Enhancing DNA immunization

Virology

Volumn 268, Issue 2, 2000, Pages 233-238

  Rodriguez, Fernando ^a   Whitton, J Lindsay ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; UBIQUITIN;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; GENE TARGETING; IMMUNIZATION; LYSOSOME; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN SECRETION; PROTEIN TARGETING; PROTEIN TRANSPORT; RNA TRANSCRIPTION; SHORT SURVEY; T LYMPHOCYTE ACTIVATION;

EID: 0034654574     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2000.0209     Document Type: Article

References (15)

1. An L. L., Rodriguez F., Harkins S., Zhang J., Whitton J. L. Quantitative and qualitative analyses of the immune responses induced by a multivalent minigene DNA vaccine. Vaccine. 2000.
2. Boyle J. S., Brady J. L., Lew A. M. Enhanced responses to a DNA vaccine encoding a fusion antigen that is directed to sites of immune induction. Nature. 392:1998;408-411.
3. Donnelly J. J., Ulmer J. B., Liu M. A. DNA vaccines. Life Sci. 60:1997;163-172.
4. Fourie A. M., Yang Y. Molecular requirements for assembly and intracellular transport of class I major histocompatibility complex molecules. Curr. Top. Microbiol. Immunol. 232:1998;49-74.
5. Hassett D. E., Whitton J. L. DNA immunization. Trends Microbiol. 4:1996;307-312.
6. Mendoza R. B., Cantwell M. J., Kipps T. J. Cutting edge: Immunostimulatory effects of a plasmid expressing CD40 ligand (CD154) on gene immunization. J. Immunol. 159:1997;5777-5781.
7. Rodriguez F., An L. L., Harkins S., Zhang J., Yokoyama M., Widera G., Fuller J. T., Kincaid C., Campbell I. L., Whitton J. L. DNA immunization with minigenes: Low frequency of memory CTL and inefficient antiviral protection are rectified by ubiquitination. J. Virol. 72:1998;5174-5181.
8. Rodriguez F., Zhang J., Whitton J. L. DNA immunization: Ubiquitination of a viral protein enhances CTL induction, and antiviral protection, but abrogates antibody induction. J. Virol. 71:1997;8497-8503.
9. Rowell J. F., Ruff A. L., Guarnieri F. G., Staveley-O'Carroll K., Lin X., Tang J., August J. T., Siliciano R. F. Lysosome-associated membrane protein-1-mediated targeting of the HIV-1 envelope protein to an endosomal/lysosomal compartment enhances its presentation to MHC class II-restricted T cells. J. Immunol. 155:1995;1818-1828.
10. Thomson S. A., Burrows S. R., Misko I. S., Moss D. J., Coupar B. E., Khanna R. Targeting a polyepitope protein incorporating multiple class II-restricted viral epitopes to the secretory/endocytic pathway facilitates immune recognition by CD4+ cytotoxic T lymphocytes: A novel approach to vaccine design. J. Virol. 72:1998;2246-2252.
11. Tobery T. W., Siliciano R. F. Targeting of HIV-1 antigens for rapid intracellular degradation enhances cytotoxic T lymphocyte (CTL) recognition and the induction of de novo CTL responses in vivo after immunization. J. Exp. Med. 185:1997;909-920.
12. Townsend A. R. M., Bastin J., Gould K., Brownlee G., Andrew M., Coupar B., Boyle D., Chan S., Smith G. Defective presentation to class I-restricted cytotoxic T lymphocytes in vaccinia-infected cells is overcome by enhanced degradation of antigen. J. Exp. Med. 168:1988;1211-1224.
13. Wang R., Doolan D. L., Le T. P., Hedstrom R. C., Coonan K. M., Charoenvit Y., Jones T. R., Hobart P., Margalith M., Ng J., Weiss W. R., Sedegah M., deTaisne C., Norman J. A., Hoffman S. L. Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine. Science. 282:1998;476-480.
14. Whitton J. L. Antigen presentation. Current Topics in Microbiology and Immunology. 1998;Springer-Verlag, New York.
15. Wu T. C., Guarnieri F. G., Staveley-O'Carroll K. F., Viscidi R. P., Levitsky H. I., Hedrick L., Cho K. R., August J. T., Pardoll D. M. Engineering an intracellular pathway for major histocompatibility complex class II presentation of antigens. Proc. Natl. Acad. Sci. USA. 92:1995;11671-11675.