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1
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7044284602
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Reduction of consumptive coagulopathy using porcine cytomegalovirus-free cardiac porcine grafts in pig-to-primate xenotransplantation
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Mueller NJ, Kuwaki K, Dor FJ, et al. Reduction of consumptive coagulopathy using porcine cytomegalovirus-free cardiac porcine grafts in pig-to-primate xenotransplantation. Transplantation 2004; 78:1449-1453. In this paper, the concept of the 'indirect' effect of herpesviral infections (i.e. sequelae of infection extending beyond tissue damage alone) has been documented for porcine cytomegalovirus.
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Transplantation
, vol.78
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Mueller, N.J.1
Kuwaki, K.2
Dor, F.J.3
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2
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7044233724
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Herpesvirus infections in xenotransplantation: Pathogenesis and approaches
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Mueller NJ, Fishman JA. Herpesvirus infections in xenotransplantation: pathogenesis and approaches. Xenotransplantation 2004; 11:486-490.
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Xenotransplantation
, vol.11
, pp. 486-490
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Mueller, N.J.1
Fishman, J.A.2
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4
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Early weaning of piglets fails to exclude porcine lymphotropic herpesvirus
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Mueller NJ, Kuwaki K, Knosalla C, et al. Early weaning of piglets fails to exclude porcine lymphotropic herpesvirus. Xenotransplantation 2005; 12:59-62.
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Xenotransplantation
, vol.12
, pp. 59-62
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Mueller, N.J.1
Kuwaki, K.2
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5
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1842843632
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Novel herpesviruses of Suidae: Indicators for a second genogroup of artiodactyl gammaherpesviruses
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Ehlers B, Lowden S. Novel herpesviruses of Suidae: indicators for a second genogroup of artiodactyl gammaherpesviruses. J Gen Virol 2004; 85:857-862.
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, vol.85
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Ehlers, B.1
Lowden, S.2
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0035886155
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Human cytomegalovirus productively infects porcine endothelial cells in vitro
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Degre M, Ranneberg-Nilsen T, Beck S, et al. Human cytomegalovirus productively infects porcine endothelial cells in vitro. Transplantation 2001; 72:1334-1337.
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Degre, M.1
Ranneberg-Nilsen, T.2
Beck, S.3
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7
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16244363058
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Identification of pig circovirus type 2 in New Zealand pigs
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Garkavenko O, Elliott RB, Croxson MC. Identification of pig circovirus type 2 in New Zealand pigs. Transplant Proc 2005; 37:506-509.
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Transplant Proc
, vol.37
, pp. 506-509
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Garkavenko, O.1
Elliott, R.B.2
Croxson, M.C.3
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8
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7644236588
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Molecular characterization of porcine TT virus, an orphan virus, in pigs from six different countries
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McKeown NE, Fenaux M, Halbur PG, Meng XJ. Molecular characterization of porcine TT virus, an orphan virus, in pigs from six different countries. Vet Microbiol 2004; 104:113-117.
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Vet Microbiol
, vol.104
, pp. 113-117
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McKeown, N.E.1
Fenaux, M.2
Halbur, P.G.3
Meng, X.J.4
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9
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7044261072
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Molecular investigation of hepatitis E virus infection in domestic and miniature pigs used for medical experiments
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Tanaka H, Yoshino H, Kobayashi E, et al. Molecular investigation of hepatitis E virus infection in domestic and miniature pigs used for medical experiments. Xenotransplantation 2004; 11:503-510.
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Xenotransplantation
, vol.11
, pp. 503-510
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Tanaka, H.1
Yoshino, H.2
Kobayashi, E.3
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10
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2442568009
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Infection studies on human cell lines with porcine circovirus type 1 and porcine circovirus type 2
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Hattermann K, Roedner C, Schmitt C, et al. Infection studies on human cell lines with porcine circovirus type 1 and porcine circovirus type 2. Xenotransplantation 2004; 11:284-294.
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Xenotransplantation
, vol.11
, pp. 284-294
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Hattermann, K.1
Roedner, C.2
Schmitt, C.3
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11
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1442338656
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Transplanting encephalomyocarditis virus-infected porcine islet cells reverses diabetes in recipient mice but also transmits the virus
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Brewer L, LaRue R, Hering B, et al. Transplanting encephalomyocarditis virus-infected porcine islet cells reverses diabetes in recipient mice but also transmits the virus. Xenotransplantation 2004; 11:160-170. This article shows the need for careful surveillance of exogenous viruses.
