Evidence for a stimulatory action of melanin-concentrating hormone on luteinising hormone release involving MCH1 and melanocortin-5 receptors

Journal of Neuroendocrinology

Volumn 18, Issue 3, 2006, Pages 157-167

  Murray, J F ^a,e   Hahn, J D ^b   Kennedy, A R ^c   Small, C J ^c   Bloom, S R ^c   Haskell Luevano, C ^d   Coen, C W ^b   Wilson, C A ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

^d UNIVERSITY OF FLORIDA   (United States)

^e UNIVERSITY OF WESTMINSTER   (United Kingdom)

Author keywords

D Arg8 ACTH4 10; LH; MC receptors; MCH 1 receptors; Merck compound B; SB 568849

Indexed keywords

ESTROGEN; GONADORELIN; HORMONE RECEPTOR; HORMONE RECEPTOR BLOCKING AGENT; HORMONE RECEPTOR STIMULATING AGENT; LUTEINIZING HORMONE; MELANIN CONCENTRATING HORMONE; MELANOCORTIN 5 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXPLANT; FEMALE; GONADORELIN RELEASE; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VITRO STUDY; INHIBITION KINETICS; LUTEINIZING HORMONE RELEASE; NERVE CELL; NONHUMAN; OVARIECTOMY; PREOPTIC AREA; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; ZONA INCERTA;

ANIMALS; FEMALE; GONADOTROPIN-RELEASING HORMONE; HYPOTHALAMIC HORMONES; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; LUTEINIZING HORMONE; MELANINS; OVARIECTOMY; PITUITARY HORMONES; RATS; RATS, WISTAR; RECEPTORS, CORTICOTROPIN; RECEPTORS, SOMATOSTATIN;

EID: 33645886639     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2005.01397.x     Document Type: Article

References (63)

