Interaction between clenbuterol and run training: Effects on exercise performance and MLC isoform content

Journal of Applied Physiology

Volumn 80, Issue 3, 1996, Pages 795-801

  Ingalls, Christopher P ^a   Barnes, William S ^a   Smith, Stephen B ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

hypertrophy; myofibrillar protein; myosin light chain; 2 adrenergic agonist

Indexed keywords

CLENBUTEROL; MUSCLE PROTEIN; MYOSIN LIGHT CHAIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; MALE; MOUSE; MUSCLE HYPERTROPHY; MUSCLE STRENGTH; MUSCLE TRAINING; NONHUMAN; PHYSICAL PERFORMANCE; PRIORITY JOURNAL; SKELETAL MUSCLE; TREADMILL EXERCISE;

EID: 0029917501     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1996.80.3.795     Document Type: Article

References (40)

1. Babij, P., and F. W. Booth. Clenbuterol prevents or inhibits loss of specific mRNAs in atrophying rat skeletal muscle. Am. J. Physiol. 254 (Cell Physiol. 23): C657-C660, 1988.
2. Barany, M. ATPase activity of myosin correlated with speed of muscle shortening. J. Gen. Physiol. 50: 197-218, 1967.
3. Beerman, D. H., W. R. Butler, D. E. Hogue, D. E. Fishell, R. H. Dalrymple, C. A. Ricks, and C. G. Scanes. Cimaterol-induced muscle hypertrophy and altered endocrine status in lambs. J. Anim. Sci. 65: 1514-1524, 1987.
4. Caiozzo, V. J., R. E. Herrick, and K. M. Baldwin. Influence of hyperthyroidism on maximal shortening velocity and myosin isoform distribution in skeletal muscles. Am. J. Physiol. 261 (Cell Physiol. 30): C285-C295, 1991.
5. Choo, J. J., M. A. Horan, R. A. Little, and N. J. Rothwell. Muscle wasting associated with endotoxemia in the rat: modification by the β2-adrenoceptor agonist clenbuterol. Biosci. Rep. 9: 615-621, 1989.
6. 2-agonist, clenbuterol, on muscle atrophy due to food deprivation in the rat. Metab. Clin. Exp. 39: 647-650, 1990.
7. Crow, M. T., and M. J. Kushmerick. Myosin light chain phosphorylation is associated with a decrease in energy cost for contraction in fast twitch mouse muscle. J. Biol. Chem. 257: 2121-2124, 1982.
8. Dudley, G. A., W. M. Abraham, and R. L. Terjung. Influence of exercise intensity and duration on biochemical adaptations in skeletal muscle. J. Appl. Physiol. 53: 844-850, 1982.
9. Friedman, W.A., T. Garland, Jr., and M. R. Dohm. Individual variation in locomotor behavior and maximal oxygen consumption in mice. Physiol. Behav. 52: 97-104, 1992.
10. Fuchs, F., V. Ressy, and F. N. Briggs. The interaction of cations with the calcium binding site of troponin. Biochim. Biophys. Acta 221: 407-409, 1970.
11. Gornall, A. G., C. J. Bardawill, and M. M. David. Determination of serum proteins by means of the biuret method. J. Biol. Chem. 177: 751-756, 1949.
12. Holloszy, J. O., and E. F. Coyle. Adaptations of skeletal muscle to endurance exercise and their metabolic consequence. J. Appl. Physiol. 56: 831-838, 1984.
13. Kim, Y. S., Y. B. Lee, and R. H. Dalrymple. Effects of repartioning agent cimaterol on growth, carcass and skeletal muscle characteristics in lambs. J. Anim. Sci. 65: 1392-1399, 1987.
14. 4. Nature Lond. 227: 680-685, 1970.
15. Laughlin, M. H., and R. B. Armstrong. Muscular blood flow distribution patterns as a function of running speeds in rats. Am. J. Physiol. 243 (Heart Circ. Physiol. 12): H296-H306, 1982.
16. Laughlin, M. H., and R. B. Armstrong. Adrenoreceptor effects on rat muscle blood flow during treadmill exercise. J. Appl. Physiol. 62: 1465-1472, 1987.
17. Maltin, C. A., M. I. Delday, and P. J. Reeds. The effect of a growth promoting drug, clenbuterol, on fibre frequency and area in hindlimb muscles from young male rats. Biosci. Rep. 6: 293-299, 1986.
18. Maltin, C. A., P. J, Reeds, M. I. Delday, S. H. Hay, F. G. Smith, and G. E. Lobey. Inhibition and reversal of denervation-induced atrophy by the β-agonist growth promoter, clenbuterol. Biosci. Rep. 6: 811-818, 1986.
