메뉴 건너뛰기




Volumn 33, Issue 5, 2006, Pages 655-663

Dose dependent separation of the hypertrophic and myotoxic effects of the β2 agonist clenbuterol in rat striated muscles

Author keywords

Apoptosis; Collagen; Heart muscle; Hypertrophy; Necrosis; Skeletal muscle

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CLENBUTEROL; COLLAGEN; MUSCLE PROTEIN;

EID: 33646244955     PISSN: 0148639X     EISSN: 10974598     Source Type: Journal    
DOI: 10.1002/mus.20504     Document Type: Article
Times cited : (24)

References (41)
  • 1
    • 0031775691 scopus 로고    scopus 로고
    • Effect of clenbuterol on sarcoplasmic reticulum function in single skinned mammalian skeletal muscle fibres
    • Bakker AJ, Head SI, Wareham AC, Stephenson DG. Effect of clenbuterol on sarcoplasmic reticulum function in single skinned mammalian skeletal muscle fibres. Am J Physiol 1998;274:C1718-C1726.
    • (1998) Am J Physiol , vol.274
    • Bakker, A.J.1    Head, S.I.2    Wareham, A.C.3    Stephenson, D.G.4
  • 2
    • 3242804434 scopus 로고    scopus 로고
    • Network integration of the adrenergic system in cardiac hypertrophy
    • Barki-Harrington L, Perrino C, Rockman HA. Network integration of the adrenergic system in cardiac hypertrophy. Cardiovasc Res 2004;63:391-402.
    • (2004) Cardiovasc Res , vol.63 , pp. 391-402
    • Barki-Harrington, L.1    Perrino, C.2    Rockman, H.A.3
  • 6
    • 15444370210 scopus 로고    scopus 로고
    • 2-adrenergic receptor stimulation in vivo induces apoptosis in the rat heart and soleus muscle
    • 2-Adrenergic receptor stimulation in vivo induces apoptosis in the rat heart and soleus muscle. J Appl Physiol 2005;98:1379-1386.
    • (2005) J Appl Physiol , vol.98 , pp. 1379-1386
    • Burniston, J.G.1    Tan, L.-B.2    Goldspink, D.F.3
  • 8
    • 0033869983 scopus 로고    scopus 로고
    • A physiological level of clenbuterol does not prevent atrophy or loss of force in skeletal muscle of old rats
    • Chen KD, Alway SE. A physiological level of clenbuterol does not prevent atrophy or loss of force in skeletal muscle of old rats. J Appl Physiol 2000;89:606-612.
    • (2000) J Appl Physiol , vol.89 , pp. 606-612
    • Chen, K.D.1    Alway, S.E.2
  • 9
    • 0035143578 scopus 로고    scopus 로고
    • Clenbuterol reduces soleus muscle fatigue during disuse in aged rats
    • Chen KD, Alway SE. Clenbuterol reduces soleus muscle fatigue during disuse in aged rats. Muscle Nerve 2001;24:211-222.
    • (2001) Muscle Nerve , vol.24 , pp. 211-222
    • Chen, K.D.1    Alway, S.E.2
  • 10
    • 0026663430 scopus 로고
    • Anabolic effects of clenbuterol in skeletal muscle are mediated by beta2-adrenoceptor activation
    • Choo JJ, Horan MA, Little RA, Rothwell NJ. Anabolic effects of clenbuterol in skeletal muscle are mediated by beta2-adrenoceptor activation. Am J Physiol 1992;263:E50-E56.
    • (1992) Am J Physiol , vol.263
    • Choo, J.J.1    Horan, M.A.2    Little, R.A.3    Rothwell, N.J.4
  • 11
    • 0029958460 scopus 로고    scopus 로고
    • Clenbuterol-induced fibre type transition in the soleus of adult rats
    • Criswell DS, Powers SK, Herb RA. Clenbuterol-induced fibre type transition in the soleus of adult rats. Eur J Appl Physiol 1996;74:391-396.
    • (1996) Eur J Appl Physiol , vol.74 , pp. 391-396
    • Criswell, D.S.1    Powers, S.K.2    Herb, R.A.3
  • 13
    • 0034055534 scopus 로고    scopus 로고
    • Deleterious effects of chronic clenbuterol treatment on endurance and sprint exercise performance in rats
    • Duncan ND, Williams DA, Lynch GS. Deleterious effects of chronic clenbuterol treatment on endurance and sprint exercise performance in rats. Clin Sci 2000;98:339-347.
    • (2000) Clin Sci , vol.98 , pp. 339-347
