Cytotoxicity assessment of gliotoxin and penicillic acid in Tetrahymena pyriformis

Environmental Toxicology

Volumn 21, Issue 2, 2006, Pages 111-117

  Grabsch C ^a   Wichmann, G ^a   Loffhagen, N ^a   Herbarth, O ^a   Muller A ^a  

^a HELMHOLTZ CENTRE FOR ENVIRONMENTAL RESEARCH UFZ   (Germany)

Author keywords

Cellular ATP content; Gliotoxin; MTT assay; Mycotoxins; Oxygen consumption; Penicillic acid; Tetrahymena pyriformis

Indexed keywords

HEALTH CARE; IMMUNOLOGY; ORGANIC ACIDS; OXYGEN; TOXIC MATERIALS;

CELLULAR ATP CONTENT; GLIOTOXIN; PENICILLIC ACID; TETRAHYMENA PYRIFORMIS;

MOLDS;

ADENOSINE TRIPHOSPHATE; CYTOTOXIN; GLIOTOXIN; MYCOTOXIN; OXYGEN; PENICILLIC ACID;

ASTHMA; IMMUNE SYSTEM; INFECTIOUS DISEASE; INHIBITION; PATHOGEN; PHYLOGENY; PROKARYOTE; SPORE; TOXIC MATERIAL;

ARTICLE; CELL ENERGY; CELL RESPIRATION; CELL VIABILITY; CYTOTOXICITY; FUNGUS SPORE; HEALTH HAZARD; MOULD; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; TETRAHYMENA PYRIFORMIS;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL PROLIFERATION; CYTOTOXINS; GLIOTOXIN; OXYGEN; PENICILLIC ACID; TETRAHYMENA PYRIFORMIS; TETRAZOLIUM SALTS; THIAZOLES;

FUNGI; TETRAHYMENA PYRIFORMIS;

EID: 33645918300     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.20162     Document Type: Article

References (37)

