Tetrahymena in Cytotoxicology: with special reference to effects of heavy metals and selected drugs

European Journal of Protistology

Volumn 25, Issue 1, 1989, Pages 2-25

  Nilsson, Jytte R ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Chloramphenicol; Chloroquine; Cisplatin; Heavy metals; Methotrexate; Tetrahymena; Toxicology

Indexed keywords

EID: 0001432601     PISSN: 09324739     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0932-4739(89)80074-4     Document Type: Review

References (219)

1. Protein synthesis in vitro with Tetrahymena mitochondrial ribosomes
2. Fine structure, reconstruction and possible functions of components of the cortex of Tetrabymena pyriformis
3. Microbiological evaluation of protein quality. I. A colorimetric method for the determination of the growth of Tetrabymena geleii W in protein suspensions
4. Some actions of sulfonylurease charted with protozoan reagents
5. Protein quality of foodstuffs determined with Tetrabymena tbermopbila and rat
6. Mechanisms of chlordiazepoxide hydrochloride on Tetrabymena pyriformis
7. The interaction of cadmium with calcium and cisplatin with chloride. Effect on the locomotor rate of Tetrabymena pyriformis
8. Cadmium toxicity and accumulation by Tetrabymena pyriformis in contaminated river waters
9. Comparative action of two epimeric polyether carboxylic antibiotics (nigericin and epinigericin) on Tetrabymena pyriformis population dynamics in exponential cultures or synchronous cultures
10. Potentials of a synchronized culture of Tetrabymena pyriformis for toxicity studies of mycotoxins
11. Effect of chlorpromazine on active transport of amino acids in Tetrabymena
12. Lysosomes in Tetrabymena
13. Electrophoretic characterization of classical Tetrabymena pyriformis strains
14. Alleviation of the toxicity of copper to Tetrabymena pyriformis by nontoxic iron
15. Interaction of organo-mercurials with heat-synchronized Tetrabymena
16. Growth characteristics of Tetrabymena
17. Synchronization of the cell cycle of Tetrabymena by starvation and refeeding
18. Toxicity bioassay of heavy metals in water using Tetrabymena pyriformis
19. Detoxication of zinc and cadmium by freshwater protozoan Tetrabymena pyriformis. I. The effect of water hardness
20. Modifications des mitochondries et synthèse de l’ADN mitochondrial de Tetrabymena pyriformis après action du bromure d’éthidium
21. Quinacrine: site of inhibition of synchronized cell division in Tetrahymena
22. Quinacrine: inhibition of synchronized cell division in Tetrahymena
23. The lethal effect of certain antimalarial drugs on Tetrahymena pyriformis
24. Qualitative and quantitative electron probe analysis of cytoplasmic granules in Tetrahymena pyriformis
25. Effects of calcium and strontium on divalent ion content of refractive granules in Tetrahymena pyriformis
26. Antimalarials: effects on in vivo and in vitro protein synthesis
27. The effects of antimalarial drugs on uptake and incorporation of macromolecular precursors by Tetrahymena pyriformis
28. Studies on the mode of action of primaquine using Tetrahymena pyriformis
29. Quinine: effect on Tetrahymena pyriformis. I. Inhibition of synchronized cell division and site of action
30. Quinine-effect on Tetrahymena pyriformis. II. Comparative activity of the sterioisomers, quinidine and quinine
31. Quinine: effect on Tetrahymena pyriformis. III. Energetics of isolated mitochondria in the presence of quinine and other antimalarial drugs
32. Mirex and Acoclor 1254: effect on and accumulation by Tetrahymena pyriformis strain W
33. The polychlorinated biphenyls, Aroclors 1248 and 1260: effect on and accumulation by Tetrahymena pyriformis
34. Comparative studies on holotrichous ciliates in Colpidium-Glaucoma-Leucophrys-Tetrahymena group. II. Morphology, life cycles and systematic status of strains in pure culture
35. The literature on Tetrahymena: its history, growth, and recent trends
36. Tetrahymena, a ciliate genus of unusual importance in modern biological research
37. Type-specimens for ten species of Tetrahymena (Protozoa: Ciliophora)
38. History, taxonomy, ecology, and evolution of species of Tetrahymena
39. Guide to the literature on Tetrahymena: a companion piece to Eilliot's “general bibliography”
40. “Paramecium aurelia” and “Tetrahymena pyriformis”: current status of the taxonomy and nomenclature of these popularly known and widely used ciliates
