New HIV-1 reverse transcriptase inhibitors based on a tricyclic benzothiophene scaffold: Synthesis, resolution, and inhibitory activity

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 11, 2006, Pages 3034-3038

  Krajewski, Krzysztof ^a   Zhang, Yijun ^a   Parrish, Damon ^b   Deschamps, Jeffrey ^b   Roller, Peter P ^a   Pathak, Vinay K ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NAVAL RESEARCH LABORATORY   (United States)

Author keywords

CD spectra; Chiral separation; Reverse transcriptase inhibitors; RT inhibitory assay; Synthesis; X ray structures

Indexed keywords

ANTIVIRUS AGENT; BENZOTHIOPHENE; DIMETHYL 1 (1 PIPERIDYNYL)CYCLOBUTA[B][1]BENZOTHIOPHENE 2,2A(7BH) DICARBOXYLATE; DIMETHYL 1 (1 PIPERIDYNYL)CYCLOBUTA[B][1]BENZOTHIOPHENE 2,2A(7BH) DICARBOXYLATE DERIVATIVE; EFAVIRENZ; NEVIRAPINE; NSC 380292; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CIRCULAR DICHROISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENANTIOMER; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; NONHUMAN; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

CIRCULAR DICHROISM; CYCLIZATION; HIV-1 REVERSE TRANSCRIPTASE; MOLECULAR STRUCTURE; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33646033414     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.02.049     Document Type: Article

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