The use of a cocktail of single chain Fv antibody fragments to improve the in vitro and in vivo targeting of melanoma

Journal of Experimental and Clinical Cancer Research

Volumn 25, Issue 1, 2006, Pages 45-53

  Pacifico, M D ^a   Pearl, R A ^a   Kupsch, J M ^a  

^a MOUNT VERNON HOSPITAL   (United Kingdom)

Author keywords

Cocktail; Immunoscintigraphy; Melanoma; scFv

Indexed keywords

ANTIGEN; EPITOPE; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL MODEL; HUMAN; HUMAN CELL; IMMUNOSCINTIGRAPHY; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MELANOMA; METASTASIS; MOUSE; MUSCLE; NONHUMAN; PRIORITY JOURNAL; SCINTIGRAPHY; SPLEEN; TUMOR LOCALIZATION; XENOGRAFT;

ANIMALS; ANTIGENS, NEOPLASM; CELL LINE, TUMOR; EPITOPES; HUMANS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOTHERAPY; IONS; MELANOMA; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; RADIONUCLIDE IMAGING;

EID: 33646081267     PISSN: 03929078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. CancerStats UK at www.cruk.co.uk. Cancer Research UK, 2005.
2. Severi G., Giles G.G., Robertson C., Boyle P., Autier P.: Mortality from cutaneous melanoma: evidence for contrasting trends between populations. Br. J. Cancer 82: 1887-9, 2000.
3. Buraggi G.L.: Radioimmunodetection of malignant melanoma with the 225.28S monoclonal antibody to HMW-MAA. Nuklearmedizin 25: 220-4, 1986.
4. Siccardi A.G.: Tumor immunoscintigraphy by means of radiolabeled monoclonal antibodies: multicenter studies of the Italian National Research Council-Special Project "Biomedical Engineering. Cancer Res. 50: 899s-903s, 1990.
5. Larson S.M., Carrasquillo J.A., Krohn K.A. et al.: Localization of 131I-labeled p97-specific Fab fragments in human melanoma as a basis for radiotherapy. J. Clin. Invest. 72: 2101-14, 1983.
6. Adams G.P., R. Schier R., McCall A.M. et al.: Prolonged in vivo tumour retention of a human diabody targeting the extracellular domain of human HER2/neu. Br. J. Cancer 77: 1405-12, 1998.
7. Colcher D., Bird R., Roselli M. et al.: In vivo tumor targeting of a recombinant single-chain antigen-binding protein. J. Natl. Cancer Inst. 82: 1191-7, 1990.
8. Begent R.H., Verhaar M.J., Chester K.A. et al.: Clinical evidence of efficient tumor targeting based on single-chain Fv antibody selected from a combinatorial library. Nature Med. 2: 979-84, 1996.
9. Kupsch J-M., Tidman N., Bishop J.A., McKay I., Leigh I., Crowe J.S.: Generation and selection of monoclonal antibodies, single chain Fv and antibody fusion phage specific for human melanoma-associated antigens. Melanoma Res. 5: 403-411, 1995.
10. Kupsch J-M., Tidman N., Kang N. V. et al.: Isolation of human tumor-specific antibodies by selection of an antibody phage library on melanoma cells. Clinical Cancer Res. 5: 925-931, 1999.
11. Kang N.V., Hamilton S., Odili J., Wilson G., Kupsch J-M.: In vivo targeting of malignant melanoma by 125Iodine- and 99mTechnetium-labeled single-chain Fv fragments against high molecular weight melanoma-associated antigen. Clinical Cancer Res. 6: 4921-31, 2000.
12. Kozlowski J.M., Fidler I.J., Campbell D., Xu D.L., Kaighn M.E., Hart I.R.: Metastatic behaviour of human tumor cell lines grown in the nude mouse. Cancer Res. 44: 3522-3529, 1984.