    • Duncan, N.D.1    Williams, D.A.2    Lynch, G.S.3
  • 14
    • 0021364167 scopus 로고
    • Chronic effects of beta2-adrenergic agonists on body composition and protein synthesis in the rat
    • Emery PW, Rothwell NJ, Stock MJ, Winter PD. Chronic effects of beta2-adrenergic agonists on body composition and protein synthesis in the rat. Biosci Rep 1984;4:83-91.
    • (1984) Biosci Rep , vol.4 , pp. 83-91
    • Emery, P.W.1    Rothwell, N.J.2    Stock, M.J.3    Winter, P.D.4
  • 15
    • 3543120028 scopus 로고    scopus 로고
    • Catecholamine-induced apoptosis and necrosis in cardiac and skeletal myocytes of the rat in vivo: The same or separate death pathways?
    • Goldspink DF, Burniston JG, Ellison GM, Clark WA, Tan LB. Catecholamine-induced apoptosis and necrosis in cardiac and skeletal myocytes of the rat in vivo: the same or separate death pathways? Exp Physiol 2004;89:407-416.
    • (2004) Exp Physiol , vol.89 , pp. 407-416
    • Goldspink, D.F.1    Burniston, J.G.2    Ellison, G.M.3    Clark, W.A.4    Tan, L.B.5
  • 16
    • 21644438991 scopus 로고    scopus 로고
    • Chronic beta-agonist administration affects cardiac function of adult but not old rats, independent of beta-adrenoceptor density
    • Gregorevic P, Ryall JG, Plant DR, Sillence MN, Lynch GS. Chronic beta-agonist administration affects cardiac function of adult but not old rats, independent of beta-adrenoceptor density. Am J Physiol 2005;289:H344-H349.
    • (2005) Am J Physiol , vol.289
    • Gregorevic, P.1    Ryall, J.G.2    Plant, D.R.3    Sillence, M.N.4    Lynch, G.S.5
  • 17
    • 0026663634 scopus 로고
    • Stimulation of actin and myosin synthesis in rat gastrocnemius muscle by clenbuterol; evidence for translational control
    • Hesketh JE, Campbell GP, Lobley GE, Maltin CA, Acamovic F, Palmer RM. Stimulation of actin and myosin synthesis in rat gastrocnemius muscle by clenbuterol; evidence for translational control. Comp Biochem Physiol 1992;102C:23-27.
    • (1992) Comp Biochem Physiol , vol.102 C , pp. 23-27
    • Hesketh, J.E.1    Campbell, G.P.2    Lobley, G.E.3    Maltin, C.A.4    Acamovic, F.5    Palmer, R.M.6
  • 18
    • 0036239191 scopus 로고    scopus 로고
    • Skeletal muscle hypertrophy and anti-hypertrophic effects of clenbuterol are mediated by the beta2-adrenergic receptor
    • Hinkle RT, Hodge KMB, Cody DB, Sheldon RJ, Kobilka BK, Isfort R. Skeletal muscle hypertrophy and anti-hypertrophic effects of clenbuterol are mediated by the beta2-adrenergic receptor. Muscle Nerve 2002;25:729-734.
    • (2002) Muscle Nerve , vol.25 , pp. 729-734
    • Hinkle, R.T.1    Hodge, K.M.B.2    Cody, D.B.3    Sheldon, R.J.4    Kobilka, B.K.5    Isfort, R.6
  • 19
    • 0029917501 scopus 로고    scopus 로고
    • Interaction between clenbuterol and run training: Effects on exercise performance and MLC isoform content
    • Ingalls CP, Barnes WS, Smith SB. Interaction between clenbuterol and run training: effects on exercise performance and MLC isoform content. J Appl Physiol 1996;80:795-801.
    • (1996) J Appl Physiol , vol.80 , pp. 795-801
    • Ingalls, C.P.1    Barnes, W.S.2    Smith, S.B.3
  • 20
    • 0028989683 scopus 로고
    • Different beta-adrenergic receptor density in different rat skeletal fibre types
    • Jenson J, Brors O, Dahl HA. Different beta-adrenergic receptor density in different rat skeletal fibre types. Pharmacol Toxicol 1995;76:380-385.
    • (1995) Pharmacol Toxicol , vol.76 , pp. 380-385
    • Jenson, J.1    Brors, O.2    Dahl, H.A.3
  • 21
    • 0036897813 scopus 로고    scopus 로고
    • Clenbuterol diminishes aerobic performance in horses
    • Kearns CF, McKeever KH. Clenbuterol diminishes aerobic performance in horses. Med Sei Sports Exerc 2002;34:1976-1985.
