Prognostic value of HSP27 in head and neck squamous cell carcinoma: A retrospective analysis of 57 tumours

Anticancer Research

Volumn 26, Issue 2 B, 2006, Pages 1343-1349

  Lo Muzio, Lorenzo ^a,i   Campisi, Giuseppina ^b   Farina, Antonio ^c   Rubini, Corrado ^d   Ferrari, Francesca ^e   Falaschini, Silvia ^a   Leonardi, Rosalia ^f   Carinci, Francesco ^g   Stalbano, Stefania ^h   De Rosa, Gaetano ^h  

^a UNIVERSITY OF FOGGIA   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

^d UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^e UNIVERSITY OF VERONA   (Italy)

^f UNIVERSITY OF CATANIA   (Italy)

^g UNIVERSITY OF FERRARA   (Italy)

^h UNIVERSITY OF NAPLES FEDERICO II   (Italy)

ⁱ NONE   (Italy)

Author keywords

Head and neck cancer; HSP27; Immunohistochemistry; Squamous cell carcinoma; Survival

Indexed keywords

CISPLATIN; FLUOROURACIL; HEAT SHOCK PROTEIN 27; TUMOR MARKER;

ADULT; AGED; ANTIBODY LABELING; ARTICLE; CANCER CHEMOTHERAPY; CANCER GRADING; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; FEMALE; HEAD AND NECK CARCINOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MOUTH CARCINOMA; MULTIVARIATE ANALYSIS; PATIENT MONITORING; PREVALENCE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RETROSPECTIVE STUDY; SQUAMOUS CELL CARCINOMA; UNIVARIATE ANALYSIS;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; FEMALE; HEAD AND NECK NEOPLASMS; HEAT-SHOCK PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; LOGISTIC MODELS; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; RETROSPECTIVE STUDIES; SURVIVAL RATE;

