Neuroprotective effect of mexiletine in the central nervous system of diabetic rats

Molecular and Cellular Biochemistry

Volumn 286, Issue 1-2, 2006, Pages 125-131

  Ates, Ozkan ^a   Cayli, Suleyman R ^a   Altinoz, Eyup ^a   Yucel, Neslihan ^a   Kocak, Ayhan ^a   Tarim, Ozcan ^a   Durak, Akif ^a   Turkoz, Yusuf ^a   Yologlu, Saim ^a  

^a INONU UNIVERSITY   (Turkey)

Author keywords

Central nervous system; Diabetes mellitus; Lipid peroxidation; Mexiletine; Oxidative damage; Streptozotocin

Indexed keywords

FREE RADICAL; GLUTATHIONE; MALONALDEHYDE; MEXILETINE; NITRIC OXIDE; STREPTOZOCIN; XANTHINE OXIDASE;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEUROPATHY; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME ANALYSIS; HISTOPATHOLOGY; HYPERGLYCEMIA; LIPID PEROXIDATION; MALE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PROTEIN LOCALIZATION; RAT; RAT STRAIN; STREPTOZOCIN DIABETES; TISSUE SECTION;

ANIMALS; BLOOD GLUCOSE; BRAIN STEM; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CEREBRAL CORTEX; DIABETES MELLITUS, EXPERIMENTAL; HIPPOCAMPUS; INJECTIONS, INTRAPERITONEAL; MALE; MALONDIALDEHYDE; MEXILETINE; NEUROPROTECTIVE AGENTS; NITRIC OXIDE; RATS; RATS, WISTAR; SPINAL CORD; TIME FACTORS; XANTHINE OXIDASE;

ANIMALIA; RATTUS NORVEGICUS;

EID: 33646236111     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-005-9102-6     Document Type: Article

References (50)