41. The unicellular Tetrahymena as a model cell for receptor research
42. Studies on the growth and feeding of Tetrahymena pyriformis in axenic and monoxenic culture
43. Croissance des cultures et morphologie des mitochondries chez des mutants à hérédité cytoplasmique, résistants au chloramphenicol, de Tetrahymena pyriformis
44. Detoxication of zinc and cadmium by the freshwater protozoan Tetrahymena pyriformis. II. Growth experiments and ultrastructural studies on sequestration of heavy metals
45. The fate of mitochondria during aging in Tetrahymena pyriformis
46. Morphology of Tetrahymena
47. Toxicity of antitoxidants to Tetrahymena pyriformis
48. Mechanisms of action of aminoglycoside antibodies in eucaryotic protein synthesis
49. Methods with Tetrahymena
50. Microbiological evaluation of protein quality with Tetrahymena pyriformis W. 1. Characteristics of growth of the organism and determination of relative nutritive values of intact proteins
51. Stable and unstable morphological states generated by cadmium treatment and heat shocks in Euplotes (Ciliata Hypotrichida) with some references to Tetrahymena pyriformis (Ciliata Hymenostomatida)
52. Cortical development in Tetrahymena
53. The insecticide Azadirachtin reduces predominantly cellular RNA in Tetrahymena
54. The significant cytostomal pattern of the “Glaucoma-Colpidium group”, and a proposed new genus and species, Tetrahymena geleii
55. Heavy metal detoxication in the mussel Mytilus edulis — Composition of the Cd-containing kidney granules (tertiary lysosomes)
56. Effect of chloramphenicol on replication of mitochondria in Tetrahymena
57. The structure of Tetrabymena pyriformis mitochondrial DNA. I. Strain differences and occurrence of inverted repetitions
58. Enhancement of methotrexate nephrotoxicity after cisplatin therapy
59. Action comparée de deux antibiotiques épi-mères (nigéricine et épinigéricine) sur l’ultrastructure de Tetrabymena pyriformis
60. Effect of atabrine on Tetrabymena geleii (Protozoa, Ciliata)
61. Protozoa as pharmacological tools: the phenothiazine tranquilizers
62. Synchronous divisions in Tetrabymena pyriformis as studied in an inorganic medium
63. The use of protozoa in analysis
64. Antiprotozoal activity in citrinin
65. The relationship of cardiolipin biosynthesis to mitochondrial protein synthesis in Tetrabymena pyriformis
66. Eine einfache Methode zur Synchronisation grösserer Populationen des Ciliaten Tetrabymena pyriformis (Ehrenberg)
67. Largescale selection synchrony of Tetrabymena thermopbila
68. Tetrabymena actin: localization and possible biological roles of actin in Tetrabymena cells
69. The nutrition of Tetrabymena: essential nutrients, feeding, and digestion
70. Factors influencing toxicity of cadmium to Tetrabymena pyriformis: particulate or soluble form and degree of complexation
71. Influence of cadmium on Tetrabymena pyriformis in axenic culture
72. Protozoa as toxicological tools
73. Protozoological approaches to the cellular basis of mammalian stress repair
74. Microbiological assays
75. Protozoa as tools for nutrition research
76. ++, on two ciliates Tetrabymena pyriformis and Euplotes vannus
77. A comparative study of chloramphenicol (CAP) action on resistant mutants and on wild-type strains of several species of two ciliates Hymenostomatida (Tetrabymena and Colpidium)
78. Adrenergic drugs on the cell cycle
79. Regulation of calcium, cobalt and zinc by Tetrabymena elliotti
80. In vivo identification of Tetrabymena actin probed by DMSO induction of nuclear bundles
81. Morphometric studies of mitochondria in Tetrabymena pyriformis exposed to chloramphenicol or ethidium bromide
82. Inhibition of growth and of thymidine incorporation into DNA in Tetrabymena by chlorpromazine, primozide and penfluidol
83. The biochemistry of ciliates in pure culture
84. Targeting of liposomes containing methotrexate towards Tetrabymena pyriformis cells
85. The influence of growth and culture condition of Tetrabymena on cellular effect of cadmium
86. Effects of nickel on the rates of endocytosis, motility, and proliferation in Tetrabymena and determinations on the cell content of the metal
87. A new principle of continuous flow cell cultivation
88. +), and pH
89. Studies on cell growth and cell division. II. Selective activity of chloramphenicol and azaserine on cell growth and cell division
90. Effects of some environmental factors on the biochemistry, physiology, and metabolism of Tetrabymena
