Anti-inflammatory and anti-oxidant activity of a new class of phenyl-pyrazolone derivatives

Current Drug Discovery Technologies

Volumn 3, Issue 1, 2006, Pages 67-73

  Cusan, C ^a   Altinier, G ^a   Sosa, S ^a   Sibilla, F ^a   Bucar, F ^b   Tubaro, A ^a   Prato, M ^a   Spalluto, G ^a   Da Ros, T ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

^b UNIVERSITY OF GRAZ   (Austria)

Author keywords

Anti inflammatory activity; Anti oxidant activity; Phenidone; Phenyl pyrazolone derivative

Indexed keywords

AMINOPHENAZONE; CROTON OIL; INDOMETACIN; LIPOXYGENASE; MECLOFENAMIC ACID; PHENIDONE; PHENYLBUTAZONE; PROSTAGLANDIN SYNTHASE; PYRAZOLONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG ACTIVITY; DRUG MECHANISM; EDEMA; ENZYME INHIBITION; IN VIVO STUDY; INFLAMMATION; LIPOPHILICITY; MALE; MOUSE; NONHUMAN; OXIDATION REDUCTION POTENTIAL; PRIORITY JOURNAL;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; MALE; MICE; PYRAZOLONES;

EID: 33645837464     PISSN: 15701638     EISSN: None     Source Type: Journal    
DOI: 10.2174/157016306776637573     Document Type: Article

References (28)

