Antioxidants reverse depression of the hypoxic ventilatory response by acetazolamide in man

Journal of Physiology

Volumn 572, Issue 3, 2006, Pages 849-856

  Teppema, Luc J ^a   Bijl, Hans ^a   Romberg, Raymonda R ^a   Dahan, Albert ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAZOLAMIDE; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; ASCORBINEZUUR CF; CARBON DIOXIDE; CARBONATE DEHYDRATASE; OXYHEMOGLOBIN; PLACEBO; POTASSIUM CHANNEL;

ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; BLOOD GAS ANALYSIS; BREATHING REFLEX; CAROTID BODY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG ANTAGONISM; DRUG EFFECT; DRUG MECHANISM; FEMALE; HUMAN; HYPERCAPNIA; HYPOXIA; MALE; OXIDATION REDUCTION REACTION; OXYGEN SATURATION; OXYGEN SENSING; PRIORITY JOURNAL; REGULATORY MECHANISM; ARTERIAL PH; BREATHING; CARBON DIOXIDE BREATHING; NORMAL HUMAN; OXIDATION REDUCTION STATE; OXYGEN CONSUMPTION;

ACETAZOLAMIDE; ADULT; ANOXIA; ANTIOXIDANTS; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; FEMALE; HUMANS; INJECTIONS, INTRAVENOUS; MALE; OXYGEN; PLACEBO EFFECT; PULMONARY VENTILATION;

EID: 33645812962     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2005.104174     Document Type: Article

References (47)

