Channel blockers reduce angiotensin II-induced superoxide generation and inhibit lectin-like oxidized low-density lipoprotein receptor-1 expression in endothelial cells

Hypertension Research

Volumn 29, Issue 2, 2006, Pages 105-116

  Toba, Hiroe ^a   Shimizu, Takahiro ^a   Miki, Shunsuke ^a   Inoue, Riyako ^a   Yoshimura, Akiko ^a   Tsukamoto, Rie ^a   Sawai, Naoki ^a   Kobara, Miyuki ^a   Nakata, Tetsuo ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Angiotensin II; Atherosclerosis; Calcium channel blockade; Lectin like oxidized low density lipoprotein receptor 1

Indexed keywords

AMLODIPINE; ANGIOTENSIN II; CALCIUM CHANNEL BLOCKING AGENT; HEME OXYGENASE 1; HYDROETHIDINE; INTERCELLULAR ADHESION MOLECULE 1; MANIDIPINE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; VASCULAR CELL ADHESION MOLECULE 1; CELL ADHESION MOLECULE; OLR1 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; ATHEROGENESIS; CELL STIMULATION; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME INHIBITION; ENZYME SYNTHESIS; HEART PROTECTION; MALE; NONHUMAN; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; AORTA; CELL CULTURE; CYTOLOGY; INFLAMMATION; METABOLISM; OXIDATIVE STRESS; WISTAR RAT;

ANGIOTENSIN II; ANIMALS; AORTA; CALCIUM CHANNEL BLOCKERS; CELL ADHESION MOLECULES; CELLS, CULTURED; CHEMOKINE CCL2; ENDOTHELIAL CELLS; HEME OXYGENASE-1; INFLAMMATION; MALE; NADPH OXIDASE; OXIDATIVE STRESS; RATS; RATS, WISTAR; RNA, MESSENGER; SCAVENGER RECEPTORS, CLASS E; SUPEROXIDES;

EID: 33645834145     PISSN: 09169636     EISSN: 13484214     Source Type: Journal    
DOI: 10.1291/hypres.29.105     Document Type: Article

References (37)

