Evidence behind the WHO guidelines: Hospital care for children: Efficacy and safety of artemisinin derivatives in children with malaria

Journal of Tropical Pediatrics

Volumn 52, Issue 2, 2006, Pages 78-82

  Bar Zeev, Naor ^a   White, Nick ^b  

^a ROYAL CHILDREN'S HOSPITAL   (Australia)

^b Wellcome Trust South East Asia Unit ^*  (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMETHER; ARTEMISININ DERIVATIVE; ARTESUNATE; CLINDAMYCIN; FANSIDAR; MEFLOQUINE; QUININE; TETRACYCLINE;

AFRICA; BRAIN MALARIA; CHILD; CHILDHOOD MORTALITY; CLINICAL TRIAL; COMA; CONVALESCENCE; DIZZINESS; DRUG ABSORPTION; DRUG EFFICACY; DRUG SAFETY; EVIDENCE BASED MEDICINE; FEVER; GAMETOCYTE; HEART ARRHYTHMIA; HOSPITAL CARE; HUMAN; HYPOGLYCEMIA; INJECTION SITE PAIN; MALARIA CONTROL; MALARIA FALCIPARUM; META ANALYSIS; NEUROTOXICITY; NONHUMAN; OUTCOMES RESEARCH; PARASITE TRANSMISSION; PLASMODIUM FALCIPARUM; PRACTICE GUIDELINE; PRURITUS; QT PROLONGATION; REVIEW; SEIZURE; SOUTHEAST ASIA; SYSTEMATIC REVIEW; TENESMUS; TINNITUS; URTICARIA; WORLD HEALTH ORGANIZATION;

ADOLESCENT; ADULT; ANIMALS; ANTI-INFECTIVE AGENTS; ANTIMALARIALS; ARTEMISININS; CHILD; CHILD, PRESCHOOL; HOSPITALIZATION; HUMANS; MALARIA, FALCIPARUM; META-ANALYSIS; PLASMODIUM FALCIPARUM; PRACTICE GUIDELINES; RANDOMIZED CONTROLLED TRIALS; SESQUITERPENES; WORLD HEALTH ORGANIZATION;

EID: 33645889643     PISSN: 01426338     EISSN: 14653664     Source Type: Journal    
DOI: 10.1093/tropej/fml005     Document Type: Review

References (55)