1. Wilkes BC, Hruby VJ, Sherbrooke WC, Castrucci AM, Hadley ME. Synthesis and biological actions of melanin concentrating hormone. Biochem Biophys Res Commun 1984; 122: 613-619.
2. Baker BI. Melanin concentrating hormone. In: Hadley ME, ed. The Melanotropic Peptides, vol. 2. Bocca Rouge, LA: CRC Press, 1988: 159-174.
3. Skofitsch G, Jacobowitz DM, Zamir N. Immunohistochemical localization of a melanin concentrating hormone-like peptide in the rat brain. Brain Res Bull 1985; 15: 635-649.
4. O'Donohoe TL, Miller RL, Jacobowitz DM. Identification, characterization and stereotaxic mapping of intraneuronal αMSH-like immunoreactive peptides in discrete regions of the rat brain. Brain Res 1979;179: 101-123.
5. Bittencourt JC, Presse F, Arias C, Petro C, Vaughan J, Nahon JL, Vale W, Sawchenko PE. The melanin concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization. J Comp Neurol 1992; 319: 218-245.
6. Gonzalez MI, Baker BI, Wilson CA. Stimulatory effect of melanin concentrating hormone on luteinizing hormone release. Neuroendocrinology 1997; 66: 254-262.
7. Kim MS, Small CJ, Russell SH, Morgan DG, Abbott CR, al Ahmed SH, Hay DL, Ghatei MA, Smith DM, Bloom SR. Effects of melanocortin receptor ligands on thyrotropic-releasing hormone release evidence for the differential roles of melanocortin 3 & 4 receptors. J Neuroendocrinol 2002; 14: 276-282.
8. Kennedy AR, Todd JF, Stanley SA, Abbott CR, Small CJ, Ghatei MA, Bloom SR. Melanin-concentrating hormone (MCH) suppresses thyroid stimulating hormone (TSH) release in vivo and in vitro, via the hypothalamus and the pituitary. Endocrinology 2001; 142: 3265-3268.
9. Gonzalez MI, Vaziri S, Wilson CA. Behavioural effects of α-MSH and MCH after central administration in the female rat. Peptides 1996; 17: 171-177.
10. Ludwig DS, Mountjoy KG, Tatro JB, Gillette JA, Frederich RC, Flier JS, Maratos-Flier E. Melanin concentrating hormone: A functional melanocortin antagonist in the hypothalamus. Am J Physiol 1998; 274: E627-E633.
11. Miller CL, Hruby VJ, Matsunaga TO, Bickford PC. α-MSH and MCH are functional antagonists in a CNS auditory paradigm. Peptides 1993; 14: 431-440.
12. Sanchez M, Baker BI, Celis ME. Melanin concentrating hormone (MCH) antagonises the effects of α-MSH and neuropeptide E-I on grooming and locomoter activities in the rat. Peptides 1997; 18: 393-396.
13. Verret L, Goutagny R, Fort P, Cagnon L, Salvert D, Leger L, Boissard R, Salin P, Peyron C, Luppi P-H. A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep. BMC Neurosci 2003; 4: 19-33.
14. Opp MR, Obal F, Krueger JM. Effects of alpha-MSH on sleep, behavior, and brain temperature interaction with IL 1. Am J Physiol 1988; 255: R914-R922.
15. Kennedy AR, Todd JF, Dhillo WS, Seal LJ, Ghatei MA, O'Toole CP, Jones M, Witty D, Winborne K, Riley G, Hervieu G, Wilson S, Bloom SR. Effect of direct injection of melanin-concentrating hormone into the paraventricular nucleus: Further evidence for a stimulatory role in the adrenal axis via SLC-1. J Neuroendocrinol 2003; 15: 268-272.
16. Fekete C, Legradi G, Mihaly E, Tatro JB, Rand WM, Lechan RM. Alpha-melanocyte stimulating hormone prevents fasting-induced suppression of corticotrophin-releasing hormone gene expression in the rat hypothalamus paraventricular nucleus. Neurosci Letts 2000; 289: 152-156.
17. Pereira-da-Silva M, Torsoni MA, Nourani HV, Augusto VD, Souza CT, Gasparetti AL, Carivalheira JB, Ventrucci G, Marcondes MC, Cruz-Neto AP, Saad MJ, Boschero AC, Carneiro EM, Velloso LA. Hypothalamic melanin-concentrating hormone is induced by cold exposure and participates in the control of energy expenditure in rats. Endocrinology 2003; 144: 4831-4840.
18. Sinha PS, Schoith HB, Tatro JB. Roles of the melanocortin-4 receptor in antipyretic and hyperthermic actions of centrally administered alpha-MSH. Brain Res 2004; 1001: 150-158.
19. Varas N, Perez M, Monzon ME, de Barioglio SR. Melanin-concentrating hormone, hippocampal nitric oxide levels and memory retention. Peptides 2002; 23: 2213-2221.
20. Yehuda S. Effects of alpha-MSH, TRH and AVP on learning and memory, pain threshold, and motor activity: Preliminary results. Int J Neurosci 1987; 32: 703-709.
21. Nahon J-L. The melanin-concentrating hormone: From the peptide to the gene. Crit Rev Neurobiol 1994; 8: 221-262.
