Expression of human PQBP-1 in Drosophila impairs long-term memory and induces abnormal courtship

FEBS Letters

Volumn 580, Issue 9, 2006, Pages 2335-2340

  Yoshimura, Natsue ^a   Horiuchi, Daisuke ^a   Shibata, Masao ^b   Saitoe, Minoru ^c   Qi, Mei ling ^a,c   Okazawa, Hitoshi ^a,c,d  

^a Medical Research Institute   (Japan)

^b Medical & Biological Laboratories Co Ltd   (Japan)

^c TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Memory; Mental retardation; Polyglutamine; PQBP 1 PQBP1; Transcription

Indexed keywords

POLYGLUTAMINE BINDING PROTEIN 1; PROTEIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; COURTSHIP; DROSOPHILA; FRAMESHIFT MUTATION; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; INTELLIGENCE; LONG TERM MEMORY; MALE; MEMORY DISORDER; MENTAL DEFICIENCY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEQUENCE HOMOLOGY; TRANSGENIC ORGANISM;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BEHAVIOR, ANIMAL; CARRIER PROTEINS; DISEASE MODELS, ANIMAL; DROSOPHILA MELANOGASTER; FRAMESHIFT MUTATION; HUMANS; MALE; MEMORY; MENTAL RETARDATION; NUCLEAR PROTEINS; PROTEIN STRUCTURE, TERTIARY;

ANIMALIA;

EID: 33646003299     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2006.03.056     Document Type: Article

References (21)

1. Waragai M., Lammers C.-H., Takeuchi S., Imafuku I., Udagawa Y., Kanazawa I., Kawabata M., Mouradian M.M., and Okazawa H. PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell death. Hum. Mol. Genet. 8 (1999) 977-987
2. Okazawa H., Rich T., Chang A., Lin X., Waragai M., Kajikawa M., Enokido Y., Komuro A., Kato S., Shibata M., Hatanaka H., Mouradian M.M., Sudol M., and Kanazawa I. Interaction between mutant ataxin-1 and PQBP-1 affects transcription and cell death. Neuron 34 (2002) 701-713
3. Busch A., Engemann S., Lurz R., Okazawa H., Lehrach H., and Wanker E.E. Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease. J. Biol. Chem. 278 (2003) 41452-41461
4. Okazawa H., Sudol M., and Rich T. PQBP-1 (Np/PQ): a polyglutamine tract-binding and nuclear inclusion-forming protein. Brain Res Bull. 56 (2001) 273-280
5. Sudol M., and Hunter T. New wrinkles on the old domain. Cell 103 (2000) 1001-1004
6. Waragai M., Junn E., Kajikawa M., Takeuchi S., Kanazawa I., Shibata M., Mouradian M.M., and Okazawa H. PQBP-1/Npw38, a nuclear protein binding to the polyglutamine tract, interacts with U5-15kD/dim1p via the carboxyl-terminal domain. Biochem. Biophys. Res. Commun. 273 (2000) 592-595
7. Zhang Y., Lindblom T., Chang A., Sudol M., Sluder A.E., and Golemis E.A. Evidence that dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for dim1 interactions with hnRNP F and Npw38/PQBP-1. Gene 257 (2000) 33-43
8. Kalscheuer V.M., Freude K., Musante L., Jensen L.R., Yntema H.G., Gecz J., Sefiani A., Hoffmann K., Moser B., Haas S., Gurok U., Haesler S., Aranda B., Nshedjan A., Tzschach A., Hartmann N., Roloff T.C., Shoichet S., Hagens O., Tao J., Van Bokhoven H., Turner G., Chelly J., Moraine C., Fryns J.P., Nuber U., Hoeltzenbein M., Scharff C., Scherthan H., Lenzner S., Hamel B.C., Schweiger S., and Ropers H.H. Mutations in the polyglutamine binding protein 1 gene cause X-linked mental retardation. Nat. Genet. 35 (2003) 313-315
9. Kleefstra T., Franken C.E., Arens Y.H., Ramakers G.J., Yntema H.G., Sistermans E.A., Hulsmans C.F., Nillesen W.N., van Bokhoven H., de Vries B.B., and Hamel B.C. Genotype-phenotype studies in three families with mutations in the polyglutamine-binding protein 1 gene (PQBP1). Clin. Genet. 66 (2004) 318-326
10. Lenski C., Abidi F., Meindl A., Gibson A., Platzer M., Frank Kooy R., Lubs H.A., Stevenson R.E., Ramser J., and Schwartz C.E. Novel truncating mutations in the polyglutamine tract binding protein 1 gene (PQBP1) cause renpenning syndrome and X-linked mental retardation in another family with microcephaly. Am. J. Hum. Genet. 74 (2004) 777-780
11. Stevenson R.E., Bennett C.W., Abidi F., Kleefstra T., Porteous M., Simensen R.J., Lubs H.A., Hamel B.C.J., and Schwartz C.E. Renpenning syndrome comes into focus. Am. J. Med. Genet. 134 (2005) 415-421
12. Tully T., and Quinn W.G. Classical conditioning and retention in normal and mutant Drosophila melanogaster. J. Comp. Physiol. [A] 157 (1985) 263-277
13. Hoshino M., Qi M.-L., Yoshimura N., Miyashita T., Tagawa K., Wada Y.-i., Enokido Y., Marubuchi S., Harjes P., Arai N., Oyanagi K., Blandino G., Sudol M., Rich T., Kanazawa I., Wanker E.E., Saitoe M., and Okazawa H. Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73. J. Cell Biol. 172 (2006) 589-604
14. Chan B., Villella A., Funes P., and Hall J.C. Courtship and other behaviors affected by a heat-sensitive, molecularly novel mutation in the cacophony calcium-channel gene of Drosophila. Genetics 162 (2002) 135-153
15. O'Dell K.M., Jamieson D., Goodwin S.F., and Kaiser K. Abnormal courtship conditioning in males mutant for the RI regulatory subunit of Drosophila protein kinase A. J. Neurogenet. 13 (1999) 105-118
16. Kuniyoshi H., Baba K., Ueda R., Kondo S., Awano W., Juni N., and Yamamoto D. Lingerer, a Drosophila gene involved in initiation and termination of copulation, encodes a set of novel cytoplasmic proteins. Genetics 162 (2002) 1775-1789
17. Rendahl K.G., and Hall J.C. Temporally manipulated rescue of visual and courtship abnormalities caused by a nonA mutation in Drosophila. J. Neurogenet. 10 (1996) 247-256
18. Wan L., Dockendorff T.C., Jongens T.A., and Dreyfuss G. Characterization of dFMR1, a Drosophila melanogaster homolog of the fragile X mental retardation protein. Mol. Cell. Biol. 20 (2000) 8536-8547
19. Zhang Y.Q., Bailey A.M., Matthies H.J., Renden R.B., Smith M.A., Speese S.D., Rubin G.M., and Broadie K. Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function. Cell 107 (2001) 591-603
20. Zhang Y.Q., and Broadie K. Fathoming fragile X in fruit flies. Trends Genet. 21 (2005) 37-45
21. Dockendorff T.C., Su H.S., McBride S.M., Yang Z., Choi C.H., Siwicki K.K., Sehgal A., and Jongens T.A. Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest. Neuron 34 (2002) 973-984