Designing physiogenomic studies

Pharmacogenomics

Volumn 7, Issue 2, 2006, Pages 157-158

  Holford, Theodore R ^a   Windermuth, Andreas ^b   Ruaño, Gualberto ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Genomas Inc   (United States)

Author keywords

Bonferroni adjustment; Multiple testing; Physiogenomics; Sample size; SNP arrays

Indexed keywords

ALLELE; ARTICLE; GENE FREQUENCY; GENE TECHNOLOGY; GENETIC SUSCEPTIBILITY; GENOMICS; HUMAN; MATHEMATICAL COMPUTING; MEDICAL RESEARCH; MICROARRAY ANALYSIS; PREVALENCE; PROGNOSIS; SAMPLE SIZE; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; LETTER; METHODOLOGY;

GENOMICS; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; RESEARCH DESIGN; SAMPLE SIZE;

EID: 33645959853     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/14622416.7.2.157     Document Type: Article

References (10)

1. Holford TR, Windemuth A, Ruaño G: Personalizing public health. Personalized Medicine 2, 239-249 (2005).
2. Risch N, Merikangas K: The future of genetic studies of complex human diseases. Science 273, 1516-1517 (1996).
3. Reinere A, Yekutiele D, Benjamini Y: Identifying differentially expressed genes using false discovery rate controlling procedures. Bioinformatics 19, 368-375 (2003).
4. Benjamini Y, Hochberg Y: Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. [Ser. B] 57, 289-300 (1995).
5. Benjamini Y, Hochberg Y. On the adaptive control of the false discovery rate in multiple testing with independent statistics. JEBS25, 60-83 (2000).
6. Ohashi J, Tokunaga K: The power of genome-wide association studies of complex disease genes: statistical limitations of indirect approaches using SNP markers. J Hum. Genet. 46, 478-482 (2001).
7. Rosner B: Fundamentals of Biostatistics. Wadsworth Publishing Co., Belmont, CA, USA (1995).
8. Abramowitz M, Stegun IA: Handbook of Mathematical Functrions with Formulae Giaphs, and Mathematical Tables. US Government Printing Office, Washington, DC, USA (1970).
9. Simon R, Wang S-J: Use of genomic signatures in therapeutics development in oncology and other diseases. Pharmacogenomics J. (Epub ahead of print) (2006).
10. Marchini J, Donnelly P, Cardon LR: Genome-wide strategies for detecting multiple loci that influence complex diseases. Nature Genet. 37, 413-417 (2005).