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Xenotransplantation
, vol.11
, pp. 160-170
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Brewer, L.1
LaRue, R.2
Hering, B.3
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12
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7044253643
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Prevalent human coxsackie B-5 virus infects porcine islet cells primarily using the coxsackie-adenovirus receptor
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Myers SE, Brewer L, Shaw DP, et al. Prevalent human coxsackie B-5 virus infects porcine islet cells primarily using the coxsackie-adenovirus receptor. Xenotransplantation 2004; 11:536-546. This paper highlights an often neglected scenario, the infection of the xenograft by recipient-derived pathogens.
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(2004)
Xenotransplantation
, vol.11
, pp. 536-546
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Myers, S.E.1
Brewer, L.2
Shaw, D.P.3
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13
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23944490461
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Analysis of pig-to-human porcine endogenous retrovirus transmission in a triple-species kidney xenotransplantation model
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Winkler ME, Winkler M, Burian R, et al. Analysis of pig-to-human porcine endogenous retrovirus transmission in a triple-species kidney xenotransplantation model. Transpl Int 2005; 17:848-858. An elegant model of investigation using a human-derived interposition graft.
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Transpl Int
, vol.17
, pp. 848-858
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Winkler, M.E.1
Winkler, M.2
Burian, R.3
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14
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17444431233
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Lack of cross-species transmission of porcine endogenous retrovirus in pig-to-baboon xenotransplantation with sustained depletion of anti-alphagal antibodies
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Moscoso I, Hermida-Prieto M, Manez R, et al. Lack of cross-species transmission of porcine endogenous retrovirus in pig-to-baboon xenotransplantation with sustained depletion of anti-alphagal antibodies. Transplantation 2005; 79:777-782.
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Transplantation
, vol.79
, pp. 777-782
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Moscoso, I.1
Hermida-Prieto, M.2
Manez, R.3
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15
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13944267206
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Absence of PERV infection in baboons after transgenic porcine liver perfusion
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Nishitai R, Ikai I, Shiotani T, et al. Absence of PERV infection in baboons after transgenic porcine liver perfusion. J Surg Res 2005; 124:45-51.
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J Surg Res
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Nishitai, R.1
Ikai, I.2
Shiotani, T.3
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16
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16244402319
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Transplantation of micro- and macroencapsulated piglet islets into mice and monkeys
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Elliott RB, Escobar L, Calafiore R, et al. Transplantation of micro- and macroencapsulated piglet islets into mice and monkeys. Transplant Proc 2005; 37:466-469.
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Transplant Proc
, vol.37
, pp. 466-469
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Elliott, R.B.1
Escobar, L.2
Calafiore, R.3
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17
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16244406566
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Transplantation of neonatal porcine islets and Sertoli cells into nonimmunosuppressed nonhuman primates
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Isaac JR, Skinner S, Elliot R, et al. Transplantation of neonatal porcine islets and Sertoli cells into nonimmunosuppressed nonhuman primates. Transplant Proc 2005; 37:487-488.
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Transplant Proc
, vol.37
, pp. 487-488
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Isaac, J.R.1
Skinner, S.2
Elliot, R.3
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18
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23844513273
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Prevalence of porcine endogenous retrovirus in Chinese pig breeds and in patients treated with a porcine liver cell-based bioreactor
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Liu Q, Liu Z, Dalakas E. Prevalence of porcine endogenous retrovirus in Chinese pig breeds and in patients treated with a porcine liver cell-based bioreactor. World J Gastroenterol 2005; 11:4727-4730.
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World J Gastroenterol
, vol.11
, pp. 4727-4730
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Liu, Q.1
Liu, Z.2
Dalakas, E.3
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19
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20944450446
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No evidence of in vitro and in vivo porcine endogenous retrovirus infection after plasmapheresis through the AMC-bioartificial liver
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Di Nicuolo G, van de Kerkhove MP, Hoekstra R, et al. No evidence of in vitro and in vivo porcine endogenous retrovirus infection after plasmapheresis through the AMC-bioartificial liver. Xenotransplantation 2005; 12:286-292.
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(2005)
Xenotransplantation
, vol.12
, pp. 286-292
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Di Nicuolo, G.1
Van De Kerkhove, M.P.2
Hoekstra, R.3
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20
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17144426826
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The screening and identification of endogenous retrovirus free CEMPs
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Lu Q, Han H, Lian Z, et al. The screening and identification of endogenous retrovirus free CEMPs. Sci China C Life Sci 2004; 47:562-566. The development of swine lacking transmissible PERV would be a major advance in xenotransplantation. Further confirmation is needed.
