Immunohistochemical detection of GLUT1, p63 and phosphorylated histone H1 in head and neck squamous intraepithelial neoplasia: Evidence for aberrations in hypoxia-related, cell cycle- and stem-cell-regulatory pathways

Histopathology

Volumn 48, Issue 6, 2006, Pages 708-716

  Burstein, D E ^a   Nagi, C ^a   Kohtz, D S ^a   Lumerman, H ^a   Wang, B Y ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

GLUT1; Histone H1; Hypoxia; p63; Phosphorylation specific antibodies; Squamous dysplasia; Squamous intraepithelial neoplasia

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; GLUCOSE TRANSPORTER 1; HISTONE H1; PROTEIN P63;

ARTICLE; CANCER INVASION; CELL CYCLE REGULATION; CELL HYPOXIA; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE MARKER; ENZYME REGULATION; HEAD AND NECK CANCER; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; STEM CELL;

ANOXIA; CARCINOMA IN SITU; CELL CYCLE; DISEASE PROGRESSION; DNA-BINDING PROTEINS; GLUCOSE TRANSPORTER TYPE 1; HEAD AND NECK NEOPLASMS; HISTONES; HUMANS; IMMUNOHISTOCHEMISTRY; PHOSPHOPROTEINS; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TUMOR MARKERS, BIOLOGICAL; TUMOR STEM CELLS; TUMOR SUPPRESSOR PROTEINS;

EID: 33645965614     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2006.02407.x     Document Type: Article

References (37)

