Dose Escalation of Three-dimensional Conformal Radiotherapy for Locally Recurrent Nasopharyngeal Carcinoma: A Prospective Randomised Study

Clinical Oncology

Volumn 18, Issue 4, 2006, Pages 293-299

  Li, J C ^a,b   Hu, C S ^a   Jiang, G L ^a   Mayr, N A ^c   Wang, J Z ^c   He, X Y ^a   Wu, Y Ru ^a  

^a FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

3D CRT; dose escalation; nasopharyngeal carcinoma; re irradiation; recurrence

Indexed keywords

ADULT; ARTICLE; BLEEDING; BONE METASTASIS; BRAIN DISEASE; CANCER RECURRENCE; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; COMPUTER ASSISTED RADIOTHERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DENTAL CARIES; DISEASE FREE SURVIVAL; EXTERNAL BEAM RADIOTHERAPY; FEASIBILITY STUDY; FEMALE; FOLLOW UP; HUMAN; LEUKOPENIA; LYMPH NODE METASTASIS; MALE; MUCOSA INFLAMMATION; NASOPHARYNX CARCINOMA; PRIORITY JOURNAL; PROSPECTIVE STUDY; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RADIATION NECROSIS; RANDOMIZED CONTROLLED TRIAL; SURVIVAL RATE; THREE DIMENSIONAL COMPUTER ASSISTED RADIOTHERAPY; TREATMENT OUTCOME; TRISMUS; XEROSTOMIA;

ADULT; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; HUMANS; MALE; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; NEOPLASM RECURRENCE, LOCAL; PROSPECTIVE STUDIES; RADIOTHERAPY, CONFORMAL; SURVIVAL ANALYSIS;

EID: 33645885639     PISSN: 09366555     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clon.2006.02.003     Document Type: Article

References (43)

