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Volumn 100, Issue 5, 2005, Pages 453-460

Relevance of the NOS3 T-786C and G894T variants for cholinergic and adrenergic coronary vasomotor responses in man

Author keywords

Acetylcholine; Coronary circulation; Endothelial constitutive nitric oxide synthase; Endothelium; Linkage disequilibrium; Polymorphism

Indexed keywords

ACETYLCHOLINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLYCERYL TRINITRATE; LACTIC ACID;

EID: 24944433586     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00395-005-0530-y     Document Type: Article
Times cited : (12)

References (36)
  • 1
    • 0033608950 scopus 로고    scopus 로고
    • Augmented alpha-adrenergic constriction of atherosclerotic human coronary arteries
    • 10217647
    • Baumgart D, Haude M, Gorge G et al. (1999) Augmented alpha-adrenergic constriction of atherosclerotic human coronary arteries. Circulation 99:2090-2097 10217647
    • (1999) Circulation , vol.99 , pp. 2090-2097
    • Baumgart, D.1    Haude, M.2    Gorge, G.3
  • 2
    • 0032589708 scopus 로고    scopus 로고
    • G protein beta3 subunit 825T allele and enhanced coronary vasoconstriction on alpha(2)-adrenoceptor activation
    • 10559144
    • Baumgart D, Naber C, Haude M et al. (1999) G protein beta3 subunit 825T allele and enhanced coronary vasoconstriction on alpha(2)-adrenoceptor activation. Circ Res 85:965-969 10559144
    • (1999) Circ. Res. , vol.85 , pp. 965-969
    • Baumgart, D.1    Naber, C.2    Haude, M.3
  • 3
    • 0037373275 scopus 로고    scopus 로고
    • Discovering genotypes underlying human phenotypes: Past successes for mendelian disease, future approaches for complex disease
    • 10.1038/ng1090
    • Botstein D, Risch N (2003) Discovering genotypes underlying human phenotypes: Past successes for mendelian disease, future approaches for complex disease. Nat Genet 33 Suppl:228-237 10.1038/ng1090
    • (2003) Nat. Genet. , vol.33 , Issue.SUPPL. , pp. 228-237
    • Botstein, D.1    Risch, N.2
  • 4
    • 0037372779 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase gene polymorphisms and risk ofcoronary artery disease
    • 10.1373/49.3.389
    • Colombo MG, Paradossi U, Andreassi MG et al. (2003) Endothelial nitric oxide synthase gene polymorphisms and risk of coronary artery disease. Clin Chem 49:389-395 10.1373/49.3.389
    • (2003) Clin. Chem. , vol.49 , pp. 389-395
    • Colombo, M.G.1    Paradossi, U.2    Andreassi, M.G.3
  • 5
    • 10744219801 scopus 로고    scopus 로고
    • Promoter but Not Exon 7 Polymorphismof Endothelial Nitric Oxide Synthase Affects Training-Induced Correction of Endothelial Dysfunction
    • 12907461
    • Erbs S, Baither Y, Linke A et al. (2003)Promoter but Not Exon 7 Polymorphism of Endothelial Nitric Oxide Synthase Affects Training-Induced Correction of Endothelial Dysfunction. Arterioscler Thromb Vasc Biol 23:1814-1819 12907461
    • (2003) Arterioscler. Thromb. Vasc. Biol. , vol.23 , pp. 1814-1819
    • Erbs, S.1    Baither, Y.2    Linke, A.3
  • 6
    • 0035854834 scopus 로고    scopus 로고
    • Acidic hydrolysis as a mechanism for the cleavage of the Glu(298) ->Asp variant of human endothelial nitric-oxide synthase
    • 10.1074/jbc.M103647200
    • Fairchild TA, Fulton D, Fontana JT, Gratton JP, McCabe TJ, Sessa WC (2001)Acidic hydrolysis as a mechanism for the cleavage of the Glu(298) ->Asp variant of human endothelial nitric-oxide synthase. J Biol Chem 276:26674-26679 10.1074/jbc.M103647200
    • (2001) J. Biol. Chem. , vol.276 , pp. 26674-26679