1. Armstrong WB Meyskens FL Jr. Chemoprevention of head and neck cancer OtolaryngolHead Neck Surg 2000 122 728 735
2. Yang A McKeon F p63 and p73: p53 mimics, menaces and more Nature RevMolCell Biol 2000 1 199 207
3. Yang A Schweitzer R Sun D et al. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development Nature 1999 398 714 718
4. Mills AA Zheng B Wang XJ Vogel H Roop DR Bradley A p63 is a p53 homologue required for limb and epidermal morphogenesis Nature 1999 398 708 713
5. Pellegrini G Dellambra E Golisano O et al. p63 identifies keratinocyte stem cells ProcNatl AcadSciUSA 2001 98 3156 3161
6. Wang BY Gil J Kaufman D Li G Kohtz DS Burstein DE p63 in pulmonary epithelium, pulmonary squamous neoplasms and other pulmonary tumors HumPathol 2002 33 921 926
7. Bashan N Burdett E Hundal HS Klip A Regulation of glucose transport and GLUT1 glucose transporter expression by O2 in muscle cells in culture AmJPhysiol 1992 262 C682 690
8. Stein I Neeman M Shweiki D Itin A Keshet E Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes MolCell Biol 1995 15 5363 5368
9. Ebert BL Firth JD Ratcliffe PJ Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences JBiolChem 1995 270 29083 29089
10. Younes M Lechago LV Somoano JR Mosharaf M Lechago J Wide expression of the human erythrocyte glucose transporter Glut1 in human cancers Cancer Res 1996 56 1164
11. Haber RS Rathan A Weiser KR et al. GLUT1 glucose transporter expression in colorectal carcinoma: a marker for poor prognosis Cancer 1998 83 34 40
12. Wang BW Kalir T Sabo E Sherman DE Cohen C Burstein DE Immunohistochemical staining of GLUT1 in benign, hyperplastic and malignant endometrial epithelia Cancer 2000 88 2774 2781
13. Kalir T Wang BY Goldfischer M et al. Immunohistochemical staining of GLUT1 in benign, borderline, and malignant ovarian epithelia Cancer 2002 94 1078 1082
14. Cole F Fasy TM Rao SS de Peralto MA Kohtz DS Growth factors which repress myoblast differentiation sustain phosphorylation of a specific site on histone H1 JBiolChem 1993 268 15
15. Burstein DE Oami S Dembitzer F et al. Monoclonal antibody specific for histone H1 phosphorylated by cyclin-dependent kinases. A novel immunohistochemical probe of proliferation and neoplasia ModPathol 2002 15 705 711
16. Irwin MS Kaelin WG Jr. Role of the newer p53 family proteins in malignancy Apoptosis 2001 6 17 29
17. Burstein DE Reder I Weiser K Tong T Pritsker A Haber R GLUT1 glucose transporter: a highly sensitive marker of malignancy in body cavity effusions ModPathol 1998 11 392 396
18. Kafanas A Wang BY Kalir T et al. Immunohistochemical visualization of histone H1 phosphorylation in squamous intraepithelial lesions of the gynecologic tract HumPathol 2003 34 166 173
19. Choi H-R Batsakis JG Zhan F Sturgis E Luna MA el-Naggar AK Differential expression of p53 gene family members p63 and p73 in head and neck squamous tumorigenesis HumPathol 2002 33 158 164
20. Pruneri G Pignataro L Manzotti M et al. p63 in laryngeal squamous cell carcinoma: evidence for a role of TA-p63 down-regulation in tumorigenesis and lack of prognostic implications of p63 immunoreactivity LabInvest 2002 82 1327 1334
21. Weber A Billlmann U Bootz F Wittikind C Tannapfel A Expression of p53 and its homologues in primary and recurrent squamous cell carcinomas of the head and neck IntJCancer 2002 99 22 28
22. Faridoni-Laurens L Bosq J Janot F et al. p73 expression in basal layers of head and neck squamous epithelium: a role in differentiation and carcinogenesis in concert with p53 and p63? Oncogene 2001 20 5302 5312
23. Glickman JN Yang A Shahsafaei A McKeon F Odze RD Expression of p53-related protein p63 in the gastrointestinal tract and in esophageal metaplastic and neoplastic disorders HumPathol 2001 32 1157 1165
24. Reis-Filho JS Torio B Albergaria A Schmitt FC P63 expression in normal skin and usual cutaneous carcinomas JCutanPathol 2002 29 517 523
25. Quade BJ Yang A Wang Y et al. Expression of the p53 homologue p63 in early cervical neoplasia GynecolOncol 2001 80 24 29
26. Shweiki D Itin A Soffer D Keshet E Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis Nature 1992 359 843 845
27. Stein I Neeman M Shweiki D Itin A Keshet E Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes MolCell Biol 1995 15 5363 5368
28. Nevill BW Day TA Oral cancer and precancerous lesions CA Cancer JClin 2002 52 195 215
29. Reisser C Eichhorn K Herold-Mende C Born AI Bannasch P Expression of facilitative glucose transport proteins during development of squamous cell carcinomas of the head and neck IntJCancer 1999 80 194 198
30. Burstein DE Nagi C Kohtz DS Lee L Wang B Immunodetection of GLUT1, p63 and phospho-histone H1 in invasive head and neck squamous carcinoma: correlation of immunohistochemical staining patterns with keratinization Histopathology 2006 48 717 722
31. Mineta H Miura K Takebayashi S et al. Prognostic value of glucose transporter 1 expression in patients with hypopharyngeal carcinoma Anticancer Res 2002 22 3489 3494
32. Mellanen P Minn H Grenman R Harkonen P Expression of glucose transporters in head-and-neck tumors IntJCancer 1994 56 622 629
33. Murakami T Nishiyama T Shirotani T et al. Identification of two enhancer elements in the gene encoding the type 1 glucose transporter from the mouse which are responsive to serum, growth factor, and oncogenes JBiolChem 1992 267 9300 9306
34. Iliopoulos O Levy AP Jiang C Kaelin WG Jr. Goldberg MA Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein ProcNatl AcadSciUSA 1996 93 10595 10599
35. Rafferty MA Fenton JE Jones AS An overview of the role and inter-relationship of epidermal growth factor receptor, cyclin D and retinoblastoma protein on the carcinogenesis of squamous cell carcinoma of the larynx ClinOtolaryngol 2001 26 317 320
36. Michalides RJAM van de Breke M Balm F Defects in G1-S cell cycle control in head and neck cancer: a review Head Neck 2002 24 694 704
37. Gonzalez-Moles MA Ruiz-Avila I Rodriguez-Archilla A Martinez-Lara I Suprabasal expression of Ki-67 antigen as a marker for the presence and severity of oral epithelial dysplasia Head Neck 2000 22 658 661