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(2004)
Sci China C Life Sci
, vol.47
, pp. 562-566
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Lu, Q.1
Han, H.2
Lian, Z.3
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21
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3042753390
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No transmission of porcine endogenous retrovirus after transplantation of adult porcine islets into diabetic nude mice and immunosuppressed rats
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Goto M, Maeda A, Elfman L, et al. No transmission of porcine endogenous retrovirus after transplantation of adult porcine islets into diabetic nude mice and immunosuppressed rats. Xenotransplantation 2004; 11:340-346.
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(2004)
Xenotransplantation
, vol.11
, pp. 340-346
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Goto, M.1
Maeda, A.2
Elfman, L.3
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22
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23844514812
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Porcine endogenous retroviruses PERV-A and PERV-B infect neither mouse cells in vitro nor SCID mice in vivo
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Irgang M, Karlas A, Laue C, et al. Porcine endogenous retroviruses PERV-A and PERV-B infect neither mouse cells in vitro nor SCID mice in vivo. Intervirology 2005; 48:167-173.
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(2005)
Intervirology
, vol.48
, pp. 167-173
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Irgang, M.1
Karlas, A.2
Laue, C.3
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23
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3042826829
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Porcine endogenous retroviral nucleic acid in peripheral tissues is associated with migration of porcine cells post islet transplant
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Binette TM, Seeberger KL, Lyon JG, et al. Porcine endogenous retroviral nucleic acid in peripheral tissues is associated with migration of porcine cells post islet transplant. Am J Transplant 2004; 4:1051-1060. The difficulty of distinguishing between microchimersim and true infection is clearly documented in this paper.
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(2004)
Am J Transplant
, vol.4
, pp. 1051-1060
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Binette, T.M.1
Seeberger, K.L.2
Lyon, J.G.3
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24
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20444410422
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Prevention of PERV infections in pig to human xenotransplantation by the RNA interference silences gene
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Tokyo
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Miyagawa S, Nakatsu S, Nakagawa T, et al. Prevention of PERV infections in pig to human xenotransplantation by the RNA interference silences gene. J Biochem (Tokyo) 2005; 137:503-508. For the first time, RNA interference as a potential method of controlling PERV transmission is documented with porcine cells.
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(2005)
J Biochem
, vol.137
, pp. 503-508
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Miyagawa, S.1
Nakatsu, S.2
Nakagawa, T.3
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25
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3042611661
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Inhibition of porcine endogenous retroviruses by RNA interference: Increasing the safety of xenotransplantation
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Karlas A, Kurth R, Denner J. Inhibition of porcine endogenous retroviruses by RNA interference: increasing the safety of xenotransplantation. Virology 2004; 325:18-23.
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(2004)
Virology
, vol.325
, pp. 18-23
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Karlas, A.1
Kurth, R.2
Denner, J.3
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26
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0036598540
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Microchimerism and transmission of porcine endogenous retrovirus from a pig cell line or specific pathogen-free pig islets to mouse tissues and human cells during xenografts in nude mice
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Clemenceau B, Jegou D, Martignat L, Sai P. Microchimerism and transmission of porcine endogenous retrovirus from a pig cell line or specific pathogen-free pig islets to mouse tissues and human cells during xenografts in nude mice. Diabetologia 2002; 45:914-923.
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Diabetologia
, vol.45
, pp. 914-923
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Clemenceau, B.1
Jegou, D.2
Martignat, L.3
Sai, P.4
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27
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1842682754
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Natural antibodies prevent in vivo transmission of porcine islet-derived endogenous retrovirus to human cells
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McKane BW, Ramachandran S, Xu XC, et al. Natural antibodies prevent in vivo transmission of porcine islet-derived endogenous retrovirus to human cells. Cell Transplant 2004; 13:137-143.
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Cell Transplant
, vol.13
, pp. 137-143
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McKane, B.W.1
Ramachandran, S.2
Xu, X.C.3
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28
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2942617088
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Porcine cell microchimerism but lack of productive porcine endogenous retrovirus (PERV) infection in naive and humanized SCID-beige mice treated with porcine peripheral blood mononuclear cells
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Kuddus RH, Metes DM, Nalesnik MA, et al. Porcine cell microchimerism but lack of productive porcine endogenous retrovirus (PERV) infection in naive and humanized SCID-beige mice treated with porcine peripheral blood mononuclear cells. Transpl Immunol 2004; 13:15-24.