    • Fairchild, T.A.1    Fulton, D.2    Fontana, J.T.3    Gratton, J.P.4    McCabe, T.J.5    Sessa, W.C.6
  • 7
    • 3843050416 scopus 로고    scopus 로고
    • Endothelial venodilator response in carriers of genetic polymorphisms involved in NO synthesis and degradation
    • 15255799
    • Fricker R, Hesse C, Weiss J et al. (2004)Endothelial venodilator response in carriers of genetic polymorphisms involved in NO synthesis and degradation. Br J Clin Pharmacol 58:169-177 15255799
    • (2004) Br. J. Clin. Pharmacol. , vol.58 , pp. 169-177
    • Fricker, R.1    Hesse, C.2    Weiss, J.3
  • 8
    • 0036900387 scopus 로고    scopus 로고
    • The endothelial nitric oxide synthase(Glu298Asp and -786T>C) gene polymorphisms are associated with coronaryin-stent restenosis
    • 10.1053/euhj.2002.3400
    • Gomma AH, Elrayess MA, Knight CJ, Hawe E, Fox KM, Humphries SE (2002)The endothelial nitric oxide synthase (Glu298Asp and -786T>C) gene polymorphisms are associated with coronary in-stent restenosis. Eur Heart J 23:1955-19562 10.1053/euhj.2002.3400
    • (2002) Eur. Heart J. , vol.23 , pp. 1955-19562
    • Gomma, A.H.1    Elrayess, M.A.2    Knight, C.J.3    Hawe, E.4    Fox, K.M.5    Humphries, S.E.6
  • 9
    • 0034977966 scopus 로고    scopus 로고
    • Heterogeneity in hand veins responses to acetylcholine is not associated with polymorphisms in the G protein beta3-subunit (C825T) and endothelial nitric oxide synthase (G894T)genes but with serum low density lipoprotein cholesterol
    • 10.1097/00008571-200106000-00005
    • Grossmann M, Dobrev D, Siffert W, Kirch W (2001) Heterogeneity in hand veins responses to acetylcholine is not associated with polymorphisms in the Gproteinbeta3-subunit (C825T) and endothelial nitric oxide synthase (G894T)genes but with serum low density lipoprotein cholesterol. Pharmacogenetics 11:307-316 10.1097/00008571-200106000-00005
    • (2001) Pharmacogenetics , vol.11 , pp. 307-316
    • Grossmann, M.1    Dobrev, D.2    Siffert, W.3    Kirch, W.4
  • 10
    • 0035932773 scopus 로고    scopus 로고
    • Relationship between the G894T polymorphism(Glu298Asp variant) in endothelial nitric oxide synthase andnitric oxide-mediated endothelial functionin human atherosclerosis
    • 11298374
    • Guzik TJ, Black E, West NE et al. (2001) Relationship between the G894T polymorphism(Glu298Asp variant) in endothelial nitric oxide synthase and nitric oxide-mediated endothelial function in human atherosclerosis. Am J Med Genet 100:130-137 11298374
    • (2001) Am. J. Med. Genet. , vol.100 , pp. 130-137
    • Guzik, T.J.1    Black, E.2    West, N.E.3
  • 11
    • 0034651799 scopus 로고    scopus 로고
    • Alpha-adrenergic coronary vasoconstriction and myocardial ischemia inhumans
    • 10673263
    • Heusch G, Baumgart D, Camici P et al. (2000) Alpha-adrenergic coronary vasoconstriction and myocardial ischemia inhumans. Circulation 101:689-694 10673263
    • (2000) Circulation , vol.101 , pp. 689-694
    • Heusch, G.1    Baumgart, D.2    Camici, P.3
  • 13
    • 0037438803 scopus 로고    scopus 로고
    • Emerging importance of alpha-adrenergic coronary vasoconstriction in acute coronary syndromes and its genetic background
    • 10.1016/S0735-1097(02)02703-1
    • Heusch G (2003) Emerging importance ofalpha-adrenergic coronary vasoconstriction in acute coronary syndromes and its genetic background. J Am Coll Cardiol 41:195-196 10.1016/S0735-1097(02)02703-1
    • (2003) J. Am. Coll. Cardiol. , vol.41 , pp. 195-196
    • Heusch, G.1
  • 14
    • 0345192295 scopus 로고    scopus 로고
    • A common variant of the endothelial nitric oxide synthase (Glu298 ->Asp) is a major risk factor for coronary artery disease in the UK