13. Casey J.L., Keep P.A., Chester K.A., Robson L., Hawkins R.E., Begent R.H.: Purification of bacterially expressed single chain Fv antibodies for clinical applications using metal chelate chromatography. J. Immunol. Methods 197: 105-116, 1995.
14. Gibson T.J.: Studies on the Epstein-Barr virus genome (Thesis). Cambridge, England: Cambridge University, 1984.
15. Stahli C., Miggiano V., Stacker J., Staehelin T., Haring P., Takacs B.: Distinction of epitopes by monoclonal antibodies. Methods Enzymol. 92: 242-53, 1983.
16. Friguet, B., Djavadi-Ohaniance L., Pages J., Bussard A, Goldberg M.: A convenient enzyme-linked immunosorbent assay for testing whether monoclonal antibodies recognize the same antigenic site. Application to hybridomas specific for the beta 2-subunit of Escherichia coli tryptophan synthase. J. Immunol. Methods 60: 351-8, 1983.
17. Kang N.V., Hamilton S., Sanders R., Wilson G.D., Kupsch J-M.: Efficient in vivo targeting of malignant melanoma by single chain Fv antibody fragments. Melanoma Res. 9: 545-556, 1999.
18. Adams G.P., Schier R., Marshall K. et al.: Increased affinity leads to improved selective tumor delivery of single-chain Fv antibodies. Cancer Res. 58: 485-90, 1998.
19. Milenic D.E., Yokota T., Filpula D.R. et al.: Construction, binding properties, metabolism, and tumor targeting of a single-chain Fv derived from the pancarcinoma monoclonal antibody CC49. Cancer Res. 51: 6363-71, 1991.
20. Whitlow M., Bell B.A., Feng S.L. et al.: An improved linker for single-chain Fv with reduced aggregation and enhanced proteolytic stability. Protein Eng. 6: 989-95, 1993.
21. Jackson H., Bacon L., Pedley, R.B. et al.: Antigen specificity and tumour targeting efficiency of a human carcinoembryonic antigen specific scFv and affinity-matured derivatives. Br. J. Cancer. 78: 181-8, 1998.
22. Ziai M.R., Imberti L., Nicotra M.R. et al.: Analysis with monoclonal antibodies of the molecular and cellular heterogeneity of human high molecular weight melanoma associated antigen. Cancer Res. 47: 2474-80, 1987.
23. Natali P., Bigotti A., Cavaliere R. et al: Heterogeneous expression of melanoma-associated antigens and HLA antigens by primary and multiple metastatic lesions removed from patients with melanoma. Cancer Res. 45: 2883-9, 1985.
24. Matzku S., Kirchgessner H., Schmid U., Temponi M., Ferroni S.: Melanoma targeting with a cocktail of monoclonal antibodies to distinct determinants of the human HMW-MAA. J. Nucl. Med. 30: 390-7, 1989.
25. Munz D.L., Alavi A., Koprowski H., Herlyn M.: Improved radioimmunoimaging of human tumor xenografts by a mixture of monoclonal antibody F(ab')2 fragments. J. Nucl. Med. 27: 1739-45, 1986.
26. Kawabata S., Yokayama K., Watanbe N. et al.: Is tumour targeting optimized with a mixture of monoclonal antibodies? J. Nucl. Med. 29: 750-751, 1988.
27. Chatal J.F., Saccavini J.C., Fumoleau P. et al.: Immunoscintigraphy of colon carcinoma. J. Nucl. Med. 25: 307-14, 1984.
28. Wahl R.L., Liebert M., Headington J. et al: Lymphoscintigraphy in melanoma: initial evaluation of a low protein dose monoclonal antibody cocktail. Cancer Res. 50: 941s-948s, 1990.
29. Song Y.Q., Wang G.F., Dai X.L., Xie H.: Enhanced radioimmunotherapeutic efficacy of a monoclonal antibody cocktail against SMMC-7721 human hepatocellular carcinoma. Cell Res. 8: 241-7, 1998.