91. Biochemical and ultrastructural changes in Tetrabymena pyriformis during starvation
92. 2]
93. Stimulation of cell growth of Tetrabymena pyriformis and Clamydonmonas reinhardtii by trace elements
94. A hypothesis of nuclear-mitochondrial interactions for the control of mitochondrial biogenesis based on experiments with Tetrahymena pyriformis
95. Chloromycetin and growth of certain protozoa
96. Sur la nutrition des infusoires
97. Chloramphenicol and Chlortetracycline inhibition of amino acid incorporation into proteins in a cell-free system from Tetrahymena pyriformis
98. Inhibition of macro-molecule syntheses in a ciliate protozoan, Tetrahymena pyriformis by hexachlorocyclohexane (HCH) isomers
99. Changes of cellular structure and subcellular enzymatic patterns during activation of glyconeogenesis in Tetrahymena pyriformis
100. Response of division-synchronized protozoa to morphine and levorpha-nol
101. 9-tetrahydrocannabinol on cell division and macromolecu-lar synthesis in division-synchronized protozoa
102. Susceptibility of micro-organisms to chloramphenicol (Chloromycetin)
103. Effects of ethidium bromide on growth and morphology of Tetrahymena pyriformis
104. Effects of chloramphenicol and cycloheximide on the biosynthesis of mitochondrial ribosomes in Tetrahymena
105. Effects of 4-nitroquinoline 1-oxide and related compounds on normally and synchronously dividing Tetrahymena pyriformis GL
106. On the deposition and utilization of inorganic pyrophosphate in Tetrahymena pyriformis
107. Digestion
108. The isolation and characterization of a cadmium and zinc-binding protein from Tetrahymena pyriformis
109. Induction of a metallothionein-like protein in Tetrahymena pyriformis by metal ions
110. Characterization of the species of the Tetrahymena pyriformis complex
111. Isozymic characterization of three mating groups of the Tetrahymena pyriformis complex
112. Macronuclear changes in Tetrahymena pyriformis GL during the cell cycle and in response to alterations in environmental conditions
113. Further studies on vacuole formation in Tetrahymena pyriformis GL
114. Effects of DMSO on vacuole formation, contractile vacuole function, and nuclear division in Tetrahymena pyriformis GL
115. Physiological and structural studies on Tetrahymena pyriformis GL. With special reference to endocytosis and to structural changes during the cell cycle and in response to alterations in the cellular environment
116. Reversible inhibition of RNA synthesis in Tetrahymena pyriformis GL by dimethyl sulfoxide: an electron microscope autoradiographic study
117. Effects of dimethyl sulfoxide on Tetrahymena pyriformis GL. Fine structural changes and their reversibility
118. Retention of lead within digestive vacuoles in Tetrahymena
119. Intracellular distribution of lead in Tetrahymena during continuous exposure to the metal
120. Phagotrophy in Tetrahymena
121. Effects of dimethyl sulphoxide on ATP content and protein synthesis in Tetrahymena
122. On cell organelles in Tetrahymena. With special reference to mitochondria and peroxisomes
123. Effects of copper on phagocytosis in Tetrahymena
124. Methotrexate permits a limited number of cell doublings and affects mitochondrial substructure in Tetrahymena
125. On starvation-induced autophagy in Tetrahymena
126. Effects of chloramphenicol on the physiology and fine structure of Tetrahymena pyriformis GL: correlation between diminishing inner mitochondrial membrane and cell doublings
127. Cytotoxic effects of cisplatin, cis-dichlorodiammineplatinum(II), on Tetrahymena
128. Dose- and pH-dependent effects of chloroquine on Tetrahymena
129. Calcium-rich, refractile granules in Tetrahymena pyriformis and their possible role in the intracellular ion-regulation
130. Coated pits and pinocytosis in Tetrahymena
131. Microscopical studies on the macronucleus of heat-synchronized Tetrahymena pyriformis GL
132. On nucleolar DNA replication in Tetrahymena pyriformis GL-8: an electron microscope autoradiographic study of heat synchronized and exponentially multiplying cells
133. Metallothionein deserves attention
134. The effect of inhalational anaesthetics on the swimming velocity of Tetrabymena pyriformis
135. Three new “biological” species of Tetrabymena (T. begewischi n. sp., T. sonneborni n. sp., T. nipissingi n. sp.) and temperature tolerance of members of the “pyriformis” complex.