    • 10510054
    • Hingorani AD, Liang CF, Fatibene J et al. (1999) A common variant of the endothelial nitric oxide synthase (Glu298 ->Asp) is a major risk factor for coronary artery disease in the UK. Circulation 100:1515-1520 10510054
    • (1999) Circulation , vol.100 , pp. 1515-1520
    • Hingorani, A.D.1    Liang, C.F.2    Fatibene, J.3
  • 15
    • 0027480298 scopus 로고
    • Endothelium-dependent relaxation competes with alpha 1- andalpha 2- adrenergic constriction in the canine epicardial coronary microcirculation
    • 8384938
    • Jones CJ, DeFily DV, Patterson JL, Chilian WM (1993) Endothelium-dependent relaxation competes with alpha 1- andalpha 2- adrenergic constriction in the canine epicardial coronary microcirculation. Circulation 87:1264-1274 8384938
    • (1993) Circulation , vol.87 , pp. 1264-1274
    • Jones, C.J.1    DeFily, D.V.2    Patterson, J.L.3    Chilian, W.M.4
  • 16
    • 0025277646 scopus 로고
    • Control of coronary vascular tone by nitric oxide
    • 2160870
    • Kelm M, Schrader J (1990) Control of coronary vascular tone by nitric oxide. Circ Res 66:1561-1575 2160870
    • (1990) Circ. Res. , vol.66 , pp. 1561-1575
    • Kelm, M.1    Schrader, J.2
  • 17
    • 0037076794 scopus 로고    scopus 로고
    • Glu298Asp endothelial nitric oxide synthase gene polymorphism interacts with environmental and dietary factors to influence endothelial function
    • 10.1161/01.RES.0000020562.07492.D4
    • Leeson CP, Hingorani AD, Mullen MJ etal. (2002) Glu298Asp endothelial nitric oxide synthase gene polymorphism interacts with environmental and dietary factors to influence endothelial function. Circ Res 90:1153-1158 10.1161/01.RES.0000020562.07492.D4
    • (2002) Circ. Res. , vol.90 , pp. 1153-1158
    • Leeson, C.P.1    Hingorani, A.D.2    Mullen, M.J.3
  • 18
    • 0037394422 scopus 로고    scopus 로고
    • Effect of the Asp298 variant of endothelial nitric oxide synthase on survival for patients with congestive heart failure
    • 10.1161/01.CIR.0000060540.93836.AA
    • McNamara DM, Holubkov R, Postava L etal. (2003) Effect of the Asp298 variant of endothelial nitric oxide synthase on survival for patients with congestive heart failure. Circulation 107:1598-602 10.1161/ 01.CIR.0000060540.93836.AA
    • (2003) Circulation , vol.107 , pp. 1598-1602
    • McNamara, D.M.1    Holubkov, R.2    Postava, L.3
  • 19
    • 0031902667 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase gene is positively associated with essential hypertension
    • 9674630
    • Miyamoto Y, Saito Y, Kajiyama N et al. (1998) Endothelial nitric oxide synthase gene is positively associated with essential hypertension. Hypertension 32:3-8 9674630
    • (1998) Hypertension , vol.32 , pp. 3-8
    • Miyamoto, Y.1    Saito, Y.2    Kajiyama, N.3
  • 21
    • 0037565530 scopus 로고    scopus 로고
    • Role of the eNOS Glu298Asp variant on the GNB3825T allele dependent determination of alpha-adrenergic coronary constriction
    • 10.1097/00008571-200305000-00007
    • Naber CK, Baumgart D, Heusch G et al. (2003) Role of the eNOS Glu298Asp variant on the GNB3825T allele dependent determination of alpha-adrenergic coronary constriction. Pharmacogenetics 13:279-284 10.1097/00008571-200305000-00007
    • (2003) Pharmacogenetics , vol.13 , pp. 279-284
    • Naber, C.K.1    Baumgart, D.2    Heusch, G.3
  • 22
    • 0033673774 scopus 로고    scopus 로고
    • Interaction of the ACE Dallele and the GNB3 825T allele in myocardial infarction
    • 11116112
