Syntheses of glucose derivatives of E5564-related compounds and their LPS-antagonistic activities

Carbohydrate Research

Volumn 341, Issue 7, 2006, Pages 811-822

  Shiozaki, Masao ^a   Iwano, Yuji ^a   Doi, Hiromi ^b   Tanaka, Daisuke ^b   Shimozato, Takaichi ^b   Kurakata, Shin ichi ^b  

^a Chemtech Labo Inc   (Japan)

^b DAIICHI SANKYO CO   (Japan)

Author keywords

E5564; Lipid A analogue of glucose glucose (1 6) linked disaccharide; LPS antagonist; RsDPLA

Indexed keywords

AMINES; BLOOD; DRUG DOSAGE; ENZYME INHIBITION; GLUCOSE; SYNTHESIS (CHEMICAL);

E5564; LIPID A ANALOGUE OF GLUCOSE-GLUCOSE Α-(1→6)-LINKED DISACCHARIDE; LPS-ANTAGONIST; RSDPLA;

DERIVATIVES;

2 (PHOSPHONOOXY)ETHYL 2,3 DI O DODECYL 6 O [(6 O METHYL) 3 O (3 METHOXYDECYL) 2 O [OCTADEC 11 ENYL] 4 O PHOSPHONO ALPHA DEXTRO GLUCOPYRANOCYL] ALPHA DEXTRO GLUCOPYRANOSIDE; 2 (PHOSPHONOOXY)ETHYL 2,3 DI O DODECYL 6 O [6 O METHYL 3 O (3 METHOXYDECYL) 2 O [11 OCTADECENYL] 4 O PHOSPHONO BETA DEXTRO GLUCOPYRANOCYL] ALPHA DEXTRO GLUCOPYRANOSIDE; 2 [(PHOSPHONO)OXY]ETHYL 6 O [3 O [3 METHOXYDECYL] 6 O METHYL 2 O [11 OCTADECENOYL] 4 O (PHOSPHONO) BETA DEXTRO GLUCOPYRANOSYL] 2,3 DI O DODECYL ALPHA DEXTRO GLUCOPYRANOSIDE; ANTIINFECTIVE AGENT; E 5564; GALACTOSAMINE; GLUCOSE DERIVATIVE; LIPOPOLYSACCHARIDE; PHOSPHONO 3 O DODECYL 6 O [2 DEOXY 3 O [3 (METHOXY)DECYL] 6 O METHYL 2 O [11 OCTADECENYL] 4 O PHOSPHONO BETA DEXTRO GLUCOPYRANOSYL] 2 O [3 HYDROXYTETRADECYL] ALPHA,BETA GLUCOPYRANOSIDE; PHOSPHONO 3 O DODECYL 6 O [3 O [3 (METHOXY)DECYL] 6 O METHYL 2 O [11 OCTADECENOYL] 4 O PHOSPHONO BETA DEXTRO GLUCOPYRANOSYL] 2 O [3 (HYDROXY)TETRADECYL] ALPHA,BETA DEXTRO GLUCOPYRANOSIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BLOOD; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG ACTIVITY; DRUG SYNTHESIS; HUMAN; IC 50; IN VIVO STUDY; INJECTION; MALE; MOUSE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL;

ANIMALS; BLOOD; ENZYME-LINKED IMMUNOSORBENT ASSAY; GALACTOSAMINE; GLUCOSE; HUMANS; INHIBITORY CONCENTRATION 50; INJECTIONS, INTRAVENOUS; LIPID A; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED C3H; MOLECULAR STRUCTURE; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 33646074515     PISSN: 00086215     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carres.2006.02.023     Document Type: Article

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