136. The toxicity of liposomal chloramphenicol for Tetrabymena pyriformis
137. 14C] chloramphenicol by Tetrabymena pyriformis
138. Induction and isolation of mutants in Tetrabymena
139. Effect of diphenyl, o-phenylphenol and 2-(4-thiazoyl)benzimidazole on growth of Tetrabymena pyriformis
140. Toxicity of copper sulphate to the alga Spirulina platensis, and the ciliate Tetrabymena pyriformis
141. Isolement de mutants à hérédité cytoplasmique, réstistants au chloramphénicol, chez Tetrabymena pyriformis
142. Interactions between mitochondria and their cellular environment in a cytoplasmic mutant of Tetrabymena pyriformis resistant to chloramphenicol
143. Biochemical and ultrastructural data on Tetrabymena pyriformis treated with copper and cadmium
144. Microbiological evaluation of protein quality
145. Cummulative or delayed nephrotoxicity after cisplatin (DDP) treatment
146. Techniques used in the study of synchronous Tetrabymena
147. Mitochondria of Tetrabymena pyriformis: enumeration and sizing of isolated organelles using a Coulter counter and pulse-height analyser
148. Sedimentation characteristics of mitochondria, peroxisomes and lysosomes from ciliate protozoon Tetrabymena pyriformis. strain ST after chloramphenicol-inhibited growth
149. The growth rate of Tetrabymena geleii HS under optimal conditions
150. The effects of cadmium on the growth pattern and ultrastructure of the ciliate Tetrabymena pyriformis, and antagonistic effect of calcium
151. Toxic action of Colistin and penicillin V and G on Tetrabymena. II. Inhibition of phagocytic activity
152. Toxic action of Colistin and penicillins V and G on Tetrabymena. I. Lethal effect and influence on multiplication
153. Bioassay of toxic substances for ciliated protozoa
154. Effect of crude oil and petroleum-degrading microorganisms on the growth of freshwater and soil protozoa
155. The toxicity of the dispersant corexit 9527 and oil-dispersant mixtures to ciliate protozoa
156. Determination and interpretation of hydrocarbon toxicity to ciliate protozoa
157. Some effects of chloramphenicol and ethidium bromide on Tetrabymena pyriformis
158. Microbiological evaluation of protein quality with Tetrabymena pyriformis W. 2. Relative nutritive values of proteins in foodstuffs
159. Platinum complexes for the treatment of cancer
160. Inhibition of cell division in Escherichia coli by electrolysis products from a platinum electrode
161. The isolation and identification of “volutin” granules from Tetrabymena
162. Transport phenomena associated with the deposition and disappearance of pyrophosphate granules in Tetrabymena pyriformis
163. Studies on the function of intracellular ribonucleases. I. The action of cobalt and nickel on Tetrabymena pyriformis W
164. Lysosomal physiology in Tetrabymena. IV. Effect of dichloroisoproterenol on the intracellular source of released acid hydrolases
165. Chloramphenicol-induced growth arrest in animal cells
166. Growth cycle-dependent overproduction and accumulation of protoporphyrin IX in Tetrabymena: effect of heavy metals
167. Response of fresh-water protozoan artificial communities to metals
168. Effect of organophos-phorus insecticides on the growth of Tetrabymena pyriformis
169. Form of cadmium in rat liver subcellular particle
170. Induction of synchronous cell division in mass cultures of Tetrahymena pyriformis
171. Temperatur-induced synchronous divisions in the ciliate protozoon Tetrahymena pyriformis growing in synthetic and proteose-peptone medium
172. Cytotoxicity of synthetic fuel products on Tetrahymena pyriformis. I. Phenol
173. Cytotoxicity of synthetic fuel products on Tetrahymena pyriformis. II. Shale oil retort water
174. Relationships of quantitative structure-activity to comparative toxicity of selected phenols in the Pimephales promelas and Tetrahymena pyriformis test systems
175. Intermediary metabolism of Tetrahymena
176. Preliminary findings on the use of protozoa (Tetrahymena thermophila) as models for ocular irritation testing in rabbits
