Acetylation of UBF changes during the cell cycle and regulates the interaction of UBF with RNA polymerase I

Nucleic Acids Research

Volumn 34, Issue 6, 2006, Pages 1798-1806

  Meraner, Joachim ^b   Lechner, Markus ^b   Loidl, Adele ^b   Goralik Schramel, Maria ^b   Voit, Renate ^a   Grummt, Ingrid ^a   Loidl, Peter ^b  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DIRECTED RNA POLYMERASE; HISTONE DEACETYLASE 1; PAF53 PROTEIN; POLYCLONAL ANTIBODY; PROTEIN DERIVATIVE; RIBOSOME DNA; RNA PRECURSOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; UPSTREAM BINDING FACTOR; HISTONE DEACETYLASE; RIBOSOME RNA; TRANSCRIPTION FACTOR UBF;

ACETYLATION; ANIMAL CELL; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CONTROLLED STUDY; DEACETYLATION; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; RNA SYNTHESIS; TRANSCRIPTION INITIATION; ANIMAL; BIOSYNTHESIS; CELL CYCLE; CELL STRAIN 3T3; GENETICS; METABOLISM; TRANSACTIVATION;

ANIMALIA;

ACETYLATION; ANIMALS; CELL CYCLE; HISTONE DEACETYLASES; MICE; NIH 3T3 CELLS; POL1 TRANSCRIPTION INITIATION COMPLEX PROTEINS; RNA POLYMERASE I; RNA, RIBOSOMAL; TRANS-ACTIVATION (GENETICS);

EID: 33645818534     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkl101     Document Type: Article

References (38)