19. Miller, M, F., D. K. Garcia, M. E. Coleman, P. A. Ekeren, D. K. Lunt, K. A. Wagner, M. Procknor, T. H. Welsh, Jr., and S. B. Smith. Adipose tissue, longissimus muscle and anterior pituitary growth and function in clenbuterol-fed heifers. J. Anim. Sci. 66: 12-20, 1988.
20. Mole, P. Exercise metabolism. In: Exercise Medicine. Physiological Principles and Clinical Application. New York: Academic, 1983, p. 43-81.
21. Moreland, T. S., and M. J. Kushmerick. Metabolic adaptation in the skeletal muscle of mice intoxicated with a poorly-metabolized analogue of creatine (Abstract). Biophys. J. 51: 478A, 1987.
22. Moreland, T. S., and M. J. Kushmerick. Administration of a creatine analogue induces isomyosin transitions in muscle. Am J. Physiol. 257 (Cell Physiol. 26): C810-C816, 1989.
23. Rothwell, N. J., and M. J. Stock. Modification of body composition by clenbuterol in normal and dystrophic (mdx) mice. Biosci. Rep. 5: 755-760, 1985.
24. 2-adrenoceptor agonist clenbuterol. Br. J. Pharmacol. 90: 601-607, 1987.
25. Saubert, C. W., R. B. Armstrong, R. E. Shepherd, and P. D. Gollnick. Anaerobic enzyme adaptations to sprint training in rats. Pfluegers Arch. 341: 305-312, 1973.
26. 2-agonist fenoterol on contractile and biochemical properties of skeletal muscle. Med. Sci. Sports Exercise 22, Suppl. : S73, 1990.
27. Smith, S. B., S. K. Davis, J. J. Wilson, R. T. Stone, F. Y. Wu, D. K. Garcia, D, K. Lumt, and A. M. Schiavetta. Bovine fast-twitch myosin light chain-1: cloning and mRNA amount in muscle of cattle treated with clenbuterol. Am. J. Physiol. 268 (Endocrinol. Metab. 31): E858-E865, 1995.
28. Staron, R. S., and D. Pette. The multiplicity of myosin light and heavy chain combinations in muscle fibers. In: The Dynamic State of Muscle Fibers, edited by D. Pette. New York: de Gruyter, 1990, p. 315-328.
29. Staudte, H. W., G. U. Exner, and D. Pette. Effects of short-term, high-intensity (sprint) training on some contractile and metabolic characteristics of fast and slow muscle of the rat. Pfluegers Arch. 344: 159-168, 1973.
30. Sweeney, H. L., B. F. Bowman, and J. T. Stull. Myosin light chain phosphorylation in vertebrate striated muscle: regulation and function. Am. J. Physiol. 264 (Cell Physiol. 33): C1085-C1095, 1993.
31. Sweeney, H. L., M. J. Kushmerick, K. Mabuchi, F. A. Sreter, and J. Gergely. Myosin alkali light chain and heavy chain variations correlate with altered shortening velocity of isolated skeletal muscle fibers. J. Biol. Chem. 263: 9034-9039, 1988.
32. Torgan, C. E., J. T. Brozinick, Jr., E. A. Banks, M. Y. Cortez, R. E. Wilcox, and J. L. Ivy. Exercise training and clenbuterol reduce insulin resistance of obese Zucker rats. Am. J. Physiol. 264 (Endocrinol. Metab. 27): E373-E379, 1993.
33. Torgan, C. E., G. J. Etgen, Jr., J. T. Brozinick, Jr., R. E. Wilcox, and J. L. Ivy. Interaction of aerobic exercise training and clenbuterol: effects on insulin-resistant muscle. J. Appl. Physiol. 75: 1471-1476, 1993.
34. Trevidi, B., and W. H. Danforth. Effect of pH on the kinetics of frog muscle phosphofructokinase. J. Biol. Chem. 241: 4110-4112, 1966.
35. Tsika, R. W., R. E. Herrick, and K. M. Baldwin. Time course of adaptations in rat skeletal muscle isomyosins during compensatory growth and regression. J. Appl. Physiol. 63: 2111-2121, 1987.
36. Tsika, R. W., R. E. Herrick, and K. M. Baldwin. Effect of anabolic steroids on skeletal muscle mass during hindlimb suspension. J. Appl. Physiol. 63: 2122-2127, 1987.
37. 2-adrenergic agonist on muscular size and performance. Med. Sci. Sports Exercise 25, SuppL: S157, 1993.
38. Yang, Y. T., and M. A. McElligott. Multiple actions of β-adrenergic agonists on skeletal muscle and adipose tissue. Biochem. J. 261: 1-10, 1989.
39. 2-agonist, retards atrophy in denervated muscles. Am. J. Physiol. 254 (Endocrinol. Metab. 17): E152-E155, 1987.
40. 2-receptor agonist. Am. J. Physiol. 254 (Endocrinol. Metab. 17): E726-E732, 1988.