EID: 33645823223     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Carta F, Demuro PP, Zanini C, Santona A, Castiglia D, D'atri S, Ascierto PA, Napolitano M, Cossu A, Tadolini B, Turrini F, Manca A, Sini MC, Palmieri G and Rozzo AC: Analysis of candidate genes through a proteomics-based approach in primary cell lines from malignant melanomas and their metastases. Melanoma Res 15: 235-244, 2005.
2. Thanner F, Sutterlin MW, Kapp M, Rieger L, Morr AK, Kristen P, Dietl J, Gassel AM and Muller T: Heat shock protein 27 is associated with decreased survival in node-negative breast cancer patients. Anticancer Res 25: 1649-1653, 2005.
3. Jonak C, Metze D, Traupe H, Happle R, Konig A and Trautinger F: The expression of the 27-kd heat shock protein in keratinization disorders: an immunohistological study. Hum Pathol 36: 686-693 2005.
4. El-Ghobashy AA, Shaaban AM, Innes J, Prime W and Herrington CS: Upregulation of heat shock protein 27 in metaplastic and neoplastic lesions of the endocervix. Int J Gynecol Cancer 15 (3): 503-509, 2005.
5. Lichtenfels R, Seliger B and Atkins D: Heat shock proteins in renal cell carcinomas. Contrib Nephrol 148: 35-56, 2005.
6. Langer T, Lu C, Echols H, Flanagan J, Hayer MK and Hartl FU: Successive action of DnaK, DnaJ and GroEL along the pathway of chaperone-mediated protein folding. Nature 356: 683-689, 1992.
7. Kaufmann SH: Heat shock proteins and the immune response. Immunol Today 11: 129-136, 1990.
8. Ellis J: Protein folding. Cytosolic chaperonin confirmed. Nature 358: 191, 1992.
9. Benjamin IJ: Stress proteins: is their application in clinical medicine on the horizon? Hepatol 18: 1532-1534, 1993.
10. Slater S, Jalleh R, Gilbertson J, Lampert I, Williamson R and Foster CS: Expression of heat shock proteins in chronic pancreatitis: protective or pathogenic roles? Lab Invest 76: 533-545, 1997.
11. Raine CS, Wu E, Ivanyi J, Katz D and Brosnan CF: Multiple sclerosis: a protective or a pathogenic role for heat shock protein 60 in the central nervous system? Lab Invest 75: 109-123, 1996.
12. Milarski KL, Welch WJ and Morimoto RI: Cell cycle-dependent association of HSP70 with specific cellular proteins. J Cell Biol 108: 413-423, 1989.
13. Morimoto RI, Tisseres A and Georgopoulos CS: Stress Proteins in Biology and Medicine. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press, 1990.
14. Morimoto RI: Cells in stress: transcriptional activation of heat shock genes. Science 259: 1409-1410, 1993.
15. Ciocca DR, Clark GM, Tandon AK, Fuqua SA, Welch WJ and McGuire WL: Heat shock protein hsp70 in patients with axillary lymph node-negative breast cancer: prognostic implications. J Natl Cancer Inst 85: 570-574, 1993.
16. Tomei LD and Cope FO: Apoptosis: The Molecular Basis of Cell Death. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press, 1991.
17. Mehlen P, Schulze-Osthoff K and Arrigo AP: Small stress proteins as novel regulators of apoptosis. Heat shock protein 27 blocks Fas/APO-1- and staurosporine-induced cell death. J Biol Chem 271: 16510-16514, 1996.
18. Clarke AR: Molecular chaperones in protein folding and translocation. Curr Opin Struct Biol 6: 43-50, 1996.
19. Multhoff G, Botzler C, Wiesnet M, Muller E, Meier T, Wilmanns W and Issels RD: A stress-inducible 72-kDa heat-shock protein (HSP72) is expressed on the surface of human tumor cells, but not on normal cells. Int J Cancer 61: 272-279, 1995.
20. Sharpe JC, Abel PD, Gilbertson JA, Brawn P and Foster CS: Modulated expression of human leukocyte antigen class I and class II determinants in hyperplastic and malignant human prostatic epithelium. Br J Urol 74: 609-616, 1994.
21. Thor A, Benz C, Moore D, 2nd, Goldman E, Edgerton S, Landry J, Schwartz L, Mayall B, Hickey E and Weber LA: Stress response protein (srp-27) determination in primary human breast carcinomas: clinical, histologic, and prognostic correlations. J Natl Cancer Inst 83: 170-178, 1991.
22. Chamness GC, Ruiz A, Fulcher L, Clark G, Fuqua SAW and McGuire WL: Estrogen-inducible heat shock protein (HSP 27) predicts recurrence in node-negative breast cancer. Proc Am Assoc Cancer Res 30: A1002, 1989.
23. Tandon AK, Clark GM, Chamness GC, Fuqua SAW, Welch WJ, Riehl RM and McGuire WL: Heat shock/stress response proteins: biological and clinical significance in breast cancer. Proc Am Soc Clin Oncol 9: A84 1990.
24. Conroy SE, Sasieni PD, Amin V, Wang DY, Smith P, Fentiman IS and Latchman DS: Antibodies to heat-shock protein 27 are associated with improved survival in patients with breast cancer. Br J Cancer 77: 1875-1879, 1998.
25. Lo Muzio L, Leonardi R, Mariggio MA, Mignogna MD, Rubini C, Vinella A, Pannone G, Giannetti L, Serpico R, Testa NF, De Rosa G and Staibano S: HSP27 as possible prognostic factor in patients with oral squamous cell carcinoma. Histol Histopathol 19: 119-128, 2004.
26. Mese H, Sasaki A, Nakayama S, Yoshioka N, Yoshihama Y, Kishimoto K and Matsumura T: Prognostic significance of heat shock protein 27 (HSP27) in patients with oral squamous cell carcinoma. Oncol Rep 9: 341-344, 2002.