22. Vrong N, Larsen PJ, Clausen JT, Kristensen P. Neurochemical characterization of hypothalamic cocaine-amphetamine-regulated transcript neurones. J Neurosci 1999; 19: 1-8.
23. Brischoux F, Cvetkovic V, Griffond B, Fellmann D, Risold PY. Time of genesis determines projection and neurokinin-3 expression patterns of diencephalic neurons containing melanin-concentrating hormone. Eur J Neurosci 2002; 16: 1672-1680.
24. Gao X-B, Ghosh PK, van den Pol AN. Neurons synthesizing melanin-concentrating hormone identified by selective receptor gene expression after transfection in vitro: Transmitter responses. J Neurophysiol 2003; 90: 3978-3985.
25. Bayer L, Risold PY, Griffond B, Fellmann D. Rat diencephalic neurones producing melanin-concentrating hormone are influenced by ascending cholinergic projections. Neuroscience 1999; 91: 1087-1101.
26. Elias CF, Bittencourt JC. Study of the origins of melanin-concentrating hormone and neuropeptide EI immunoreactive projections to the periaqueductal gray. Brain Res 1997; 155: 255-271.
27. Bittencourt JC, Elias CF. Melanin-concentrating hormone and neuropeptide EI projections from the central hypothalamus area and zona incerta to the medial septal nucleus and spinal cord: A study using multiple removal traces. Brain Res 1998; 805: 1-19.
28. Presse F, Nahon J-L. Differential regulation of melanin-concentrating hormone gene expression in distinct hypothalamic areas under osmotic stimulation in rat. Neuroscience 1993; 55: 709-720.
29. Murray JF, Baker BI, Levy A, Wilson CA. The influence of gonadal steroids on pre-pro melanin-concentrating hormones mRNA in female rats. J Neuroendocrinol 2000; 12: 53-59.
30. Knollema S, Brown ER, Vale W, Sawchenko PE. Novel hypothalamic and preoptic sites of prepro-melanin-concentrating hormone messenger ribonucleic acid and peptide expression in lactating rats. J Neuroendocrinol 1992; 4: 709-717.
31. Schlumberger SE, Talke-Messerer C, Zumsteg U, Eberle AN. Expression of receptors for melanin-concentrating hormone (MCH) in different tissues and cell lines. J Recept Signal Transd Res 2002; 22: 509-531.
32. Mountjoy KG, Robbins LS, Mortrud MT, Cone RD. The cloning of a family of genes that encode the melanotropin receptors. Science 1992; 257: 543-546.
33. Murray JF, Adan RAH, Walker R, Baker BI, Thody AJ, Nijenhuis WAH, Yukitake J, Wilson CA. Melanin-concentrating hormone, melanocortin receptors and regulation of luteinizing hormone release. J Neuroendocrinol 2000; 12: 217-223.
34. Khorram O, McCann SM. Neuroendocrine effects of melanotropins. In: Hadley ME, ed. The Melanotropic Peptides, vol. 2. Bocca Rouge, LA: CRC Press, 1988: 145-157.
35. Gallardo GP, Chiocchio SR, Tramezzani JH. Changes of melanin-concentrating hormone related to LHRH release in the median eminence of rats. Brain Res 2004; 1030: 152-158.
36. Chiocchio SR, Gallardo MGP, Louzan P, Gutnisky V, Tramezzani JH. Melanin-concentrating hormone stimulates the release of luteinizing hormone-releasing hormone and gonadotrophins in the female rat acting at both median eminence and pituitary levels. Biol Reprod 2001; 64: 1466-1472.
37. Tsukamura H, Thompson RC, Tsukahara S, Ohkura S, Maekawa F, Moriyama R, Niwa Y, Foster DL, Maeda K. Intracerebroventricular administration of melanin-concentrating hormone suppresses pulsatile luteinizing hormone release in the female rat. J Neuroendocrinol 2000; 12: 529-534.
38. Johnson CN, Jones M, O'Toole CA, Stemp G, Thewlis DM, Witty D. Preparation of carboxamide compounds and their use as antagonists of a human 11CBY receptor. PCT International Application 2002; pp 77. CODEN: PIXXD2 WO 0210146 A1 20020207 CAN 136: 167394 AN 2002:107327 CAPLUS 2002.
39. Bednarek MA, Hreniuk DL, Tan C, Palyha OC, MacNeil DJ, Van der Ploeg LH, Howard AD, Feighner SD. Synthesis & biological evaluation in vitro of selective high affinity peptide antagonists of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor. Biochemistry 2002; 41: 6383-6390.
40. Shearman LP, Camacho RE, Stribling DS, Zhou D, Bednarek MA, Hreniuk DL, Feighner SD, Tan CP, Howard AD, Van der Ploeg LHT, MacIntyre DE, Hickey GJ, Strack AM. Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats. Eur J Pharmacol 2003; 475: 37-47.
41. Adan RAH, Oosterom J, Ludvigsdottir G, Brakkee JA, Burbach JPH, Gispen WH. Identification of antagonists for melanocortin MC3, MC4 and MC5 receptors. Eur J Pharmacol 1994; 269: 331-337