    • (2002) Med Sei Sports Exerc , vol.34 , pp. 1976-1985
    • Kearns, C.F.1    McKeever, K.H.2
  • 22
    • 0029797113 scopus 로고    scopus 로고
    • Effects of beta2-agonist administration and exercise on contractile activation of skeletal muscle fibres
    • Lynch GS, Hayes A, Campbell SP, Williams DA. Effects of beta2-agonist administration and exercise on contractile activation of skeletal muscle fibres. J Appl Physiol 1996;81:1610-1618.
    • (1996) J Appl Physiol , vol.81 , pp. 1610-1618
    • Lynch, G.S.1    Hayes, A.2    Campbell, S.P.3    Williams, D.A.4
  • 23
    • 0024854595 scopus 로고
    • Effects of clenbuterol and propranolol on muscle mass: Evidence that clenbuterol stimulates muscle beta-adrenoceptors to induce hypertrophy
    • MacLennan PA, Edwards RHT. Effects of clenbuterol and propranolol on muscle mass: evidence that clenbuterol stimulates muscle beta-adrenoceptors to induce hypertrophy. Biochem J 1989;264:573-579.
    • (1989) Biochem J , vol.264 , pp. 573-579
    • MacLennan, P.A.1    Edwards, R.H.T.2
  • 24
    • 0026530583 scopus 로고
    • Denervation increases clenbuterol sensitivity in muscle from young rats
    • Maltin CA, Delday MI, Hay SM, Baillie AG. Denervation increases clenbuterol sensitivity in muscle from young rats. Muscle Nerve 1992;15:188-192.
    • (1992) Muscle Nerve , vol.15 , pp. 188-192
    • Maltin, C.A.1    Delday, M.I.2    Hay, S.M.3    Baillie, A.G.4
  • 25
    • 0024321559 scopus 로고
    • The action of the beta-agonist clenbuterol on protein metabolism in innervated and denervated phasic muscles
    • Maltin CA, Hay SM, Delday MI, Lobley GE, Reeds JP. The action of the beta-agonist clenbuterol on protein metabolism in innervated and denervated phasic muscles. Biochem J 1989;261:965-971.
    • (1989) Biochem J , vol.261 , pp. 965-971
    • Maltin, C.A.1    Hay, S.M.2    Delday, M.I.3    Lobley, G.E.4    Reeds, J.P.5
  • 29
    • 33244482444 scopus 로고    scopus 로고
    • Tissue specific and variable collagen proliferation in Swiss albino mice treated with clenbuterol
    • in press
    • Patiyal SN, Katoch S. Tissue specific and variable collagen proliferation in Swiss albino mice treated with clenbuterol. Physiol Res (in press).
    • Physiol Res
    • Patiyal, S.N.1    Katoch, S.2
  • 30
    • 0028862316 scopus 로고
    • Clenbuterol induces hypertrophy of the latissimus dorsi muscle and heart in the rat with molecular and phenotypic changes
    • Petrou M, Wynne DG, Boheler KR, Yacoub MH. Clenbuterol induces hypertrophy of the latissimus dorsi muscle and heart in the rat with molecular and phenotypic changes. Circulation 1995;92:483-489.
    • (1995) Circulation , vol.92 , pp. 483-489
    • Petrou, M.1    Wynne, D.G.2    Boheler, K.R.3    Yacoub, M.H.4
  • 31
    • 0033830095 scopus 로고    scopus 로고
    • Skeletal muscle myosin heavy chain isoforms and energy metabolism after clenbuterol treatment in the rat
    • Rajab PJF, Riaz S, Tomlinson D, Ball D, Greenhaff PL. Skeletal muscle myosin heavy chain isoforms and energy metabolism after clenbuterol treatment in the rat. Am J Physiol 2000;279:R1076-R1081.
    • (2000) Am J Physiol , vol.279
    • Rajab, P.J.F.1    Riaz, S.2    Tomlinson, D.3    Ball, D.4    Greenhaff, P.L.5
  • 32
    • 0023633716 scopus 로고
    • Effect of a selective beta2-adrenergic agonist (clenbuterol) on energy balance and body composition in normal and protein deficient rats
    • Rothwell NJ, Stock MJ. Effect of a selective beta2-adrenergic agonist (clenbuterol) on energy balance and body composition in normal and protein deficient rats. Biosci Rep 1987;7:933-940.
    • (1987) Biosci Rep , vol.7 , pp. 933-940