1. Korenromp E, Miller J, Nahlen B, Wardlaw T, Young M. World Malaria Report. 2005 World Health Organisation/Roll Back Malaria/United Nations Children's Fund.
2. Arrow K, Panosian CB, Gelband H. Saving lives buying time: Economics of malaria drugs in an age of resistance. 2004 Washington DC: National Academies Press.
3. Arrow KJ, Gelband H, Jamison DT. Making anti-malarial agents available in Africa. N Engl J Med 2005; 353 (4): 333-5.
4. WHO/UNICEF The Africa Malaria Report 2003. 2003 Geneva.
5. Hastings IM, D'Alessandro U. Modelling a predictable disaster: The rise and spread of drug-resistant malaria. Parasitol Today 2000; 16 (8): 340-7.
6. White N, Antimalarial drug resistance and combination chemotherapy. Phil Trans R Soc Lond B Biol Sci 1999; 354 (1384): 739-49.
7. Marsh K, Malaria disaster in Africa. Lancet 1998; 352 (9132): 924.
8. World Health Organization Children and Malaria - Information Sheet Number 5 in Roll Back Malaria. 2005: Geneva.
9. Hien TT, Tam DT, Cuc NT, Arnold K, Comparative effectiveness of artemisinin suppositories and oral quinine in children with acute falciparum malaria. Trans R Soc Trop Med Hyg 1991; 85 (2): 210-1.
10. Magill A, Panosian C, Making antimalarial agents available in the United States. N Engl J Med 2005; 353 (4): 335-7.
11. Sidhu JS, Ashton M, Huong NV, et al. Artemisinin population pharmacokinetics in children and adults with uncomplicated falciparum malaria. Br J Clin Pharmacol 1998; 45 (4): 347-54.
12. Oxford Centre for Evidence-Based Medicine Levels of Evidence and Grades of Recommendation. 1998.
13. Dondorp A, Nosten F, Stepniewska K, Day N, White N. Artesunate versus quinine for treatment of severe falciparum malaria: A randomised trial. Lancet 2005; 366 (9487): 717-25.
14. Aceng JR, Byarugaba JS, Tumwine JK. Rectal artemether versus intravenous quinine for the treatment of cerebral malaria in children in Uganda: randomised clinical trial. BMJ 2005; 330(7487): 334.
15. Olumese PE, Bjorkman A, Gbadegesin RA, Adeyemo AA, Walker O. Comparative efficacy of intramuscular artemether and intravenous quinine in Nigerian children with cerebral malaria. Acta Trop 1999; 73 (3): 231-6.
16. Walker O, Salako LA, Omokhodion SI, Sowunmi A. An open randomized comparative study of intramuscular artemether and intravenous quinine in cerebral malaria in children. Trans R Soc Trop Med Hyg 1993; 87 (5): 564-6.
17. van Hensbroek MB, Onyiorah E, Jaffar S, et al. A trial of artemether or quinine in children with cerebral malaria. N Engl J Med 1996; 335 (2): 69-75.
18. Moyou-Somo R, Tietche F, Ondoa M, et al. Clinical trial of beta-arteether versus quinine for the treatment of cerebral malaria in children in Yaounde Cameroon. Am J Trop Med Hyg 2001; 64 (5-6): 229-32.
19. Cao XT, Bethell DB, Pham TP, et al. Comparison of artemisinin suppositories intramuscular artesunate and intravenous quinine for the treatment of severe childhood malaria. Trans Roy Soc Trop Med Hyg 1997; 91 (3): 335-42.
20. Thuma PE, Bhat GJ, Mabeza GF, et al. A randomized controlled trial of artemotil (beta-arteether) in Zambian children with cerebral malaria. Am J Trop Med Hyg 2000; 62 (4): 524-9.
21. Taylor TE, Wills BA, Courval JM, Molyneux ME. Intramuscular artemether vs intravenous quinine: An open randomized trial in Malawian children with cerebral malaria. Trop Med Int Health 1998; 3 (1): 3-8.
22. Huda SN, Shahab T, Ali SM, Afzal K, Khan HM. A comparative clinical trial of artemether and quinine in children th severe malaria. Indian Pediatr 2003; 40 (10): 939-45.
23. Satti GM, Elhassan SH, Ibrahim SA. The efficacy of artemether versus quinine in the treatment of cerebral malaria. J Egypt Soc Parasitol 2002; 32 (2): 611-23.
24. Taylor TE, Wills BA, Kazembe P, et al. Rapid coma resolution th artemether in Malawian children with cerebral malaria. Lancet 1993; 341 (8846): 661-2.
25. Salako LA, Walker O, Sowunmi A, Omokhodion SJ, Adio R, Oduola AM. Artemether in moderately severe and cerebral malaria in Nigerian children. Trans Roy Soc Trop Med Hyg 1994; 88 (Suppl 1): S13-5.
26. Adam I, Idris HM, Mohamed-Ali AA, Aelbasit IA, Elbashir MI. Comparison of intramuscular artemether and intravenous quinine in the treatment of Sudanese children with severe falciparum malaria. East Afr Med J 2002; 79 (12): 621-5.
27. Artemether-Quinine Meta-analysis Study Group A meta-analysis using individual patient data of trials comparing artemether with quinine in the treatment of severe falciparum malaria. Trans Roy Soc Trop Med Hyg 2001; 95 (6): 37-50.
28. Pittler MH, Ernst E. Artemether for severe malaria: A meta-analysis of randomized clinical trials. Clin Infect Dis 1999; 28 (3): 597-601.
29. Courval JM, et al. Meta-analysis of open randomized trials comparing artemether versus quinine for cerebral malaria in African children. Jap J Trop Med Hygiene 1996; 24 (Suppl 1): 97-100.
