Press, San Diego.
35. 2)glucose. Biochem. J. 302, 31-38.
36. Rowley D. A. and Halliwell B. (1982) Superoxide-dependent formation of hydroxyl radicals in the presence of thiol compounds. FEBS Lett. 138, 33-36.
37. Sachs C. H. and Jonsson G. (1975) Mechanisms of action of 6-hydroxydopamine. Pharmacology 24, 1-8.
38. Sies H. (1985) Oxidative Stress: Oxidants and Antioxidants, pp. xv-xxii. Academic Press, London.
39. Slivka A., Mytilineou C., and Cohen C. (1987) Histochemical evaluation of glutathione in brain. Brain Res. 409, 275-284.
40. Vitorica J., Machado A., and Satrústegui J. (1984) Age-dependent variations in peroxide-utilizing enzymes from rat brain mitochondria and cytoplasm. J. Neurochem. 42, 351-357.