    • Rothwell, N.J.1    Stock, M.J.2
  • 33
    • 1542329713 scopus 로고    scopus 로고
    • Beta 2-agonist administration reverses muscle wasting and improves muscle function in aged rats
    • Ryall JG, Plant DR, Gregorevic P, Sillence MN, Lynch GS. Beta 2-agonist administration reverses muscle wasting and improves muscle function in aged rats. J Physiol (Lond) 2004;555:175-188.
    • (2004) J Physiol (Lond) , vol.555 , pp. 175-188
    • Ryall, J.G.1    Plant, D.R.2    Gregorevic, P.3    Sillence, M.N.4    Lynch, G.S.5
  • 34
    • 0036118015 scopus 로고    scopus 로고
    • Chronic clenbuterol administration negatively alters cardiac function
    • Sleeper MM, Kearns CF, McKeever KH. Chronic clenbuterol administration negatively alters cardiac function. Med Sci Sports Exerc 2002;34:643-650.
    • (2002) Med Sci Sports Exerc , vol.34 , pp. 643-650
    • Sleeper, M.M.1    Kearns, C.F.2    McKeever, K.H.3
  • 36
    • 0002032973 scopus 로고
    • Sirius red F3BA as a stain for connective tissue
    • Sweet F, Puchtler H, Rosenthal SI. Sirius red F3BA as a stain for connective tissue. Arch Pathol 1964;78:69-72.
    • (1964) Arch Pathol , vol.78 , pp. 69-72
    • Sweet, F.1    Puchtler, H.2    Rosenthal, S.I.3
  • 37
    • 0037379901 scopus 로고    scopus 로고
    • Characterisation of adrenoceptor involvement in skeletal and cardiac myotoxicity induced by sympathomimetic agents: Towards a new bioassay for beta-blockers
    • Tan L-B, Burniston JG, Clark WA, Ng Y, Goldspink DF. Characterisation of adrenoceptor involvement in skeletal and cardiac myotoxicity induced by sympathomimetic agents: towards a new bioassay for beta-blockers. J Cardiovasc Pharmacol 2003;41:518-525.
    • (2003) J Cardiovasc Pharmacol , vol.41 , pp. 518-525
    • Tan, L.-B.1    Burniston, J.G.2    Clark, W.A.3    Ng, Y.4    Goldspink, D.F.5
  • 38
    • 0033928135 scopus 로고    scopus 로고
    • Beta-agonist-induced alterations in organ weights and protein content: Comparison of racemic clenbuterol and its enantiomers
    • Von Deutsch DA, Abukhalaf IK, Wineski LE, Aboul-Enein HY, Pitts SA, Parks BA, et al. Beta-agonist-induced alterations in organ weights and protein content: comparison of racemic clenbuterol and its enantiomers. Chirality 2000;12:637-648.
    • (2000) Chirality , vol.12 , pp. 637-648
    • Von Deutsch, D.A.1    Abukhalaf, I.K.2    Wineski, L.E.3    Aboul-Enein, H.Y.4    Pitts, S.A.5    Parks, B.A.6
  • 39
    • 0024333198 scopus 로고
    • Multiple actions of beta adrenergic actions on skeletal muscle and adipose tissue
    • Yang YT, McElligott MA. Multiple actions of beta adrenergic actions on skeletal muscle and adipose tissue. Biochem J 1989;261:1-10.
    • (1989) Biochem J , vol.261 , pp. 1-10
    • Yang, Y.T.1    McElligott, M.A.2
  • 40
    • 21644478996 scopus 로고    scopus 로고
    • Clenbuterol induces muscle-specific attenuation of atrophy through effects on the ubiquitin-proteasome pathway
    • Yimlamai T, Dodd SL, Borst SE, Park S. Clenbuterol induces muscle-specific attenuation of atrophy through effects on the ubiquitin-proteasome pathway. J Appl Physiol 2005;91:71-80.
    • (2005) J Appl Physiol , vol.91 , pp. 71-80
    • Yimlamai, T.1    Dodd, S.L.2    Borst, S.E.3    Park, S.4
  • 41
    • 0023931913 scopus 로고
    • Slow to fast alterations in skeletal muscle fibers caused by clen-buterol, a beta 2-receptor agonist
    • Zeman RJ, Ludemann R, Easton TG, Etlinger JD. Slow to fast alterations in skeletal muscle fibers caused by clen-buterol, a beta 2-receptor agonist. Am J Physiol 1988;254: E726-E732.
    • (1988) Am J Physiol , vol.254
    • Zeman, R.J.1    Ludemann, R.2    Easton, T.G.3    Etlinger, J.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.