30. Murphy S, English M, Waruiru C, et al. An open randomized trial of artemether versus quinine in the treatment of cerebral malaria in African children. Trans Roy Soc Trop Med Hyg 1996; 90 (3): 298-301.
31. Marsh K, Forster D, Waruiru C, et al. Indicators of life-threatening malaria in African children. N Engl J Med 1995; 332 (21): 1399-404.
32. McIntosh HM, Olliaro P. Artemisinin derivatives for treating severe malaria. Cochrane Database Syst Rev 2000(2): CD000527.
33. Mohanty AK, Rath BK, Mohanty R, Samal AK, Mishra K. Randomized control trial of quinine and artesunate in complicated malaria. Indian J Pediatr 2004; 71(4): 291-5.
34. Barnes KI, Mwenechanya J, Tembo M, et al. Efficacy of rectal artesunate compared with parenteral quinine in initial treatment of moderately severe malaria in African children and adults: A randomised study. Lancet 2004; 363 (9421): 1598-605.
35. Luxemburger C, Nosten F, Raimond SD, Chongsuphajaisiddhi T, White NJ. Oral artesunate in the treatment of uncomplicated hyperparasitemic falciparum malaria. Am J Trop Med Hyg 1995; 53 (5): 522-5.
36. Danis M, et al. Results obtained with I.M. artemether versus I.V. quinine in the treatment of severe malaria in a multicentre study in Africa. Jap J Trop Med Hygiene 1996. 24 (Suppl 1): 93-96.
37. Bich NN, De Vries PJ, Van Thien H, et al. Efficacy and tolerance of artemisinin in short combination regimens for the treatment of uncomplicated falciparum malaria. Am J Trop Med Hyg 1996; 55 (4): 438-43.
38. Ramharter M, Oyakhirome S, Klouwenberg PK, et al. Artesunate-clindamycin versus quinine-clindamycin in the treatment of Plasmodium falciparum malaria: A randomized controlled trial. Clin Infect Dis 2005. 40 (12): 1777-84.
39. de Vries PJ, Bich NN, Van Thien H, et al. Combinations of artemisinin and quinine for uncomplicated falciparum malaria: Efficacy and pharmacodynamics. Antimicrob Agents Chemother 2000; 44 (5): 1302-8.
40. White NJ, Krishna S. Treatment of malaria: Some considerations and limitations of the current methods of assessment. Trans Roy Soc Trop Med Hyg 1989; 83 (6): 767-77.
41. Kwiatkowski D. Febrile temperatures can synchronize the growth of Plasmodium falciparum in vitro. J Exp Med 1989; 169 (1): 357-61.
42. Long HY, Lell B, Dietz K, Kremsner PG, Plasmodium falciparum: In vitro growth inhibition by febrile temperatures. Parasitol Res 2001; 87 (7): 553-5.
43. Afolabi BB, Okoromah CN, Intramuscular arteether for treating severe malaria. Cochrane Database Syst Rev 2004 (4): CD004391.
44. Newton CR, Chokwe T, Schellenberg JA, Winstanley PA, Forster D, Peshu N, Kirkham FJ, Marsh K. Coma scales for children with severe falciparum malaria. Trans Roy Soc Trop Med Hyg 1997; 91 (2): 161-5.
45. Brewer TG, Peggins JO, Grate SJ, et al. Neurotoxicity in animals due to arteether and artemether. Trans Roy Soc Trop Med Hyg 1994; 88 (Suppl 1): S33-6.
46. Nontprasert A, Nosten-Bertrand M, Pukrittayakamee S, Vanijanonta S, Angus BJ, White NJ, Assessment of the neurotoxicity of parenteral artemisinin derivatives in mice. Am J Trop Med Hyg 1998; 59 (4): 519-22.
47. Newton PN, Day NP, White NJ. Misattribution of central ne ous system dysfunction to artesunate. Clin Infect Dis 2005; 41(11): 1687-8; author reply 1688.
48. White NJ. Assessment of the pharmacodynamic properties of antimalarial drugs in vivo. Antimicrob Agents Chemother 1997; 41 (7): 1413-22.
49. Brewster DR, Kwiatkowski D, White NJ, Neurological sequelae of cerebral malaria in children. Lancet 1990; 336 (8722): 1039-43.
50. Woodrow CJ, Haynes RK, Krishna S. Artemisinins. Postgrad Med J 2005; 81 (952): 71-8.
51. Price RN, Nosten F, Luxemburger C, ter Kuile FO, Paiphun L, Chongsuphajaisiddhi T, White NJ. Effects of artemisinin derivatives on malaria transmissibility. Lancet 1996; 347 (9016): 1654-8.
52. Pukrittayakamee S, et al. Activities of artesunate and primaquine against asexual- and sexual-stage parasites in falciparum malaria. Antimicrob Agents Chemother 2004; 48 (4): 1329-34.
53. von Seidlein L, Jawara M, Coleman R, Doherty T, Walraven G, Targett G. Parasitaemia and gametocytaemia after treatment with chloroquine pyrimethamine/sulfadoxine and pyrimethamine/sulfadoxine combined with artesunate in young Gambians with uncomplicated malaria. Trop Med Int Health 2001; 6 (2): 92-8.
54. Esamai F, Ayuo P, Owino-Ongor W, et al. Rectal dihydroartemisinin versus intravenous quinine in the treatment of severe malaria: A randomised clinical trial. East Afr Med J 2000; 77 (5): 273-8.
55. Maitland K, Nadel S, Pollard AJ, Williams TN, Newton CR, Levin M. Management of severe malaria in children: Proposed guidelines for the United Kingdom. BMJ 2005; 331 (7512): 337-43.