1. Hsu M.M., and Tu S.M. Nasopharyngeal carcinoma in Taiwan. Clinical manifestations and results of therapy. Cancer 52 (1983) 362-368
2. Mould R.F., and Tai T.H. Nasopharyngeal carcinoma: treatments and outcomes in the 20th century. Br J Radiol 75 (2002) 307-339
3. Sanguineti G., Geara F.B., Garden A.S., et al. Carcinoma of the nasopharynx treated by radiotherapy alone: determinants of local and regional control. Int J Radiat Oncol Biol Phys 37 (1997) 985-996
4. Teo P., Yu P., Lee W.Y., et al. Significant prognosticators after primary radiotherapy in 903 nondisseminated nasopharyngeal carcinoma evaluated by computer tomography. Int J Radiat Oncol Biol Phys 36 (1996) 291-304
5. Zhang E.P., Lian P.G., Cai K.L., et al. Radiation therapy of nasopharyngeal carcinoma: prognostic factors based on a 10-year follow-up of 1302 patients. Int J Radiat Oncol Biol Phys 16 (1989) 301-305
6. Chua D.T., Sham J.S., and Au G.K. A phase II study of capecitabine in patients with recurrent and metastatic nasopharyngeal carcinoma pretreated with platinum-based chemotherapy. Oral Oncol 39 (2003) 361-366
7. Ma B.B., Tannock I.F., Pond G.R., Edmonds M.R., and Siu L.L. Chemotherapy with gemcitabine-containing regimens for locally recurrent or metastatic nasopharyngeal carcinoma. Cancer 5 (2002) 2516-2523
8. Wang C.C. Re-irradiation of recurrent nasopharyngeal carcinoma - treatment techniques and results. Int J Radiat Oncol Biol Phys 13 (1987) 953-956
9. Lengyel E., Baricza K., Somogyi A., et al. Reirradiation of locally recurrent nasopharyngeal carcinoma. Strahlenther Onkol 179 (2003) 298-305
10. Chua D.T., Sham J.S., Hung K.N., Leung L.H., Cheng P.W., and Kwong P.W. Salvage treatment for persistent and recurrent T1-2 nasopharyngeal carcinoma by stereotactic radiosurgery. Head Neck 23 (2001) 791-798
11. Hall C.E., Harris R., A'Hern R., et al. Le Fort I osteotomy and low-dose rate Ir192 brachytherapy for treatment of recurrent nasopharyngeal tumours. Radiother Oncol 66 (2003) 41-48
12. Ashamalla H., Rafla S., Zaki B., Ikoro N.C., and Ross P. Radioactive gold grain implants in recurrent and locally advanced head-and-neck cancers. Brachytherapy 1 (2002) 161-166
13. Kwong D.L., Wei W.I., Cheng A.C., et al. Long term results of radioactive gold grain implantation for the treatment of persistent and recurrent nasopharyngeal carcinoma. Cancer 91 (2001) 1105-1111
14. Fee Jr. W.E., Moir M.S., Choi E.C., and Goffinet D. Nasopharyngectomy for recurrent nasopharyngeal cancer: a 2- to 17-year follow-up. Arch Otolaryngol Head Neck Surg 128 (2002) 280-284
15. Ibrahim H.Z., Moir M.S., and Fee W.W. Nasopharyngectomy after failure of 2 courses of radiation therapy. Arch Otolaryngol Head Neck Surg 128 (2002) 1196-1197
16. Wei W.I. Cancer of the nasopharynx: functional surgical salvage. World J Surg 27 (2003) 844-848
17. Pai P.C., Chuang C.C., Wei K.C., Tsang N.M., Tseng C.K., and Chang C.N. Stereotactic radiosurgery for locally recurrent nasopharyngeal carcinoma. Head Neck 24 (2002) 748-753
18. Xiao J., Xu G., and Miao Y. Fractionated stereotactic radiosurgery for 50 patients with recurrent or residual nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 51 (2001) 164-170
19. Hsiung C.Y., Yorke E.D., Chui C.S., et al. Intensity-modulated radiotherapy versus conventional three-dimensional conformal radiotherapy for boost or salvage treatment of nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 53 (2002) 638-647
20. Kam M.K., Chau R.M., Suen J., Choi P.H., and Teo P.M. Intensity-modulated radiotherapy in nasopharyngeal carcinoma: dosimetric advantage over conventional plans and feasibility of dose escalation. Int J Radiat Oncol Biol Phys 56 (2003) 145-157
21. Xia P., Fu K.K., Wong G.W., Akazawa C., and Verhey L.J. Comparison of treatment plans involving intensity-modulated radiotherapy for nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 48 (2000) 329-337
22. Jen Y.M., Lin Y.S., Su W.F., et al. Dose escalation using twice-daily radiotherapy for nasopharyngeal carcinoma: dose heavier dosing result in a happier ending?. Int J Radiat Oncol Biol Phys 54 (2002) 14-22