1. Baynes J: Role of oxidative stres in development of complications in diabetes. Diabetes 40: 405-412, 1991
2. Grene DA, Stevens MJ, Obrosova I, Feldman EL: Glucose-induced oxidative stress and programmed cell death in diabetic neuropathy. Eur. J. Pharmacol 375: 217-223, 1999
3. Low PA, Nickander KK, Tritschler HJ: The role of oxidative stress and antioxidant treatment in experimental diabetic neuropathy. Diabetes 46: 38-42, 1997
4. Zaltzberg H, Kanter Y, Aviram M, Levy Y: Increased plasma oxidizability and decreased erythrocyte and plasma antioxidative capacity in patients with NIDDM. Isr Med Assoc J 1: 228-231, 1999
5. Slatter DA, Bolton CH, Bailey AJ: The importance of lipid-derived malondialdehyde in diabetes mellitus. Diabetologia 43: 550-557, 2000
6. Kristal BS, Koopmans SJ, Jackson CT, Ikeno Y, Park BS, Yu BP: Oxidant-mediated repression of the mitochondrial transcription in diabetic rats. Free Rad Biol Med 22: 813-822, 1997
7. Bonnefont-Rousselot D, Bastard JP, Jaudon MC, Delattre J: Consequences of the diabetic status on the oxidant/antioxidant balance. Diabet Metabol 26: 163-176, 2000
8. Matsumoto S, Koshiishi I, Inoguchi T, Nawata H, Utsumi H: Confirmation of superoxide generation via xanthine oxidase in streptozotocin-induced diabetic mice. Free Radic Res 37(7): 767-772, 2003
9. Ovtscharoff W, Bozhilova-Pastirova A, Christova T: Postnatal development of neurons expressing NADPH-diaphorase and parvalbumin in the parietal cortex of male and female rats. Acta Histochem 104: 23-28, 2002
10. Revsin Y, Saravia F, Roig P, Lima A, Kloet ER, Homo-Delarche F, De Nicola AF: Neuronal and astroglial alterations in the hippocampus of a mouse model for type 1 diabetes. Brain Res 1038(1): 22-31, 2005
11. Petty MA, Poulet P, Haas H, Namer LJ, Wagner J: Reduction of trauma brain injury-induced cerebral edema by a free radical scavenger. Eur J Pharmacol 307: 149-155, 1996
12. De Luca A, Pierno S, Natuzzi F, Franchini C, Duranti A, Lentini G, Tortorella V, Jockusch H, Camerino DC: Evaluation of the antimyotonic activity of mexiletine and some new analogs on sodium currents of single muscle fibers and on the abnormal excitability of the myotonic ADR mouse. J Pharmacol Exp Ther 282: 93-100, 1997
13. Desaphy JF, Conte Camerino D, Franchini C, Lentini G, Tortorella V, De Luca A: Increased hind rance on the chiral carbon atom of mexiletine enhances the block of rat skeletal muscle Na(+) channels in a model of myotonia induced by ATX. Br J Pharmacol 128: 1165-1174, 1999
14. Kaptanoǧlu E, Caner H, Sürücü S, Akbiyik F: Effect of mexiletine on lipid peroxidation and early ultrastructural findings in experimental spinal cord injury. J Neurosurg 91: 200-204, 1999
15. Lee EJ, Ayoub IA, Haris FB, Hassan M, Ogilvy CS, Maynard KI: Mexiletine and magnesium independently, but not combined, protect against permanent focal cerebral ischemia in Wistar rats. J Neurosci Res 58: 442-448, 1999
16. Menkü A, Koç RK, Tayfur V, Saraymen R, Narin F, Akdemir H: Effects of mexiletine, ginkgo biloba extract (EGb 761), and their combination on experimental head injury. Neurosurg Rev 26: 288-291, 2003
17. Oskarsson P, Ljunggren JG, Lins PE: Efficacy andsafety of mexiletine in the treatment of painful diabetic neuropathy. The mexiletine study group. Diabetes Care 20: 1594-1597, 1997
18. Baydas G, Reiter RJ, Yasar A, Tuzcu M, Akdemir I, Nedzvetskii VS: Melatonin reduces glial reactivity in the hippocampus, cortex, and cerebellum of streptozotocin-induced diabetic rats. Free Radic Biol Med 35(7): 797-80, 2003
19. Uchiyama M, Mihara M: Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 86: 271-278, 1978
20. Elman GL: Tissue sulphydryl groups. Arch Biochem Biophys 82: 70-77, 1959
21. Prajda N, Weber G: Malignant transforDation-linked imbalance: decreased xanthine oxidase activity in hepatomas. FEBS Lett. 59 (2): 245-249, 1975
22. Jungersten L, Edlund A, Petersson AS, Wennmalm A: Plasma nitrate as an index of nitric oxide formation in man: Analyses of kinetics and confounding factors. Clin Physiol 16: 369-379, 1996
23. Zeballos GA, Bernstein RD, Thompson CI, Forfia PR, Seyedi N, Shen W, Kaminski PM, Wolin MS, Hintze TH: Pharmacodynamics of plasma nitrate/ nitrite as an indication of nitric oxide formation in conscious dogs. Circulation 91: 2982-2988, 1995
24. Ozbek E, Turkoz Y, Gokdeniz R, Davarci M, Ozugurlu F: Increased nitric oxide production in the spermatic vein of patients with varicocele. Eur Urol 37(2): 172-175, 2000