1. Harrison DG, Cai H, Landmesser U, Griendling KK: Interactions of angiotensin H with NAD(P)H oxidase, oxidant stress and cardiovascular disease. J Renin Angiotensin Aldosterone Syst 2003; 4: 51-61.
2. Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G, The Heart Outcomes Prevention Evaluation Study Investigators: Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. N Engl J Med 2000; 342: 145-153.
3. Matsusaka T, Ichikawa I: Biological functions of angiotensin and its receptors. Annu Rev Physiol 1997; 59: 395-412.
4. Sawamura T, Kume N, Aoyama T, et al: An endothelial receptor for oxidized low-density lipoprotein. Nature 1997; 386: 73-77.
5. Chen M, Masaki T, Sawamura T: LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: Implications in endothelial dysfunction and atherosclerosis. Pharmacol Ther 2002; 95: 89-100.
6. Ueno T, Kaname S, Takaichi K, et al: LOX-1, an oxidized low-density lipoprotein receptor, was upregulated in the kidneys of chronic renal failure rats. Hypertens Res 2003; 26:117-122.
7. Sakurai K, Sawamura T: Stress and vascular responses: Endothelial dysfunction via lectin-like oxidized low-density lipoprotein receptor-1: Close relationships with oxidative stress. J Pharmacol Sci 2003; 91: 182-186.
8. Li DY, Chen HJ, Staples ED, et al: Oxidized low-density lipoprotein receptor LOX-1 and apoptosis in human atherosclerotic lesions. J Cardiovasc Pharmacol Ther 2002; 7: 147-153.
9. Chen M, Kakutani M, Minami M, et al: Increased expression of lectin-like oxidized low density lipoprotein receptor-1 in initial atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits. Arterioscler Thromb Vasc Biol 2000;20:1107-1115.
10. The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group: Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antibypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 2002; 288: 2981-2997.
11. G-nitro-L-arginine methyl ester-induced hypertensive rat aorta: Vasoprotective effects beyond the blood pressure-lowering effects of amlodipine and manidipine. Hypertens Res 2005; 28: 689-700.
12. Takai S, Jin D, Sakaguchi M, et al: Comparative effects of candesartan and amlodipine in a monkey atherosclerotic model. Hypertens Res 2004; 27: 517-522.
13. Pitt B, Byington RP, Furberg CD, et al, PREVENT Investigators: Effect of amlodipine on the progression of atherosclerosis and the occurrence of clinical events. Circulation 2000; 102: 1503-1510.
14. Chen L, Haught WH, Yang B, Saldeen TG, Parathasarathy S, Mehta JL: Preservation of endogenous antioxidant activity and inhibition of lipid peroxidation as common mechanisms of antiatherosclerotic effects of vitamin E, lovastatin and amlodipine. J Am Coll Cardiol 1997; 30: 569-575.
15. Yao K, Sato H, Sonoda R, Ina Y, Suzuki K, Ohno T: Effects of benidipine and candesartan on kidney and vascular function in hypertensive Dahl rats. Hypertens Res 2003; 26: 569-576.
16. Lai YM, Fukuda N, Su JZ, et al: Novel mechanisms of the antiproliferative effects of amlodipine in vascular smooth muscle cells from spontaneously hypertensive rats. Hypertens Res 2002; 25: 109-115.
17. Yasunari K, Maeda K, Nakamura M, Watanabe T, Yoshikawa J: Benidipine, a long-acting calcium channel blocker, inhibits oxidative stress in polymorphonuclear cells in patients with essential hypertension. Hypertens Res 2005; 28: 107-112.
18. Cominacini L, Pasini AF, Pastorino AM, et al: Comparative effects of different dihydropyridines on the expression of adhesion molecules induced by TNF-alpha on endothelial cells. J Hypertens 1999; 17: 1837-1841.
19. On YK, Kim CH, Oh BH, Lee MM, Park YB: Effects of angiotensin converting enzyme inhibitor and calcium antagonist on endothelial function in patients with essential hypertension. Hypertens Res 2002; 25: 365-371.
20. Mak IT, Zhang J, Weglicki WB: Protective effects of dihydropyridine Ca-blockers against endotheliaI cell oxidative injury due to combined nitric oxide and superoxide. Pharmacol Res 2002; 45: 27-33.
21. Harada S, Nakata T, Oguni A, et al: Contrasting effects of angiotensin type 1 and 2 receptors on nitric oxide release under pressure. Hypertens Res 2002; 25: 779-786.
22. Rueekschloss U, Quinn MT, Holtz J, Morawietz H: Dose-dependent regulation of NAD(P)H oxidase expression by angiotensin II in human endothelial cells: Protective effect of angiotensin II type 1 receptor blockade in patients with coronary artery disease. Arterioscler Thromb Vasc Biol 2002; 22: 1845-1851.
23. Miller FJ Jr, Gutterman DD, Rios CD, Heistad DD, Davidson BL: Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis. Circ Res 1998; 82: 1298-1305.
24. Colden-Stanfield M, Schilling WP, Ritchie AK, Eskin SG, Navarro LT, Kunze DL: Bradykinin-induced increases in cytosolic calcium and ionic currents in cultured bovine aortic endothelial cells. Circ Res 1987; 61: 632-640.
25. Adams DJ, Barakeh J, Laskey R, Van Breemen C: Ion channels and regulation of intracellular calcium in vascular endothelial cells. FASEB J 1989; 3: 2389-2400.
26. Higashi Y, Sasaki S, Nakagawa K, Matsuura H, Oshima T, Chayama K: Endothelial function and oxidative stress in renovascular hypertension. N Engl J Med 2002; 346: 1954-1962.
27. Zhang H, Schmeisser A, Garlichs CD, et al: Angiotensin II-induced superoxide anion generation in human vascular endothelial cells: Role of membrane-bound NADH-/NADPH-oxidases. Cardiovasc Res 1999; 44: 215-222.
28. Umemoto S, Tanaka M, Kawahara S, et al: Calcium antagonist reduces oxidative stress by upregulating Cu/Zn superoxide dismutase in stroke-prone spontaneously hypertensive rats. Hypertens Res 2004; 27: 877-885.
29. Calo LA, Zaghetto F, Pagnin E, Davis PA, Semplicini A, Pessina AC: Effect of manidipine on gene expression and protein level of oxidative stress-related proteins: p22phox and HO-1: Relevance for antihypertensive and anti-remodeling effects. J Cardiovasc Pharmacol 2004; 43: 531-538.
30. Davies MJ, Woolf N, Rowles PM, Pepper J: Morphology of the endothelium over atherosclerotic plaques in human coronary arteries. Br Heart J 1988; 60: 459-464.
31. Li H, Cybulsky MI, Gimbrone MA Jr, Libby P: An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium. Arterioscler Thromb 1993; 13: 197-204.
32. Nakashima Y, Raines EW, Plump AS, Breslow JL, Ross R: Upregulation of VCAM-1 and ICAM-1 at atherosclerosisprone sites on the endothelium in the ApoE-deficient mouse. Arterioscler Thromb Vasc Biol 1998; 18: 842-851.
33. Porteri E, Rizzoni D, Piccoli A, et al: Effects of hypotensive and non-hypotensive doses of manidipine on structure, responses to endothelin-1 and ICAM-1 production in mesenteric small resistance arteries of spontaneously hypertensive rats. Blood Press 1998; 7: 324-330.
34. Kataoka C, Egashira K, Ishibashi M, et al: Novel anti-inflammatory actions of amlodipine in a rat model of arteriosclerosis induced by long-term inhibition of nitric oxide synthesis. Am J Physiol Heart Circ Physiol 2004; 286: H768-H774.
35. Nagase M, Ando K, Nagase T, Kaname S, Sawamura T, Fujita T: Redox-sensitive regulation of lox-I gene expression in vascular endothelium. Biochem Biophys Res Commun 2001; 281: 720-725.
36. Zhou MS, Jaimes EA, Raij L: Inhibition of oxidative stress and improvement of endothelial function by amlodipine in angiotensin II-infused rats. Am J Hypertens 2004; 17: 167-171.
37. Thum T, Borlak J: Mechanistic role of cytochrome P450 monooxygenases in oxidized low-density lipoprotein-induced vascular injury: Therapy through LOX-1 receptor antagonism? Circ Res 2004; 94: e1-e13.