Chronic morphine treatment increases the expression of the neural cell adhesion molecule in the dorsal horn of the mouse spinal cord

Neuroscience Letters

Volumn 399, Issue 3, 2006, Pages 202-205

  Suzuki, Masami ^a   Narita, Minoru ^a   Narita, Michiko ^a   Niikura, Keiichi ^a   Suzuki, Tsutomu ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

Metabotropic glutamate receptor 5 (mGluR5); Morphine; Neural cell adhesion molecule (NCAM); Tolerance

Indexed keywords

METABOTROPIC RECEPTOR 5; MORPHINE; NERVE CELL ADHESION MOLECULE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; EXCITATORY JUNCTION POTENTIAL; IMMUNOREACTIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SPINAL CORD DORSAL HORN;

ANIMALS; BLOTTING, WESTERN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED ICR; MORPHINE; NARCOTICS; NEURAL CELL ADHESION MOLECULES; POSTERIOR HORN CELLS; RECEPTORS, METABOTROPIC GLUTAMATE; SPINAL CORD;

EID: 33646130390     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2006.01.066     Document Type: Article

References (13)

1. Alvarez F.J., Villalba R.M., Carr P.A., Grandes P., and Somohano P.M. Differential distribution of metabotropic glutamate receptors 1a, 1b, and 5 in the rat spinal cord. J. Comp. Neurol. 422 (2000) 464-487
2. Bie B., and Pan Z.Z. Increased glutamate synaptic transmission in the nucleus raphe magnus neurons from morphine-tolerant rats. Mol. Pain 1 (2005) 7
3. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal. Biochem. 72 (1976) 248-254
4. Dityatev A., Dityateva G., and Schachner M. Synaptic strength as a function of post- versus presynaptic expression of the neural cell adhesion molecule NCAM. Neuron 26 (2000) 207-217
5. Hylden J.L., and Wilcox G.L. Intrathecal morphine in mice: a new technique. Eur. J. Pharmacol. 67 (1980) 313-316
6. Kahn L., Alonso G., Normand E., and Manzoni O.J. Repeated morphine treatment alters polysialylated neural cell adhesion molecule, glutamate decarboxylase-67 expression and cell proliferation in the adult rat hippocampus. Eur. J. Neurosci. 21 (2005) 493-500
7. Kozela E., Pilc A., and Popik P. Inhibitory effects of MPEP, an mGluR5 antagonist, and memantine, an N-methyl-d-aspartate receptor antagonist, on morphine antinociceptive tolerance in mice. Psychopharmacology 165 (2003) 245-251
8. Narita M., Suzuki M., Narita M., Niikura K., Nakamura A., Miyatake M., Aoki T., Yajima Y., and Suzuki T. Involvement of spinal metabotropic glutamate receptor 5 in the development of tolerance to morphine-induced antinociception. J. Neurochem. 94 (2005) 1297-1305
9. Narita M., Suzuki M., Narita M., Yajima Y., Suzuki R., Shioda S., and Suzuki T. Neuronal protein kinase Cγ-dependent proliferation and hypertrophy of spinal cord astrocytes following repeated in vivo administration of morphine. Eur. J. Neurosci. 19 (2004) 479-484
10. Sheng M., and Kim J.M. Postsynaptic signaling and plasticity mechanisms. Science 289 (2002) 766-780
11. Smith F.L., Smith P.A., Dewey W.L., and Javed R.R. Effects of mGlu1 and mGlu5 metabotropic glutamate antagonists to reverse morphine tolerance in mice. Eur. J. Pharmacol. 492 (2004) 137-142
12. Trujillo K.A., and Akil H. Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801. Science 251 (1991) 85-87
13. Washbourne P., Dityatev A., Scheiffele P., Biederer T., Weiner J.A., Christopherson K.S., and El-Husseini A. Cell adhesion molecules in synapse formation. J. Neurosci. 24 (2004) 9244-9249