27. Ito T, Kawabe R, Kurasono Y, Hara M, Kitamura H, Fujita K and Kanisawa M: Expression of heat shock proteins in squamous cell carcinoma of the tongue: an immunohistochemical study. J Oral Pathol Med 27: 18-22, 1998.
28. Fortin A, Raybaud-Diogene H, Tetu B, Huot J, Blondeau L and Landry J: Markers of neck failure in oral cavity and oropharyngeal carcinomas treated with radiotherapy. Head Neck 23: 87-93, 2001.
29. Leonardi R, Pannone G, Magro G, Kudo Y, Takata T and Lo Muzio L: Differential expression of heat shock protein 27 in normal oral mucosa, oral epithelial dysplasia and squamous cell carcinoma. Oncol Rep 9: 261-266, 2002.
30. Sobin LH and Wittekind CH: UICC: TNM Classification of Malignant Tumours. New York, Wiley-Liss Inc., 1997.
31. Ord RA and Blanchaert RHJ: Current management of oral cancer. A multidisciplinary approach. J Am Dent Assoc 132 Suppl: 19S-23S, 2001.
32. Kawanishi K, Shiozaki H, Doki Y, Sakita I, Inoue M, Yano M, Tsujinaka T, Shamma A and Monden M: Prognostic significance of heat shock proteins 27 and 70 in patients with squamous cell carcinoma of the esophagus. Cancer 85: 1649-1657, 1999.
33. Parkin DM, Pisani P and Ferlay J: Estimates of the worldwide incidence of eighteen major cancers in 1985. Int J Cancer 54: 594-606, 1993.
34. Wadsworth JD, Somers KD, Stack BC, Cazares L, Malik G, Adam B, Wrigth GL and Semmes J: Identification of patients with head and neck cancer using protein profiles. Arch Otolaryngol Head and Neck Surg 130: 98-104, 2004.
35. Spafford MF, Koch WM, Reed AL, Califano JA, Xu LH, Eisenberger CF, Yip L, Leong PL, Wu L, Liu SX, Jeronimo C, Westra WH and Sidransky D: Detection of head and neck squamous cell carcinoma among exfoliated oral mucosal cells by microsatellite analysis. Clin Cancer Res 7: 607-612, 2001.
36. Rosas SL, Koch W, da Costa Carvalho MG, Wu L, Califano J, Westra W, Jen J and Sidransky D: Promoter hypermethylation patterns of p16, O6-methylguanine-DNA-methyltransferase, and death-associated protein kinase in tumors and saliva of head and neck cancer patients. Cancer Res 61: 939-942, 2001.
37. Fliss MS, Usadel H, Caballero OL, Wu L, Buta MR, Eleff SM, Jen J and Sidransky D: Facile detection of mitochondrial DNA mutations in tumors and body fluids. Science 287: 2017-2019, 2000.
38. Ferrarini M, Heltai S, Zocchi MR and Rugarli C: Unusual expression and localization of heat-shock proteins in human tumor cells. Int J Cancer 51: 613-619, 1992.
39. Devaja O, King RJ, Papadopoulos A and Raju KS: Heat-shock protein 27 (HSP27) and its role in female reproductive organs. Eur J Gynaecol Oncol 18: 16-22, 1997.
40. van Diest PJ, van Dam P, Henzen-Logmans SC, Berns E, van der Burg ME, Green J and Vergote I: A scoring system for immunohistochemical staining: consensus report of the task force for basic research of the EORTC-GCCG. European Organization for Research and Treatment of Cancer-Gynaecological Cancer Cooperative Group. J Clin Pathol 50: 801-804, 1997.
41. Parcellier A, Schmitt E, Gurbuxani S, Seigneurin-Berny D, Pance A, Chantome A, Plenchette S, Khochbin S, Solary E and Garrido C: HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation. Mol Cell Biol 23: 5790-5802, 2003.
42. Parcellier A, Gurbuxani S, Schmitt E, Solary E and Garrido C: Heat shock proteins, cellular chaperones that modulate mitochondrial cell death pathways. Biochem Biophys Res Commun 304: 505-512, 2003.
43. Lavoie JN, Gingras-Breton G, Tanguay RM and Landry J: Induction of Chinese hamster HSP27 gene expression in mouse cells confers resistance to heat shock. HSP27 stabilization of the microfilament organization. J Biol Chem 268: 3420-3429, 1993.
44. Landry J, Lambert H, Zhou M, Lavoie JN, Hickey E, Weber LA and Anderson CW: Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II. J Biol Chem 267: 794-803, 1992.
45. Benndorf R, Hayess K, Ryazantsev S, Wieske M, Behlke J and Lusch G: Phosphorylation and supramolecular organization of murine small heat shock protein HSP25 abolish its actin polymerization-inhibiting activity. J Biol Chem 269: 20780-20784, 1994.
46. Mehlen P, Kretz-Remy C, Preville X and Arrigo AP: Human hsp27, Drosophila hsp27 and human alphaB-crystallin expression-mediated increase in glutathione is essential for the protective activity of these proteins against TNF alpha-induced cell death. EMBO J 15: 2695-2706, 1996.
47. Richards EH, Hickey E, Weber L and Master JR: Effect of overexpression of the small heat shock protein HSP27 on the heat and drug sensitivities of human testis tumor cells. Cancer Res 56: 2446-2451, 1996.
48. Hitotsumatsu T, Iwaki T, Fukui M and Tateishi J: Distinctive immunohistochemical profiles of small heat shock proteins (heat shock protein 27 and alpha B-crystallin) in human brain tumors. Cancer 77: 352-361, 1996.
49. Gandour-Edwards R, McClaren M and Isseroff RR: Immunolocalization of low-molecular-weight stress protein HSP 27 in normal skin and common cutaneous lesions. Am J Dermatopathol 16: 504-509, 1994.