177. The influence of cobalt on the growth of the protozoan, Tetrahymena
178. Radiocobalt accumulation in Tetrahymena
179. Phosphonoacetic acid: effect on and disposition by Tetrahymena
180. Chloromycetin: biological studies.
181. Aquatic chemistry
182. Non-random cell distribution in continuous-flow cultures of Tetrahymena
183. Enzyme immunoassay for Tetrahymena-metallothionein by a heterogeneous sandwich method
184. Determination of the labile species of zinc by anodic stripping staircase voltam-metry, with special reference to correlation with the toxicity to Tetrahymena
185. The effect of selected antibiotics on Tetrahymena pyriformis
186. Mechanism of temperature-induced synchrony in Tetrahymena pyriformis. Analysis of the leading cause of synchronization
187. Methods for the study and cultivation of protozoa
188. The effects of mercuric compounds on dividing cells
189. The effects of four mercury compounds on the generation time and cell division in Tetrahymena pyriformis, WH14
190. Sublethal cytotoxic effects of mercuric chloride on the ciliate Tetrahymena pyriformis
191. The effect of chloramphenicol on growth and mitochondrial function of the ciliate Protozoon Tetrahymena pyriformis strain ST
192. Synchronization of DNA synthesis in Tetrahymena populations by temporary limitation of access to thymine compounds
193. Growth inhibition by copper and copper intake in Tetrahymena pyriformis GL
194. Respiratory inhibition by copper in Tetrahymena pyriformis GL
195. Possible roles of calmodulin in a ciliated protozoan Tetrahymena
196. Kinetics of growth of the ciliate Tetrahymena pyriformis on Escherichia coli
197. DNA polymerase activity in methotrexate plus uridine treated Tetrahymena
198. Continuous synchronous culture of Tetrahymena pyriformis
199. Structural development in synchronously dividing Tetrahymena pyriformis
200. Morphogenese events in normal and synchronously dividing Tetrahymena
201. Long-term maintenance of Tetrahymena spp
202. Differential density labeling and gradient centrifugation. A new procedure for selection synchrony
203. Antimitotic agents and macronuclear division of ciliates. II. Endogenous recovery from colchicine and colcemid — a new method of synchronization in Tetrahymena pyriformis GL
204. Antimitotic agents and macronuclear division of ciliates. IV. Reassembly of microtubules in macronuclei of Tetrahymena adapting to colchicine
205. Detection of heavy metal toxicity by Tetrahymena pyriformis culture method
206. Antagonistic effect of calcium on acute toxicity of cadmium to Tetrahymena pyriformis
207. Responses of Tetrahymena pyriformis to cadmium exposure — With special reference to a metallothionein-like protein
208. Determination of maximal growth rate using continuous culture
209. Testing for the toxicity of chemicals with Tetrahymena pyriformis
210. Products of mitochondrial protein synthesis in Tetrahymena
211. Cell division and protein synthesis
212. Thymine starvation by inhibition of uptake and synthesis of thymine-compounds in Tetrahymena
213. Synchrony in Tetrahymena by heat shocks spaced a normal cell generation apart
214. Action of narcotic and hallucinogenic agents on the cell cycle
215. Purification and characterization of an inducible mitochondrial DNA polymerase from Tetrahymena thermophila