Antibodies to heat-shock protein 27 are associated with improved survival in patients with breast cancer

British Journal of Cancer

Volumn 77, Issue 11, 1998, Pages 1875-1879

  Conroy, S E ^a   Sasieni, P D ^b   Amin, V ^a   Wang, D Y ^c   Smith, P ^d   Fentiman, I S ^d   Latchman, D S ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d GUY S HOSPITAL   (United Kingdom)

Author keywords

Antibody response; Breast cancer; Heat shock protein

Indexed keywords

ANTIBODY; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 70;

ANTIBODY BLOOD LEVEL; ARTICLE; BREAST CANCER; CANCER SURVIVAL; FEMALE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

EID: 0031750178     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1998.312     Document Type: Article

References (31)

1. Ciocca DR, Clark GM, Tandon AK, Fuqua SAW, Welch WJ and McGuire WL (1993) Heat shock protein hsp70 in patients with axillary lymph node-negative breast cancer: prognostic implications. J Natl Cancer Inst 85: 570-574
2. Conroy SE and Latchman DS (1996) Do heat shock proteins have a role in breast cancer? Br J Cancer 74: 717-721
3. Conroy SE, Faulds GB, Williams W, Latchman DS and Isenberg DA (1994) Detection of autoantibodies to the 90 kD heat shock protein in SLE and other autoimmune diseases. Br J Rheumatol 33: 923-926
4. Conroy SE, Gibson SL, Brunstrom G, Isenberg D, Luqmani Y and Latchman DS (1995) Autoantibodies to the 90 kD heat shock protein in sera of breast cancer patients. Lancet 345: 126-127
5. Conroy SE, Sassieni PD, Fentiman I and Latchman DS (1997) Autoantibodies to the 90 kD heat shock protein and poor survival in breast cancer patients. Eur J Cancer (press).
6. Creighton TE (1990) Protein folding. Biochem J 270: 1-16
7. Dhillon VB, McCallum S, Norton PM, Twomey BM, Erkeller-Yuksel FM, Isenberg DA, Dhillon VB, Latchman DS and Lydyard PM (1992) Surface expression of heat shock protein 90 by blood mononuclear cells from patients with systemic lupus erythematosis. J Autoimmunity 5: 803-814
8. Eskeller-Yuksel F, Lydyard P, Isenberg DA and Latchman DS (1993) Differential heat shock protein overexpression and its clinical relevance in systemic lupus erythematosis. Ann Rheum Dis 52: 436-442
9. Faulds GB, Isenberg DA and Latchman DS (1994) The tissue-specific elevation in synthesis of the 90 kD heat shock protein precedes the onset of disease in lupus prone MRL/1pr mice. J Rheumatol 21: 234-238
10. Faulds GB, Conroy SE, Madaeo M, Isenberg DA and Latchman DS (1995) Increased levels of autoantibodies to HSPs with increasing age in MRL/1pr mice. Br J Rheumatol 358-365
11. Ferrarini M, Heltai S, Zocchi MR and Rugarli C (1992) Unusual expression and localization of heat shock proteins in human tumor cells. Int J Cancer 51: 613-619
12. Jameel A, Skilton RA, Campbell TA, Chandler SK, Coombes RC and Luqmani YA (1992) Clinical and biological significance of hsp90 alpha in human breast cancer. Int J Cancer 50: 409-415
13. Jameel A, Law M, Coombes RC and Luqmani YA (1993) Significance of heat shock protein 90 as a prognostic indicator in breast cancer. Int J Oncol 2: 1075-1080
14. Konno A, Sato N, Yagihashi A, Torigoe T, Cho J, Torimoto K, Hara I, Wada Y, Okubo M, Takahashi and Kikuchi K (1989) Heat or stress inducible transformation associated cell surface antigen on the activated H-ras oncogene-transfected rat fibroblast. Cancer Res 49: 6578-6582
15. Latchman DS (1991) Heat shock proteins and human disease. J R Coll Phys 25: 295-300
16. Lindquist S (1986) The heat shock response. Annu Rev of Biochem 55: 1151-1191
17. Lindquist S and Craig EA (1988) The heat shock proteins. Annu Rev Gen 22: 631-677
18. Love S and King RJB (1994) A 27 kDa heat shock protein that has anomalous prognostic powers in early and advanced breast cancer. Br J Cancer 69: 743-748
19. Lukacs KV, Lowrie DB, Stokes RW and Colston MJ (1993) Tumor cells transfected with a bacterial heat shock gene lose tumourigenicity and induce protection against tumours. J Exp Med 343-348
20. Lukacs KV, Nakakes A, Atkins CJ, Lowrie DB and Colston MJ (1997) In vivo gene therapy of malignant tumours with heat shock protein 65 gene. Gene Ther 4: 346-350
21. Multhoff G, Botzler C, Wiesnet M, Maller E, Meier T and Wilmanns WA (1995) A stress inducible 72 kDa heat shock protein (hsp72) is expressed on the surface of human tumors but not on normal cells. Int J Cancer 61: 272-279
22. Ritossa F (1962) A new puffing pattern induced and temperature shock and DNP in Drosophila. Experientia 18: 571-573
23. Srivastava PK (1994) Peptide binding heat shock protein in the endoplasmic reticulum. Role in immune response to cancer and in antigen presentation. Adv Cancer Res 62: 153-177
24. Srivastava PK and Heike M (1991) Tumor specific immunogenicity of stress induced proteins. Convergence of two evolutionary pathways of antigen presentation. Sem Immunol 3: 57-66
25. Srivastava PK and Old LJ (1988) Individually distinct transplantation antigens of chemically induced mouse tumours. Immunol Today 9: 78-83
26. Srivastava PK, De Leo AB and Old LJ (1986) Tumour rejection antigens of chemically induced sarcomas of inbred mice. Proc Natl Acad Sci USA 83: 3407-3411
27. Thor A, Benz C, Moore D, Goldman E, Edgerton S, Landry J, Schwartz L, Mayall B, Hickey E and Weber LA (1991) Stress response protein (srp-27) determination in primary human breast carcinomas: clinical, histologic, and prognostic correlations. J Natl Cancer Inst 83: 154-155
28. Tissieres A, Mitchell HK and Tracey UM (1974) Proteins synthesis in salivary glands of D. melanogasler. Relation to chromosome puffs. J Mol Biol 84: 389-398
29. Tsuboi N, Ishikawa M, Tamura Y, Takayama S, Tobioka H, Matsuura A, Hirayoshi K, Nagata K, Sato N and Kikuchi K (1994) Monoclonal antibody specifically reacting against 73-kilodalton heat shock cognate protein: possible expression on mammalian cell surface. Hybridoma 13: 373-381
30. Udono H and Srivastava PK (1993) Heat shock protein 70 associated peptides elicit specific cancer immunity. J Exp Med 178: 1391-1396
31. Ullrich SJ, Robinson EA, Lain LW, Willingham M and Appella EA (1986) A mouse tumour specific transplantation antigen is a heat shock related protein. Proc Natl Acad Sci USA 10: 3121-3125