42. Holder JR, Marques FF, Xiang Z, Bauzo RM, Haskell-Leuvano C. Characterization of aliphatic cyclic and aromatic N-terminally 'capped' His-D-Phe-Arg-Trp-NH2 tetrapeptides at the melanocortin receptors. Eur J Pharmacol 2003; 462: 41-52.
43. Siddiqui A, Kotecha K, Salicioni A-M, Kalia V, Murray JF, Wilson CA. Serotonin inhibits luteinizing hormone release via 5-HTIA receptors in the zona incerta of ovariectomised, anaesthetised rats primed with steroids. Neuroendocrinology 2000; 72: 272-283.
44. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. New York, NY: Academic Press, 1998.
45. Russell SH, Small CJ, Kennedy AR, Stanley SA, Seth A, Murphy KG, Taheri S, Ghatei MA, Bloom SR. Orexin A interactions in the hypothalamo-pituitary gonadal axis. Endocrinology 2001; 142:5294-5302.
46. Beak SA., Heath MM, Small CJ, Morgan DG, Ghatei MA, Taylor AD, Buckingham JC, Bloom SR, Smith DM. Glucagon-like peptide-1 stimulates luteinizing hormone-releasing hormone secretion in rodent hypothalamic neuronal cell line. J Clin Invest 1998; 10 1334-1341.
47. Watson RE, Wiegand SJ, Clough RW, Hoffman GE. Use of cryoprotectant to maintain long-term peptide immunoreactivity and tissue morphology. Peptides 1986; 7: 155-159.
48. Kendall MG, Stuart JA. The Advanced Theory of Statistics. London: Griffin, 1968.
49. Matthews JNS, Altman DG, Campbell MJ, Royston P. Analysis of serial measurements in medial research. BMJ 1990; 300: 230-235.
50. Witkin JW, Paden CM, Silverman AJ. The luteinizing hormone-releasing-hormone (LHRH) systems in the rat brain. Neuroendocrinology 1982; 35: 429-438.
51. Kalra SP. Mandatory neuropeptide-steroid signaling for the preovulatory luteinizing hormone-releasing hormone discharge. Endocrine Rev 1993; 14: 507-536.
52. Hervieu GJ, Cluderay JE, Harrison D, Meakin J, Maycox P, Nasir S, Leslie RA. The distribution of the mRNA and protein product for the melanin-concentrating hormone (MCH) receptor gene, SCL-1, in the central nervous system of the rat. Eur J Neurosci 2000; 12: 1194-1216.
53. Wilson CA, James MD, Grierson JP, Hole DR. The involvement of the catecholaminergic systems in the zona incerta in the steroidal control of gonadotrophin release and female sexual behaviour. Neuroendocrinology 1991; 53: 354-360.
54. Le WW, Berghorn KA, Rassnick S, Hoffman GE. Periventricular preoptic area neurons coactivated with luteinizing hormone (LH)-releasing hormone (LHRH) neurons at the time of the LH surge are LHRH afferents. Endocrinology 1999; 140: 510-519.
55. Williamson-Hughes PS, Grove KL, Smith MS. Melanin concentrating hormone (MCH). A novel neural pathway for regulation of GnRH neurons. Brain Res 2005; 1041: 117-124.
56. Murray JF, Pellatt LJ, Wilson CA. The immunolocalization of melanocortin 5 receptors (MC5R) in the female rat hypothalamus. Proceedings of the Fifth International Congress of Neuroendocrinology, Bristol, UK, 2002: 342.
57. Chen W, Kelly MA, Opitz-Araya X, Thomas RE, Low MJ, Cone RD. Exocrine gland dysfunction in MC5-R-deficient mice: Evidence for co-ordinated regulation of exocrine gland function by melanocortin peptides. Cell 1997; 91: 789-798.
58. van der Kraan M, Adan RAH, Entwistle ML, Gispen WH, Burbach PH, Tatro JB. Expression of melanocortin-5 receptor in secretory epithelia supports a functional role in exocrine and endocrine glands. Endocrinology 1998; 139: 2348-2355.
59. Terrillon S, Bouvier M. Roles of G-protein-coupled receptor dimerization. EMBO Rep 2004; 5: 30-34.
60. Hawes BE, Kil E, Green B, O'Neill K, Fried S, Graziano MP. The melanin-concentrating hormone receptor couples to multiple G proteins to activate diverse intracellular signalling pathways. Endocrinology 2000; 141: 4524-4532.
61. Pissios P, Trombly DJ, Tzameli I, Maratos-Flier E. Melanin-concentrating hormone receptor 1 activates extracellular signal-regulating kinase and synergises with Gs-couple pathways. Endocrinology 2003; 144: 3514-3523.
62. Mountjoy KG, Kong PL, Taylor JA, Willard DH, Wilkison WO. Melanocortin receptor-mediated mobilization of intracellular free calcium in HEK 293 cells. Physiol Genomics 2001; 5: 11-19.
63. Hoogduijn MJ, McGurk S, Smit NPM, Nibbering PH, Ancans J, van der Laarse A, Thody AJ. Ligand-dependent activation of the melanocortin 5 receptor: cAMP production and ryanodine receptor-dependent elevations of [Ca(2+)]. Biochem Biophys Res Commun 2002; 290: 844-850.