DNA vaccines expressing B and T cell epitopes can protect mice from FMDV infection in the absence of specific humoral responses

Vaccine

Volumn 24, Issue 18, 2006, Pages 3889-3899

  Borrego, Belen ^a   Fernandez Pacheco, Paloma ^a   Ganges, Llilianne ^a   Domenech, Nieves ^a,c   Fernandez Borges, Natalia ^d   Sobrino, Francisco ^a,b   Rodríguez, Fernando ^d  

^a Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c HOSPITAL JUAN CANALEJO   (Spain)

^d CENTRE DE RECERCA EN SANITAT ANIMAL CRESA   (Spain)

Author keywords

Cellular immune response; DNA immunization; Foot and mouth disease virus; Mouse model; Protection; Serum neutralization; Vaccine

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DNA VACCINE; EPITOPE; FOOT AND MOUTH DISEASE VACCINE; HYBRID PROTEIN; NEUTRALIZING ANTIBODY; PRION PROTEIN; SIGNAL PEPTIDE; STRUCTURAL PROTEIN; STRUCTURAL PROTEIN VP1; STRUCTURAL PROTEIN VP4; SYNTHETIC PEPTIDE; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIGEN PRESENTATION; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; FOOT AND MOUTH DISEASE; FOOT AND MOUTH DISEASE VIRUS; HOST; HUMORAL IMMUNITY; IMMUNIZATION; IMMUNOGENICITY; LYSOSOME; MOLECULAR CLONING; MOUSE; MOUSE STRAIN; NEWBORN; NONHUMAN; PLASMID; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; VIREMIA; VIRUS GENE;

ANIMALS; ANTIBODIES, VIRAL; ANTIGENS, CD; ANTIGENS, CD36; ANTIGENS, DIFFERENTIATION; CD4-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; EPITOPES, B-LYMPHOCYTE; EPITOPES, T-LYMPHOCYTE; FOOT-AND-MOUTH DISEASE; FOOT-AND-MOUTH DISEASE VIRUS; GENETIC VECTORS; IMMUNITY, CELLULAR; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; MICE; NEUTRALIZATION TESTS; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; UBIQUITIN; VACCINES, DNA; VIRAL VACCINES; VIREMIA;

EID: 33646125401     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2006.02.028     Document Type: Article

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