SanJ, an ATP-dependent picolinate-CoA ligase, catalyzes the conversion of picolinate to picolinate-CoA during nikkomycin biosynthesis in Streptomyces ansochromogenes

Metabolic Engineering

Volumn 8, Issue 3, 2006, Pages 183-195

  Niu, Guoqing ^a,b   Liu, Gang ^a   Tian, Yuqing ^a   Tan, Huarong ^a  

^a INSTITUTE OF MICROBIOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Adenylate forming enzymes; Nikkomycin biosynthesis; Picolinate; Picolinate CoA ligase; sanJ; Streptomyces ansochromogenes

Indexed keywords

ANTIBIOTICS; BIOSYNTHESIS; ENZYME INHIBITION; ESCHERICHIA COLI; ESTERS; GENES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

ADENYLATE-FORMING ENZYMES; NIKKOMYCIN BIOSYNTHESIS; PICOLINATE-COA LIGASE; SANJ; STREPTOMYCES ANSOCHROMOGENES;

ENZYME KINETICS;

4 HYDROXYBENZOIC ACID; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; ANISIC ACID; BENZOIC ACID; ENZYME; KANAMYCIN; LIGASE; MAGNESIUM; NICOTINIC ACID; NIKKOMYCIN; PICOLINATE COENZYME A LIGASE; PICOLINIC ACID; SANJ PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CATALYSIS; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; GENE CLUSTER; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STREPTOMYCES; STREPTOMYCES ANSOCHROMOGENE;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; AMINOGLYCOSIDES; CATALYSIS; COENZYME A LIGASES; ENZYME ACTIVATION; MOLECULAR SEQUENCE DATA; PICOLINIC ACIDS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; STREPTOMYCES; SUBSTRATE SPECIFICITY;

ESCHERICHIA COLI; STREPTOMYCES; STREPTOMYCES ANSOCHROMOGENES;

EID: 33646118511     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2005.12.002     Document Type: Article

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