    • Naber CK, Husing J, Wolfhard U, Erbel R, Siffert W (2000) Interaction of the ACE D allele and the GNB3 825T allele in myocardial infarction. Hypertension 36:986-989 11116112
    • (2000) Hypertension , vol.36 , pp. 986-989
    • Naber, C.K.1    Husing, J.2    Wolfhard, U.3    Erbel, R.4    Siffert, W.5
  • 23
    • 0033535841 scopus 로고    scopus 로고
    • T-786 ->C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm
    • 10359729
    • Nakayama M, Yasue H, Yoshimura M etal. (1999) T-786 ->C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm Circulation 99 2864-2870 10359729
    • (1999) Circulation , vol.99 , pp. 2864-2870
    • Nakayama, M.1    Yasue, H.2    Yoshimura, M.3
  • 25
    • 0034602718 scopus 로고    scopus 로고
    • Predicting the range of linkage disequilibrium
    • 10.1073/pnas.97.1.2
    • Ott J (2000) Predicting the range of linkage disequilibrium. Proc Natl Acad Sci USA 97:2-3 10.1073/pnas.97.1.2
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 2-3
    • Ott, J.1
  • 26
    • 0033595014 scopus 로고    scopus 로고
    • G894T polymorphism in the endothelial nitric oxide synthase gene is associated with an enhanced vascular responsiveness to phenylephrine
    • 10377070
    • Philip I, Plantefeve G, Vuillaumier-Barrot S et al. (1999) G894T polymorphism in the endothelial nitric oxide synthase gene is associated with an enhanced vascular responsiveness to phenylephrine. Circulation 99:3096-3098 10377070
    • (1999) Circulation , vol.99 , pp. 3096-3098
    • Philip, I.1    Plantefeve, G.2    Vuillaumier-Barrot, S.3
  • 27
    • 0037454272 scopus 로고    scopus 로고
    • The T-786C endothelial nitric oxide synthase genotype is a novel risk factor for coronary artery disease in Caucasian patients of the GENICA study
    • 10.1016/S0735-1097(02)03012-7
    • Rossi GP, Cesari M, Zanchetta M et al. (2003) The T-786C endothelial nitric oxide synthase genotype is a novel risk factor for coronary artery disease in Caucasian patients of the GENICA study. J Am Coll Cardiol 41:930-937 10.1016/S0735-1097(02)03012-7
    • (2003) J. Am. Coll. Cardiol. , vol.41 , pp. 930-937
    • Rossi, G.P.1    Cesari, M.2    Zanchetta, M.3
  • 28
    • 0037454141 scopus 로고    scopus 로고
    • The T-786C and Glu298Asp polymorphisms of the endothelial nitric oxide gene affect the forearm blood flow responses of Caucasian hypertensive patients
    • 10.1016/S0735-1097(02)03011-5
    • Rossi GP, Taddei S, Virdis A et al. (2003)The T-786C and Glu298Asp polymorphismsof the endothelial nitric oxidegene affect the forearm blood flow responses of Caucasian hypertensive patients. J Am Coll Cardiol 41:938-945 10.1016/S0735-1097(02)03011-5
    • (2003) J. Am. Coll. Cardiol. , vol.41 , pp. 938-945
    • Rossi, G.P.1    Taddei, S.2    Virdis, A.3
  • 29
    • 0033669591 scopus 로고    scopus 로고
    • Functional gene testing of the Glu298Asp polymorphism of the endothelial NO synthase
    • 10.1097/00004872-200018120-00010
    • Schneider MP, Erdmann J, Delles C, FleckE, Regitz-Zagrosek V, Schmieder RE(2000) Functional gene testing of theGlu298Asp polymorphism of the endothelial NO synthase. J Hypertens 18:1767-1773 10.1097/ 00004872-200018120-00010
    • (2000) J. Hypertens. , vol.18 , pp. 1767-1773
    • Schneider, M.P.1    Erdmann, J.2    Delles, C.3    Fleck, E.4    Regitz-Zagrosek, V.5    Schmieder, R.E.6
  • 30
    • 0031748762 scopus 로고    scopus 로고
    • Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction
    • 10.1016/S0735-1097(98)00167-3
    • Shimasaki Y, Yasue H, Yoshimura M et al. (1998) Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction. J Am Coll Cardiol 31:1506-1510 10.1016/ S0735-1097(98)00167-3
