Tricyclic pharmacophore-based molecules as novel integrin αvβ3 antagonists. Part IV: Preliminary control of αvβ3 selectivity by meta-oriented substitution

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 12, 2006, Pages 4158-4181

  Kubota, Dai ^a   Ishikawa, Minoru ^a   Ishikawa, Midori ^a   Yahata, Naokazu ^a   Murakami, Shoichi ^a   Fujishima, Kazuyuki ^a   Kitakaze, Masafumi ^a   Ajito, Keiichi ^a  

^a MEIJI SEIKA KAISHA LTD   (Japan)

Author keywords

Acute ischemic disease; Integrin IIb 3 antagonist; Integrin v 3 selective antagonist; meta Oriented substitution

Indexed keywords

ALPHA2BETA3 INTEGRIN; ARGINYLGLYCYLASPARTIC ACID; BENZENE; HETEROCYCLIC COMPOUND; INTEGRIN; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR;

ARTICLE; CELL ADHESION; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PHARMACOPHORE; SUBSTITUTION REACTION;

AORTA; CELL ADHESION; HUMANS; INTEGRIN ALPHAVBETA3; MOLECULAR CONFORMATION; MYOCYTES, SMOOTH MUSCLE; PIPERAZINES; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VITRONECTIN;

EID: 33646195201     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.01.062     Document Type: Article

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