1. 1 and OK cell lines. Cell Biol Toxicol 14:323-332.
2. Braithwaite AW, Eichner AD, Waring P, Müllbacher A. 1987. The immunomodulating agent gliotoxin causes genomic DNA fragmentation. Mol Immunol 24:47-55.
3. Chan PK, Hayes AW. 1982. In vitro metabolism of penicillic acid with mouse-liver homogenate fractions. Food Chem Toxicol 20:61-65.
4. Dayeh VR, Grominsky S, DeWitte-Ori SJ, Sotornik D, Yeung CR, Lee LEJ, Lynn DH, Bols NC. 2005. Comparing a ciliate and a fish cell line for their sensitivity to several classes of toxicants by the novel application of multiwell filter plates to Tetrahymena. Res Microbiol 156:93-103.
5. Dias N, Nicolau A, Carvalho GS, Mota M, Lima N. 1999. Miniaturization and application of the MTT assay to evaluate metabolic activity of protozoa in the presence of toxicants. J Basic Microbiol 39:103-108.
6. Eichner RD, Waring P, Geue AM, Braithwaite AW, Müllbacher A. 1988. Gliotoxin causes oxidative damage to plasmid and cellular DNA. Biological Chem 263:3772-3777.
7. Fischer G, Mueller T, Schwalbe R, Ostrowsky R, Dott W. 2000. Species-specific profiles of mycotoxins produced in cultures and associated with conidia of airborne fungi derived from biowaste. Int J Hyg Environ Health 203:105-116.
8. Flannigan B, McCabe EM, McGarry F. 1991. Allergenic and toxigenic micro-organisms in houses. Soc Appl Bacteriol Symp Ser 20:61S-73S.
9. Garett MH, Rayment PR, Hooper MA, Abramson MJ, Hooper BM. 1998. Indoor airborne fungal spores, house dampness and associations with environmental factors and respiratory health in children. Clin Exp Allergy 28:459-467.
10. Gräf W. 1985. Ciliata bioassay of Erlangen. GIT-Fachzeitschrift Labor 29:601-614.
11. Gravesen S, Nielsen PA, Iversen R, Nielson KF. 1999. Microfungal contamination of damp buildings-examples of risk constructions and risk materials. Environ Health Persp 107:505-508.
12. Hanelt M, Gareis M, Kollarcik B. 1994. Cytotoxicity of mycotoxins evaluated by the MTT-cell culture assay. Mycopathologia 128:167-174.
13. Hayes AW. 1977. Effect of the mycotoxins, penicillic acid, on Tetrahymena pyriformis. Toxicon 15:497-504.
14. Herbarth O, Diez U, Lehmann I, Müller A, Rolle-Kampczyk U, Wichmann G. 2002. Umweltmedizinische Untersuchungen beim Vorliegen einer Schimmelpilzbelastung und Erfassung immunmodulatorischer Effekte. In Keller R, Senkpiel K, Samson RA, Hoekstra ES, editors. Umgebungsanalyse bei gesundheitlichen Beschwerden durch mikrobielle Belastung im Innenraum: Lübeck, p 35-90.
15. Horak B. 1987. Preliminary study on the concentration and species composition of bacteria, fungi and mites in samples of house dust from Silesia (Poland). Allergol Immunopathol (Madr) 15:161-166.
16. Husman T. 1996. Health effects of indoor-air microorganisms. Scand J Work Environ Health 22:5-13.
17. Kweon Y-O, Paik Y-H, Schnabl B, Qian T, Lemaster JJ, Brenner DA. 2003. Gliotoxin-mediated apoptosis of activated human hepatic stellate cells. J Hepatol 39:38-46.
18. Loffhagen N, Härtig C, Babel W. 2003. Energization of Comamonas testosteroni ATCC 17454 for indicating toxic effects of chlorophenoxy herbicides. Arch Environ Contam Toxicol 45:317-323.
19. Lundin A, Thore A. 1975. Analytical information obtainable by evaluation of the time course of fireflybioluminescence in the assay of ATP. Anal Biochem 66:47-63.
20. Massolo L, Müller A, Tueros M, Rehwagen M, Franck U, Ronco A, Herbarth O. 2002. Assessment of mutagenic and toxicity in different size fraction of air particulates from La Plata (Argentine) and Leipzig (Germany). Environ Toxicol 17:219-231.
21. McNeel SV, Kreutzer RA. 1996. Fungi and indoor air quality. Health Environ Digest 10:9-10.
22. Meklin T, Husman T, Vepsäläinen A, Vahtereisto M, Koivisto J, Halla-Aho J, Hyvärinen A, Moschandreas D, Nevalainen A. 2002. Indoor air microbes and respiration symptoms of children in moisture damaged and reference schools. Indoor Air 12:175-183.
23. Müller A, Lehmann I, Seiffert A, Diez U, Wetzig H, Borte M, Herbarth O. 2002. Increased incidence of allergic sensitisation and respiratory diseases due to mould exposure: Results of the Leipzig Allergy Risk children Study (LARS). Int J Hyg Envir Heal 204:363-365.
24. Mosmann T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Met 65:55-63.
25. Nicolau A, Dias N, Mota M, Lima N. 2001. Trends in the use of protozoa in the assessment of waste water treatment. Res Microbiol 152:621-630.
26. Nieminen SM, Mäki-Paakkanen J, Hirvonen M-R, Roponen M, von Wright A. 2002. Genotoxicity of gliotoxin, a secondary metabolite of Aspergillus fumigatus, in a battery of short-term test system. Mutat Res 520:161-170.
27. Nilsson JR. 1998. Tetrahymena in Cytotoxicology: with special reference to effects of heavy metals and selected drugs. Eur J Protistol 25:2-25.
28. Nishie K, Cutler HG, Cole RJ. 1989. Toxicity of trichothecenes, moniliformin, zearalenone/ol, griseofulvin, patulin, PR-toxin and rubratoxin B on protozoan Tetrahymena pyriformis. Res Commun Mol Path 65:197-210.
29. Rylander R. 1995. Respiration disease caused by bioaerosols - exposure and diagnosis. In Johanning E, Yang CS, editors. Fungi and bacteria in indoor air environments. Proceedings of the International Conference, Saratoga Springs, NY. p 45-55.
30. Rylander R. 2003. Environmental risk factors for respiratory infections. Arch Environ Health 55:300-303.
31. Sauvant MP, Pepin D, Piccini E. 1999. Tetrahymena pyriformis-a tool for toxicological studies-a review. Chemosphere 38:1631-1669.
32. Sparagano OA. 1995. Griseofulvin: Generation time and ATP changes in the ciliate Tetrahymena pyriformis. Life Sci 57:897-901.
33. Sorenson WG. 1995. Aerolized mycotoxins: Implications for occupational settings. In Johanning E, Yang CS, editors. Fungi and bacteria in indoor air environments. Proceedings of the International Conference, Saratoga Springs, NY. p 57-68.
34. Waring P. 1990. DNA fragmentation induced in macrophages by gliotoxin does not require protein synthesis and is preceded by raised inositol triphosphate levels. J Biol Chem 265:14476-14480.
35. Waring P, Khan T, Sjaarda A. 1997. Apoptosis induced by gliotoxin is preseded by phosphorylation of histone H3 and enhanced sensitivity of chromatin to nuclease digestion. J Biol Chem 272:17929-17936.
36. Wichmann G, Herbarth O, Lehmann I. 2002. The mycotoxins citrinin, gliotoxin and patulin affect Th1 rather than Th2 cytokine production in vitro. Environ Toxicol 17:211-218.
37. Wichmann G, Krumm B, Drößler K, Herbarth O, Lehmann I. 2003. The effect of gliotoxin and patulin on human T cell function. Indoor Built Environ 12:255-258.