25. Sano T, Umeda F, Hashimoto T, Nowata H, Utsumi H: Oxidative stress measurement by in vivo electron spin resonance spectroscopy in rats with streptozotocin-induced diabetes. Diabetologia 41: 1355-1360, 1998
26. Fern R, Ransom BR, Stys PK, Waxman SG: Pharmacological protection of CNS white matter during anoxia: Actions of phenytoin, carbamazepine and diazepam. J Pharmacol Exp Ther 266: 1549-1555, 1993
27. Stys PK, Ransom BR, Waxmann SG: Tertiary and quaternary local anesthetics protect central nervous system white matter from anoxic injury at concentrations that do not block excitability. J Neurophysiol 67: 236-240, 1992
28. 2+ exchanger. J Neurosci 12: 430-439, 1992
29. Bhattacharyya A, Oppenheim RW, Prevette D, Moore BW, Brackenbury R, Ratner N: S100 is present in developing chicken neurones, and Schwann cells, and promotes neuron survival in vivo. J Neurobiol 23: 451-466, 1992
30. Cerutti SM, Chadi G: S100 immunoreactivity is increased in reactive astrocytes of the visual pathways following a mechanical lesion of the rat occipital cortex. Cell Biol Int 24: 35-49, 2000
31. Marshak DR, Pesce SA, Stanley LC, Griffin WS: Increased S100 neurotrophic activity in Alzheimer disease temporal lobe. Neurobiol. Aging 13: 1-7, 1992
32. Moosmann B, Behl C: Antioxidants as treatment for neurodegenerative disorders, Expert Opin. Investig. Drugs 11: 1407-1435, 2002
33. Norton WT, Aquino DA, Hozumi I, Chiu FC, Brosnan CF: Quantitative aspects of reactive gliosis: A review. Neurochem. Res 17: 877-885, 1992
34. Hawkins CL, Davies MJ: Generation and propagation of radical reactions on proteins. Biochem Biophys Acta 1504: 196-219, 2001
35. Luxford C, Dean RT, Davies MJ: Radicals derived from histone hydro peroxides damage nucleobases in RNA and DNA. Chem Res Toxicol 13: 665-672, 2000
36. Mclennan SV, Heffernan S, Wright L, Rae C, Fisher E, Yue DK, Turtle JR: Changes in hepatic glutathione metabolism in diabetes. Diabetes 40: 344-348, 1991
37. Mullarkey CJ, Edelstein D, Brownlee M: Free radical generation by early glycation products: A mechanism for accelerated atherogenesis in diabetes. Biochem Biophys Res Commun 173: 932-939, 1990
38. Chang CZ, Winardi D, Loh JK, Kung SS, Howng SL, Jeng AY, Kwan AL: Alteration of Ischemic Reperfusion Injury in the Rat Neocortex by a Potent Antioxidant Mexiletine. Acta Neurochir (Wien) 144: 189-193, 2002
39. Demirpençe E, Caner H, Bavbek M, Kilinç K: Antioxidant action of the antiarrhythmic drug mexiletine in brain membranes. Jpn J Pharmacol 81: 7-11, 1999
40. Tachi Y, Okuda Y, Bannai C, Bannai S, Shinohara M, Shimpuku H, Yamashita K, Ohura K: Hyperglycemia in diabetic rats reduces the glutathione content in the aortic tissue. Life Sci 69: 1039-1047, 2001
41. Dincer Y, Akcay T, Alademir Z, Ilkova H: Effect of oxidative stress on glutathione pathway in red blood cells from patients with insulin-dependent diabetes mellitus. Metabolism 51: 1360-1362, 2002
42. Hile R, Nishino T: Flavoprotein structure and mechanism. 4. Xanthine oxidase and xanthine dehydrogenase. FASEB J 9(11): 995-1003, 1995
43. Corte ED, Stirpe F: The regulation of rat liver xanthine oxidase. Involvement of thiol groups in the conversion of the enzyme activity from dehydrogenase (type D) into oxidase (type O) and purification of the enzyme. Biochem J 126 (3): 739-745, 1972
44. Parks DA, Williams TK, Beckman JS: Conversion of xanthine dehydrogenase to oxidase in ischemic rat intestine: A reevaluation. American Journal of Physiology 254: 768-774, 1988
45. Desco MC, Asensi M, Marquez R, Valls JM, Vento M, Pallardo FV, Sastre J, Vina J: Xanthine oxidase is involved in free radical production in type 1 diabetes: Protection by allopurinol. Diabetes 51: 1118-1124, 2002
46. Moncada S, Higgs A: The L-arginine-nitric oxide pathway. N Engl J Med. 329 (27): 2002-2012, 1993
47. Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G: Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 84 (24): 9265-9269, 1987
48. Peunova N, Enikolopov G: Amplification of calcium-induced gene transcription by nitric oxide in neuronal cells. Nature 364 (6436): 450-453, 1993
49. Ischiropoulos H, Zhu L, Beckman JS: Peroxynitrite formation from macrophage-derived nitric oxide. Arch Biochem Biophys 298(2): 446-451, 1992
50. Kapoor R, Davies M, Blaker PA, Hall SM, Smith KJ: Blockers of sodium and calcium entry protect axons from nitric oxide-mediated degeneration. Ann Neurol 53(2): 174-180, 2003