Functional studies of the MACPF domain of human complement protein C8α reveal sites for simultaneous binding of C8β, C8γ, and C9

Biochemistry

Volumn 45, Issue 16, 2006, Pages 5290-5296

  Slade, Daniel J ^a   Chiswell, Brian ^a   Sodetz, James M ^a  

^a UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS; DIMERS; ESCHERICHIA COLI; POLYMERIZATION; PROTEINS;

C-TERMINAL MODULES; HUMAN C8; MEMBRANE ATTACK COMPLEX/PERFORIN (MACPF) DOMAIN; SELF-POLYMERIZATION;

BIOCHEMISTRY;

COMPLEMENT COMPONENT C8; COMPLEMENT COMPONENT C8ALPHA; COMPLEMENT COMPONENT C8BETA; COMPLEMENT COMPONENT C8GAMMA; COMPLEMENT COMPONENT C9; COMPLEMENT MEMBRANE ATTACK COMPLEX; PERFORIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; DISULFIDE BOND; ESCHERICHIA COLI; HEMOLYSIS; HUMAN; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION;

BINDING SITES; COMPLEMENT C8; COMPLEMENT C9; GENE EXPRESSION; HEMOLYSIS; HUMANS; MEMBRANE GLYCOPROTEINS; PORE FORMING CYTOTOXIC PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

ESCHERICHIA COLI;

EID: 33645971303     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0601860     Document Type: Article

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