A physiological level of clenbuterol does not prevent atrophy or loss of force in skeletal muscle of old rats

Journal of Applied Physiology

Volumn 89, Issue 2, 2000, Pages 606-612

  Chen, Kuangjen D ^a   Alway, Stephen E ^a,b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Disuse; Hypokinesia; Isometric contraction; Muscle strength; Myosin heavy chain; Sarcopenia; Agonist

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CLENBUTEROL; MYOSIN HEAVY CHAIN;

AGED; AGING; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; MUSCLE ATROPHY; MUSCLE FORCE; MUSCLE ISOMETRIC CONTRACTION; MUSCLE STRENGTH; NONHUMAN; PRIORITY JOURNAL; RAT; SARCOMERE; SENESCENCE; SKELETAL MUSCLE; SOLEUS MUSCLE;

EID: 0033869983     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.2000.89.2.606     Document Type: Article

References (38)

1. Effects of clenbuterol on normal and denervated muscle growth and contractility
2. Influence of simulated bed rest and intermittent weight bearing on single skeletal muscle fiber function in aged rats
3. Muscle torque in young and older untrained and endurance trained men
4. Quantitative and qualitative morphological properties of the soleus motor nerve and the L5 ventral root in young and old rats. Relation to the number of soleus fibers
5. Aminohydroxybutane bisphosphonate and clenbuterol prevent bone changes and retard muscle atrophy respectively in tail-suspended rats
6. CLenbuterol prevents or inhibits loss of specific mRNAs in atrophying rat skeletal muscle
7. Decreased myofibrillar protein breakdown following treatment with clenbuterol
8. Beta-adrenergic potentiation of E-C coupling increases force in rat skeletal muscle
9. Effects of clenbuterol on skeletal muscle mass, body composition, and recovery from surgical stress in senescent rats
10. Effect of clenbuterol on recovery of muscle mass and carcass protein content following dietary protein depletion in young and old rats
11. Effects of clenbuterol on recovery of muscle mass and carcass protein content following experimental hyperthyroidism in old rats
12. 2-adrenoceptor activation
13. Muscle atrophy and hypoplasia with aging: Impact of training and food restriction
14. CLenbuterol increases the expression of myogenin but not myoD in immobilized rat muscles
15. Rat aortic vasoreactivity is altered by old age and hindlimb unloading
16. Contractile and biochemical properties of rat soleus and plantaris after hindlimb suspension
17. Effects of clenbuterol on contractile and biochemical properties of skeletal muscle
18. Beneficial versus adverse effects of long-term use of clenbuterol in mdx mice
19. Models of disuse: A comparison of hindlimb suspension and immobilization
20. Selective accumulation of MyoD and myogenin mRNAs in fast and slow adult skeletal muscle is controlled by innervation and hormones
21. Effects of aging on the total number of muscle fibers and motoneurons of the tibialis anterior and soleus muscles in the rat
22. Effect of aging on rat skeletal muscle β-AR function in male Fischer 344 x Brown Norway rats
23. Myogenic regulatory factors in myofibers and proliferating satellite cells
24. Hypertrephy-stimulated myogenic regulatory factor mRNA increases are attenuated in fast muscle of aged quails
25. Denervation increases clenbuterol sensitivity in muscle from young rats
26. CLenbuterol, a β-adrenoceptor agonist, increases relative muscle strength in orthopaedic patients
27. Myogenin, MyoD, and myosin expression after pharmacologically and surgically induced hypertrophy
28. Enhanced expression of myogenic regulatory genes in aging skeletal muscle
29. Stimulation of muscle growth by clenbuterol: Lack of effect on muscle protein biosynthesis
30. Hypogravity-induced atrophy of rat soleus and extensor digitorum longus muscles
31. Rat hindlimb unloading: Soleus histochemistry, ultrastructure, and electromyography
32. Functional significance of compensatory overloaded rat fast muscle
33. Muscle adaptations to hindlimb suspension in mature and old Fischer 344 rats
34. Identical responses of fast muscle to sustained activity by low-frequency simulation in young and aging rats
35. Electrophoretic separation of rat skeletal muscle myosin heavy-chain isoforms
36. Atrophy of the soleus muscles by hindlimb unweighting
37. Single soleus muscle fiber function after hindlimb unweighting in adult and aged rats
38. Skeletal muscle β-adrenergic receptors: Variations due to fiber type and training