Phenotypic analysis of alveolar macrophages and lymphocytes following allergen inhalation by atopic subjects with mild asthma

Respiratory Medicine

Volumn 100, Issue 5, 2006, Pages 918-925

  Lensmar, C ^a   Katchar, K ^a   Eklund, A ^a   Grunewald, J ^a   Wahlstrom J ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Allergen challenge; Alveolar macrophage; Atopic asthma; Bronchoalveolar lavage; Phenotype; T cell

Indexed keywords

ALLERGEN; CD14 ANTIGEN; CD4 ANTIGEN; CD69 ANTIGEN; CD8 ANTIGEN; CD86 ANTIGEN; HLA ANTIGEN CLASS 2;

ADULT; ALLERGIC ASTHMA; ANTIBODY LABELING; ANTIGEN PRESENTING CELL; ARTICLE; BLOOD SAMPLING; CELL INTERACTION; CELL MATURATION; CELL POPULATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; EOSINOPHIL COUNT; FEMALE; FLOW CYTOMETRY; FORCED EXPIRATORY VOLUME; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; LUNG ALVEOLUS MACROPHAGE; LUNG LAVAGE; MALE; MAST CELL; PEAK EXPIRATORY FLOW; PRIORITY JOURNAL; PROVOCATION TEST; QUANTITATIVE ANALYSIS; T LYMPHOCYTE ACTIVATION;

ADULT; ALLERGENS; ANTIGENS, CD; ASTHMA; BRONCHIAL PROVOCATION TESTS; BRONCHOALVEOLAR LAVAGE FLUID; EOSINOPHILS; FEMALE; FLOW CYTOMETRY; HUMANS; HYPERSENSITIVITY, IMMEDIATE; MACROPHAGES, ALVEOLAR; MALE; T-LYMPHOCYTES;

EID: 33645876744     PISSN: 09546111     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rmed.2005.08.014     Document Type: Article

References (32)