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Transpl Immunol
, vol.13
, pp. 15-24
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Kuddus, R.H.1
Metes, D.M.2
Nalesnik, M.A.3
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29
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85047691376
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Mouse retrovirus mediates porcine endogenous retrovirus transmission into human cells in long-term human-porcine chimeric mice
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Yang YG, Wood JC, Lan P, et al. Mouse retrovirus mediates porcine endogenous retrovirus transmission into human cells in long-term human-porcine chimeric mice. J Clin Invest 2004; 114:695-700. This pivotal paper reports for the first time that transmission of PERV from pig to human cells in the mouse model is mediated by pseudotyping. This important finding questions recent findings of pig-to-human PERV transmission in mouse models. The role of pseudotyping as a means of broadening viral tropism will need careful assessment, however.
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(2004)
J Clin Invest
, vol.114
, pp. 695-700
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Yang, Y.G.1
Wood, J.C.2
Lan, P.3
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30
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22844444094
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Pseudotyping of porcine endogenous retrovirus by xenotropic murine leukemia virus in a pig islet xenotransplantation model
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Martina Y, Kurian S, Cherqui S, et al. Pseudotyping of porcine endogenous retrovirus by xenotropic murine leukemia virus in a pig islet xenotransplantation model. Am J Transplant 2005; 5:1837-1847. These authors extend the findings of Yang et al. Ref. [29] using human-tropic PERV-A and PERV-B.
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(2005)
Am J Transplant
, vol.5
, pp. 1837-1847
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Martina, Y.1
Kurian, S.2
Cherqui, S.3
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31
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3543060485
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Porcine endogenous retroviruses infect cells lacking cognate receptors by an alternative pathway: Implications for retrovirus evolution and xenotransplantation
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Lavillette D, Kabat D. Porcine endogenous retroviruses infect cells lacking cognate receptors by an alternative pathway: implications for retrovirus evolution and xenotransplantation. J Virol 2004; 78:8868-8877. Transmission of PERV can occur even in the absence of its cognate receptor. This alternative pathway considerably enlarges the tropism of PERV and has important implications for its infectious potential.
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(2004)
J Virol
, vol.78
, pp. 8868-8877
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Lavillette, D.1
Kabat, D.2
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32
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4043149343
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Characterization of germline porcine endogenous retroviruses from Large White pig
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Scobie L, Taylor S, Logan NA, et al. Characterization of germline porcine endogenous retroviruses from Large White pig. J Gen Virol 2004; 85:2421-2428.
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(2004)
J Gen Virol
, vol.85
, pp. 2421-2428
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Scobie, L.1
Taylor, S.2
Logan, N.A.3
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33
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10044284510
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Evidence and consequence of porcine endogenous retrovirus recombination
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Bartosch B, Stefanidis D, Myers R, et al. Evidence and consequence of porcine endogenous retrovirus recombination. J Virol 2004; 78:13880-13890. Shows that PERV-A preferentially recombines with PERV-C to generate a more infectious recombinant PERV-A/C.
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(2004)
J Virol
, vol.78
, pp. 13880-13890
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Bartosch, B.1
Stefanidis, D.2
Myers, R.3
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34
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10044242836
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Determinants of high titer in recombinant porcine endogenous retroviruses
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Harrison I, Takeuchi Y, Bartosch B, Stoye JP. Determinants of high titer in recombinant porcine endogenous retroviruses. J Virol 2004; 78:13871-13879. This paper describes mechanisms leading to an increased infectivity of recombined PERV-A/C.
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(2004)
J Virol
, vol.78
, pp. 13871-13879
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Harrison, I.1
Takeuchi, Y.2
Bartosch, B.3
Stoye, J.P.4
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35
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21244445014
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Porcine endogenous retrovirus encodes xenoantigens involved in porcine cellular xenograft rejection by mice
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Simeonovic CJ, Ziolkowski AF, Popp SK, et al. Porcine endogenous retrovirus encodes xenoantigens involved in porcine cellular xenograft rejection by mice. Transplantation 2005; 79:1674-1682. Shows that PERV acts as a xenoantigen and enhances xenograft rejection.