1. Bailey DM (2003). Radical dioxygen: From gas to (unpaired!) electrons. Adv Exp Med Biol 543, 201-221.
2. Bartsch P, Bailey DM, Berger MM, Knauth M & Baumgartner RW (2004). Acute mountain sickness: Controversies and advances. High Alt Med Biol 5, 110-124.
3. Bendahhou S, Cunmmins TR, Griggs RC, Fu YH & Ptacek LJ (2001). Sodium channel inactivation defects are associated with acetazolamide-exacerbated hypokalemic periodic paralysis. Ann Neurol 50, 417-420.
4. Buckler KJ, Vaughan-Jones RD, Peers C & Nye PC (1991). Intracellular pH and its regulation in isolated type I carotid body cells of the neonatal rat. J Physiol 436, 107-129.
5. Buckler KJ, Williams BA & Honore E (2000). An oxygen-, acid- and anaesthetic-sensitive TASK-like background potassium channel in rat arterial chemoreceptor cells. J Physiol 525, 135-142.
6. Burton GW, Joyce A & Ingold KU (1983). Is vitamin E the only lipid-soluble, chain-breaking antioxidant in human blood plasma and erythrocyte membranes?Arch Biochem Biophys 221, 281-290.
7. Ciftci M, Bülbül M, Gül M, Gümüstekin K, Dane S & Süleyman H (2005). Effects of nicotine and vitamin E on carbonic anhydrase activity in some rat tissues i n vivo and in vitro. J Enzyme Inhib Med Chem 20, 103-108.
8. Dahan A, van den Elsen MJ, Berkenbosch A, DeGoede J, Olievier IC, van Kleef JW & Bovill JG (1994). Effects of subanesthetic halothane on the ventilatory responses to hypercapnia and acute hypoxia in healthy volunteers. Anesthesiology 80, 727-738.
9. Frei B, England L & Ames BN (1989). Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci U S A 86, 6377-6381.
10. Gonzalez C, Almaraz L, Obeso A & Rigual R (1994). Carotid body chemoreceptors: From natural stimuli to sensory discharges. Physiol Rev 74, 829-898.
11. Gonzalez C, Sanz-Alfayate G, Agapito MT, Gomez-Nino A, Rocher A & Obeso A (2002). Significance of ROS in oxygen sensing in cell systems with sensitivity to physiological hypoxia. Respir Physiol Neurobiol 132, 17-41.
12. 2 chemosensitivity. Blood 99, 1552-1555.
13. Hohne C, Krebs MO, Seiferheld M, Boemke W, Kaczmarczyk G & Swenson ER (2004). Acetazolamide prevents hypoxic pulmonary vasoconstriction in conscious dogs. J Appl Physiol 97, 515-521.
14. Holder LB & Hayes SL (1965). Diffusion of sulfonamides in aqueous buffers and into red cells. Mol Pharmacol 1, 266-279.
15. Hurt JD, Tu C & Laipis PJ (1998). Isolation and expression of murine carbonic anhydrase IV. Protein Expr Purif 12, 7-16.
16. 2 catalyzed by carbonic anhydrase III from cat muscle. J Biol Chem 260, 3484-3489.
17. Kourie JI (1998). Interaction of reactive oxygen species with ion transport mechanisms. Am J Physiol 275, C1-C24.
18. Kronenberg RS & Drage CW (1973). Attenuation of the ventilatory and heart rate responses to hypoxia and hypercapnia with aging in normal men. J Clin Invest 52, 1812-1819.
19. Lahiri S (2000). Historical perspectives of cellular oxygen sensing and responses to hypoxia. J Appl Physiol 88, 1467-1473.
20. Lehmann B, Linner E & Wistrand PJ (1969). The pharmacokinetics of acetazolamide in relation to its use in the treatment of glaucoma and to its effect as an inhibitor of carbonic anhydrases. Adv Biosci 5, 197-217.
21. Liu Y & Gutterman DD (2002). Oxidative stress and potassium channel function. Clin Exp Pharmacol Physiol 29, 305-311.
22. Perez-Garcia MT, Colinas O, Miguel-Velado E, Moreno Dominguez A & Lopez-Lopez JR (2004). Characterisation of the Kv channels of mouse carotid body chemoreceptors cells and their role in oxygen sensing. J Physiol 557, 457-471.
23. 2+] in oxygen-sensing tissues. Respir Physiol 115, 215-227.
24. 2+ channels by carbonic anhydrase inhibitors. J Pharmacol Sci 95, 240-247.
25. Maren TH (1967). Carbonic anhydrase: Chemistry, physiology and inhibition. Physiol Rev 47, 595-761.
26. Maren TH (1977). Use of inhibitors in physiological studies of carbonic anhydrase. Am J Physiol 232, F291-F297.
27. Maren TH & Robinson B (1960). The pharmacology of acetazolamide as related to cerebrospinal fluid and the treatment of hydrocephalus. Bull Johns Hopkins Hosp 106, 1-24.
28. Moore DE (2002). Drug-induced cutaneous photosensitivity: Incidence, mechanism, prevention and management. Drug Saf 25, 345-372.
29. Peterson DD, Pack AI, Silage DA & Fishman AP (1981). Effects of aging on ventilatory and occlusion pressure responses to hypoxia and hypercapnia. Am Rev Respir Dis 124, 387-391.
30. Pickkers P, Garcha RS, Schachter M, Smits P & Hughes AD (1999). Inhibition of carbonic anhydrase accounts for the direct vascular effects of hydrochlorothiazide. Hypertension 33, 1043-1048.
31. Pokorski M & Marczak M (2003). Ascorbic acid enhances hypoxic ventilatory reactivity in elderly subjects. J Int Med Res 31, 448-457.
32. Prabhakar N (2000). Oxygen sensing by the carotid body chemoreceptors. J Appl Physiol 88, 2287-2295.
33. Raisanen SR, Lehenkari P, Tasanen M, Rahkila P, Harkonen PL & Vaananen HK (1999). Carbonic anhydrase III protects cells from hydrogen peroxide-induced apoptosis. FASEB J 13, 513-522.
34. + channels of rat chemoreceptor cells by a membrane-restricted and CO-sensitive mechanism. Circ Res 89, 430-436.
35. Selvaag E (1996). Inhibition of thiazide photohemolysis in vitro by antioxidants and a nitrogen atmosphere. Photodermatol Photoimmunol Photomed 12, 211-215.
36. Swenson ER & Hughes JM (1993). Effects of acute and chronic acetazolamide on resting ventilation and ventilatory responses in men. J Appl Physiol 74, 230-237.
37. Teppema LJ & Dahan A (2004). Low-dose acetazolamide reduces the hypoxic ventilatory response in the anesthetized cat. Respir Physiol Neurobiol 140, 43-51.
38. 2 stimulus interaction within the peripheral chemoreceptors in the anaesthetised cat. J Physiol 537, 221-229.
39. Teppema LJ, Nieuwenhuijs D, Sarton E, Romberg R, Olievier CN, Wards DS & Dahan A (2002). Antioxidants prevent depression of the acute hypoxic ventilatory response by subanaesthetic halothane in men. J Physiol 544, 931-938.
40. Teppema LJ, Rochette F & Demedts M (1992). Ventilatory effects of acetazolamide in cats during hypoxemia. J Appl Physiol 72, 1717-1723.
41. Teppema LJ, Romberg RR & Dahan A (2005). Antioxidants reverse reduction of the human hypoxic ventilatory response by subanesthetic isoflurane. Anesthesiology 102, 47-53.
42. Tricarico D, Barbieri M, Mele A, Carbonara G & Camerino DC (2004). Carbonic anhydrase inhibitors are specific openers of skeletal musclee BK channel of K + -deficient rats. FASEB J 18, 760-761.
43. van den Elsen MJLJ, Dahan A, DeGoede J, Berkenbosch A & van Kleef J (1995). Influences of subanesthetic isoflurane on ventilatory control in humans. Anesthesiology 83, 478-490.
44. Williams SE, Wootton P, Mason MS, Bould J, Iles DE, Riccardi D, Peers C & Kemp PJ (2004). Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel. Science 306, 2093-2097.
45. Wyatt CN & Peers C (1995). Ca 2+ -activated K+ channels in isolated type I cells of the neonatal rat carotid body. J Physiol 483, 559-565.
46. Yamamoto Y, Fujimura M, Nishita T, Nishijima K, Atoji Y & Suzuki Y (2003). Immunohistochemical localization of carbonic anhydrase isozymes in the rat carotid body. J Anat 202, 573-577.
47. Yano I, Takayama A, Takano M, Inatami M, Tanihara H, Ogura I, Honda Y & Inui K (1998). Pharmacokinetics and pharmacodynamics of acetazolamide in patients with transient intraocular pressure elevation. Eur J Clin Pharmacol 54, 63-68.