Altered cardiac metabolic phenotype after prolonged inhibition of NO synthesis in chronically instrumented dogs

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 290, Issue 4, 2006, Pages

  D'Agostino, Chiara ^a   Labinskyy, Volodymyr ^a   Lionetti, Vincenzo ^b   Chandler, Margaret P ^c   Lei, Biao ^a   Matsuo, Ken ^a   Bellomo, Michelle ^a   Xu, Xiaobin ^a   Hintze, Thomas H ^a   Stanley, William C ^b,c   Recchia, Fabio A ^a,b  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b SCUOLA SUPERIORE SANT ANNA   (Italy)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Heart; Metabolism; Nitric oxide

Indexed keywords

ANGIOTENSIN II; FATTY ACID; GLUCOSE; GLUCOSE TRANSPORTER 1; LACTIC ACID; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OLEIC ACID; PYRUVATE DEHYDROGENASE;

ANIMAL EXPERIMENT; ARTICLE; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; DOG; ENZYME ACTIVITY; ENZYME INHIBITION; FATTY ACID OXIDATION; GLUCOSE OXIDATION; HEART LEFT VENTRICLE; HEART MUSCLE METABOLISM; HEMODYNAMICS; MALE; NONHUMAN; OXYGEN CONSUMPTION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; ADAPTATION; ANIMAL; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; HEART; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; METABOLISM; MONITORING; PHYSIOLOGY; TIME;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; CARBOHYDRATE METABOLISM; DOGS; HEART; MALE; MONITORING, PHYSIOLOGIC; MYOCARDIUM; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHENOTYPE; TIME FACTORS; VENTRICULAR FUNCTION, LEFT;

EID: 33646103434     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00745.2005     Document Type: Article

References (28)