1. Busse W.W., and Lemanske Jr. R.F. Asthma. N Engl J Med 344 5 (2001) 350-362
2. Peters-Golden M. The alveolar macrophage: the forgotten cell in asthma. Am J Respir Cell Mol Biol 31 1 (2004) 3-7
3. Holt P.G., Oliver J., Bilyk N., et al. Downregulation of the antigen presenting cell function (s) of pulmonary dendritic cells in vivo by resident alveolar macrophages. J Exp Med 177 2 (1993) 397-407
4. Careau E., and Bissonnette E.Y. Adoptive transfer of alveolar macrophages abrogates bronchial hyperresponsiveness. Am J Respir Cell Mol Biol 31 1 (2004) 22-27
5. Agea E., Forenza N., Piattoni S., et al. Expression of B7 co-stimulatory molecules and CD1a antigen by alveolar macrophages in allergic bronchial asthma. Clin Exp Allergy 28 11 (1998) 1359-1367
6. Chanez P., Vignola A.M., Lacoste P., Michel F.B., Godard P., and Bousquet J. Increased expression of adhesion molecules (ICAM-1 and LFA-1) on alveolar macrophages from asthmatic patients. Allergy 48 8 (1993) 576-580
7. Viksman M.Y., Liu M.C., Bickel C.A., Schleimer R.P., and Bochner B.S. Phenotypic analysis of alveolar macrophages and monocytes in allergic airway inflammation. I. Evidence for activation of alveolar macrophages, but not peripheral blood monocytes, in subjects with allergic rhinitis and asthma. Am J Respir Crit Care Med 155 3 (1997) 858-863
8. Viksman M.Y., Bochner B.S., Peebles R.S., Schleimer R.P., and Liu M.C. Expression of activation markers on alveolar macrophages in allergic asthmatics after endobronchial or whole-lung allergen challenge. Clin Immunol 104 1 (2002) 77-85
9. Gosset P., Tsicopoulos A., Wallaert B., et al. Increased secretion of tumor necrosis factor alpha and interleukin-6 by alveolar macrophages consecutive to the development of the late asthmatic reaction. J Allergy Clin Immunol 88 4 (1991) 561-571
10. Borish L., Mascali J.J., Dishuck J., Beam W.R., Martin R.J., and Rosenwasser L.J. Detection of alveolar macrophage-derived IL-1 beta in asthma. Inhibition with corticosteroids. J Immunol 149 9 (1992) 3078-3082
11. John M., Lim S., Seybold J., et al. Inhaled corticosteroids increase interleukin-10 but reduce macrophage inflammatory protein-1alpha, granulocyte-macrophage colony-stimulating factor, and interferon-gamma release from alveolar macrophages in asthma. Am J Respir Crit Care Med 157 1 (1998) 256-262
12. Tang C., Rolland J.M., Ward C., et al. Differential regulation of allergen-specific T(H2)- but not T(H1)-type responses by alveolar macrophages in atopic asthma. J Allergy Clin Immunol 102 3 (1998) 368-375
13. Tang C., Rolland J.M., Li X., Ward C., Bish R., and Walters E.H. Alveolar macrophages from atopic asthmatics, but not atopic nonasthmatics, enhance interleukin-5 production by CD4+ T cells. Am J Respir Crit Care Med 157 4 Pt 1 (1998) 1120-1126
14. Furuie H., Yamasaki H., Suga M., and Ando M. Altered accessory cell function of alveolar macrophages: a possible mechanism for induction of Th2 secretory profile in idiopathic pulmonary fibrosis. Eur Respir J 10 4 (1997) 787-794
15. Katchar K., Wahlstrom J., Eklund A., and Grunewald J. Highly activated T-cell receptor AV2S3(+) CD4(+) lung T-cell expansions in pulmonary sarcoidosis. Am J Respir Crit Care Med 163 7 (2001) 1540-1545
16. Dahlen B., Zetterstrom O., Bjorck T., and Dahlen S.E. The leukotriene-antagonist ICI-204, 219 inhibits the early airway reaction to cumulative bronchial challenge with allergen in atopic asthmatics. Eur Respir J 7 2 (1994) 324-331
17. Eklund A., and Blaschke E. Relationship between changed alveolar-capillary permeability and angiotensin converting enzyme activity in serum in sarcoidosis. Thorax 41 8 (1986) 629-634
18. Soderberg M., Lundgren R., Bjermer L., and Angstrom T. Inhaled methacholine does not influence the cellular composition of bronchoalveolar lavage fluid. Allergy 48 3 (1993) 173-176
19. Van Neerven R.J., Van de Pol M.M., Van der Zee J.S., Stiekema F.E., De Boer M., and Kapsenberg M.L. Requirement of CD28-CD86 costimulation for allergen-specific T cell proliferation and cytokine expression. Clin Exp Allergy 28 7 (1998) 808-816
20. Larche M., Till S.J., Haselden B.M., et al. Costimulation through CD86 is involved in airway antigen-presenting cell and T cell responses to allergen in atopic asthmatics. J Immunol 161 11 (1998) 6375-6382
21. van Hal P.T., Wijkhuijs J.M., Mulder P.G., and Hoogsteden H.C. Proliferation of mature and immature subpopulations of bronchoalveolar monocytes/macrophages and peripheral blood monocytes. Cell Prolif 28 10 (1995) 533-543
22. Krombach F., Gerlach J.T., Padovan C., et al. Characterization and quantification of alveolar monocyte-like cells in human chronic inflammatory lung disease. Eur Respir J 9 5 (1996) 984-991
23. Lensmar C., Prieto J., Dahlen B., Eklund A., Grunewald J., and Roquet A. Airway inflammation and altered alveolar macrophage phenotype pattern after repeated low-dose allergen exposure of atopic asthmatic subjects. Clin Exp Allergy 29 12 (1999) 1632-1640
24. Beasley R., Roche W.R., Roberts J.A., and Holgate S.T. Cellular events in the bronchi in mild asthma and after bronchial provocation. Am Rev Respir Dis 139 3 (1989) 806-817
25. Poston R.N., Chanez P., Lacoste J.Y., Litchfield T., Lee T.H., and Bousquet J. Immunohistochemical characterization of the cellular infiltration in asthmatic bronchi. Am Rev Respir Dis 145 4 Part 1 (1992) 918-921
26. Monteseirin J., Bonilla I., Chacon P., et al. Allergen-dependent CD14 modulation and apoptosis in monocytes from allergic patients. Allergy 58 10 (2003) 1027-1032
27. Moffatt M.F., and Cookson W.O. Genetics of asthma and inflammation: the status. Curr Opin Immunol 11 6 (1999) 606-609
28. Buckova D., Holla L.I., Schuller M., Znojil V., and Vacha J. Two CD14 promoter polymorphisms and atopic phenotypes in Czech patients with IgE-mediated allergy. Allergy 58 10 (2003) 1023-1026
29. Baldini M., Lohman I.C., Halonen M., Erickson R.P., Holt P.G., and Martinez F.D. A Polymorphism* in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E. Am J Respir Cell Mol Biol 20 5 (1999) 976-983
30. Heidenreich S., Schmidt M., August C., Cullen P., Rademaekers A., and Pauels H.G. Regulation of human monocyte apoptosis by the CD14 molecule. J Immunol 159 7 (1997) 3178-3188
31. Wahlstrom J., Gigliotti D., Roquet A., Wigzell H., Eklund A., and Grunewald J. T cell receptor Vbeta expression in patients with allergic asthma before and after repeated low-dose allergen inhalation. Clin Immunol 100 1 (2001) 31-39
32. Ekberg-Jansson A., Arva E., Nilsson O., Lofdahl C.G., and Andersson B. A comparison of the expression of lymphocyte activation markers in blood, bronchial biopsies and bronchoalveolar lavage: evidence for an enrichment of activated T lymphocytes in the bronchoalveolar space. Respir Med 93 8 (1999) 563-570