1. Moss,T. and Stefanovsky,V.Y. (1995) Promotion and regulation of ribosomal transcription in eukaryotes by RNA polymerase I. Prog. Nucleic Acid Res. Mol. Biol., 50, 25-66.
2. Moss,T. and Stefanovsky,V.Y. (2002) At the center of eukaryotic life. Cell, 109, 545-548.
3. Conconi,A., Widmer,R.M., Koller,T. and Sogo,J. (1989) Two different chromatin structures coexist in ribosomal RNA genes throughout the cell cycle. Cell, 57, 753-761.
4. French,S.L., Osheim,Y.N., Cioci,F., Nomura,M. and Beyer,A.L. (2003) In exponentially growing Saccharomyces cerevisiae cells, rRNA synthesis is determined by the summed RNA polymerase I loading rather than by the number of active genes. Mol. Cell. Biol., 23, 1558-1568.
5. Grummt,I. (2003) Life on a planet of its own: Regulation of RNA polymerase I transcription in the nucleolus. Genes Dev., 17, 1691-1702.
6. Reeder,R.H. (1999) Regulation of RNA polymerase I transcription in yeast and vertebrates. Progr. Nucleic Acid Res. Mol. Biol., 62, 293-327.
7. Klein,J. and Grummt,I. (1999) Cell cycle-dependent regulation of RNA polymerase I transcription: The nucleolar transcription factor UBF is inactive in mitosis and early G1. Proc. Natl Acad. Sci. USA, 96, 6096-6101.
8. Oskarsson,T. and Trumpp,A. (2005) The Myc trilogy: Lord of RNA polymerases. Nature Cell Biol., 7, 215-217.
9. Tuan,J.C., Zhai,W. and Comai,L. (1999) Recruitment of TATA-binding protein-TAFI complex SL1 to the human ribosomal DNA promoter is mediated by the carboxy-terminal activation domain of upstream binding factor (UBF) and is regulated by UBF phosphorylation. Mol. Cell. Biol., 19, 2872-2879.
10. Voit,R. and Grummt,I. (2001) Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription. Proc. Natl Acad. Sci. USA, 98, 13631-13636.
11. O'Mahony,D.J., Xie,W.Q., Smith,S.D., Singer,H.A. and Rothblum,L.I. (1992) Differential phosphorylation and localization of the transcription factor UBF in vivo in response to serum deprivation. In vitro dephosphorylation of UBF reduces its transactivation properties. J. Biol. Chem., 267, 35-38.
12. Voit,R., Schnapp,A., Kuhn,A., Rosenbauer,H., Hirschmann,P., Stunnenberg,H.G. and Grummt,I. (1992) The nucleolar transcription factor mUBF is phosphorylated by casein kinase II in the C-terminal hyperacidic tail which is essential for transactivation. EMBO J., 11, 2211-2218.
13. Hirschler-Laszkiewicz,I., Cavanaugh,A., Hu,Q., Catania,J., Avantaggiati,M.L. and Rothblum,L.I. (2001) The role of acetylation in rDNA transcription. Nucleic Acids Res., 29, 4114-4124.
14. Pelletier,G., Stefanovsky,V.Y., Faubladier,M., Hirschler-Laszkiewicz,I., Savard,J., Rothblum,L.I., Cote,J. and Moss,T. (2000) Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription. Mol. Cell, 6, 1059-1066.
15. Cavanaugh,A.H., Hempel,W.M., Taylor,L.J., Rogalsky,V., Todorov,G. and Rothblum,L.I. (1995) Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product. Nature, 374, 177-180.
16. Ciarmatori,S., Scott,P.H., Sutcliffe,J.E., McLees,A., Alzuherri,H.M., Dannenberg,J.H., te Riele,H., Grummt,I., Voit,R. and White,R.J. (2001) Overlapping functions of the pRb family in the regulation of rRNA synthesis. Mol. Cell. Biol., 21, 5806-5814.
17. Hannan,K.M., Hannan,R.D., Smith,S.D., Jefferson,L.S., Lun,M. and Rothblum,L.I. (2000) Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1. Oncogene, 19, 4988-4999.
18. Budde,A. and Grummt,I. (1999) p53 represses ribosomal gene transcription. Oncogene, 19, 1119-1124.
19. Voit,R., Schäfer,K. and Grummt,I. (1997) Mechanism of repression of RNA polymerase I transcription by the retinoblastoma protein. Mol. Cell. Biol., 17, 4230-4237.
20. Seither,P., Zatsepina,P., Hoffmann,M. and Grummt,I. (1997) Constitutive and strong association of PAF53 with RNA polymerase I. Chromosoma, 106, 216-225.
21. Muramatsu,M., Hayashi,Y., Onishi,T., Sakai,M. and Kashiyama,T. (1974) Rapid isolation of nucleoli from detergent purified nuclei of various tumor and tissue culture cells. Exp. Cell Res., 88, 345-351.
22. Lechner,T., Lusser,A., Brosch,G., Eberharter,A., Goralik-Schramel,M. and Loidl,P. (1996) A comparative study of histone deacetylases of plant, fungal and vertebrate cells. Biochim. Biophys. Acta, 1296, 181-188.
23. Hanada,K., Song,C.Z., Yamamoto,K., Yano,K., Maeda,Y., Yamaguchi,K. and Muramatsu,M. (1996) RNA polymerase I associated factor 53 binds to the nucleolar transcription factor UBF and functions in specific rDNA transcription. EMBO J., 15, 2217-2226.
24. Mais,C., Wright,J.E., Prieto,J.-L., Raggett,S.L. and McStay,B. (2005) UBF-binding site arrays form pseudo-NORs and sequester the RNA polymerase I transcription machinery. Genes Dev., 19, 50-64.
25. Schnapp,G., Santori,F., Carles,C., Riva,M. and Grummt,I. (1994) The HMG-box containing nucleolar transcription factor UBF interacts with a specific subunit of RNA polymerase I. EMBO J., 13, 190-199.
26. Bell,S.P., Learned,R.M., Jantzen,H.M. and Tjian,R. (1988) Functional cooperativity between transcription factors UBF1 and SL1 mediates human ribosomal RNA synthesis. Science, 241, 1192-1197.
27. Zhai,W. and Comai,L. (2000) Repression of RNA polymerase I transcription by the tumor suppressor p53. Mol. Cell. Biol., 20, 5930-5938.
28. 1-specific cdk-cyclin complexes activates the nucleolar transcription factor UBF. EMBO J., 18, 1891-1899.
29. Stefanovsky,V.Y., Pelletier,G., Hannan,R., Gagnon-Kugler,T., Rothblum,L.I. and Moss,T. (2001) An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF. Mol. Cell, 8, 1063-1073.
30. Hannan,K.M., Brandenburger,Y., Jenkins,A., Sharkey,K., Cavanaugh,A., Rothblum,L.I., Moss,T., Poortinga,G., McArthur,G.A., Pearson,R.B. et al. (2003)mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF. Mol. Cell. Biol., 23, 8862-8877.
31. Chan,H.M., Krstic-Demonacos,M., Smith,L., Demonacos,C. and La Thangue,N.B. (2001) Acetylation control of the retinoblastoma tumour-suppressor protein. Nature Cell Biol., 3, 667-674.
32. Gu,W. and Roeder,R.G. (1997) Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell, 90, 595-606.
33. Vervoorts,J., Lüscher-Firzlaff,J.M., Rottmann,S., Lilischkis,R., Walsemann,G., Dohmann,K., Austen,M. and Lüscher,B. (2003) Stimulation of c-myc transcriptional activity and acetylation by recruitement of the cofactor CBP. EMBO Rep., 4, 484-490.
34. Bode,A.M. and Dong,Z. (2004) Post-translational modification of p53 in tumorigenesis. Nature Rev. Cancer, 4, 793-805.
35. Choi,C.H., Hiromura,M. and Usheva,A. (2003) Transcription factor II B acetylates itself to regulate transcription. Nature, 424, 965-969.
36. Halkidou,K., Logan,I.R., Cook,S., Neal,D.E. and Robson,C.N. (2004) Putative involvement of the histone acetyltransferase Tip60 in ribosomal gene transcription. Nucleic Acids Res., 32, 1654-1665.
37. Bier,M., Fath,S. and Tschochner,H. (2004) The composition of the RNA polymerase I transcription machinery switches from initiation to elongation mode. FEBS Lett., 564, 41-46.
38. Grummt,I. and Pikaard,C.S. (2003) Epigenetic silencing of RNA polymerase I transcription. Nature Rev. Mol. Cell. Biol., 4, 641-649.