1. ω-nitro-L-arginine methyl ester administration on glucose tolerance and skeletal muscle glucose transport in the rat. Nitric Oxide 3: 312-320, 1999.
2. Barouch LA, Harrison RW, Skaf MW, Rosas GO, Cappola TP, Kobeissi ZA, Hobai IA, Lemmon CA, Burnett AL, O'Rourke B, Rodriguez ER, Huang PL, Lima JA, Berkowitz DE, and Hare JM. Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms. Nature 416: 337-339, 2002.
3. Brown GC and Cooper CE. Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase. FEBS Lett 356: 295-298, 1994.
4. Bryant NJ, Govers R, and James DE. Regulated transport of the glucose transporter GLUT4. Nat Rev Mol Cell Biol 3: 267-277, 2002.
5. Depre C, Vanoverschelde JL, Goudemant JF, Mottet I, and Hue L. Protection against ischemic injury by nonvasoactive concentrations of nitric oxide synthase inhibitors in the perfused rabbit heart. Circulation 92: 1911-1918, 1995.
6. Gertz EW, Wisneski JA, Neese R, Bristow JD, Searle GL, and Hanlon JT. Myocardial lactate metabolism: evidence of lactate release during net chemical extraction in man. Circulation 63: 1273-1279, 1981.
7. Grieve DJ, MacCarthy PA, Gall NP, Cave AC, and Shah AM. Divergent biological actions of coronary endothelial nitric oxide during progression of cardiac hypertrophy. Hypertension 38: 267-273, 2001.
8. Heymes C, Vanderheyden M, Bronzwaer JG, Shah AM, and Paulus WJ. Endomyocardial nitric oxide synthase and left ventricular preload reserve in dilated cardiomyopathy. Circulation 99: 3009-3016, 1999.
9. Lei B, Lionetti V, Young ME, Chandler MP, d'Agostino C, Kang E, Altarejos M, Matsuo K, Hintze TH, Stanley WC, and Recchia FA. Paradoxical downregulation of the glucose oxidation pathway despite enhanced flux in severe heart failure. J Mol Cell Cardiol 36: 567-576, 2004.
10. Lei B, Matsuo K, Labinskyy V, Sharma N, Chandler MP, Ahn A, Hintze TH, Stanley WC, and Recchia FA. Exogenous nitric oxide reduces glucose transporters translocation and lactate production in ischemic myocardium in vivo. Proc Natl Acad Sci USA 102: 6966-6971, 2005.
11. Martin C, Schulz R, Post H, Gres P, and Heusch G. Effect of NO synthase inhibition on myocardial metabolism during moderate ischemia. Am J Physiol Heart Circ Physiol 284: H2320-H2324, 2003.
12. Molina y Vedia L, McDonald B, Reep B, Brune B, Di Silvio M, Billiar TR, and Lapetina EG. Nitric oxide-induced S-nitrosylation of glyceraldehyde-3- phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation. J Biol Chem 267: 24929-24932, 1992.
13. Paulus WJ and Bronzwaer JG. Nitric oxide's role in the heart: control of beating or breathing? Am J Physiol Heart Circ Physiol 287: H8-H13, 2004.
14. Post H, d'Agostino C, Lionetti V, Castellari M, Kang EY, Altarejos M, Xu X, Hintze TH, and Recchia FA. Reduced left ventricular compliance and mechanical efficiency after prolonged inhibition of NO synthesis in conscious dogs. J Physiol 552: 233-239, 2003.
15. Puybasset L, Bea ML, Ghaleh B, Giudicelli JF, and Berdeaux A. Coronary and systemic hemodynamic effects of sustained inhibition of nitric oxide synthesis in conscious dogs. Evidence for cross talk between nitric oxide and cyclooxygenase in coronary vessels. Circ Res 79: 343-357, 1996.
16. Recchia FA, McConnell PI, Loke KE, Xu X, Ochoa M, and Hintze TH. Nitric oxide controls cardiac substrate utilization in the conscious dog. Cardiovasc Res 44: 325-332, 1999.
17. Recchia FA, Osorio JC, Chandler MP, Xu X, Panchal AR, Lopaschuk GD, Hintze TH, and Stanley WC. Reduced synthesis of NO causes marked alterations in myocardial substrate metabolism in conscious dogs. Am J Physiol Endocrinol Metab 282: E197-E206, 2002.
18. Russell RR III, Yin R, Caplan MJ, Hu X, Ren J, Shulman GI, Sinusas AJ, and Young LH. Additive effects of hyperinsulinemia and ischemia on myocardial GLUT1 and GLUT4 translocation in vivo. Circulation 98: 2180-2186, 1998.
19. Saavedra WF, Paolocci N, St. John ME, Skaf MW, Stewart GC, Xie JS, Harrison RW, Zeichner J, Mudrick D, Marban E, Kass DA, and Hare JM. Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart. Circ Res 90: 297-304, 2002.
20. Sambandam N, Lopaschuk GD, Brownsey RW, and Allard MF. Energy metabolism in the hypertrophied heart. Heart Fail Rev 7: 161-173, 2002.
21. Schoder H, Knight RJ, Kofoed KF, Schelbert HR, and Buxton DB. Regulation of pyruvate dehydrogenase activity and glucose metabolism in post-ischaemic myocardium. Biochim Biophys Acta 1406: 62-72, 1998.
22. Shankar RR, Wu Y, Shen HQ, Zhu JS, and Baron AD. Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance. Diabetes 49: 684-687, 2000.
23. Stanley WC, Recchia FA, and Lopaschuk GD. Myocardial substrate metabolism in the normal and failing heart. Physiol Rev 85: 1093-1129, 2005.
24. Starnes JW, Wilson DF, and Erecinska M. Substrate dependence of metabolic state and coronary flow in perfused rat heart. Am J Physiol Heart Circ Physiol 249: H799-H806, 1985.
25. Sterk JP, Stanley WC, Hoppel CL, and Kerner J. A radiochemical pyruvate dehydrogenase assay: activity in heart. Anal Biochem 313: 179-182, 2003.
26. Tada H, Thompson CI, Recchia FA, Loke KE, Ochoa M, Smith CJ, Shesely EG, Kaley G, and Hintze TH. Myocardial glucose uptake is regulated by nitric oxide via endothelial nitric oxide synthase in Langendorff mouse heart. Circ Res 86: 270-274, 2000.
27. Taegtmeyer H, Goodwin GW, Doenst T, and Frazier OH. Substrate metabolism as a determinant for postischemic functional recovery of the heart. Am J Cardiol 80: 3A-10A, 1997.
28. Wu Y, Huang A, Sun D, Falck JR, Koller A, and Kaley G. Gender-specific compensation for the lack of NO in the mediation of flow-induced arteriolar dilation. Am J Physiol Heart Circ Physiol 280: H2456-H2461, 2001.