23. Lu J.J., Shakespeare T.P., Tan L.K., Goh B.C., and Cooper J.S. Adjuvant fractionated high-dose-rate intracavitary brachytherapy after external beam radiotherapy in T1 and T2 nasopharyngeal carcinoma. Head Neck 26 (2004) 389-395
24. Gwi E.K., Jihoon L., Hee C.P., et al. A feasibility study using three-dimensional conformal boost technique in locally advanced carcinoma of the nasopharynx. Acta Oncol 40 (2001) 582-587
25. Hao S.P., Tsang N.M., and Chang C.N. Salvage surgery for recurrent nasopharyngeal carcinoma. Arch Otolaryngol Head Neck Surg 128 (2002) 63-67
26. Hsu M.M., Hong R.L., Ting L.L., Ko J.Y., Sheen T.S., and Lou P.J. Factors affecting the overall survival after salvage surgery in patients with recurrent nasopharyngeal carcinoma at the primary site: experience with 60 cases. Arch Otolaryngol Head Neck Surg 127 (2001) 798-802
27. Kajanti M., Blomqvist C., Lehtonen H., Kouri M., Wiklund T., and Holsti L.R. Biweekly dose escalation in curative accelerated hyperfractionation for advanced head and neck cancer: a feasibility study. Int J Radiat Oncol Biol Phys 39 (1997) 837-840
28. Lee N., Hoffman R., Phillips T.L., et al. Managing nasopharyngeal carcinoma with intracavitary brachytherapy: one institution's 45-year experience. Brachytherapy 1 (2004) 74-82
29. Lu J.J., Shakespeare T., Goh B.C., et al. Adjuvant high-dose rate brachytherapy after chemoradiation for treatment of early T-stage nasopharyngeal carcinoma. Am J Clin Oncol 27 (2004) 132-135
30. Chua D.T., Sham J.S., Kwong P.W., Hung K.N., and Leung L.H. Linear accelerator-based stereotactic radiosurgery for limited, locally persistent, and recurrent nasopharyngeal carcinoma: efficacy and complications. Int J Radiat Oncol Biol Phys 56 (2003) 177-183
31. Amstrong J., Zelefsky M., Leibel S., et al. Strategy for dose escalation using 3-dimensional conformal radiation therapy for lung cancer. Ann Oncol 6 (1995) 693-697
32. Leibel S.A., Heimann R., Kutcher G.J., et al. Three-dimensional conformal radiotherapy in locally advanced carcinoma of the prostate: preliminary results of a phase I dose-escalation study. Int J Radiat Oncol Biol Phys 28 (1993) 55-65
33. Cho J.H., Kim G.E., Cho K.H., et al. Hyperfractionated re-irradiation using a 3-dimensional conformal technique for locally recurrent carcinoma of the nasopharynx; preliminary results. Yonsei Med J 42 (2001) 55-64
34. Shin S.S., Ahn Y.C., Lim do H., Park W., and Huh S.J. High dose 3-dimensional re-irradiation for locally recurrent nasopharyngeal cancer. Yonsei Med J 45 (2004) 100-106
35. Lin R., Slater J.D., Yonemoto L.T., et al. Nasopharyngeal carcinoma: repeat treatment with conformal proton therapy - dose-volume histogram analysis. Radiology 213 (1999) 489-494
36. Schaefer U., Micke O., Schueller P., et al. Recurrent head and neck cancer: retreatment of previously irradiated areas with combined chemotherapy and radiation therapy - results of a prospective study. Radiology 216 (2000) 371-376
37. Lu T.X. Advance in diagnosis and management of local recurrent nasopharyngeal carcinoma. [in Chinese]. Ai Zheng 23 (2004) 230-234
38. Lee A.W., Foo W., Law S.C., et al. Reirradiation for recurrent nasopharyngeal carcinoma: factors affecting the therapeutic ratio and ways for improvement. Int J Radiat Oncol Biol Phys 38 (1997) 43-52
39. Lu T.X., Mei W.Y., Teh B.S., et al. Initial experience using intensity-modulated radiotherapy for recurrent nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 58 (2004) 682-687
40. Farias T.P., Dias F.L., Lima R.A., et al. Prognostic factors and outcome for nasopharyngeal carcinoma. Arch Otolaryngol Head Neck Surg 129 (2003) 794-799
41. Young Y.H., Lin C.Y., Lou P.J., and Hsu M.M. Intracranial relapse of nasopharyngeal carcinoma manifested as sudden deafness. Otol Neurotol 22 (2001) 392-396
42. Ching A.S., Chong V.F., and Khoo J.B. CT evaluation of nasolacrimal relapse of nasopharyngeal carcinoma. Clin Radiol 58 (2003) 642-647
43. Yen R.F., Hong R.L., Tzen K.Y., et al. Whole-body 18F-FDG PET in recurrent or metastatic nasopharyngeal carcinoma. J Nucl Med 46 (2005) 770-774