    • (1998) J. Am. Coll. Cardiol. , vol.31 , pp. 1506-1510
    • Shimasaki, Y.1    Yasue, H.2    Yoshimura, M.3
  • 31
    • 0032794634 scopus 로고    scopus 로고
    • Worldwide ethnic distribution of the G protein beta3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and Black African individuals
    • 10477144
    • Siffert W, Forster P, Jockel KH et al. (1999) Worldwide ethnic distribution ofthe G protein beta3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and Black African individuals. J Am Soc Nephrol 10:1921-1930 10477144
    • (1999) J. Am. Soc. Nephrol. , vol.10 , pp. 1921-1930
    • Siffert, W.1    Forster, P.2    Jockel, K.H.3
  • 32
    • 0036020984 scopus 로고    scopus 로고
    • Effects of endothelial nitric oxide synthase gene polymorphisms on platelet function, nitric oxide release, and interactions with estradiol
    • 10.1097/00008571-200207000-00008
    • Tanus-Santos JE, Desai M, Deak LR et al. (2002) Effects of endothelial nitric oxide synthase gene polymorphisms on platelet function, nitric oxide release, and interactions with estradiol. Pharmacogenetics 12:407-413 10.1097/00008571-200207000-00008
    • (2002) Pharmacogenetics , vol.12 , pp. 407-413
    • Tanus-Santos, J.E.1    Desai, M.2    Deak, L.R.3
  • 33
    • 0035174449 scopus 로고    scopus 로고
    • Effects of ethnicity on the distribution of clinically relevant endothelial nitric oxide variants
    • 10.1097/00008571-200111000-00011
    • Tanus-Santos JE, Desai M, Flockhart DA (2001) Effects of ethnicity on the distribution of clinically relevant endothelial nitric oxide variants. Pharmacogenetics 11:719-725 10.1097/00008571-200111000-00011
    • (2001) Pharmacogenetics , vol.11 , pp. 719-725
    • Tanus-Santos, J.E.1    Desai, M.2    Flockhart, D.A.3
  • 34
    • 0034646248 scopus 로고    scopus 로고
    • Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: Cleavage of proteins with aspartate vs. glutamate at position 298
    • 10.1073/pnas.97.6.2832
    • Tesauro M, Thompson WC, Rogliani P, Qi L, Chaudhary PP, Moss J (2000) Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: cleavage of proteins with aspartate vs. glutamate at position 298. Proc Natl Acad Sci USA 97:2832-2835 10.1073/pnas.97.6.2832
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 2832-2835
    • Tesauro, M.1    Thompson, W.C.2    Rogliani, P.3    Qi, L.4    Chaudhary, P.P.5    Moss, J.6
  • 35
    • 0034768750 scopus 로고    scopus 로고
    • Association analyses between genetic polymorphisms of endothelial nitric oxide synthase gene and hypertension in Japanese: The Suita Study
    • 10.1097/00004872-200111000-00003
    • Tsujita Y, Baba S, Yamauchi R et al. (2001)Association analyses between genetic polymorphisms of endothelial nitric oxide synthase gene and hypertension in Japanese: The Suita Study. J Hypertens 19:1941-1948 10.1097/00004872-200111000-00003
    • (2001) J. Hypertens. , vol.19 , pp. 1941-1948
    • Tsujita, Y.1    Baba, S.2    Yamauchi, R.3
  • 36
    • 0033850271 scopus 로고    scopus 로고
    • Genetic risk factors for coronary artery spasm: Significance of endothelial nitric oxide synthase gene T-786 ->C and missense Glu298Asp variants
    • 10979242
    • Yoshimura M, Yasue H, Nakayama M etal. (2000) Genetic risk factors for coronary artery spasm: Significance of endothelial nitric oxide synthase geneT-786 ->C and missense Glu298Asp variants. J Investig Med 48:367-374 10979242
    • (2000) J. Investig. Med. , vol.48 , pp. 367-374
    • Yoshimura, M.1    Yasue, H.2    Nakayama, M.3


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