1. Dowling, E. J., Symons, A. M., Parke, D. V.: Free radical production at the site of an acute inflammatory reaction as measured by chemiluminescence. Agents Actions 19(3-4), 203, (1986).
2. Rekka E., Chrysselis M., Siskou I., Kourounakis A.: Synthesis of new azulene derivatives and study of their effect on lipid peroxidation and lipoxygenase activity. Chem. Pharm. Bull. 50(7), 904, (2002).
3. Cuzzocrea S., Thiemermann C., Salvemini D.: Potential therapeutic effect of antioxidant therapy in shock and inflammation. Curr. Med. Chem., 11(9), 1147, (2004).
4. Halliwell B., Hoult J.R., Blake D.R.: Oxidants, inflammation, and anti-inflammatory drugs. FASEB J. 2(13), 2867, (1988).
5. Nakamura Y., Watanabe S., Miyake N., Kohno H., Osawa T.: Dihydrochalcones: Evaluation as novel radical scavenging antioxidant. J. Agric. Food Chem., 51(11), 3309, (2003).
6. Wang T., Qin L., Liu B., Yuxin L., Wilson B., Eling T.E., Langenbach R., Taniura S., Hong J.-S.: Role of reactive oxygen species in LPS-induced production of prostaglandin E2 in microglia. J. Neurochem. 88(4), 939, (2004).
7. Kuhn C., Bekemeier H., Hirschelmann R., Giessler A. J.: Action of cyclooxygenase (COX) and lipoxygenase (LOX) inhibitors as well as of oxygen free radical scavengers (OFRS) in the inflammation-induced vasodepression. Biomed. Biochim. Acta 47(10-11), S320, (1988).
8. Ara G., Teicher B.A.: Cyclooxygenase and lipoxygenase inhibitors in cancer therapy. Prostag. Leukotr. Ess. 54(1), 3, (1996).
9. Sekhar Rao K.C., Divakar S., Naveen Babu K., Appu Rao A.G., Karanth N.G., Sattur A.P.: Nigerloxin, a novel inhibitor of aldose reductase and lipoxygenase with free radical scavenging activity from Aspergillus niger CFR-W-105. J. Antibiot. 55(9), 789, (2002).
10. Cash C.D.: Are the reactive oxygen-derived species (ROS) interactive properties of the many therapeutic drugs from various categories pertinent to their beneficial effects? Gen. Pharmacol. 28(2), 169, (1997).
11. Maffei Facino R., Carini M., Saibene L.: Scavenging of free radicals by tenoxicam. A participating mechanism in the antirheumatic/antiinflammatory efficacy of the drug. Arch. Pharm. 329(10), 457, (1996).
12. Dianzani M.U., Torrielli M.V., Paradisi L., Franzone J.S.: Influence of antioxidants and oxygen scavengers on experimental inflammatory processes. Eur. J. Rheumatol. Infl. 1(3), 187, (1978).
13. Leval X., Julemont F., Delarge J., Pirotte B., Dogne J.M.: New trends in dual 5-LOX/COX inhibition. Curr. Med. Chem. 9(9), 941, (2002).
14. Charlier C., Michaux C.: Dual inhibition of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) as a new strategy to provide safer non-steroidal anti-inflammatory drugs. Eur. J. Med. Chem. 38(7-8), 645, (2003).
15. Sen T., Dhara A.K., Bhattacharjee S., Pal S., Nag Chaudhuri A.K.: Antioxidant activity of the methanol fraction of Pluchea indica root extract. Phytother. Res. 16(4), 331, (2002).
16. Fernandes E., Costa D., Toste S.A., Lima J.L., Reis S.: In vitro scavenging activity for reactive oxygen and nitrogen species by nonsteroidal antiinflammatory indole, pyrrole, and oxazole derivative drugs. Free Radic. Biol. Med. 37(11), 1895, (2004).
17. Lau C.S., Belch J.J.F.: The in vitro free radical-scavenging activity of tenidap, a new dual cyclooxygenase and 5-lipoxygenase inhibitor. Mediat. Inflamm. 1(2), 141, (1992).
18. Fujiwara T.: Drug hour. 15. Inhibition of the formation and scavenging of active oxygen and free radicals by the anti-inflammatory and anti-ulcer agent rebamipide. Pharma Med. 16(8), 185, (1998).
19. Bonne C., Tissie G., Trong N.N., Latour E, Coquelet C.: Free radical scavenging capacity and anti-inflammatory activity of CBS-113 A. Adv. Exp. Med. Biol. 264, 257, (1990).
20. Hlasta D., Casey F.B., Ferguson E.W., Gangell S.J., Heimann M.R., Jaeger E.P., Kullnig R.K., Gordon R.J.: 5-Lipoxygenase inhibitors: the synthesis and structure-activity relationships of a series of 1-phenyl-3-pyrazolidinones. J. Med. Chem. 34(5), 1560, (1991).
21. Cusan C., Spalluto G., Prato M., Adams M., Bodensieck A., Bauer R., Tubaro A., Bernardi P., Da Ros, T.: Synthesis and biological evaluation of new phenidone analogues as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors. Farmaco 60(1), 7, (2005).
22. Tubaro A., Dri P., Delbello G., Zilli C., Della Loggia R.: The Croton oil ear test revisited. Agents Actions 17(3-4), 347, (1985).
23. Yamaguchi T., Takamura H., Matoba T., Terao J.: HPLC method for evaluation of the free radical-scavenging activity of food by using 1,1-diphenyl-2-picrylhydrazyl. Biosci. Biotech. Bioch. 62(2), 1201, (1998).
24. Malterud K.E., Farbrot T.L., Huse A.E., Sund R.B.: Antioxidant and radical scavenging effects of anthraquinones and anthrones. Pharmacology 47(Suppl.1), 77, (1993).
25. Cos P., Rajan P., Vedernikova I., Calomme M., Pieters L., Vlietinck A.J., Augustyns K., Haemers A., Vanden Berghe D.: In vitro antioxidant profile of phenolic acid derivatives. Free Radic. Res. 36(6), 711, (2002).
26. Kahkonen M.P., Heinonen M.: Antioxidant activity of anthocyanins and their aglycons. J. Agric. Food Chem. 51(3), 628, (2003).
27. Miller A.L.: The etiologies, pathophysiology, and alternative/ complementary treatment of asthma. Alter. Med. Rev. 6(1), 20, (2001).
28. Miller A.L.: Antioxidant Flavonoids: Structure, function and clinical usage. Alter. Med. Rev. 1(2), 103, (1996).