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(2005)
Transplantation
, vol.79
, pp. 1674-1682
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Simeonovic, C.J.1
Ziolkowski, A.F.2
Popp, S.K.3
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36
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2542546542
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Human immune responses to porcine endogenous retrovirus-derived peptides presented naturally in the context of porcine and human major histocompatibility complex class I molecules: Implications in xenotransplantation of porcine organs
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Ramachandran S, Jaramillo A, Xu XC, et al. Human immune responses to porcine endogenous retrovirus-derived peptides presented naturally in the context of porcine and human major histocompatibility complex class I molecules: implications in xenotransplantation of porcine organs. Transplantation 2004; 77:1580-1588. Shows that PERV-derived CD8-restricted epitopes add to the immunogenicity of xenografts.
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(2004)
Transplantation
, vol.77
, pp. 1580-1588
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Ramachandran, S.1
Jaramillo, A.2
Xu, X.C.3
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37
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1942471983
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Activation of primary porcine endothelial cells induces release of porcine endogenous retroviruses
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Cunningham DA. Dos Santos Cruz GJ, Fernandez-Suarez XM, et al. Activation of primary porcine endothelial cells induces release of porcine endogenous retroviruses Transplantation 2004; 77:1071-1079. Activation of the endothelial interface between recipient and xenograft induces release of PERV.
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(2004)
Transplantation
, vol.77
, pp. 1071-1079
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Cunningham, D.A.1
Dos Santos Cruz, G.J.2
Fernandez-Suarez, X.M.3
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38
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0347064333
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Monitoring for potentially xenozoonotic viruses in New Zealand pigs
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Garkavenko O, Muzina M, Muzina Z, et al. Monitoring for potentially xenozoonotic viruses in New Zealand pigs. J Med Virol 2004; 72:338-344.
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(2004)
J Med Virol
, vol.72
, pp. 338-344
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Garkavenko, O.1
Muzina, M.2
Muzina, Z.3
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39
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14644406764
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Prevention, detection, and management of early bacterial and fungal infections in a preclinical cardiac xenotransplantation model that achieves prolonged survival
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Teotia SS, Walker RC, Schirmer JM, et al. Prevention, detection, and management of early bacterial and fungal infections in a preclinical cardiac xenotransplantation model that achieves prolonged survival. Xenotransplantation 2005; 12:127-133.
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(2005)
Xenotransplantation
, vol.12
, pp. 127-133
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Teotia, S.S.1
Walker, R.C.2
Schirmer, J.M.3
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40
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0742271153
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Control of microbial contamination during surgical harvest of pig renal xenografts
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Tucker AW, Foweraker JE, Belcher CE, et al. Control of microbial contamination during surgical harvest of pig renal xenografts. Xenotransplantation 2004; 11:91-96.
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(2004)
Xenotransplantation
, vol.11
, pp. 91-96
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Tucker, A.W.1
Foweraker, J.E.2
Belcher, C.E.3
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41
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17144421240
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Reluctance of French patients with type 1 diabetes to undergo pig pancreatic islet xenotransplantation
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Deschamps JY, Roux FA, Gouin E, Sai P. Reluctance of French patients with type 1 diabetes to undergo pig pancreatic islet xenotransplantation. Xenotransplantation 2005; 12:175-180. Infectious risk as a major danger of xenotransplantation still ranks high in public opinion and in the potential recipients of a xenograft.
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(2005)
Xenotransplantation
, vol.12
, pp. 175-180
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Deschamps, J.Y.1
Roux, F.A.2
Gouin, E.3
Sai, P.4
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42
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8644235766
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Monitoring for presence of potentially xenotic viruses in recipients of pig islet xenotransplantation
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Garkavenko O, Croxson MC, Irgang M, et al. Monitoring for presence of potentially xenotic viruses in recipients of pig islet xenotransplantation. J Clin Microbiol 2004; 42:5353-5356. No evidence of PERV transmission was found in this group of 14 patients, with a maximum follow-up of 9 years. Except for one, none of the recipients was immunosuppressed.
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(2004)
J Clin Microbiol
, vol.42
, pp. 5353-5356
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Garkavenko, O.1
Croxson, M.C.2
Irgang, M.3
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43
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Xenotransplantation of porcine neonatal islets of Langerhans and Sertoli cells: A 4-year study
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Valdes-Gonzalez RA, Dorantes LM, Garibay GN, et al. Xenotransplantation of porcine neonatal islets of Langerhans and Sertoli cells: a 4-year study. Eur J Endocrinol 2005; 153:419-427.
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Eur J Endocrinol
, vol.153
, pp. 419-427
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Valdes-Gonzalez, R.A.1
Dorantes, L.M.2
Garibay, G.N.3
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