An overview of the role and inter-relationship of epidermal growth factor receptor, cyclin D and retinoblastoma protein on the carcinogenesis of squamous cell carcinoma of the larynx

Clinical Otolaryngology and Allied Sciences

Volumn 26, Issue 4, 2001, Pages 317-320

  Rafferty, M A ^a   Fenton, J E ^a   Jones, A S ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Cyclin D; EGFR; Immunohistochemistry; Laryngeal squamous cell carcinoma; Molecular biology; Retinoblastoma protein

Indexed keywords

CYCLIN A; CYCLIN B; CYCLIN D; CYCLIN DEPENDENT KINASE; CYCLIN E; EPIDERMAL GROWTH FACTOR RECEPTOR; RECEPTOR PROTEIN; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F;

CARCINOGENESIS; CELL CYCLE; CELL DIVISION; CELL GROWTH; HETEROZYGOSITY LOSS; HUMAN; IMMUNOHISTOCHEMISTRY; LARYNX CARCINOMA; MOLECULAR BIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTO ONCOGENE; REVIEW; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA;

CARCINOMA, SQUAMOUS CELL; CELL DIVISION; COCARCINOGENESIS; CYCLINS; GENES, CDC; HUMANS; IMMUNOHISTOCHEMISTRY; LARYNGEAL NEOPLASMS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RETINOBLASTOMA PROTEIN; SIGNAL TRANSDUCTION;

EID: 0034787037     PISSN: 03077772     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2273.2001.00478.x     Document Type: Review

References (28)

1. Induction of cell cycle arrest by inhibitiors of epidermal growth factor receptor (EGFR) kinase activity. Meeting abstract
2. Oncogenes and tumour suppressor genes in squamous cell carcinoma of the head and neck. Oral oncology
3. Abnormal patterns of cyclin D1 expression and G1 regulation in human head and neck cancer
4. Cyclin D1 amplification as a new predictive classification for squamous cell carcinoma of the esophagus, adding gene information
5. Cyclin D1 gene amplification in human laryngeal squamous cell carcinomas: Prognostic significance and clinical implication
6. PRAD-1/cyclin D1 gene amplification correlates with messengar RNA overexpression and tumor progression in human laryngeal carcinomas
7. Cyclin D1 protein expression and function in human breast cancer
8. A clinicopathological study of overexpression of cyclin D1 and of p53 in a series of 248 patients with operable breast cancer
9. Cyclin D1 protein expression is related to clinical progression in laryngeal squamous cell carcinomas
10. Prognostic significance of cyclin D1 protein levels in early-stage larynx cancer treated with primary radiation
11. Chromosomal abnormalities involving 11q13 are associated with poor prognosis in squamous cell carcinoma of the head and neck
12. Amplification of cyclin D1 in squamous cell carcinoma of the head and neck and the prognostic value of chromosomal abnormalities and cyclin D1 overexpression
13. Functional interaction of the retinoblastoma protein with mammalian D-type cyclins
14. Cyclin D1 expression is regulated by the retinoblastoma protein
15. Altered expression of the cyclin D1 and retinblastoma genes in human esophageal cancer
16. Cyclin D1 overexpression related to retinoblastoma protein expression as a prognostic marker in human oesophageal squamous cell carcinoma
17. Determination of the prognostic value of cyclin D1 overexpression in breast cancer
18. Abnormalities and the implication of retinoblastoma locus and its protein product in head and neck cancers
19. Ligand specific activation of HER4/pl80 erbB4, a fourth member of the epidermal growth factor receptor family
20. Requirements for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor
21. Blockage of EGF receptor signal transduction causes reversible arrest of normal and immortal human mammary epithelial cells with synchronous re-entry into the cell cycle
22. Asynchronous modulation of transforming growth factor alpha and epidermal growth factor receptor protein expression in progression of premalignant lesions to head and neck squamous cell carcinoma
23. Inhibition of epidermal growth factor receptor gene expression and function decreases proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells
24. Phase 1 studies of anti-epidermal growth factor receptor chimeric monoclonal antibody C225 in patients with EGFR overexpressing tumours
25. Correlation of cisplatin sensitivity with differential alteration of EGFR expression in head and neck cancer cells
26. Potential indicators of radiosensitivity in squamous cell carcinoma of the head and neck
27. Prognostic value of EGFR and TGF-alpha in early laryngeal cancer treated with radiotherapy
28. Prognostic significance of epidermal growth factor receptor in laryngeal squamous cell carcinoma